Prolyl and Lysyl Hydroxylase Activities of Human Skin Fibroblasts: Effects of Donor Age and Ascorbate View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1980-11

AUTHORS

Saood Murad, Arunthathy Sivarajah, Sheldon R Pinnell

ABSTRACT

Prolyl and lysyl hydroxylase activities in cultures of human skin fibroblasts from fetal to 94-yr-old donors were measured. In contrast to earlier studies with whole skin, neither prolyl nor lysyl hydroxylase activity was found related to donor age. Prolyl hydroxylase activity increased 3- to 6-fold when cell extracts were incubated with ascorbate and other hydroxylation cofactors before assay. A similar increase in prolyl hydroxylase activity occurred when cells were incubated with ascorbate. Lysyl hydroxylase activity remained unaltered under these conditions. More... »

PAGES

404-407

References to SciGraph publications

  • 1975-10. Collagen synthesized and modified by aging fibroblasts in culture in IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY
  • 1974. Biosynthesis of Collagen in CONNECTIVE TISSUES
  • 1976. Intracellular Steps in the Biosynthesis of Collagen in BIOCHEMISTRY OF COLLAGEN
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1111/1523-1747.ep12523660

    DOI

    http://dx.doi.org/10.1111/1523-1747.ep12523660

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1010681747

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/6253574


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