Distinctive Integrin Expression in the Newly Forming Epidermis During Wound Healing in Humans View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1993-10

AUTHORS

A Cavani, G Zambruno, A Marconi, V Manca, M Marchetti, A Giannetti

ABSTRACT

The integrin receptor family plays a fundamental role in mediating cell attachment to a variety of extracellular matrix molecules. In normal human epidermis, the alpha 2 beta 1, alpha 3 beta 1, alpha 6 beta 4, and alpha v beta 5 integrin heterodimers are expressed and appear largely confined to the basal cell layer. In the present study, beta 1, beta 4, and alpha v integrin expression in the epidermis during wound healing in humans was examined. Punch biopsies were performed on healthy volunteers. At daily intervals up to day 8, and at days 11, 14, 21, and 28, the wound site was surgically removed. Using immunofluorescence microscopy, several modifications of the integrin expression pattern were observed on migrating keratinocytes during the re-epithelialization phase of the wound-healing process: i) alpha v expression was strongly enhanced and polarized at the basal pole of basal keratinocytes; ii) among the beta 1 integrins, alpha 3 beta 1 was overexpressed and distributed over the entire basal keratinocyte membrane and a weak alpha 5 beta 1 reactivity became evident; and iii) alpha 6 beta 4 was detected as a linear staining along the newly forming dermal-epidermal junction. Moreover, both during the re-epithelialization phase and during the first 2 weeks after wound closure, alpha 3, alpha 6, alpha v, beta 1, and beta 4 were no longer confined to the basal layer, as in normal epidermis, but were also found on several suprabasal cell layers. These results suggest that alpha v beta 5, alpha 3 beta 1, and alpha 5 beta 1 may be the main integrin receptors mediating keratinocyte spreading and migration over the provisional matrix of the wound bed. More... »

PAGES

600-604

References to SciGraph publications

  • 1985-08. Spreading and Enhanced Motility of Human Keratinocytes on Fibronectin in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 1990-06. Fibronectin Matrix Deposition and Fibronectin Receptor Expression in Healing and Normal Skin in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 1991-05. Tissue Vitronectin in Normal Adult Human Dermis Is Non-Covalently Bound to Elastic Tissue in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 1991-05. Vitronectin: Effects on Keratinocyte Motility and Inhibition of Collagen-Induced Motility in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 1985-10. Fibronectin-Mediated Keratinocyte Migration and Initiation of Fibronectin Receptor Function In Vitro in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 1987-04. Activation of Human Keratinocyte Fibronectin Receptor Function in Relation to Other Ligand-Receptor Interactions in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 1989-01. Adhesion molecule mapping in normal human skin in ARCHIVES OF DERMATOLOGICAL RESEARCH
  • 1985-05. Fibronectin, As Well As Other Extracellular Matrix Proteins, Mediate Human Keratinocyte Adherence in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 1987-12. Thrombospondin in Early Human Wound Tissue in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 1988-11. Stimulatory Effects of Transforming Growth Factor-beta and Epidermal Growth Factor on Epidermal Cell Outgrowth from Porcine Skin Explant Cultures in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 1992-01. Migration of a Human Keratinocyte Cell Line (HACAT) to Interstitial Collagen Type I Is Mediated by the α2β1-Integrin Receptor in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 1991-09. Expression of β4 Integrins in Human Skin: Comparison of Epidermal Distribution with β1-Integrin Epitopes, and Modulation by Calcium and Vitamin D3 in Cultured Keratinocytes in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 1990-07. Expression of Integrins in Junctional and Dystrophic Epidermolysis Bullosa in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1111/1523-1747.ep12366057

