Direct and Indirect Effects of UVA on Skin Vessel Leakiness View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1982-12

AUTHORS

Bent Staberg, Anne-Marie Worm, Holger Brodthagen, Niels Rossing

ABSTRACT

By using the suction blister technique we have investigated the leakiness of skin vessels in healthy volunteers after whole-body suberythemogenic doses of UVA radiation (a quadrant on one side of the abdominal skin was shielded with lead-rubber). The accumulation of intravenously injected labeled albumin in blister fluid was slightly elevated 1 day after irradiation and increased significantly 2 days later. The blister concentrations of 4 endogenous plasma proteins (albumin, transferrin, IgG, and alpha 2-macroglobulin) were elevated 1 day after radiation exposure and normalized 2 days later. All changes were equal on irradiated and nonirradiated skin. It is concluded that UVA radiation can induce a continued or biphasic increased leakage of plasma proteins in the skin vessels, due to a humoral rather than to a direct physical effect of the radiation on the vessel walls. It is suggested that an increased microvascular leakiness in organs other than the skin might be present. More... »

PAGES

358-360

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1111/1523-1747.ep12529425

DOI

http://dx.doi.org/10.1111/1523-1747.ep12529425

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1005692308

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7142735


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