Expression and Function of Nerve Growth Factor and Nerve Growth Factor Receptor on Cultured Keratinocytes View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1994-07

AUTHORS

C Pincelli, C Sevignani, R Manfredini, A Grande, F Fantini, L Bracci-Laudiero, L Aloe, S Ferrari, A Cossarizza, A Giannetti

ABSTRACT

Keratinocytes, a key cellular component both for homeostasis and pathophysiologic processes of the skin, secrete a number of cytokines and are stimulated by several growth factors. Nerve growth factor (NGF) is synthesized in the skin and basal keratinocytes express the low-affinity nerve growth factor receptor (NGF-R). We present evidence that normal human keratinocytes in culture express the low- and the high-affinity NGF-R both at the mRNA level, as determined by reverse-transcription polymerase chain reaction and at the protein level, as shown by cytofluorimetric analysis. NGF significantly stimulates the proliferation of normal human keratinocytes in culture in a dose-dependent manner. This effect can be prevented by the addition of both an anti-NGF neutralizing antibody and a high-affinity NGF-R (trk) specific inhibitor, the natural alkaloid K252a. By contrast, keratinocyte proliferation is not inhibited by an anti-low-affinity NGF-R monoclonal antibody, thus suggesting that NGF effect on human keratinocytes is mediated by the high-affinity NGF-R. Moreover, NGF mRNA is expressed in normal human keratinocytes and NGF is secreted by keratinocytes in increasing amounts during growth, as detected by enzyme-linked immunosorbent assay. These results suggest that NGF could act as a cytokine in human skin and take part in disorders of keratinocyte proliferation. More... »

PAGES

13-18

References to SciGraph publications

  • 1983-07. Calcium-Regulated Differentiation of Normal Human Epidermal Keratinocytes in Chemically Defined Clonal Culture and Serum-Free Serial Culture in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 1992-12. Expression of Growth-Associated Protein 43 and Nerve Growth Factor Receptor in Human Skin: A Comparative Immunohistochemical Investigation in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 1991-03. Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF in NATURE
  • 1987-02. Gene transfer and molecular cloning of the rat nerve growth factor receptor in NATURE
  • 1989-01. Nerve growth factor regulates expression of neuropeptide genes in adult sensory neurons in NATURE
  • 1983-06. Human β-nerve growth factor gene sequence highly homologous to that of mouse in NATURE
  • 1987-03. Timing and site of nerve growth factor synthesis in developing skin in relation to innervation and expression of the receptor in NATURE
  • 1988-03. Effects of Substance P and Substance K on the Growth of Cultured Keratinocytes in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 1990-12. Evidence for an Epidermal Cytokine Network in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 1992-04. Substance P Is Diminished and Vasoactive Intestinal Peptide Is Augmented in Psoriatic Lesions and These Peptides Exert Disparate Effects on the Proliferation of Cultured Human Keratinocytes in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 1993-09. Prolactin Stimulates Proliferation of Cultured Human Keratinocytes in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1111/1523-1747.ep12388914

