The Activated Keratinocyte: A Model for Inducible Cytokine Production by Non-Bone-Marrow-Derived Cells in Cutaneous Inflammatory and Immune Responses View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1990-06

AUTHORS

T S Kupper

ABSTRACT

Keratinocytes, fibroblasts, endothelial cells, and other sessile cells resident to human skin can be induced in vitro to synthesize and secrete cytokine molecules. Cytokines are small protein molecules produced upon injury or cellular activation which influence immune and inflammatory events; as such, they have been best understood previously as products of leukocytes. The appreciation that cultured non-bone marrow-derived cells from skin could produce cytokines capable of initiating an inflammatory response or facilitating an immune response has led to speculation that cells resident to skin may be less passive participants in such phenomena than previously thought. Using as a model the cultured keratinocyte, which produces both interleukin-1 alpha and beta and an interleukin-1 receptor, models of autocrine and paracrine activation of this cell have been constructed. Such "activated keratinocytes," or by analogy other activated resident skin cells, produce a spectrum of cytokines in vitro which could potentially influence leukocyte adhesion to endothelium, direction migration of leukocytes towards the activated cell (presumably an inflammatory nidus), and activation of leukocyte functions in situ. The putative role of regulation of cytokine and cytokine-receptor regulation in mediating the activation of such cells (and thus, presumably, local inflammation) is discussed. An important aspect of this hypothetical model is that in the absence of activation (which characterizes normal uninflamed skin), cytokine production and its consequences do not occur. The conclusion reached is that based on in vitro data it is plausible to guess that local inflammatory or immune responses can be both initiated and facilitated by locally produced cytokines. More... »

