Thy-1+ Dendritic Epidermal Cells in Mice: Precursor Frequency Analysis and Cloning of Concanavalin A-Reactive Cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1988-05

AUTHORS

A Takashima, J L Nixon-Fulton, P R Bergstresser, R E Tigelaar

ABSTRACT

Bulk cultures of mouse Thy-1+ dendritic epidermal cells (Thy-1+ DEC) have been shown to proliferate in response to concanavalin A (Con A) and IL-2, to secrete IL-2-like growth factors, and to lyse target cells such as YAC-1. Limiting dilution microculture was utilized in order to determine the precursor frequency of Con A-responsive Thy-1+ DEC in suspensions of AKR/J epidermal cells as well as whether these several functional activities all reside within a single Thy-1+ DEC precursor. Precursor frequency analysis of cultures established with limiting numbers of FACS-purified Thy-1+ DEC, irradiated syngeneic splenic filler cells and exogenous IL-2 indicated that approximately 20% of Thy-1+ DEC proliferated in response to Con A. Parallel microcultures in which purified Thy-1+ DEC were plated at a density of 0.5 cells/well were used to establish clones. Twenty clones were characterized phenotypically, and ten of these were also tested for their capacities to proliferate in response to Con A or IL-2, to secrete IL-2-like growth factors, and to exhibit cytotoxicity. All clones were Thy-1+ and L3T4-, but while most were also Lyt-2-, several contained 3%-18% dull Lyt-2+ cells. Functional studies revealed that each clone displayed all of the above functional activities, albeit with substantial quantitative variation. Clones with the highest cytotoxic activity had relatively low responsiveness to Con A or IL-2 and included all clones containing dull Lyt-2+ cells; conversely, clones with the highest proliferative responses had relatively low cytotoxic activity and were all Lyt-2-. This degree of functional and phenotypic heterogeneity among cloned Thy-1+ DEC may reflect their particular states of activation or differentiation; whether it reflects the biologically relevant in vivo activities of these cells must still be determined. More... »

PAGES

671-678

References to SciGraph publications

  • 1985-06. FACS Purification of Bone Marrow-Derived Epidermal Populations in Mice: Langerhans Cells and Thy-1+ Dendritic Cells in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 1983-09. Thy-1 Antigen-Bearing Dendritic Cells Populate Murine Epidermis in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 1986-07. A functional T3 molecule associated with a novel heterodimer on the surface of immature human thymocytes in NATURE
  • 1987-02. Two forms of the T-cell receptor γ protein found on peripheral blood cytotoxic T lymphocytes in NATURE
  • 1987-02. A γ-chain complex forms a functional receptor on cloned human lymphocytes with natural killer-like activity in NATURE
  • 1983-09. Expression of Thy-1 Antigen by Murine Epidermal Cells in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 1985-05. The human T-cell receptor in JOURNAL OF CLINICAL IMMUNOLOGY
  • 1987-07. Regulation of T-cell receptor γ-chain RNA expression in murine Thy-1+ dendritic epidermal cells in NATURE
  • 1988-07. Phenotypic Heterogeneity and Cytotoxic Activity of Con A and IL-2-Stimulated Cultures of Mouse Thy-1+ Epidermal Cells in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 1986-06. Culture and Characterization of Murine Dendritic Thy-1+ Epidermal Cells in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 1986-03. A T3-like protein complex associated with the antigen receptor on murine T cells in NATURE
  • 1984-08. Thy-1 Antigen-Bearing Dendritic Cells in Murine Epidermis Are Derived from Bone Marrow Precursors in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 1987-06. A new T-cell receptor gene located within the alpha locus and expressed early in T-cell differentiation in NATURE
  • 1986-11. Presence of Ti (WT31) negative T lymphocytes in normal blood and thymus in NATURE
  • 1984-07. Thy-1+ Dendritic Cells in Murine Epidermis Are Bone Marrow-Derived in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 1987-03. Differential expression of two distinct T-cell receptors during thymocyte development in NATURE
  • 1987-11. Major histocompatibility complex-linked specificity of γδ receptor-bearing T lymphocytes in NATURE
  • 1987-02. A T-cell receptor γ/CD3 complex found on cloned functional lymphocytes in NATURE
  • 1986-07. Identification of a putative second T-cell receptor in NATURE
  • 1987-12. Delta is the C x-gene product in the γ/δ antigen receptor of dendritic epidermal cells in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1111/1523-1747.ep12560835