    DOI

    http://dx.doi.org/10.1111/1523-1747.ep12388914

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1004862512

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/8027574


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Clinical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antibodies, Monoclonal", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Base Sequence", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Carbazoles", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Division", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cells, Cultured", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Dose-Response Relationship, Drug", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Enzyme-Linked Immunosorbent Assay", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Flow Cytometry", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Fluorescent Antibody Technique", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Indole Alkaloids", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Keratinocytes", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Molecular Sequence Data", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Nerve Growth Factors", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Polymerase Chain Reaction", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Protein Kinase C", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "RNA, Messenger", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Receptors, Nerve Growth Factor", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "University of Modena and Reggio Emilia", 
              "id": "https://www.grid.ac/institutes/grid.7548.e", 
              "name": [
                "Department of Hematology, University of Modena, Italy."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pincelli", 
            "givenName": "C", 
            "id": "sg:person.0667102637.20", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0667102637.20"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Sevignani", 
            "givenName": "C", 
            "id": "sg:person.0674534001.53", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0674534001.53"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Manfredini", 
            "givenName": "R", 
            "id": "sg:person.01153321671.40", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153321671.40"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Grande", 
            "givenName": "A", 
            "id": "sg:person.01131677060.96", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131677060.96"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Fantini", 
            "givenName": "F", 
            "id": "sg:person.01151456644.56", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151456644.56"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Bracci-Laudiero", 
            "givenName": "L", 
            "id": "sg:person.0777637572.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777637572.38"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Aloe", 
            "givenName": "L", 
            "id": "sg:person.0666435121.98", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666435121.98"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Ferrari", 
            "givenName": "S", 
            "id": "sg:person.016710673632.01", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016710673632.01"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Cossarizza", 
            "givenName": "A", 
            "id": "sg:person.01220110375.49", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220110375.49"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Giannetti", 
            "givenName": "A", 
            "id": "sg:person.01167611267.01", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167611267.01"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1016/0092-8674(91)90419-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000550070"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/325593a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001205634", 
              "https://doi.org/10.1038/325593a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(91)90149-s", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006613956"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.86.15.5993", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007410793"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0014-5793(82)80438-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009652855"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.85.17.6508", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010696997"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/1523-1747.ep12365203", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010871142", 
              "https://doi.org/10.1111/1523-1747.ep12365203"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-8993(77)90772-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011705955"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-8993(77)90772-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011705955"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/12.3.1687", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012769682"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.78.7.4644", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012770554"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.9.1.24", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013243817"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.115.3.821", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016386862"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(91)90540-f", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017284579"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/303821a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019522020", 
              "https://doi.org/10.1038/303821a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/eji.1830190418", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021999421"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0140-6736(91)92168-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023369941"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci114539", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026881380"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/350158a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027423695", 
              "https://doi.org/10.1038/350158a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.77.7.4379", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029112623"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(86)90619-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031376876"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1113/jphysiol.1986.sp016014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033028550"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.85.1.270", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033180989"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.102.3.830", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033835573"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.89.6.2374", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034503214"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/337362a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034971262", 
