Thy-1+ Dendritic Epidermal Cells in Mice: Precursor Frequency Analysis and Cloning of Concanavalin A-Reactive Cells View Full Text


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Article Info

DATE

1988-05

AUTHORS

A Takashima, J L Nixon-Fulton, P R Bergstresser, R E Tigelaar

ABSTRACT

Bulk cultures of mouse Thy-1+ dendritic epidermal cells (Thy-1+ DEC) have been shown to proliferate in response to concanavalin A (Con A) and IL-2, to secrete IL-2-like growth factors, and to lyse target cells such as YAC-1. Limiting dilution microculture was utilized in order to determine the precursor frequency of Con A-responsive Thy-1+ DEC in suspensions of AKR/J epidermal cells as well as whether these several functional activities all reside within a single Thy-1+ DEC precursor. Precursor frequency analysis of cultures established with limiting numbers of FACS-purified Thy-1+ DEC, irradiated syngeneic splenic filler cells and exogenous IL-2 indicated that approximately 20% of Thy-1+ DEC proliferated in response to Con A. Parallel microcultures in which purified Thy-1+ DEC were plated at a density of 0.5 cells/well were used to establish clones. Twenty clones were characterized phenotypically, and ten of these were also tested for their capacities to proliferate in response to Con A or IL-2, to secrete IL-2-like growth factors, and to exhibit cytotoxicity. All clones were Thy-1+ and L3T4-, but while most were also Lyt-2-, several contained 3%-18% dull Lyt-2+ cells. Functional studies revealed that each clone displayed all of the above functional activities, albeit with substantial quantitative variation. Clones with the highest cytotoxic activity had relatively low responsiveness to Con A or IL-2 and included all clones containing dull Lyt-2+ cells; conversely, clones with the highest proliferative responses had relatively low cytotoxic activity and were all Lyt-2-. This degree of functional and phenotypic heterogeneity among cloned Thy-1+ DEC may reflect their particular states of activation or differentiation; whether it reflects the biologically relevant in vivo activities of these cells must still be determined. More... »

PAGES

671-678

References to SciGraph publications

  • 1985-06. FACS Purification of Bone Marrow-Derived Epidermal Populations in Mice: Langerhans Cells and Thy-1+ Dendritic Cells in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 1983-09. Thy-1 Antigen-Bearing Dendritic Cells Populate Murine Epidermis in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 1986-07. A functional T3 molecule associated with a novel heterodimer on the surface of immature human thymocytes in NATURE
  • 1987-02. Two forms of the T-cell receptor γ protein found on peripheral blood cytotoxic T lymphocytes in NATURE
  • 1987-02. A γ-chain complex forms a functional receptor on cloned human lymphocytes with natural killer-like activity in NATURE
  • 1983-09. Expression of Thy-1 Antigen by Murine Epidermal Cells in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 1985-05. The human T-cell receptor in JOURNAL OF CLINICAL IMMUNOLOGY
  • 1987-07. Regulation of T-cell receptor γ-chain RNA expression in murine Thy-1+ dendritic epidermal cells in NATURE
  • 1988-07. Phenotypic Heterogeneity and Cytotoxic Activity of Con A and IL-2-Stimulated Cultures of Mouse Thy-1+ Epidermal Cells in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 1986-06. Culture and Characterization of Murine Dendritic Thy-1+ Epidermal Cells in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 1986-03. A T3-like protein complex associated with the antigen receptor on murine T cells in NATURE
  • 1984-08. Thy-1 Antigen-Bearing Dendritic Cells in Murine Epidermis Are Derived from Bone Marrow Precursors in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 1987-06. A new T-cell receptor gene located within the alpha locus and expressed early in T-cell differentiation in NATURE
  • 1986-11. Presence of Ti (WT31) negative T lymphocytes in normal blood and thymus in NATURE
  • 1984-07. Thy-1+ Dendritic Cells in Murine Epidermis Are Bone Marrow-Derived in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 1987-03. Differential expression of two distinct T-cell receptors during thymocyte development in NATURE
  • 1987-11. Major histocompatibility complex-linked specificity of γδ receptor-bearing T lymphocytes in NATURE
  • 1987-02. A T-cell receptor γ/CD3 complex found on cloned functional lymphocytes in NATURE
  • 1986-07. Identification of a putative second T-cell receptor in NATURE
  • 1987-12. Delta is the C x-gene product in the γ/δ antigen receptor of dendritic epidermal cells in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1111/1523-1747.ep12560835

    DOI

    http://dx.doi.org/10.1111/1523-1747.ep12560835

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/2896217


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