    DOI

    http://dx.doi.org/10.1111/1523-1747.ep12560835

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1032343333

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/2896217


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Immunology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antigens, Surface", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Division", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Clone Cells", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Concanavalin A", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cytological Techniques", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cytotoxicity, Immunologic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Dendritic Cells", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Epidermis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Interleukin-2", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice, Inbred Strains", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Phenotype", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Thy-1 Antigens", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "The University of Texas Southwestern Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.267313.2", 
              "name": [
                "Departments of Dermatology, University of Texas Southwestern Medical Center, Dallas 75235."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Takashima", 
            "givenName": "A", 
            "id": "sg:person.01160624146.24", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01160624146.24"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Nixon-Fulton", 
            "givenName": "J L", 
            "id": "sg:person.01312023355.53", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01312023355.53"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Bergstresser", 
            "givenName": "P R", 
            "id": "sg:person.0706634704.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706634704.34"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Tigelaar", 
            "givenName": "R E", 
            "id": "sg:person.01026011635.28", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026011635.28"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1073/pnas.83.6.1852", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000074015"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1600-065x.1983.tb01072.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001083381"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/1523-1747.ep12273454", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002131914", 
              "https://doi.org/10.1111/1523-1747.ep12273454"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.84.13.4586", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003355913"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.84.8.2430", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004627856"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/1523-1747.ep12463290", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005695927", 
              "https://doi.org/10.1111/1523-1747.ep12463290"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/328263a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005793912", 
              "https://doi.org/10.1038/328263a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.161.6.1368", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007523426"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/325689a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007558346", 
              "https://doi.org/10.1038/325689a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.164.2.580", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009436978"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/326079a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010900728", 
              "https://doi.org/10.1038/326079a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/325723a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013934831", 
              "https://doi.org/10.1038/325723a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.83.24.9689", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013959694"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.82.9.2925", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014984604"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/320272a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014999509", 
              "https://doi.org/10.1038/320272a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0065-2776(08)60005-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018925931"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/eji.1830140815", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023614150"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/1523-1747.ep12518326", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026393276", 
              "https://doi.org/10.1111/1523-1747.ep12518326"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0022-1759(82)90003-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026942030"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0022-1759(82)90003-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026942030"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0167-5699(86)90076-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028916688"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/322145a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031159648", 
              "https://doi.org/10.1038/322145a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/1523-1747.ep12261808", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031668765", 
              "https://doi.org/10.1111/1523-1747.ep12261808"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00915505", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032119572", 
              "https://doi.org/10.1007/bf00915505"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/325683a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033468458", 
              "https://doi.org/10.1038/325683a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/1523-1747.ep12262587", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034929137", 
              "https://doi.org/10.1111/1523-1747.ep12262587"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/322179a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035159334", 
              "https://doi.org/10.1038/322179a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/1523-1747.ep12275611", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035453808", 
              "https://doi.org/10.1111/1523-1747.ep12275611"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/1523-1747.ep12518332", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038844438", 