              "https://doi.org/10.1038/337362a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0306-4522(91)90322-f", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037401607"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0306-4522(91)90322-f", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037401607"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0896-6273(91)90067-a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037692861"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(90)90801-k", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037771370"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/1523-1747.ep12456487", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037972529", 
              "https://doi.org/10.1111/1523-1747.ep12456487"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.86.16.6367", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038193858"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.86.24.10059", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038762168"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/1523-1747.ep12874944", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038845261", 
              "https://doi.org/10.1111/1523-1747.ep12874944"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/1523-1747.ep12540422", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038880161", 
              "https://doi.org/10.1111/1523-1747.ep12540422"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.88.20.9302", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045291383"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/1523-1747.ep12614465", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045316675", 
              "https://doi.org/10.1111/1523-1747.ep12614465"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.77.8.4751", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045435530"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/326353a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046299855", 
              "https://doi.org/10.1038/326353a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/eji.1830220414", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046738449"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.4.5.683", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047055958"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.168.4.1395", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049289717"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0304-3940(92)90762-v", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051411520"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0304-3940(92)90762-v", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051411520"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/1523-1747.ep12499846", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052984396", 
              "https://doi.org/10.1111/1523-1747.ep12499846"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1850549", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062510386"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.3306916", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062606018"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075584088", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077047012", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077296885", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077341266", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077365387", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077373910", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/physrev.1980.60.4.1284", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1081595476"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "1994-07", 
        "datePublishedReg": "1994-07-01", 
        "description": "Keratinocytes, a key cellular component both for homeostasis and pathophysiologic processes of the skin, secrete a number of cytokines and are stimulated by several growth factors. Nerve growth factor (NGF) is synthesized in the skin and basal keratinocytes express the low-affinity nerve growth factor receptor (NGF-R). We present evidence that normal human keratinocytes in culture express the low- and the high-affinity NGF-R both at the mRNA level, as determined by reverse-transcription polymerase chain reaction and at the protein level, as shown by cytofluorimetric analysis. NGF significantly stimulates the proliferation of normal human keratinocytes in culture in a dose-dependent manner. This effect can be prevented by the addition of both an anti-NGF neutralizing antibody and a high-affinity NGF-R (trk) specific inhibitor, the natural alkaloid K252a. By contrast, keratinocyte proliferation is not inhibited by an anti-low-affinity NGF-R monoclonal antibody, thus suggesting that NGF effect on human keratinocytes is mediated by the high-affinity NGF-R. Moreover, NGF mRNA is expressed in normal human keratinocytes and NGF is secreted by keratinocytes in increasing amounts during growth, as detected by enzyme-linked immunosorbent assay. These results suggest that NGF could act as a cytokine in human skin and take part in disorders of keratinocyte proliferation.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1111/1523-1747.ep12388914", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1020153", 
            "issn": [
              "0022-202X", 
              "1523-1747"
            ], 
            "name": "Journal of Investigative Dermatology", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "103"
          }
        ], 
        "name": "Expression and Function of Nerve Growth Factor and Nerve Growth Factor Receptor on Cultured Keratinocytes", 
        "pagination": "13-18", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "172bc75746c0b22e941138500e22f6e4cf56accb909cbc5bf27a73c7c83e435e"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "8027574"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "0426720"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1111/1523-1747.ep12388914"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1004862512"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1111/1523-1747.ep12388914", 
          "https://app.dimensions.ai/details/publication/pub.1004862512"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T22:19", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8690_00000421.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.nature.com/jid/journal/v103/n1/full/5611180a.html"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1111/1523-1747.ep12388914'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1111/1523-1747.ep12388914'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1111/1523-1747.ep12388914'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1111/1523-1747.ep12388914'