PAGES

146s-150s

Identifiers

URI

http://scigraph.springernature.com/pub.10.1111/1523-1747.ep12876130

DOI

http://dx.doi.org/10.1111/1523-1747.ep12876130

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1023815507

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2141048


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibody Formation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biological Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytokines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dermatitis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interleukin-1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Keratinocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Biological", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Immunologic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Interleukin-1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Skin", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Washington University in St. Louis", 
          "id": "https://www.grid.ac/institutes/grid.4367.6", 
          "name": [
            "Department of Medicine (Dermatology), Washington University School of Medicine, St. Louis, Missouri 63110."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kupper", 
        "givenName": "T S", 
        "id": "sg:person.01342556166.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01342556166.43"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1111/1523-1747.ep12284068", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000889406", 
          "https://doi.org/10.1111/1523-1747.ep12284068"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.86.9.3045", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003408628"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci112141", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005920223"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1749-6632.1989.tb24038.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009797576"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.86.20.8029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012723354"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci113792", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014780442"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1111/1523-1747.ep12462420", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016329823", 
          "https://doi.org/10.1111/1523-1747.ep12462420"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.107.1.321", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018210299"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0167-5699(86)90124-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018895544"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.86.20.8034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019301690"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archderm.1989.01670220102017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020917500"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/1043-4666(89)91314-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021584828"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(89)90775-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027916931"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/343336a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030451293", 
          "https://doi.org/10.1038/343336a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1111/1523-1747.ep12461024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032833482", 
          "https://doi.org/10.1111/1523-1747.ep12461024"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1749-6632.1988.tb18826.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035182081"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.86.16.6367", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038193858"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.167.4.1323", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040130262"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci113090", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042580794"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000372-198710000-00007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042698147"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000372-198710000-00007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042698147"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.164.6.2095", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042990023"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/1043-4666(89)91222-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043411239"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.86.4.1273", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044499692"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1111/1523-1747.ep12470545", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048192447", 
          "https://doi.org/10.1111/1523-1747.ep12470545"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/1043-4666(89)91081-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048487847"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1749-6632.1988.tb18814.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049243248"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.84.24.9238", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050984308"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/1043-4666(89)91516-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051995899"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archderm.125.10.1406", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054097644"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.2969618", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062577598"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078904178", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079354535", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079504443", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079646324", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079663959", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1990-06", 
    "datePublishedReg": "1990-06-01", 
    "description": "Keratinocytes, fibroblasts, endothelial cells, and other sessile cells resident to human skin can be induced in vitro to synthesize and secrete cytokine molecules. Cytokines are small protein molecules produced upon injury or cellular activation which influence immune and inflammatory events; as such, they have been best understood previously as products of leukocytes. The appreciation that cultured non-bone marrow-derived cells from skin could produce cytokines capable of initiating an inflammatory response or facilitating an immune response has led to speculation that cells resident to skin may be less passive participants in such phenomena than previously thought. Using as a model the cultured keratinocyte, which produces both interleukin-1 alpha and beta and an interleukin-1 receptor, models of autocrine and paracrine activation of this cell have been constructed. Such \"activated keratinocytes,\" or by analogy other activated resident skin cells, produce a spectrum of cytokines in vitro which could potentially influence leukocyte adhesion to endothelium, direction migration of leukocytes towards the activated cell (presumably an inflammatory nidus), and activation of leukocyte functions in situ. The putative role of regulation of cytokine and cytokine-receptor regulation in mediating the activation of such cells (and thus, presumably, local inflammation) is discussed. An important aspect of this hypothetical model is that in the absence of activation (which characterizes normal uninflamed skin), cytokine production and its consequences do not occur. The conclusion reached is that based on in vitro data it is plausible to guess that local inflammatory or immune responses can be both initiated and facilitated by locally produced cytokines.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1111/1523-1747.ep12876130", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1020153", 
        "issn": [
          "0022-202X", 
          "1523-1747"
        ], 
        "name": "Journal of Investigative Dermatology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "94"
      }
    ], 
    "name": "The Activated Keratinocyte: A Model for Inducible Cytokine Production by Non-Bone-Marrow-Derived Cells in Cutaneous Inflammatory and Immune Responses", 
    "pagination": "146s-150s", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "7175fcbce075518eac6e57d2881be9bdd08081a2dfc5399f3ab89c371e89fdee"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "2141048"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0426720"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1111/1523-1747.ep12876130"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1023815507"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1111/1523-1747.ep12876130", 
      "https://app.dimensions.ai/details/publication/pub.1023815507"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T18:56", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8678_00000424.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/jid/journal/v94/n6s/full/5612949a.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1111/1523-1747.ep12876130'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1111/1523-1747.ep12876130'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1111/1523-1747.ep12876130'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1111/1523-1747.ep12876130'


 

This table displays all metadata directly associated to this object as RDF triples.