              "https://doi.org/10.1111/1523-1747.ep12518332"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.iy.02.040184.000323", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040400532"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.165.6.1725", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041293208"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/330574a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041837869", 
              "https://doi.org/10.1038/330574a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/330262a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042389746", 
              "https://doi.org/10.1038/330262a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/324268a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043510059", 
              "https://doi.org/10.1038/324268a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(86)90787-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047704535"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0008-8749(84)90002-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048868258"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.166.3.761", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050131776"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/b978-0-12-442750-1.50032-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051019396"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.iy.04.040186.003113", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051770734"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(86)90695-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052578566"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/327677a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056438778", 
              "https://doi.org/10.1038/327677a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.2883729", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062570101"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.3787252", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062621451"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078808724", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079433381", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079438644", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079474009", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079474010", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079474011", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079780813", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079820902", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1080007706", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1081603260", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1081603262", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1081732150", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082077048", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "1988-05", 
        "datePublishedReg": "1988-05-01", 
        "description": "Bulk cultures of mouse Thy-1+ dendritic epidermal cells (Thy-1+ DEC) have been shown to proliferate in response to concanavalin A (Con A) and IL-2, to secrete IL-2-like growth factors, and to lyse target cells such as YAC-1. Limiting dilution microculture was utilized in order to determine the precursor frequency of Con A-responsive Thy-1+ DEC in suspensions of AKR/J epidermal cells as well as whether these several functional activities all reside within a single Thy-1+ DEC precursor. Precursor frequency analysis of cultures established with limiting numbers of FACS-purified Thy-1+ DEC, irradiated syngeneic splenic filler cells and exogenous IL-2 indicated that approximately 20% of Thy-1+ DEC proliferated in response to Con A. Parallel microcultures in which purified Thy-1+ DEC were plated at a density of 0.5 cells/well were used to establish clones. Twenty clones were characterized phenotypically, and ten of these were also tested for their capacities to proliferate in response to Con A or IL-2, to secrete IL-2-like growth factors, and to exhibit cytotoxicity. All clones were Thy-1+ and L3T4-, but while most were also Lyt-2-, several contained 3%-18% dull Lyt-2+ cells. Functional studies revealed that each clone displayed all of the above functional activities, albeit with substantial quantitative variation. Clones with the highest cytotoxic activity had relatively low responsiveness to Con A or IL-2 and included all clones containing dull Lyt-2+ cells; conversely, clones with the highest proliferative responses had relatively low cytotoxic activity and were all Lyt-2-. This degree of functional and phenotypic heterogeneity among cloned Thy-1+ DEC may reflect their particular states of activation or differentiation; whether it reflects the biologically relevant in vivo activities of these cells must still be determined.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1111/1523-1747.ep12560835", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2440044", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2462697", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2370982", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1020153", 
            "issn": [
              "0022-202X", 
              "1523-1747"
            ], 
            "name": "Journal of Investigative Dermatology", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "5", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "90"
          }
        ], 
        "name": "Thy-1+ Dendritic Epidermal Cells in Mice: Precursor Frequency Analysis and Cloning of Concanavalin A-Reactive Cells", 
        "pagination": "671-678", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "9a13db291e8453982c5b56d7d4989e064c3d53137e7dda72794daea2ae3ed2d8"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "2896217"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "0426720"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1111/1523-1747.ep12560835"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1032343333"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1111/1523-1747.ep12560835", 
          "https://app.dimensions.ai/details/publication/pub.1032343333"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T16:29", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8669_00000427.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.nature.com/jid/journal/v90/n5/full/5613668a.html"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1111/1523-1747.ep12560835'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1111/1523-1747.ep12560835'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1111/1523-1747.ep12560835'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1111/1523-1747.ep12560835'