     

    This table displays all metadata directly associated to this object as RDF triples.

    357 TRIPLES      21 PREDICATES      99 URIs      40 LITERALS      28 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1111/1523-1747.ep12388914 schema:about N0c9c9932e6334954bfb71368aab7c690
    2 N163ff5b83ad44590802102bbcae06dc9
    3 N1faeb37afad44d94ac28e9771e686439
    4 N2ec053a41ec2408caa1be255bbc753fa
    5 N47c1e9be38874cdaa164e6a2b353cfba
    6 N4981edc5a69f440da69333515dd7cd12
    7 N6c6920afa3d74cfca329855c1161b1a5
    8 N76ca0fadfb154767aaac5178fd61963b
    9 N8e4f919243114008834052105f347684
    10 N95605b6c461d4ddc930bbd491efa4e23
    11 Na2fc499e398146ff9eb61792e2e59041
    12 Nabc1aa6ff73846128f3d244432c1e293
    13 Nb7da585f89a042af94053faa046af86d
    14 Nb8a07b996bc746beb622ef1e80d2adfc
    15 Nc2dfc25d265b431ebe6b39d79ae9e87e
    16 Nd68c6d91cdfb446792ac8365b9bca6bc
    17 Ne9906ac468ea49f5ac88160571c9cbe0
    18 Nf5ff9dd2361b47ba8058026ea20b007b
    19 Nf896a9749f50420c8e02048af35e1eda
    20 anzsrc-for:11
    21 anzsrc-for:1103
    22 schema:author Na01900a1613741ae8b100f8009b284c3
    23 schema:citation sg:pub.10.1038/303821a0
    24 sg:pub.10.1038/325593a0
    25 sg:pub.10.1038/326353a0
    26 sg:pub.10.1038/337362a0
    27 sg:pub.10.1038/350158a0
    28 sg:pub.10.1111/1523-1747.ep12365203
    29 sg:pub.10.1111/1523-1747.ep12456487
    30 sg:pub.10.1111/1523-1747.ep12499846
    31 sg:pub.10.1111/1523-1747.ep12540422
    32 sg:pub.10.1111/1523-1747.ep12614465
    33 sg:pub.10.1111/1523-1747.ep12874944
    34 https://app.dimensions.ai/details/publication/pub.1075584088
    35 https://app.dimensions.ai/details/publication/pub.1077047012
    36 https://app.dimensions.ai/details/publication/pub.1077296885
    37 https://app.dimensions.ai/details/publication/pub.1077341266
    38 https://app.dimensions.ai/details/publication/pub.1077365387
    39 https://app.dimensions.ai/details/publication/pub.1077373910
    40 https://doi.org/10.1002/eji.1830190418
    41 https://doi.org/10.1002/eji.1830220414
    42 https://doi.org/10.1016/0006-8993(77)90772-7
    43 https://doi.org/10.1016/0014-5793(82)80438-9
    44 https://doi.org/10.1016/0092-8674(86)90619-7
    45 https://doi.org/10.1016/0092-8674(90)90801-k
    46 https://doi.org/10.1016/0092-8674(91)90149-s
    47 https://doi.org/10.1016/0092-8674(91)90419-y
    48 https://doi.org/10.1016/0092-8674(91)90540-f
    49 https://doi.org/10.1016/0140-6736(91)92168-2
    50 https://doi.org/10.1016/0304-3940(92)90762-v
    51 https://doi.org/10.1016/0306-4522(91)90322-f
    52 https://doi.org/10.1016/0896-6273(91)90067-a
    53 https://doi.org/10.1073/pnas.77.7.4379
    54 https://doi.org/10.1073/pnas.77.8.4751
    55 https://doi.org/10.1073/pnas.78.7.4644
    56 https://doi.org/10.1073/pnas.85.1.270
    57 https://doi.org/10.1073/pnas.85.17.6508
    58 https://doi.org/10.1073/pnas.86.15.5993
    59 https://doi.org/10.1073/pnas.86.16.6367
    60 https://doi.org/10.1073/pnas.86.24.10059
    61 https://doi.org/10.1073/pnas.88.20.9302
    62 https://doi.org/10.1073/pnas.89.6.2374
    63 https://doi.org/10.1083/jcb.102.3.830
    64 https://doi.org/10.1083/jcb.115.3.821
    65 https://doi.org/10.1084/jem.168.4.1395
    66 https://doi.org/10.1093/nar/12.3.1687
    67 https://doi.org/10.1101/gad.4.5.683
    68 https://doi.org/10.1113/jphysiol.1986.sp016014
    69 https://doi.org/10.1126/science.1850549
    70 https://doi.org/10.1126/science.3306916
    71 https://doi.org/10.1128/mcb.9.1.24
    72 https://doi.org/10.1152/physrev.1980.60.4.1284
    73 https://doi.org/10.1172/jci114539
    74 schema:datePublished 1994-07
    75 schema:datePublishedReg 1994-07-01
    76 schema:description Keratinocytes, a key cellular component both for homeostasis and pathophysiologic processes of the skin, secrete a number of cytokines and are stimulated by several growth factors. Nerve growth factor (NGF) is synthesized in the skin and basal keratinocytes express the low-affinity nerve growth factor receptor (NGF-R). We present evidence that normal human keratinocytes in culture express the low- and the high-affinity NGF-R both at the mRNA level, as determined by reverse-transcription polymerase chain reaction and at the protein level, as shown by cytofluorimetric analysis. NGF significantly stimulates the proliferation of normal human keratinocytes in culture in a dose-dependent