Proteome Analysis of Skin Distinguishes Acute Guttate from Chronic Plaque Psoriasis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2005-01

AUTHORS

Lina M Carlén, Fabio Sánchez, Ann-Charlotte Bergman, Susanne Becker, Daniel Hirschberg, Bo Franzén, Jonathan Coffey, Hans Jörnvall, Gert Auer, Ayodele A Alaiya, Mona Ståhle

ABSTRACT

Psoriasis is a disease with considerable heterogeneity in clinical presentation. This is the first study using two-dimensional gel electrophoresis to compare global protein expression patterns in lesional and non-lesional skin from subjects with acute guttate psoriasis associated with streptococcal throat infection and chronic plaque psoriasis. Samples from experimentally induced contact eczema and normal skin from healthy controls were also included. Proteins with statistically significant differences in expression were used in hierarchical cluster analyses resulting in separation of the different samples into groups. Chronic plaque and guttate psoriasis samples were distinctly separated, indicating that they represent discrete phenotypes at the protein expression level. Interestingly, there was a trend in which guttate psoriasis lesions clustered closer to eczema than to chronic plaque psoriasis lesions, indicating that the duration of the inflammatory reaction may affect clustering. Several of the differentially expressed proteins were identified by mass spectrometry. More... »

PAGES

63-69

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1111/j.0022-202x.2004.23501.x

DOI

http://dx.doi.org/10.1111/j.0022-202x.2004.23501.x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1007090522

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15654954


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