    DOI

    http://dx.doi.org/10.1111/1523-1747.ep12366057

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1026650682

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/8409530


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Epidermis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Extracellular Matrix Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Fluorescent Antibody Technique", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Integrins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Reference Values", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Skin", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Wound Healing", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "University of Modena and Reggio Emilia", 
              "id": "https://www.grid.ac/institutes/grid.7548.e", 
              "name": [
                "Department of Dermatology, University of Modena, Italy."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cavani", 
            "givenName": "A", 
            "id": "sg:person.01126751326.36", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01126751326.36"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Zambruno", 
            "givenName": "G", 
            "id": "sg:person.01315030632.54", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01315030632.54"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Marconi", 
            "givenName": "A", 
            "id": "sg:person.01063775375.36", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063775375.36"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Manca", 
            "givenName": "V", 
            "id": "sg:person.01143252116.28", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143252116.28"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Marchetti", 
            "givenName": "M", 
            "type": "Person"
          }, 
          {
            "familyName": "Giannetti", 
            "givenName": "A", 
            "id": "sg:person.01167611267.01", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167611267.01"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1111/j.1365-2133.1991.tb14742.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000715940"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci115794", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000796099"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.113.4.907", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002871677"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(87)90179-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006950060"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(92)90115-s", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007440282"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/1523-1747.ep12276531", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007470343", 
              "https://doi.org/10.1111/1523-1747.ep12276531"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/1523-1747.ep12265466", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007765614", 
              "https://doi.org/10.1111/1523-1747.ep12265466"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.156.6.1755", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008388622"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.115.6.1737", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008760365"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2133.1990.tb01844.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009509343"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.110.4.1387", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011470705"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/1523-1747.ep12469745", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013042324", 
              "https://doi.org/10.1111/1523-1747.ep12469745"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/1523-1747.ep12276880", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014837137", 
              "https://doi.org/10.1111/1523-1747.ep12276880"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/1523-1747.ep12461198", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017512785", 
              "https://doi.org/10.1111/1523-1747.ep12461198"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci115782", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019328352"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/1523-1747.ep12470960", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019557009", 
              "https://doi.org/10.1111/1523-1747.ep12470960"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/1523-1747.ep12476480", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020545698", 
              "https://doi.org/10.1111/1523-1747.ep12476480"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.112.4.761", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022579099"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/1523-1747.ep12470980", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023023961", 
              "https://doi.org/10.1111/1523-1747.ep12470980"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/1523-1747.ep12481896", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023161081", 
              "https://doi.org/10.1111/1523-1747.ep12481896"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/1523-1747.ep12875994", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023505125", 
              "https://doi.org/10.1111/1523-1747.ep12875994"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.110.3.803", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024904480"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci114379", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026736141"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0014-4827(91)90379-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029428007"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0014-4827(90)90092-o", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030261245"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.107.3.1215", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030869748"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.81.1.224", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031354164"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/1523-1747.ep12493266", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032711917", 
              "https://doi.org/10.1111/1523-1747.ep12493266"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.78.11.6907", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032766355"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.109.4.1807", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033638179"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jcb.240260206", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035288698"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00510080", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035854347", 
              "https://doi.org/10.1007/bf00510080"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00510080", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035854347", 
              "https://doi.org/10.1007/bf00510080"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1600-0560.1989.tb00051.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036633287"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/1523-1747.ep12876104", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039851742", 
              "https://doi.org/10.1111/1523-1747.ep12876104"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.87.22.8970", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041655235"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci114957", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043211532"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.87.17.6888", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048642790"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.111.6.3141", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048705360"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.115.3.829", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049142503"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00005373-199012001-00028", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049445888"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00005373-199012001-00028", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049445888"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2133.1991.tb00422.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052547132"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077299519", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077462415", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078215307", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078375325", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078873072", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "1993-10", 
        "datePublishedReg": "1993-10-01", 
        "description": "The integrin receptor family plays a fundamental role in mediating cell attachment to a variety of extracellular matrix molecules. In normal human epidermis, the alpha 2 beta 1, alpha 3 beta 1, alpha 6 beta 4, and alpha v beta 5 integrin heterodimers are expressed and appear largely confined to the basal cell layer. In the present study, beta 1, beta 4, and alpha v integrin expression in the epidermis during wound healing in humans was examined. Punch biopsies were performed on healthy volunteers. At daily intervals up to day 8, and at days 11, 14, 21, and 28, the wound site was surgically removed. Using immunofluorescence microscopy, several modifications of the integrin expression pattern were observed on migrating keratinocytes during the re-epithelialization phase of the wound-healing process: i) alpha v expression was strongly enhanced and polarized at the basal pole of basal keratinocytes; ii) among the beta 1 integrins, alpha 3 beta 1 was overexpressed and distributed over the entire basal keratinocyte membrane and a weak alpha 5 beta 1 reactivity became evident; and iii) alpha 6 beta 4 was detected as a linear staining along the newly forming dermal-epidermal junction. Moreover, both during the re-epithelialization phase and during the first 2 weeks after wound closure, alpha 3, alpha 6, alpha v, beta 1, and beta 4 were no longer confined to the basal layer, as in normal epidermis, but were also found on several suprabasal cell layers. These results suggest that alpha v beta 5, alpha 3 beta 1, and alpha 5 beta 1 may be the main integrin receptors mediating keratinocyte spreading and migration over the provisional matrix of the wound bed.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1111/1523-1747.ep12366057", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1020153", 
            "issn": [
              "0022-202X", 
              "1523-1747"
            ], 
            "name": "Journal of Investigative Dermatology", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "4", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "101"
          }
        ], 
        "name": "Distinctive Integrin Expression in the Newly Forming Epidermis During Wound Healing in Humans", 
        "pagination": "600-604", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "7ef6065764761ccad0c01b17db8bbaa812fe5bc0dac4ae1f02c327aaaa60592a"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "8409530"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "0426720"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1111/1523-1747.ep12366057"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1026650682"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1111/1523-1747.ep12366057", 
          "https://app.dimensions.ai/details/publication/pub.1026650682"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T15:38", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8664_00000424.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.nature.com/jid/journal/v101/n4/full/5611476a.html"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1111/1523-1747.ep12366057'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1111/1523-1747.ep12366057'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1111/1523-1747.ep12366057'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1111/1523-1747.ep12366057'