manner. This effect can be prevented by the addition of both an anti-NGF neutralizing antibody and a high-affinity NGF-R (trk) specific inhibitor, the natural alkaloid K252a. By contrast, keratinocyte proliferation is not inhibited by an anti-low-affinity NGF-R monoclonal antibody, thus suggesting that NGF effect on human keratinocytes is mediated by the high-affinity NGF-R. Moreover, NGF mRNA is expressed in normal human keratinocytes and NGF is secreted by keratinocytes in increasing amounts during growth, as detected by enzyme-linked immunosorbent assay. These results suggest that NGF could act as a cytokine in human skin and take part in disorders of keratinocyte proliferation.
    77 schema:genre research_article
    78 schema:inLanguage en
    79 schema:isAccessibleForFree true
    80 schema:isPartOf N8c500be62b884aad85301e0f4ba76813
    81 N92421c6fac5f49da8d52b86be8b3d142
    82 sg:journal.1020153
    83 schema:name Expression and Function of Nerve Growth Factor and Nerve Growth Factor Receptor on Cultured Keratinocytes
    84 schema:pagination 13-18
    85 schema:productId N4b9563e9e1494984ae624d8d8603b7d3
    86 N55369ffd495f486cbc8e91eceacd643d
    87 Nb390e490002842f5ad4994ae6f7250ab
    88 Nebcff522573c4157b2a2b1afa1203225
    89 Nfed7a3aaedb64c57aa39eb585c024717
    90 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004862512
    91 https://doi.org/10.1111/1523-1747.ep12388914
    92 schema:sdDatePublished 2019-04-10T22:19
    93 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    94 schema:sdPublisher N35860bdfaa324e59bed3445d22016514
    95 schema:url http://www.nature.com/jid/journal/v103/n1/full/5611180a.html
    96 sgo:license sg:explorer/license/
    97 sgo:sdDataset articles
    98 rdf:type schema:ScholarlyArticle
    99 N0c9c9932e6334954bfb71368aab7c690 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    100 schema:name Flow Cytometry
    101 rdf:type schema:DefinedTerm
    102 N163ff5b83ad44590802102bbcae06dc9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    103 schema:name Dose-Response Relationship, Drug
    104 rdf:type schema:DefinedTerm
    105 N1a5aa6eb634b4e9a81c188d3e237bbd5 rdf:first sg:person.01153321671.40
    106 rdf:rest N3507564960594dcdb87d821b4938a610
    107 N1faeb37afad44d94ac28e9771e686439 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    108 schema:name Carbazoles
    109 rdf:type schema:DefinedTerm
    110 N2ec053a41ec2408caa1be255bbc753fa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    111 schema:name Fluorescent Antibody Technique
    112 rdf:type schema:DefinedTerm
    113 N3507564960594dcdb87d821b4938a610 rdf:first sg:person.01131677060.96
    114 rdf:rest N88cc69593c9a4a70aeeab20371d6aaf5
    115 N35860bdfaa324e59bed3445d22016514 schema:name Springer Nature - SN SciGraph project
    116 rdf:type schema:Organization
    117 N47c1e9be38874cdaa164e6a2b353cfba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    118 schema:name Polymerase Chain Reaction
    119 rdf:type schema:DefinedTerm
    120 N4981edc5a69f440da69333515dd7cd12 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    121 schema:name Humans
    122 rdf:type schema:DefinedTerm
    123 N4b9563e9e1494984ae624d8d8603b7d3 schema:name pubmed_id
    124 schema:value 8027574
    125 rdf:type schema:PropertyValue
    126 N4bdf9fe4832f413986c247f485f64f06 rdf:first sg:person.016710673632.01
    127 rdf:rest Ne1558f41eb854277aad0a2bfb9472d51
    128 N55369ffd495f486cbc8e91eceacd643d schema:name readcube_id
    129 schema:value 172bc75746c0b22e941138500e22f6e4cf56accb909cbc5bf27a73c7c83e435e
    130 rdf:type schema:PropertyValue
    131 N6c6920afa3d74cfca329855c1161b1a5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    132 schema:name Receptors, Nerve Growth Factor
    133 rdf:type schema:DefinedTerm
    134 N76ca0fadfb154767aaac5178fd61963b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    135 schema:name Antibodies, Monoclonal
    136 rdf:type schema:DefinedTerm
    137 N88cc69593c9a4a70aeeab20371d6aaf5 rdf:first sg:person.01151456644.56
    138 rdf:rest Ne8dbfb01b0774549b9cde3731b8befca
    139 N8ba30d9936cd482eaa46935faf96f24f rdf:first sg:person.0666435121.98
    140 rdf:rest N4bdf9fe4832f413986c247f485f64f06
    141 N8c500be62b884aad85301e0f4ba76813 schema:volumeNumber 103
    142 rdf:type schema:PublicationVolume