218 TRIPLES      21 PREDICATES      75 URIs      32 LITERALS      20 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1111/1523-1747.ep12876130 schema:about N0ed6cd440ee94d18963c35ce66bc049d
2 N1c74305af6c04174a2eaf9b57848462f
3 N1fb70061a9a64b00b870663f11c61cf4
4 N2690f3f8f1054dd5aafafa4f3791f356
5 N289f147d88604c73ab1c4871ca16a7e5
6 N40a445a7d71a4e8b88a66b06987a7a42
7 N5a16d2e3738541f28641b07a6d9646ae
8 N5d88fae088db462799ad477d6b38c0b1
9 N71ef0fcfcb814f6bb7b78f9a75989f6b
10 Nbe7fc56aa6664d1594c960de4597da5b
11 Ncc220f6cb02c4b0f859cd5af058f8431
12 anzsrc-for:11
13 anzsrc-for:1107
14 schema:author Nb2ba30ae41d245dcabb828d2edcdfeb0
15 schema:citation sg:pub.10.1038/343336a0
16 sg:pub.10.1111/1523-1747.ep12284068
17 sg:pub.10.1111/1523-1747.ep12461024
18 sg:pub.10.1111/1523-1747.ep12462420
19 sg:pub.10.1111/1523-1747.ep12470545
20 https://app.dimensions.ai/details/publication/pub.1078904178
21 https://app.dimensions.ai/details/publication/pub.1079354535
22 https://app.dimensions.ai/details/publication/pub.1079504443
23 https://app.dimensions.ai/details/publication/pub.1079646324
24 https://app.dimensions.ai/details/publication/pub.1079663959
25 https://doi.org/10.1001/archderm.125.10.1406
26 https://doi.org/10.1001/archderm.1989.01670220102017
27 https://doi.org/10.1016/0092-8674(89)90775-7
28 https://doi.org/10.1016/0167-5699(86)90124-6
29 https://doi.org/10.1016/1043-4666(89)91081-8
30 https://doi.org/10.1016/1043-4666(89)91222-2
31 https://doi.org/10.1016/1043-4666(89)91314-8
32 https://doi.org/10.1016/1043-4666(89)91516-0
33 https://doi.org/10.1073/pnas.84.24.9238
34 https://doi.org/10.1073/pnas.86.16.6367
35 https://doi.org/10.1073/pnas.86.20.8029
36 https://doi.org/10.1073/pnas.86.20.8034
37 https://doi.org/10.1073/pnas.86.4.1273
38 https://doi.org/10.1073/pnas.86.9.3045
39 https://doi.org/10.1083/jcb.107.1.321
40 https://doi.org/10.1084/jem.164.6.2095
41 https://doi.org/10.1084/jem.167.4.1323
42 https://doi.org/10.1097/00000372-198710000-00007
43 https://doi.org/10.1111/j.1749-6632.1988.tb18814.x
44 https://doi.org/10.1111/j.1749-6632.1988.tb18826.x
45 https://doi.org/10.1111/j.1749-6632.1989.tb24038.x
46 https://doi.org/10.1126/science.2969618
47 https://doi.org/10.1172/jci112141
48 https://doi.org/10.1172/jci113090
49 https://doi.org/10.1172/jci113792
50 schema:datePublished 1990-06
51 schema:datePublishedReg 1990-06-01
52 schema:description Keratinocytes, fibroblasts, endothelial cells, and other sessile cells resident to human skin can be induced in vitro to synthesize and secrete cytokine molecules. Cytokines are small protein molecules produced upon injury or cellular activation which influence immune and inflammatory events; as such, they have been best understood previously as products of leukocytes. The appreciation that cultured non-bone marrow-derived cells from skin could produce cytokines capable of initiating an inflammatory response or facilitating an immune response has led to speculation that cells resident to skin may be less passive participants in such phenomena than previously thought. Using as a model the cultured keratinocyte, which produces both interleukin-1 alpha and beta and an interleukin-1 receptor, models of autocrine and paracrine activation of this cell have been constructed. Such "activated keratinocytes," or by analogy other activated resident skin cells, produce a spectrum of cytokines in vitro which could potentially influence leukocyte adhesion to endothelium, direction migration of leukocytes towards the activated cell (presumably an inflammatory nidus), and activation of leukocyte functions in situ. The putative role of regulation of cytokine and cytokine-receptor regulation in mediating the activation of such cells (and thus, presumably, local inflammation) is discussed. An important aspect of this hypothetical model is that in the absence of activation (which characterizes normal uninflamed skin), cytokine production and its consequences do not occur. The conclusion reached is that based on in vitro data it is plausible to guess that local inflammatory or immune responses can be both initiated and facilitated by locally produced cytokines.
53 schema:genre research_article
54 schema:inLanguage en
55 schema:isAccessibleForFree true
56 schema:isPartOf N6ad459148b2d4396a2c99ad089ec9810
57 Nb223c26aab654a968b9b274e2d306545
58 sg:journal.1020153
59 schema:name The Activated Keratinocyte: A Model for Inducible Cytokine Production by Non-Bone-Marrow-Derived Cells in Cutaneous Inflammatory and Immune Responses