     

    This table displays all metadata directly associated to this object as RDF triples.

    280 TRIPLES      21 PREDICATES      84 URIs      30 LITERALS      18 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1111/1523-1747.ep12366057 schema:about N064a50919c4b4231839f6cbbe249573a
    2 N392f993253564233bef0e902f8d37e77
    3 N446738650d3e49609c6fe4e8982ca12f
    4 N484b6322c26f499b996a7922d60f6c0a
    5 N4cd5f5144132465baff4b37709dabc2f
    6 Na0dc178fb9fa463f9953a1388a256fa5
    7 Na4cd170f9b1942de9e371ecd46b804c5
    8 Nb1f5a6bf6c064a7b8f29720c06abf479
    9 Nf91e0171123d43dc90e6bc9f87a145c1
    10 anzsrc-for:06
    11 anzsrc-for:0601
    12 schema:author N5b444bcfefdb4a2d9d64212f60436968
    13 schema:citation sg:pub.10.1007/bf00510080
    14 sg:pub.10.1111/1523-1747.ep12265466
    15 sg:pub.10.1111/1523-1747.ep12276531
    16 sg:pub.10.1111/1523-1747.ep12276880
    17 sg:pub.10.1111/1523-1747.ep12461198
    18 sg:pub.10.1111/1523-1747.ep12469745
    19 sg:pub.10.1111/1523-1747.ep12470960
    20 sg:pub.10.1111/1523-1747.ep12470980
    21 sg:pub.10.1111/1523-1747.ep12476480
    22 sg:pub.10.1111/1523-1747.ep12481896
    23 sg:pub.10.1111/1523-1747.ep12493266
    24 sg:pub.10.1111/1523-1747.ep12875994
    25 sg:pub.10.1111/1523-1747.ep12876104
    26 https://app.dimensions.ai/details/publication/pub.1077299519
    27 https://app.dimensions.ai/details/publication/pub.1077462415
    28 https://app.dimensions.ai/details/publication/pub.1078215307
    29 https://app.dimensions.ai/details/publication/pub.1078375325
    30 https://app.dimensions.ai/details/publication/pub.1078873072
    31 https://doi.org/10.1002/jcb.240260206
    32 https://doi.org/10.1016/0014-4827(90)90092-o
    33 https://doi.org/10.1016/0014-4827(91)90379-9
    34 https://doi.org/10.1016/0092-8674(87)90179-6
    35 https://doi.org/10.1016/0092-8674(92)90115-s
    36 https://doi.org/10.1073/pnas.78.11.6907
    37 https://doi.org/10.1073/pnas.81.1.224
    38 https://doi.org/10.1073/pnas.87.17.6888
    39 https://doi.org/10.1073/pnas.87.22.8970
    40 https://doi.org/10.1083/jcb.107.3.1215
    41 https://doi.org/10.1083/jcb.109.4.1807
    42 https://doi.org/10.1083/jcb.110.3.803
    43 https://doi.org/10.1083/jcb.110.4.1387
    44 https://doi.org/10.1083/jcb.111.6.3141
    45 https://doi.org/10.1083/jcb.112.4.761
    46 https://doi.org/10.1083/jcb.113.4.907
    47 https://doi.org/10.1083/jcb.115.3.829
    48 https://doi.org/10.1083/jcb.115.6.1737
    49 https://doi.org/10.1084/jem.156.6.1755
    50 https://doi.org/10.1097/00005373-199012001-00028
    51 https://doi.org/10.1111/j.1365-2133.1990.tb01844.x
    52 https://doi.org/10.1111/j.1365-2133.1991.tb00422.x
    53 https://doi.org/10.1111/j.1365-2133.1991.tb14742.x
    54 https://doi.org/10.1111/j.1600-0560.1989.tb00051.x
    55 https://doi.org/10.1172/jci114379
    56 https://doi.org/10.1172/jci114957
    57 https://doi.org/10.1172/jci115782
    58 https://doi.org/10.1172/jci115794
    59 schema:datePublished 1993-10
    60 schema:datePublishedReg 1993-10-01
    61 schema:description The integrin receptor family plays a fundamental role in mediating cell attachment to a variety of extracellular matrix molecules. In normal human epidermis, the alpha 2 beta 1, alpha 3 beta 1, alpha 6 beta 4, and alpha v beta 5 integrin heterodimers are expressed and appear largely confined to the basal cell layer. In the present study, beta 1, beta 4, and alpha v integrin expression in the epidermis during wound healing in humans was examined. Punch biopsies were performed on healthy volunteers. At daily intervals up to day 8, and at days 11, 14, 