    143 N8e4f919243114008834052105f347684 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    144 schema:name Protein Kinase C
    145 rdf:type schema:DefinedTerm
    146 N92421c6fac5f49da8d52b86be8b3d142 schema:issueNumber 1
    147 rdf:type schema:PublicationIssue
    148 N95605b6c461d4ddc930bbd491efa4e23 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    149 schema:name RNA, Messenger
    150 rdf:type schema:DefinedTerm
    151 Na01900a1613741ae8b100f8009b284c3 rdf:first sg:person.0667102637.20
    152 rdf:rest Nc4da3a48a1a14301b6b0cf0d8ea1f7f3
    153 Na2fc499e398146ff9eb61792e2e59041 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    154 schema:name Enzyme-Linked Immunosorbent Assay
    155 rdf:type schema:DefinedTerm
    156 Nabc1aa6ff73846128f3d244432c1e293 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    157 schema:name Nerve Growth Factors
    158 rdf:type schema:DefinedTerm
    159 Nb390e490002842f5ad4994ae6f7250ab schema:name doi
    160 schema:value 10.1111/1523-1747.ep12388914
    161 rdf:type schema:PropertyValue
    162 Nb7a219732a3544819f44fed58180f927 rdf:first sg:person.01167611267.01
    163 rdf:rest rdf:nil
    164 Nb7da585f89a042af94053faa046af86d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    165 schema:name Gene Expression
    166 rdf:type schema:DefinedTerm
    167 Nb8a07b996bc746beb622ef1e80d2adfc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    168 schema:name Cell Division
    169 rdf:type schema:DefinedTerm
    170 Nc2dfc25d265b431ebe6b39d79ae9e87e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    171 schema:name Cells, Cultured
    172 rdf:type schema:DefinedTerm
    173 Nc4da3a48a1a14301b6b0cf0d8ea1f7f3 rdf:first sg:person.0674534001.53
    174 rdf:rest N1a5aa6eb634b4e9a81c188d3e237bbd5
    175 Nd68c6d91cdfb446792ac8365b9bca6bc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    176 schema:name Base Sequence
    177 rdf:type schema:DefinedTerm
    178 Ne1558f41eb854277aad0a2bfb9472d51 rdf:first sg:person.01220110375.49
    179 rdf:rest Nb7a219732a3544819f44fed58180f927
    180 Ne8dbfb01b0774549b9cde3731b8befca rdf:first sg:person.0777637572.38
    181 rdf:rest N8ba30d9936cd482eaa46935faf96f24f
    182 Ne9906ac468ea49f5ac88160571c9cbe0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    183 schema:name Keratinocytes
    184 rdf:type schema:DefinedTerm
    185 Nebcff522573c4157b2a2b1afa1203225 schema:name nlm_unique_id
    186 schema:value 0426720
    187 rdf:type schema:PropertyValue
    188 Nf5ff9dd2361b47ba8058026ea20b007b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    189 schema:name Indole Alkaloids
    190 rdf:type schema:DefinedTerm
    191 Nf896a9749f50420c8e02048af35e1eda schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    192 schema:name Molecular Sequence Data
    193 rdf:type schema:DefinedTerm
    194 Nfed7a3aaedb64c57aa39eb585c024717 schema:name dimensions_id
    195 schema:value pub.1004862512
    196 rdf:type schema:PropertyValue
    197 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    198 schema:name Medical and Health Sciences
    199 rdf:type schema:DefinedTerm
    200 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
    201 schema:name Clinical Sciences
    202 rdf:type schema:DefinedTerm
    203 sg:journal.1020153 schema:issn 0022-202X
    204 1523-1747
    205 schema:name Journal of Investigative Dermatology
    206 rdf:type schema:Periodical
    207 sg:person.01131677060.96 schema:familyName Grande
    208 schema:givenName A
    209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131677060.96
    210 rdf:type schema:Person
    211 sg:person.01151456644.56 schema:familyName Fantini
    212 schema:givenName F
    213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151456644.56
    214 rdf:type schema:Person
    215 sg:person.01153321671.40 schema:familyName Manfredini
    216 schema:givenName R
    217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153321671.40
    218 rdf:type schema:Person
    219 sg:person.01167611267.01 schema:familyName Giannetti
    220 schema:givenName A
    221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167611267.01
    222 rdf:type schema:Person
    223 sg:person.01220110375.49 schema:familyName Cossarizza
    224 schema:givenName A
    225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220110375.49
    226 rdf:type schema:Person
    227 sg:person.016710673632.01 schema:familyName Ferrari