     

    This table displays all metadata directly associated to this object as RDF triples.

    321 TRIPLES      21 PREDICATES      98 URIs      35 LITERALS      23 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1111/1523-1747.ep12560835 schema:about N038c234d3a1b4322b54626a2ff49dc88
    2 N1c303cdd2f6f42f4b827dc28f5c4e32d
    3 N24df85b38a5b41b09e54936fae8603ab
    4 N61d6f2366aa24a439d5e85771649ecca
    5 N6666d6c8852e41ef9397fcac1433b5da
    6 N871217f472ed424080c389d091fde072
    7 Nbedcb045c2574127b8d2a31b13f92536
    8 Ndc68abdfc2cd4672aac2fca24a0b48b5
    9 Ndd91ce0331af4c848ea11a15765412a0
    10 Ne7129d26d2f546a28075da47406e3890
    11 Nea0cb9b333144fe78b5196f3afcf9d86
    12 Nf1581ede48e446a28acfc15639a5d99d
    13 Nf8aca2fa72224ffeabe3f3452bb5f4c8
    14 Nfc978f0bc5d745148561146e182ac584
    15 anzsrc-for:11
    16 anzsrc-for:1107
    17 schema:author N4555877385a546538e145709dd6d2fb7
    18 schema:citation sg:pub.10.1007/bf00915505
    19 sg:pub.10.1038/320272a0
    20 sg:pub.10.1038/322145a0
    21 sg:pub.10.1038/322179a0
    22 sg:pub.10.1038/324268a0
    23 sg:pub.10.1038/325683a0
    24 sg:pub.10.1038/325689a0
    25 sg:pub.10.1038/325723a0
    26 sg:pub.10.1038/326079a0
    27 sg:pub.10.1038/327677a0
    28 sg:pub.10.1038/328263a0
    29 sg:pub.10.1038/330262a0
    30 sg:pub.10.1038/330574a0
    31 sg:pub.10.1111/1523-1747.ep12261808
    32 sg:pub.10.1111/1523-1747.ep12262587
    33 sg:pub.10.1111/1523-1747.ep12273454
    34 sg:pub.10.1111/1523-1747.ep12275611
    35 sg:pub.10.1111/1523-1747.ep12463290
    36 sg:pub.10.1111/1523-1747.ep12518326
    37 sg:pub.10.1111/1523-1747.ep12518332
    38 https://app.dimensions.ai/details/publication/pub.1078808724
    39 https://app.dimensions.ai/details/publication/pub.1079433381
    40 https://app.dimensions.ai/details/publication/pub.1079438644
    41 https://app.dimensions.ai/details/publication/pub.1079474009
    42 https://app.dimensions.ai/details/publication/pub.1079474010
    43 https://app.dimensions.ai/details/publication/pub.1079474011
    44 https://app.dimensions.ai/details/publication/pub.1079780813
    45 https://app.dimensions.ai/details/publication/pub.1079820902
    46 https://app.dimensions.ai/details/publication/pub.1080007706
    47 https://app.dimensions.ai/details/publication/pub.1081603260
    48 https://app.dimensions.ai/details/publication/pub.1081603262
    49 https://app.dimensions.ai/details/publication/pub.1081732150
    50 https://app.dimensions.ai/details/publication/pub.1082077048
    51 https://doi.org/10.1002/eji.1830140815
    52 https://doi.org/10.1016/0008-8749(84)90002-9
    53 https://doi.org/10.1016/0022-1759(82)90003-5
    54 https://doi.org/10.1016/0092-8674(86)90695-1
    55 https://doi.org/10.1016/0092-8674(86)90787-7
    56 https://doi.org/10.1016/0167-5699(86)90076-9
    57 https://doi.org/10.1016/b978-0-12-442750-1.50032-2
    58 https://doi.org/10.1016/s0065-2776(08)60005-x
    59 https://doi.org/10.1073/pnas.82.9.2925
    60 https://doi.org/10.1073/pnas.83.24.9689
    61 https://doi.org/10.1073/pnas.83.6.1852
    62 https://doi.org/10.1073/pnas.84.13.4586
    63 https://doi.org/10.1073/pnas.84.8.2430
    64 https://doi.org/10.1084/jem.161.6.1368
    65 https://doi.org/10.1084/jem.164.2.580
    66 https://doi.org/10.1084/jem.165.6.1725
    67 https://doi.org/10.1084/jem.166.3.761
    68 https://doi.org/10.1111/j.1600-065x.1983.tb01072.x
    69 https://doi.org/10.1126/science.2883729
    70 https://doi.org/10.1126/science.3787252
    71 https://doi.org/10.1146/annurev.iy.02.040184.000323
    72 https://doi.org/10.1146/annurev.iy.04.040186.003113
    73 schema:datePublished 1988-05
    74 schema:datePublishedReg 1988-05-01