21, and 28, the wound site was surgically removed. Using immunofluorescence microscopy, several modifications of the integrin expression pattern were observed on migrating keratinocytes during the re-epithelialization phase of the wound-healing process: i) alpha v expression was strongly enhanced and polarized at the basal pole of basal keratinocytes; ii) among the beta 1 integrins, alpha 3 beta 1 was overexpressed and distributed over the entire basal keratinocyte membrane and a weak alpha 5 beta 1 reactivity became evident; and iii) alpha 6 beta 4 was detected as a linear staining along the newly forming dermal-epidermal junction. Moreover, both during the re-epithelialization phase and during the first 2 weeks after wound closure, alpha 3, alpha 6, alpha v, beta 1, and beta 4 were no longer confined to the basal layer, as in normal epidermis, but were also found on several suprabasal cell layers. These results suggest that alpha v beta 5, alpha 3 beta 1, and alpha 5 beta 1 may be the main integrin receptors mediating keratinocyte spreading and migration over the provisional matrix of the wound bed.
    62 schema:genre research_article
    63 schema:inLanguage en
    64 schema:isAccessibleForFree true
    65 schema:isPartOf N03b6a8d4c05340748b9eb4ee0830163e
    66 N0935f3f65bfc4e6e96ba8228ee375c4a
    67 sg:journal.1020153
    68 schema:name Distinctive Integrin Expression in the Newly Forming Epidermis During Wound Healing in Humans
    69 schema:pagination 600-604
    70 schema:productId N110d5a3a4df0452bacea5b5d680925dc
    71 N7fab9d97a65f4afb8adb682ceccea71f
    72 N8e1607a7a26d4dd5887271f943b9f77c
    73 N99ecc873c1ac4890aa11967c9a0e0b48
    74 Nf3a553fc792f47de86dbaafce6e13462
    75 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026650682
    76 https://doi.org/10.1111/1523-1747.ep12366057
    77 schema:sdDatePublished 2019-04-10T15:38
    78 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    79 schema:sdPublisher Ncc452282c33b4862981fa02060aced83
    80 schema:url http://www.nature.com/jid/journal/v101/n4/full/5611476a.html
    81 sgo:license sg:explorer/license/
    82 sgo:sdDataset articles
    83 rdf:type schema:ScholarlyArticle
    84 N03b6a8d4c05340748b9eb4ee0830163e schema:volumeNumber 101
    85 rdf:type schema:PublicationVolume
    86 N064a50919c4b4231839f6cbbe249573a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    87 schema:name Skin
    88 rdf:type schema:DefinedTerm
    89 N0935f3f65bfc4e6e96ba8228ee375c4a schema:issueNumber 4
    90 rdf:type schema:PublicationIssue
    91 N0cc213af5d5d4e4abc579f4931d8c9f6 schema:familyName Marchetti
    92 schema:givenName M
    93 rdf:type schema:Person
    94 N110d5a3a4df0452bacea5b5d680925dc schema:name dimensions_id
    95 schema:value pub.1026650682
    96 rdf:type schema:PropertyValue
    97 N34e74f821d254bd6b2f40ecaa0373896 rdf:first N0cc213af5d5d4e4abc579f4931d8c9f6
    98 rdf:rest Nd4e33494453547d3bdb202b8fbd98670
    99 N392f993253564233bef0e902f8d37e77 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    100 schema:name Wound Healing
    101 rdf:type schema:DefinedTerm
    102 N446738650d3e49609c6fe4e8982ca12f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    103 schema:name Reference Values
    104 rdf:type schema:DefinedTerm
    105 N484b6322c26f499b996a7922d60f6c0a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    106 schema:name Adult
    107 rdf:type schema:DefinedTerm
    108 N4904cb4e884a41e3ba36770383e7a31a rdf:first sg:person.01143252116.28
    109 rdf:rest N34e74f821d254bd6b2f40ecaa0373896
    110 N4cd5f5144132465baff4b37709dabc2f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    111 schema:name Integrins
