Establishment of a Human Cutaneous T-Cell Lymphoma in C.B-17 SCID Mice View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1990-03

AUTHORS

M R Charley, M Tharp, J Locker, J S Deng, J B Goslen, T Mauro, P McCoy, E Abell, B Jegasothy

ABSTRACT

Investigation into the immunobiology of cutaneous T-cell lymphomas (CTCL) would be facilitated by the development of a suitable experimental system. The recent use of mice with severe combined immune deficiency (SCID) as a vehicle to study the human immune system prompted us to try to establish CTCL in SCID mice. We found that a CD4+ lymphocytic infiltrate characteristic of CTCL was maintained within patient skin grafts in place on natural killer cell depleted SCID mice for the month of observation. CTCL cells were not found outside the human skin graft. This chimeric model using SCID mice and patient lesional skin should provide a useful tool to characterize CTCL/skin microenvironmental interactions and to test new therapeutic approaches. More... »

PAGES

381-384

Identifiers

URI

http://scigraph.springernature.com/pub.10.1111/1523-1747.ep12874500

DOI

http://dx.doi.org/10.1111/1523-1747.ep12874500

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1010155077

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2307857


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