60 schema:pagination 146s-150s
61 schema:productId N09bf2ddb247548db9b083df2fdf34c47
62 N17e4b0bc5bfc4a26b90d23231f125c15
63 N463b014279c945729501ba412da67063
64 N6595f07e3f604242923d58b400c80ccc
65 Nb281327a4ed8481ba196af0d5ed6944b
66 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023815507
67 https://doi.org/10.1111/1523-1747.ep12876130
68 schema:sdDatePublished 2019-04-10T18:56
69 schema:sdLicense https://scigraph.springernature.com/explorer/license/
70 schema:sdPublisher N1eacd7f3cdbf4310988bb4add8912486
71 schema:url http://www.nature.com/jid/journal/v94/n6s/full/5612949a.html
72 sgo:license sg:explorer/license/
73 sgo:sdDataset articles
74 rdf:type schema:ScholarlyArticle
75 N09bf2ddb247548db9b083df2fdf34c47 schema:name pubmed_id
76 schema:value 2141048
77 rdf:type schema:PropertyValue
78 N0ed6cd440ee94d18963c35ce66bc049d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
79 schema:name Skin
80 rdf:type schema:DefinedTerm
81 N17e4b0bc5bfc4a26b90d23231f125c15 schema:name dimensions_id
82 schema:value pub.1023815507
83 rdf:type schema:PropertyValue
84 N1c74305af6c04174a2eaf9b57848462f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Biological Factors
86 rdf:type schema:DefinedTerm
87 N1eacd7f3cdbf4310988bb4add8912486 schema:name Springer Nature - SN SciGraph project
88 rdf:type schema:Organization
89 N1fb70061a9a64b00b870663f11c61cf4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Receptors, Immunologic
91 rdf:type schema:DefinedTerm
92 N2690f3f8f1054dd5aafafa4f3791f356 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Receptors, Interleukin-1
94 rdf:type schema:DefinedTerm
95 N289f147d88604c73ab1c4871ca16a7e5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Humans
97 rdf:type schema:DefinedTerm
98 N40a445a7d71a4e8b88a66b06987a7a42 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Cytokines
100 rdf:type schema:DefinedTerm
101 N463b014279c945729501ba412da67063 schema:name readcube_id
102 schema:value 7175fcbce075518eac6e57d2881be9bdd08081a2dfc5399f3ab89c371e89fdee
103 rdf:type schema:PropertyValue
104 N5a16d2e3738541f28641b07a6d9646ae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Antibody Formation
106 rdf:type schema:DefinedTerm
107 N5d88fae088db462799ad477d6b38c0b1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Models, Biological
109 rdf:type schema:DefinedTerm
110 N6595f07e3f604242923d58b400c80ccc schema:name doi
111 schema:value 10.1111/1523-1747.ep12876130
112 rdf:type schema:PropertyValue
113 N6ad459148b2d4396a2c99ad089ec9810 schema:volumeNumber 94
114 rdf:type schema:PublicationVolume
115 N71ef0fcfcb814f6bb7b78f9a75989f6b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Dermatitis
117 rdf:type schema:DefinedTerm
118 Nb223c26aab654a968b9b274e2d306545 schema:issueNumber 6
119 rdf:type schema:PublicationIssue
120 Nb281327a4ed8481ba196af0d5ed6944b schema:name nlm_unique_id
121 schema:value 0426720
122 rdf:type schema:PropertyValue
123 Nb2ba30ae41d245dcabb828d2edcdfeb0 rdf:first sg:person.01342556166.43
124 rdf:rest rdf:nil
125 Nbe7fc56aa6664d1594c960de4597da5b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Keratinocytes
127 rdf:type schema:DefinedTerm
128 Ncc220f6cb02c4b0f859cd5af058f8431 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Interleukin-1
130 rdf:type schema:DefinedTerm
131 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
132 schema:name Medical and Health Sciences
133 rdf:type schema:DefinedTerm
134 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
135 schema:name Immunology
136 rdf:type schema:DefinedTerm
137 sg:journal.1020153 schema:issn 0022-202X
138 1523-1747
139 schema:name Journal of Investigative Dermatology
140 rdf:type schema:Periodical
141 sg:person.01342556166.43 schema:affiliation https://www.grid.ac/institutes/grid.4367.6
142 schema:familyName Kupper
143 schema:givenName T S
144 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01342556166.43
145 rdf:type schema:Person
146 sg:pub.10.1038/343336a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030451293
147 https://doi.org/10.1038/343336a0
148 rdf:type schema:CreativeWork
149 sg:pub.10.1111/1523-1747.ep12284068 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000889406
150 https://doi.org/10.1111/1523-1747.ep12284068
151 rdf:type schema:CreativeWork
152 sg:pub.10.1111/1523-1747.ep12461024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032833482
153 https://doi.org/10.1111/1523-1747.ep12461024
154 rdf:type schema:CreativeWork
155 sg:pub.10.1111/1523-1747.ep12462420 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016329823
