Ontology type: schema:ScholarlyArticle Open Access: True
2005-02
AUTHORSKlaus J Busam, Hui Zhao, Daniel G Coit, Derya Kucukgol, Achim A Jungbluth, Jennifer Nobrega, Agnes Viale
ABSTRACTDesmoplastic melanoma (DM) is a variant of melanoma characterized by the presence of amelanotic fusiform melanocytes dispersed in a prominent collagenous stroma. DM behaves differently from conventional non-desmoplastic melanoma (NDM). It has a higher tendency for local recurrence and is less likely to metastasize to regional lymph nodes. In this study, we explored the possibility of distinguishing DM from NDM by gene expression profiling. RNA samples from ten primary cutaneous melanomas of similar depth of invasion were analyzed using the Affymetrix U133A oligonucleotide platform. Four tumors were DM, five were ND, and one tumor showed combined features of desmoplastic and conventional. Hierarchical cluster analysis clearly separated DM from NDM. The expression of a number of melanocyte differentiation genes was decreased in DM compared with NDM, which corresponded to immunohistochemical results. Various genes were upregulated in DM, including neurotrophic factors and genes involved in extracellular matrix production. A novel finding was the high expression of clusterin in DM, which was confirmed by immunohistochemical studies. Our results from gene expression profiling validate the distinction of DM from NDM. They also provide the opportunity to learn more about the biology of DM which had previously not yet been associated with this variant of melanoma. More... »
PAGES412-419
http://scigraph.springernature.com/pub.10.1111/j.0022-202x.2004.23600.x
DOIhttp://dx.doi.org/10.1111/j.0022-202x.2004.23600.x
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/15675962
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"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000424.jsonl",
"type": "ScholarlyArticle",
"url": "http://www.nature.com/jid/journal/v124/n2/full/5602703a.html"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1111/j.0022-202x.2004.23600.x'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1111/j.0022-202x.2004.23600.x'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1111/j.0022-202x.2004.23600.x'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1111/j.0022-202x.2004.23600.x'
This table displays all metadata directly associated to this object as RDF triples.
289 TRIPLES
21 PREDICATES
85 URIs
33 LITERALS
21 BLANK NODES