Cyclic Amp And Psoriasis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1975-07

AUTHORS

Kenneth M Halprin, Kenji Adachi, Kunihiko Yoshikawa, Victor Levine, Mei Mei Mui, S L Hsia

ABSTRACT

Evidence that an adenyl cyclase system is present in all mammalian epidermis is reviewed. This adenyl cyclase is stimulated by at least two separate types of chemicals: catecholamines, which act at a beta-adrenergic receptor site, and prostaglandins of the E series, which act at a separate site. In the psoriatic lesion, the response to these stimulators, especially to the catecholamines, is reduced. Despite this lack of response to external agents which elevate cyclic AMP, the concentration of cyclic AMP within the epidermis of the psoriatic lesion is no lower than in noninvolved skin. How cyclic nucleotides act to control cell proliferation and cell differentiation remains unclear. More... »

PAGES

170-178

Identifiers

URI

http://scigraph.springernature.com/pub.10.1111/1523-1747.ep12598119

DOI

http://dx.doi.org/10.1111/1523-1747.ep12598119

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1018714573

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/239070


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