    112 rdf:type schema:DefinedTerm
    113 N5b444bcfefdb4a2d9d64212f60436968 rdf:first sg:person.01126751326.36
    114 rdf:rest N6010d16dc2194dc0afae03ffd0d6b6bf
    115 N6010d16dc2194dc0afae03ffd0d6b6bf rdf:first sg:person.01315030632.54
    116 rdf:rest Nf9463490aa334325b6da0bc3f6ee0108
    117 N7fab9d97a65f4afb8adb682ceccea71f schema:name pubmed_id
    118 schema:value 8409530
    119 rdf:type schema:PropertyValue
    120 N8e1607a7a26d4dd5887271f943b9f77c schema:name doi
    121 schema:value 10.1111/1523-1747.ep12366057
    122 rdf:type schema:PropertyValue
    123 N99ecc873c1ac4890aa11967c9a0e0b48 schema:name nlm_unique_id
    124 schema:value 0426720
    125 rdf:type schema:PropertyValue
    126 Na0dc178fb9fa463f9953a1388a256fa5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    127 schema:name Humans
    128 rdf:type schema:DefinedTerm
    129 Na4cd170f9b1942de9e371ecd46b804c5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    130 schema:name Fluorescent Antibody Technique
    131 rdf:type schema:DefinedTerm
    132 Nb1f5a6bf6c064a7b8f29720c06abf479 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    133 schema:name Extracellular Matrix Proteins
    134 rdf:type schema:DefinedTerm
    135 Ncc452282c33b4862981fa02060aced83 schema:name Springer Nature - SN SciGraph project
    136 rdf:type schema:Organization
    137 Nd4e33494453547d3bdb202b8fbd98670 rdf:first sg:person.01167611267.01
    138 rdf:rest rdf:nil
    139 Nf3a553fc792f47de86dbaafce6e13462 schema:name readcube_id
    140 schema:value 7ef6065764761ccad0c01b17db8bbaa812fe5bc0dac4ae1f02c327aaaa60592a
    141 rdf:type schema:PropertyValue
    142 Nf91e0171123d43dc90e6bc9f87a145c1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    143 schema:name Epidermis
    144 rdf:type schema:DefinedTerm
    145 Nf9463490aa334325b6da0bc3f6ee0108 rdf:first sg:person.01063775375.36
    146 rdf:rest N4904cb4e884a41e3ba36770383e7a31a
    147 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    148 schema:name Biological Sciences
    149 rdf:type schema:DefinedTerm
    150 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    151 schema:name Biochemistry and Cell Biology
    152 rdf:type schema:DefinedTerm
    153 sg:journal.1020153 schema:issn 0022-202X
    154 1523-1747
    155 schema:name Journal of Investigative Dermatology
    156 rdf:type schema:Periodical
    157 sg:person.01063775375.36 schema:familyName Marconi
    158 schema:givenName A
    159 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063775375.36
    160 rdf:type schema:Person
    161 sg:person.01126751326.36 schema:affiliation https://www.grid.ac/institutes/grid.7548.e
    162 schema:familyName Cavani
    163 schema:givenName A
    164 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01126751326.36
    165 rdf:type schema:Person
    166 sg:person.01143252116.28 schema:familyName Manca
    167 schema:givenName V
    168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143252116.28
    169 rdf:type schema:Person
    170 sg:person.01167611267.01 schema:familyName Giannetti
    171 schema:givenName A
    172 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167611267.01
    173 rdf:type schema:Person
    174 sg:person.01315030632.54 schema:familyName Zambruno
    175 schema:givenName G
    176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01315030632.54
    177 rdf:type schema:Person
    178 sg:pub.10.1007/bf00510080 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035854347
    179 https://doi.org/10.1007/bf00510080
    180 rdf:type schema:CreativeWork