    228 schema:givenName S
    229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016710673632.01
    230 rdf:type schema:Person
    231 sg:person.0666435121.98 schema:familyName Aloe
    232 schema:givenName L
    233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666435121.98
    234 rdf:type schema:Person
    235 sg:person.0667102637.20 schema:affiliation https://www.grid.ac/institutes/grid.7548.e
    236 schema:familyName Pincelli
    237 schema:givenName C
    238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0667102637.20
    239 rdf:type schema:Person
    240 sg:person.0674534001.53 schema:familyName Sevignani
    241 schema:givenName C
    242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0674534001.53
    243 rdf:type schema:Person
    244 sg:person.0777637572.38 schema:familyName Bracci-Laudiero
    245 schema:givenName L
    246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777637572.38
    247 rdf:type schema:Person
    248 sg:pub.10.1038/303821a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019522020
    249 https://doi.org/10.1038/303821a0
    250 rdf:type schema:CreativeWork
    251 sg:pub.10.1038/325593a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001205634
    252 https://doi.org/10.1038/325593a0
    253 rdf:type schema:CreativeWork
    254 sg:pub.10.1038/326353a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046299855
    255 https://doi.org/10.1038/326353a0
    256 rdf:type schema:CreativeWork
    257 sg:pub.10.1038/337362a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034971262
    258 https://doi.org/10.1038/337362a0
    259 rdf:type schema:CreativeWork
    260 sg:pub.10.1038/350158a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027423695
    261 https://doi.org/10.1038/350158a0
    262 rdf:type schema:CreativeWork
    263 sg:pub.10.1111/1523-1747.ep12365203 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010871142
    264 https://doi.org/10.1111/1523-1747.ep12365203
    265 rdf:type schema:CreativeWork
    266 sg:pub.10.1111/1523-1747.ep12456487 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037972529
    267 https://doi.org/10.1111/1523-1747.ep12456487
    268 rdf:type schema:CreativeWork
    269 sg:pub.10.1111/1523-1747.ep12499846 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052984396
    270 https://doi.org/10.1111/1523-1747.ep12499846
    271 rdf:type schema:CreativeWork
    272 sg:pub.10.1111/1523-1747.ep12540422 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038880161
    273 https://doi.org/10.1111/1523-1747.ep12540422
    274 rdf:type schema:CreativeWork
    275 sg:pub.10.1111/1523-1747.ep12614465 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045316675
    276 https://doi.org/10.1111/1523-1747.ep12614465
    277 rdf:type schema:CreativeWork
    278 sg:pub.10.1111/1523-1747.ep12874944 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038845261
    279 https://doi.org/10.1111/1523-1747.ep12874944
    280 rdf:type schema:CreativeWork
    281 https://app.dimensions.ai/details/publication/pub.1075584088 schema:CreativeWork
    282 https://app.dimensions.ai/details/publication/pub.1077047012 schema:CreativeWork
    283 https://app.dimensions.ai/details/publication/pub.1077296885 schema:CreativeWork
    284 https://app.dimensions.ai/details/publication/pub.1077341266 schema:CreativeWork
    285 https://app.dimensions.ai/details/publication/pub.1077365387 schema:CreativeWork
    286 https://app.dimensions.ai/details/publication/pub.1077373910 schema:CreativeWork
    287 https://doi.org/10.1002/eji.1830190418 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021999421
    288 rdf:type schema:CreativeWork
    289 https://doi.org/10.1002/eji.1830220414 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046738449
    290 rdf:type schema:CreativeWork
    291 https://doi.org/10.1016/0006-8993(77)90772-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011705955
    292 rdf:type schema:CreativeWork
    293 https://doi.org/10.1016/0014-5793(82)80438-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009652855
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.1016/0092-8674(86)90619-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031376876
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.1016/0092-8674(90)90801-k schema:sameAs https://app.dimensions.ai/details/publication/pub.1037771370