    75 schema:description Bulk cultures of mouse Thy-1+ dendritic epidermal cells (Thy-1+ DEC) have been shown to proliferate in response to concanavalin A (Con A) and IL-2, to secrete IL-2-like growth factors, and to lyse target cells such as YAC-1. Limiting dilution microculture was utilized in order to determine the precursor frequency of Con A-responsive Thy-1+ DEC in suspensions of AKR/J epidermal cells as well as whether these several functional activities all reside within a single Thy-1+ DEC precursor. Precursor frequency analysis of cultures established with limiting numbers of FACS-purified Thy-1+ DEC, irradiated syngeneic splenic filler cells and exogenous IL-2 indicated that approximately 20% of Thy-1+ DEC proliferated in response to Con A. Parallel microcultures in which purified Thy-1+ DEC were plated at a density of 0.5 cells/well were used to establish clones. Twenty clones were characterized phenotypically, and ten of these were also tested for their capacities to proliferate in response to Con A or IL-2, to secrete IL-2-like growth factors, and to exhibit cytotoxicity. All clones were Thy-1+ and L3T4-, but while most were also Lyt-2-, several contained 3%-18% dull Lyt-2+ cells. Functional studies revealed that each clone displayed all of the above functional activities, albeit with substantial quantitative variation. Clones with the highest cytotoxic activity had relatively low responsiveness to Con A or IL-2 and included all clones containing dull Lyt-2+ cells; conversely, clones with the highest proliferative responses had relatively low cytotoxic activity and were all Lyt-2-. This degree of functional and phenotypic heterogeneity among cloned Thy-1+ DEC may reflect their particular states of activation or differentiation; whether it reflects the biologically relevant in vivo activities of these cells must still be determined.
    76 schema:genre research_article
    77 schema:inLanguage en
    78 schema:isAccessibleForFree true
    79 schema:isPartOf Nbde5e555fdf7412dbd20163029009128
    80 Nf7c8ddd7cf8d47788e51ae9838693538
    81 sg:journal.1020153
    82 schema:name Thy-1+ Dendritic Epidermal Cells in Mice: Precursor Frequency Analysis and Cloning of Concanavalin A-Reactive Cells
    83 schema:pagination 671-678
    84 schema:productId N833cf9406b134fe9a69698472ad63891
    85 N89e79c7837e04708b95ec0c24de606f7
    86 Nec2750a37bd04c28bcd2cced484fbe36
    87 Nef2162718e1b4cd08edcdd9492ad3eb9
    88 Nf066a9437f92409db6d00eaee0d60144
    89 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032343333
    90 https://doi.org/10.1111/1523-1747.ep12560835
    91 schema:sdDatePublished 2019-04-10T16:29
    92 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    93 schema:sdPublisher N052a5b3afaee49079ecde413158049e4
    94 schema:url http://www.nature.com/jid/journal/v90/n5/full/5613668a.html
    95 sgo:license sg:explorer/license/
    96 sgo:sdDataset articles
    97 rdf:type schema:ScholarlyArticle
    98 N038c234d3a1b4322b54626a2ff49dc88 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    99 schema:name Thy-1 Antigens
    100 rdf:type schema:DefinedTerm
    101 N052a5b3afaee49079ecde413158049e4 schema:name Springer Nature - SN SciGraph project
    102 rdf:type schema:Organization
    103 N1c303cdd2f6f42f4b827dc28f5c4e32d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    104 schema:name Animals
    105 rdf:type schema:DefinedTerm
    106 N24df85b38a5b41b09e54936fae8603ab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    107 schema:name Interleukin-2
    108 rdf:type schema:DefinedTerm
    109 N4555877385a546538e145709dd6d2fb7 rdf:first sg:person.01160624146.24
    110 rdf:rest N628712637fda47d3b22cf1262f119625
    111 N61d6f2366aa24a439d5e85771649ecca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    112 schema:name Cytological Techniques
    113 rdf:type schema:DefinedTerm
    114 N628712637fda47d3b22cf1262f119625 rdf:first sg:person.01312023355.53
    115 rdf:rest N6e710d8cbc8041c2ae6bf3e209363074
    116 N6666d6c8852e41ef9397fcac1433b5da schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    117 schema:name Clone Cells
    118 rdf:type schema:DefinedTerm
    119 N6e710d8cbc8041c2ae6bf3e209363074 rdf:first sg:person.0706634704.34
    120 rdf:rest Ne98308d9f6644385b4a531a53cec79c3
    121 N833cf9406b134fe9a69698472ad63891 schema:name dimensions_id
    122 schema:value pub.1032343333
    123 rdf:type schema:PropertyValue