    181 sg:pub.10.1111/1523-1747.ep12265466 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007765614
    182 https://doi.org/10.1111/1523-1747.ep12265466
    183 rdf:type schema:CreativeWork
    184 sg:pub.10.1111/1523-1747.ep12276531 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007470343
    185 https://doi.org/10.1111/1523-1747.ep12276531
    186 rdf:type schema:CreativeWork
    187 sg:pub.10.1111/1523-1747.ep12276880 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014837137
    188 https://doi.org/10.1111/1523-1747.ep12276880
    189 rdf:type schema:CreativeWork
    190 sg:pub.10.1111/1523-1747.ep12461198 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017512785
    191 https://doi.org/10.1111/1523-1747.ep12461198
    192 rdf:type schema:CreativeWork
    193 sg:pub.10.1111/1523-1747.ep12469745 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013042324
    194 https://doi.org/10.1111/1523-1747.ep12469745
    195 rdf:type schema:CreativeWork
    196 sg:pub.10.1111/1523-1747.ep12470960 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019557009
    197 https://doi.org/10.1111/1523-1747.ep12470960
    198 rdf:type schema:CreativeWork
    199 sg:pub.10.1111/1523-1747.ep12470980 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023023961
    200 https://doi.org/10.1111/1523-1747.ep12470980
    201 rdf:type schema:CreativeWork
    202 sg:pub.10.1111/1523-1747.ep12476480 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020545698
    203 https://doi.org/10.1111/1523-1747.ep12476480
    204 rdf:type schema:CreativeWork
    205 sg:pub.10.1111/1523-1747.ep12481896 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023161081
    206 https://doi.org/10.1111/1523-1747.ep12481896
    207 rdf:type schema:CreativeWork
    208 sg:pub.10.1111/1523-1747.ep12493266 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032711917
    209 https://doi.org/10.1111/1523-1747.ep12493266
    210 rdf:type schema:CreativeWork
    211 sg:pub.10.1111/1523-1747.ep12875994 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023505125
    212 https://doi.org/10.1111/1523-1747.ep12875994
    213 rdf:type schema:CreativeWork
    214 sg:pub.10.1111/1523-1747.ep12876104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039851742
    215 https://doi.org/10.1111/1523-1747.ep12876104
    216 rdf:type schema:CreativeWork
    217 https://app.dimensions.ai/details/publication/pub.1077299519 schema:CreativeWork
    218 https://app.dimensions.ai/details/publication/pub.1077462415 schema:CreativeWork
    219 https://app.dimensions.ai/details/publication/pub.1078215307 schema:CreativeWork
    220 https://app.dimensions.ai/details/publication/pub.1078375325 schema:CreativeWork
    221 https://app.dimensions.ai/details/publication/pub.1078873072 schema:CreativeWork
    222 https://doi.org/10.1002/jcb.240260206 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035288698
    223 rdf:type schema:CreativeWork
    224 https://doi.org/10.1016/0014-4827(90)90092-o schema:sameAs https://app.dimensions.ai/details/publication/pub.1030261245
    225 rdf:type schema:CreativeWork
    226 https://doi.org/10.1016/0014-4827(91)90379-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029428007
    227 rdf:type schema:CreativeWork
    228 https://doi.org/10.1016/0092-8674(87)90179-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006950060
    229 rdf:type schema:CreativeWork
    230 https://doi.org/10.1016/0092-8674(92)90115-s schema:sameAs https://app.dimensions.ai/details/publication/pub.1007440282
    231 rdf:type schema:CreativeWork
