Melanogenesis Is Coupled to Murine Anagen: Toward New Concepts for the Role of Melanocytes and the Regulation of Melanogenesis in ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1993-07

AUTHORS

A Slominski, R Paus

ABSTRACT

Hair is actively pigmented only when it grows: the melanogenic activity of follicular melanocytes (MC) is strictly coupled to the anagen stage of the hair cycle. In catagen, melanin formation is switched off and is absent throughout telogen. The appearance of pigmentation is preceded, and further accompanied by, a time-frame - restricted, differential pattern of tyrosinase transcription, translation, and enzyme activities during the development of anagen follicles. In this speculative review, we argue that signals required for melanin synthesis and pigment transfer to bulb keratinocytes (KC) are intrinsic to the skin, rather than coming from the serum. First, the proopiomelanocortin (POMC) gene is expressed and translated during anagen, but is below the level of detectability in telogen; POMC is a precursor protein for adrenocorticotropin and melanotropins, which are potent regulators of MC proliferation and differentiation. Second, fibroblasts and KC produce factors that affect MC proliferation and differentiation. We suggest that signals regulating follicular MC activity partially derive from cutaneous cells expressing POMC. Vice versa, MC transfer to surrounding KC pigment granules with potent bioregulatory properties. MC also produce and secrete various signal molecules that can regulate mesenchymal and epithelial cell functions. Anagen-associated melanogenesis and the cyclic production of a pigmented hair shaft result from programmed and tightly coordinated epithelial-mesenchymal-neuroectodermal interactions, in which MC may act not only as pigmentary, but also as hair growth-regulatory cells. More... »

PAGES

90s-97s

References to SciGraph publications

  • 1981. Hair Melanin and Hair Color in HAIR RESEARCH
  • 1992-11. Skin histoculture assay for studying the hair cycle in IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY
  • 1979. The Coat Colors of Mice, A Model for Mammalian Gene Action and Interaction in NONE
  • 1969-03. Melanocyte precursor cells in the hair follicle germ during the dormant stage (telogen) in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 1991. Regulation of growth and phenotype of normal human melanocytes in culture in MELANOMA RESEARCH: GENETICS, GROWTH FACTORS, METASTASES, AND ANTIGENS
  • 1992-01. Proopiomelanocortin expression in the skin during induced hair growth in mice in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 1990. Hair and Hair Diseases in NONE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1111/1523-1747.ep12362991

    DOI

    http://dx.doi.org/10.1111/1523-1747.ep12362991

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1018195368

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/8326158


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