    124 N871217f472ed424080c389d091fde072 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    125 schema:name Epidermis
    126 rdf:type schema:DefinedTerm
    127 N89e79c7837e04708b95ec0c24de606f7 schema:name doi
    128 schema:value 10.1111/1523-1747.ep12560835
    129 rdf:type schema:PropertyValue
    130 Nbde5e555fdf7412dbd20163029009128 schema:issueNumber 5
    131 rdf:type schema:PublicationIssue
    132 Nbedcb045c2574127b8d2a31b13f92536 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    133 schema:name Dendritic Cells
    134 rdf:type schema:DefinedTerm
    135 Ndc68abdfc2cd4672aac2fca24a0b48b5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    136 schema:name Cytotoxicity, Immunologic
    137 rdf:type schema:DefinedTerm
    138 Ndd91ce0331af4c848ea11a15765412a0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    139 schema:name Mice, Inbred Strains
    140 rdf:type schema:DefinedTerm
    141 Ne7129d26d2f546a28075da47406e3890 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    142 schema:name Phenotype
    143 rdf:type schema:DefinedTerm
    144 Ne98308d9f6644385b4a531a53cec79c3 rdf:first sg:person.01026011635.28
    145 rdf:rest rdf:nil
    146 Nea0cb9b333144fe78b5196f3afcf9d86 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    147 schema:name Antigens, Surface
    148 rdf:type schema:DefinedTerm
    149 Nec2750a37bd04c28bcd2cced484fbe36 schema:name pubmed_id
    150 schema:value 2896217
    151 rdf:type schema:PropertyValue
    152 Nef2162718e1b4cd08edcdd9492ad3eb9 schema:name readcube_id
    153 schema:value 9a13db291e8453982c5b56d7d4989e064c3d53137e7dda72794daea2ae3ed2d8
    154 rdf:type schema:PropertyValue
    155 Nf066a9437f92409db6d00eaee0d60144 schema:name nlm_unique_id
    156 schema:value 0426720
    157 rdf:type schema:PropertyValue
    158 Nf1581ede48e446a28acfc15639a5d99d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    159 schema:name Mice
    160 rdf:type schema:DefinedTerm
    161 Nf7c8ddd7cf8d47788e51ae9838693538 schema:volumeNumber 90
    162 rdf:type schema:PublicationVolume
    163 Nf8aca2fa72224ffeabe3f3452bb5f4c8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    164 schema:name Cell Division
    165 rdf:type schema:DefinedTerm
    166 Nfc978f0bc5d745148561146e182ac584 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    167 schema:name Concanavalin A
    168 rdf:type schema:DefinedTerm
    169 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    170 schema:name Medical and Health Sciences
    171 rdf:type schema:DefinedTerm
    172 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
    173 schema:name Immunology
    174 rdf:type schema:DefinedTerm
    175 sg:grant.2370982 http://pending.schema.org/fundedItem sg:pub.10.1111/1523-1747.ep12560835
    176 rdf:type schema:MonetaryGrant
    177 sg:grant.2440044 http://pending.schema.org/fundedItem sg:pub.10.1111/1523-1747.ep12560835
    178 rdf:type schema:MonetaryGrant
    179 sg:grant.2462697 http://pending.schema.org/fundedItem sg:pub.10.1111/1523-1747.ep12560835
    180 rdf:type schema:MonetaryGrant
    181 sg:journal.1020153 schema:issn 0022-202X
    182 1523-1747
    183 schema:name Journal of Investigative Dermatology
    184 rdf:type schema:Periodical
    185 sg:person.01026011635.28 schema:familyName Tigelaar
    186 schema:givenName R E
    187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026011635.28
    188 rdf:type schema:Person
    189 sg:person.01160624146.24 schema:affiliation https://www.grid.ac/institutes/grid.267313.2
    190 schema:familyName Takashima
    191 schema:givenName A
    192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01160624146.24
    193 rdf:type schema:Person
    194 sg:person.01312023355.53 schema:familyName Nixon-Fulton
    195 schema:givenName J L
    196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01312023355.53
    197 rdf:type schema:Person
    198 sg:person.0706634704.34 schema:familyName Bergstresser
    199 schema:givenName P R
    200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706634704.34
    201 rdf:type schema:Person