    232 https://doi.org/10.1073/pnas.78.11.6907 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032766355
    233 rdf:type schema:CreativeWork
    234 https://doi.org/10.1073/pnas.81.1.224 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031354164
    235 rdf:type schema:CreativeWork
    236 https://doi.org/10.1073/pnas.87.17.6888 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048642790
    237 rdf:type schema:CreativeWork
    238 https://doi.org/10.1073/pnas.87.22.8970 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041655235
    239 rdf:type schema:CreativeWork
    240 https://doi.org/10.1083/jcb.107.3.1215 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030869748
    241 rdf:type schema:CreativeWork
    242 https://doi.org/10.1083/jcb.109.4.1807 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033638179
    243 rdf:type schema:CreativeWork
    244 https://doi.org/10.1083/jcb.110.3.803 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024904480
    245 rdf:type schema:CreativeWork
    246 https://doi.org/10.1083/jcb.110.4.1387 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011470705
    247 rdf:type schema:CreativeWork
    248 https://doi.org/10.1083/jcb.111.6.3141 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048705360
    249 rdf:type schema:CreativeWork
    250 https://doi.org/10.1083/jcb.112.4.761 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022579099
    251 rdf:type schema:CreativeWork
    252 https://doi.org/10.1083/jcb.113.4.907 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002871677
    253 rdf:type schema:CreativeWork
    254 https://doi.org/10.1083/jcb.115.3.829 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049142503
    255 rdf:type schema:CreativeWork
    256 https://doi.org/10.1083/jcb.115.6.1737 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008760365
    257 rdf:type schema:CreativeWork
    258 https://doi.org/10.1084/jem.156.6.1755 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008388622
    259 rdf:type schema:CreativeWork
    260 https://doi.org/10.1097/00005373-199012001-00028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049445888
    261 rdf:type schema:CreativeWork
    262 https://doi.org/10.1111/j.1365-2133.1990.tb01844.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1009509343
    263 rdf:type schema:CreativeWork
    264 https://doi.org/10.1111/j.1365-2133.1991.tb00422.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1052547132
    265 rdf:type schema:CreativeWork
    266 https://doi.org/10.1111/j.1365-2133.1991.tb14742.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1000715940
    267 rdf:type schema:CreativeWork
    268 https://doi.org/10.1111/j.1600-0560.1989.tb00051.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1036633287
    269 rdf:type schema:CreativeWork
    270 https://doi.org/10.1172/jci114379 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026736141
    271 rdf:type schema:CreativeWork
    272 https://doi.org/10.1172/jci114957 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043211532
    273 rdf:type schema:CreativeWork
    274 https://doi.org/10.1172/jci115782 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019328352
    275 rdf:type schema:CreativeWork
    276 https://doi.org/10.1172/jci115794 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000796099
    277 rdf:type schema:CreativeWork
    278 https://www.grid.ac/institutes/grid.7548.e schema:alternateName University of Modena and Reggio Emilia
    279 schema:name Department of Dermatology, University of Modena, Italy.
    280 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...