Plasma Membranes in Psoriatic Cells. A Freeze-fracture Study View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1978-10

AUTHORS

R Caputo, M Innocenti, G Gasparini, D Peluchetti

ABSTRACT

A freeze-fracture study of affected and unaffected psoriatic skin has demonstrated the presence of marked modification of the plasma membrane in the psoriatic lesion. In the lower layers of the epidermis, an increase of membrane associated particles was observed in many keratinocytes, possibly representing the morphological intramembranous equivalent of changes in the outer cell membrane demonstrated with cytochemical techniques. Furthermore, in the malphighian layer, numerous gap junctions have been found, which may be interpreted as a phenomenon compensating the uncontrolled proliferation, and may represent a point of differentiation between cell proliferation in psoriasis and neoplasia. This technique confirmed the poor tendency to adhesion of keratinocytes in extrajunctional areas, which had already been shown by other morphological techniques. More... »

PAGES

245-249

References to SciGraph publications

  • 1976-07. GROWTH AND DIFFERENTIATION OF SKIN in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 1976-01. Verteilungsstörung oberflächlicher glycoconjugate der psoriatischen zellmembran in ARCHIVES OF DERMATOLOGICAL RESEARCH
  • 1975-07. CYCLIC AMP AND PSORIASIS in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 1969-09. Die normale und psoriatische Hautoberfläche in ARCHIVES OF DERMATOLOGICAL RESEARCH
  • 1977-12. MAMMALIAN EPIDERMAL BARRIER LAYER LIPIDS: COMPOSITION AND INFLUENCE ON STRUCTURE in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 1968-09. Intercellular Adhesion and Surface Coats of Epidermal Cells in Psoriasis1 in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1111/1523-1747.ep12515095

    DOI

    http://dx.doi.org/10.1111/1523-1747.ep12515095

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/701844


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