    202 sg:pub.10.1007/bf00915505 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032119572
    203 https://doi.org/10.1007/bf00915505
    204 rdf:type schema:CreativeWork
    205 sg:pub.10.1038/320272a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014999509
    206 https://doi.org/10.1038/320272a0
    207 rdf:type schema:CreativeWork
    208 sg:pub.10.1038/322145a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031159648
    209 https://doi.org/10.1038/322145a0
    210 rdf:type schema:CreativeWork
    211 sg:pub.10.1038/322179a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035159334
    212 https://doi.org/10.1038/322179a0
    213 rdf:type schema:CreativeWork
    214 sg:pub.10.1038/324268a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043510059
    215 https://doi.org/10.1038/324268a0
    216 rdf:type schema:CreativeWork
    217 sg:pub.10.1038/325683a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033468458
    218 https://doi.org/10.1038/325683a0
    219 rdf:type schema:CreativeWork
    220 sg:pub.10.1038/325689a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007558346
    221 https://doi.org/10.1038/325689a0
    222 rdf:type schema:CreativeWork
    223 sg:pub.10.1038/325723a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013934831
    224 https://doi.org/10.1038/325723a0
    225 rdf:type schema:CreativeWork
    226 sg:pub.10.1038/326079a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010900728
    227 https://doi.org/10.1038/326079a0
    228 rdf:type schema:CreativeWork
    229 sg:pub.10.1038/327677a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056438778
    230 https://doi.org/10.1038/327677a0
    231 rdf:type schema:CreativeWork
    232 sg:pub.10.1038/328263a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005793912
    233 https://doi.org/10.1038/328263a0
    234 rdf:type schema:CreativeWork
    235 sg:pub.10.1038/330262a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042389746
    236 https://doi.org/10.1038/330262a0
    237 rdf:type schema:CreativeWork
    238 sg:pub.10.1038/330574a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041837869
    239 https://doi.org/10.1038/330574a0
    240 rdf:type schema:CreativeWork
    241 sg:pub.10.1111/1523-1747.ep12261808 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031668765
    242 https://doi.org/10.1111/1523-1747.ep12261808
    243 rdf:type schema:CreativeWork
    244 sg:pub.10.1111/1523-1747.ep12262587 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034929137
    245 https://doi.org/10.1111/1523-1747.ep12262587
    246 rdf:type schema:CreativeWork
    247 sg:pub.10.1111/1523-1747.ep12273454 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002131914
    248 https://doi.org/10.1111/1523-1747.ep12273454
    249 rdf:type schema:CreativeWork
    250 sg:pub.10.1111/1523-1747.ep12275611 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035453808
    251 https://doi.org/10.1111/1523-1747.ep12275611
    252 rdf:type schema:CreativeWork
    253 sg:pub.10.1111/1523-1747.ep12463290 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005695927
    254 https://doi.org/10.1111/1523-1747.ep12463290
    255 rdf:type schema:CreativeWork
    256 sg:pub.10.1111/1523-1747.ep12518326 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026393276
    257 https://doi.org/10.1111/1523-1747.ep12518326
    258 rdf:type schema:CreativeWork
    259 sg:pub.10.1111/1523-1747.ep12518332 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038844438
    260 https://doi.org/10.1111/1523-1747.ep12518332
    261 rdf:type schema:CreativeWork
    262 https://app.dimensions.ai/details/publication/pub.1078808724 schema:CreativeWork
    263 https://app.dimensions.ai/details/publication/pub.1079433381 schema:CreativeWork
    264 https://app.dimensions.ai/details/publication/pub.1079438644 schema:CreativeWork
    265 https://app.dimensions.ai/details/publication/pub.1079474009 schema:CreativeWork
    266 https://app.dimensions.ai/details/publication/pub.1079474010 schema:CreativeWork
    267 https://app.dimensions.ai/details/publication/pub.1079474011 schema:CreativeWork