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.1016/0092-8674(91)90149-s schema:sameAs https://app.dimensions.ai/details/publication/pub.1006613956
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.1016/0092-8674(91)90419-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1000550070
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.1016/0092-8674(91)90540-f schema:sameAs https://app.dimensions.ai/details/publication/pub.1017284579
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.1016/0140-6736(91)92168-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023369941
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.1016/0304-3940(92)90762-v schema:sameAs https://app.dimensions.ai/details/publication/pub.1051411520
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.1016/0306-4522(91)90322-f schema:sameAs https://app.dimensions.ai/details/publication/pub.1037401607
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1016/0896-6273(91)90067-a schema:sameAs https://app.dimensions.ai/details/publication/pub.1037692861
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1073/pnas.77.7.4379 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029112623
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1073/pnas.77.8.4751 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045435530
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1073/pnas.78.7.4644 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012770554
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.1073/pnas.85.1.270 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033180989
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.1073/pnas.85.17.6508 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010696997
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.1073/pnas.86.15.5993 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007410793
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.1073/pnas.86.16.6367 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038193858
    326 rdf:type schema:CreativeWork
    327 https://doi.org/10.1073/pnas.86.24.10059 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038762168
    328 rdf:type schema:CreativeWork
    329 https://doi.org/10.1073/pnas.88.20.9302 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045291383
    330 rdf:type schema:CreativeWork
    331 https://doi.org/10.1073/pnas.89.6.2374 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034503214
    332 rdf:type schema:CreativeWork
    333 https://doi.org/10.1083/jcb.102.3.830 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033835573
    334 rdf:type schema:CreativeWork
    335 https://doi.org/10.1083/jcb.115.3.821 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016386862
    336 rdf:type schema:CreativeWork
    337 https://doi.org/10.1084/jem.168.4.1395 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049289717
    338 rdf:type schema:CreativeWork
    339 https://doi.org/10.1093/nar/12.3.1687 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012769682
    340 rdf:type schema:CreativeWork
    341 https://doi.org/10.1101/gad.4.5.683 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047055958
    342 rdf:type schema:CreativeWork
    343 https://doi.org/10.1113/jphysiol.1986.sp016014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033028550
    344 rdf:type schema:CreativeWork
    345 https://doi.org/10.1126/science.1850549 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062510386
    346 rdf:type schema:CreativeWork
    347 https://doi.org/10.1126/science.3306916 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062606018
    348 rdf:type schema:CreativeWork
    349 https://doi.org/10.1128/mcb.9.1.24 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013243817
    350 rdf:type schema:CreativeWork
    351 https://doi.org/10.1152/physrev.1980.60.4.1284 schema:sameAs https://app.dimensions.ai/details/publication/pub.1081595476
    352 rdf:type schema:CreativeWork
    353 https://doi.org/10.1172/jci114539 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026881380
    354 rdf:type schema:CreativeWork
    355 https://www.grid.ac/institutes/grid.7548.e schema:alternateName University of Modena and Reggio Emilia
    356 schema:name Department of Hematology, University of Modena, Italy.
    357 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...