Induction of RANTES by TWEAK/Fn14 Interaction in Human Keratinocytes View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2004-05

AUTHORS

Long Jin, Atsuhito Nakao, Masafumi Nakayama, Noriko Yamaguchi, Yuko Kojima, Nobuhiro Nakano, Ryoji Tsuboi, Ko Okumura, Hideo Yagita, Hideoki Ogawa

ABSTRACT

TNF-like weak inducer of apoptosis (TWEAK), a member of the tumor necrosis factor (TNF) family, is a multifunctional cytokine that regulate cellular proliferation, angiogenesis, inflammation, and apoptosis. In this study, we investigated the effect of TWEAK on human keratinocytes. Primary cultured normal human keratinocytes constitutively expressed a TWEAK receptor, fibroblast growth factor-inducible 14 (Fn14), and produced regulated on activation, normal T expressed and secreted (RANTES) upon TWEAK stimulation in a concentration-dependent manner. The TWEAK-induced RANTES production was abrogated by anti-Fn14 antibody, and synergistically augmented by simultaneous stimulation with transforming growth factor-beta. In addition, human keratinocytes differentiated in vitro with high Ca(2+)-containing medium showed enhanced production of RANTES upon TWEAK stimulation. Furthermore, TWEAK induced rapid phosphorylation of IkappaB-alpha in human keratinocytes. Collectively, TWEAK acts on human keratinocytes as an inducer of RANTES via Fn14. Because RANTES has been implicated in inflammation, TWEAK/Fn14 interaction in human keratinocytes may be involved in the pathophysiology of inflammatory skin disorders. More... »

PAGES

1175-1179

Identifiers

URI

http://scigraph.springernature.com/pub.10.1111/j.0022-202x.2004.22419.x

DOI

http://dx.doi.org/10.1111/j.0022-202x.2004.22419.x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1004042735

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15140220


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