    268 https://app.dimensions.ai/details/publication/pub.1079780813 schema:CreativeWork
    269 https://app.dimensions.ai/details/publication/pub.1079820902 schema:CreativeWork
    270 https://app.dimensions.ai/details/publication/pub.1080007706 schema:CreativeWork
    271 https://app.dimensions.ai/details/publication/pub.1081603260 schema:CreativeWork
    272 https://app.dimensions.ai/details/publication/pub.1081603262 schema:CreativeWork
    273 https://app.dimensions.ai/details/publication/pub.1081732150 schema:CreativeWork
    274 https://app.dimensions.ai/details/publication/pub.1082077048 schema:CreativeWork
    275 https://doi.org/10.1002/eji.1830140815 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023614150
    276 rdf:type schema:CreativeWork
    277 https://doi.org/10.1016/0008-8749(84)90002-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048868258
    278 rdf:type schema:CreativeWork
    279 https://doi.org/10.1016/0022-1759(82)90003-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026942030
    280 rdf:type schema:CreativeWork
    281 https://doi.org/10.1016/0092-8674(86)90695-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052578566
    282 rdf:type schema:CreativeWork
    283 https://doi.org/10.1016/0092-8674(86)90787-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047704535
    284 rdf:type schema:CreativeWork
    285 https://doi.org/10.1016/0167-5699(86)90076-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028916688
    286 rdf:type schema:CreativeWork
    287 https://doi.org/10.1016/b978-0-12-442750-1.50032-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051019396
    288 rdf:type schema:CreativeWork
    289 https://doi.org/10.1016/s0065-2776(08)60005-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1018925931
    290 rdf:type schema:CreativeWork
    291 https://doi.org/10.1073/pnas.82.9.2925 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014984604
    292 rdf:type schema:CreativeWork
    293 https://doi.org/10.1073/pnas.83.24.9689 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013959694
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.1073/pnas.83.6.1852 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000074015
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.1073/pnas.84.13.4586 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003355913
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.1073/pnas.84.8.2430 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004627856
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.1084/jem.161.6.1368 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007523426
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.1084/jem.164.2.580 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009436978
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.1084/jem.165.6.1725 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041293208
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.1084/jem.166.3.761 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050131776
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.1111/j.1600-065x.1983.tb01072.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1001083381
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1126/science.2883729 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062570101
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1126/science.3787252 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062621451
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1146/annurev.iy.02.040184.000323 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040400532
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1146/annurev.iy.04.040186.003113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051770734
    318 rdf:type schema:CreativeWork
    319 https://www.grid.ac/institutes/grid.267313.2 schema:alternateName The University of Texas Southwestern Medical Center
    320 schema:name Departments of Dermatology, University of Texas Southwestern Medical Center, Dallas 75235.
    321 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...