156 https://doi.org/10.1111/1523-1747.ep12462420
157 rdf:type schema:CreativeWork
158 sg:pub.10.1111/1523-1747.ep12470545 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048192447
159 https://doi.org/10.1111/1523-1747.ep12470545
160 rdf:type schema:CreativeWork
161 https://app.dimensions.ai/details/publication/pub.1078904178 schema:CreativeWork
162 https://app.dimensions.ai/details/publication/pub.1079354535 schema:CreativeWork
163 https://app.dimensions.ai/details/publication/pub.1079504443 schema:CreativeWork
164 https://app.dimensions.ai/details/publication/pub.1079646324 schema:CreativeWork
165 https://app.dimensions.ai/details/publication/pub.1079663959 schema:CreativeWork
166 https://doi.org/10.1001/archderm.125.10.1406 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054097644
167 rdf:type schema:CreativeWork
168 https://doi.org/10.1001/archderm.1989.01670220102017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020917500
169 rdf:type schema:CreativeWork
170 https://doi.org/10.1016/0092-8674(89)90775-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027916931
171 rdf:type schema:CreativeWork
172 https://doi.org/10.1016/0167-5699(86)90124-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018895544
173 rdf:type schema:CreativeWork
174 https://doi.org/10.1016/1043-4666(89)91081-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048487847
175 rdf:type schema:CreativeWork
176 https://doi.org/10.1016/1043-4666(89)91222-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043411239
177 rdf:type schema:CreativeWork
178 https://doi.org/10.1016/1043-4666(89)91314-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021584828
179 rdf:type schema:CreativeWork
180 https://doi.org/10.1016/1043-4666(89)91516-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051995899
181 rdf:type schema:CreativeWork
182 https://doi.org/10.1073/pnas.84.24.9238 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050984308
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1073/pnas.86.16.6367 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038193858
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1073/pnas.86.20.8029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012723354
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1073/pnas.86.20.8034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019301690
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1073/pnas.86.4.1273 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044499692
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1073/pnas.86.9.3045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003408628
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1083/jcb.107.1.321 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018210299
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1084/jem.164.6.2095 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042990023
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1084/jem.167.4.1323 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040130262
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1097/00000372-198710000-00007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042698147
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1111/j.1749-6632.1988.tb18814.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1049243248
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1111/j.1749-6632.1988.tb18826.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1035182081
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1111/j.1749-6632.1989.tb24038.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1009797576
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1126/science.2969618 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062577598
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1172/jci112141 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005920223
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1172/jci113090 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042580794
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1172/jci113792 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014780442
215 rdf:type schema:CreativeWork
216 https://www.grid.ac/institutes/grid.4367.6 schema:alternateName Washington University in St. Louis
217 schema:name Department of Medicine (Dermatology), Washington University School of Medicine, St. Louis, Missouri 63110.
218 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...