Modulation of Hair Growth with Small Molecule Agonists of the Hedgehog Signaling Pathway View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2005-10

AUTHORS

Rudolph D Paladini, Jacqueline Saleh, Changgeng Qian, Guang-Xin Xu, Lee L Rubin

ABSTRACT

The hedgehog (Hh) family of intercellular signaling proteins is intricately linked to the development and patterning of almost every major vertebrate organ system. In the skin, sonic hedgehog (Shh) is required for hair follicle morphogenesis during embryogenesis and for regulating follicular growth and cycling in the adult. We recently described the identification and characterization of synthetic, non-peptidyl small molecule agonists of the Hh pathway. In this study, we examined the ability of a topically applied Hh-agonist to modulate follicular cycling in adult mouse skin. We report that the Hh-agonist can stimulate the transition from the resting (telogen) to the growth (anagen) stage of the hair cycle in adult mouse skin. Hh-agonist-induced hair growth caused no detectable differences in epidermal proliferation, differentiation, or in the endogenous Hh-signaling pathway as measured by Gli1, Shh, Ptc1, and Gli2 gene expression when compared with a normal hair cycle. In addition, we demonstrate that Hh-agonist is active in human scalp in vitro as measured by Gli1 gene expression. These results suggest that the topical application of Hh-agonist could be effective in treating conditions of decreased proliferation and aberrant follicular cycling in the scalp including androgenetic alopecia (pattern hair loss). More... »

PAGES

638-646

References to SciGraph publications

  • 1980-10. Mutations affecting segment number and polarity in Drosophila in NATURE
  • 2000-03. Basal cell carcinomas in mice overexpressing Gli2 in skin in NATURE GENETICS
  • 1998-01. Activating Smoothened mutations in sporadic basal-cell carcinoma in NATURE
  • 1998-12. A Novel Human Type II Cytokeratin, K6hf, Specifically Expressed in the Companion Layer of the Hair Follicle in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2000-05. Conditional Disruption of Hedgehog Signaling Pathway Defines its Critical Role in Hair Development and Regeneration in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2001-07. A Comprehensive Guide for the Accurate Classification of Murine Hair Follicles in Distinct Hair Cycle Stages in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 1997-10. Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours in NATURE
  • 2002-12. Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists in BMC BIOLOGY
  • 1993-07. Melanogenesis Is Coupled to Murine Anagen: Toward New Concepts for the Role of Melanocytes and the Regulation of Melanogenesis in Hair Growth in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 1996-10. Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function in NATURE
  • 1999-11. Ultraviolet and ionizing radiation enhance the growth of BCCs and trichoblastomas in patched heterozygous knockout mice in NATURE MEDICINE
  • 2004-11. Tissue repair and stem cell renewal in carcinogenesis in NATURE
  • 2004-06. GLI2 Is Expressed in Normal Human Epidermis and BCC and Induces GLI1 Expression by Binding to its Promoter in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • Journal

    TITLE

    Journal of Investigative Dermatology

    ISSUE

    4

    VOLUME

    125

    Author Affiliations

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1111/j.0022-202x.2005.23867.x

    DOI

    http://dx.doi.org/10.1111/j.0022-202x.2005.23867.x

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1030241689

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/16185261


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    N-Triples is a line-based linked data format ideal for batch operations.

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    RDF/XML is a standard XML format for linked data.

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