Impairment of Enzymic and Nonenzymic Antioxidants in Skin by UVB Irradiation View Full Text


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Article Info

DATE

1989-12

AUTHORS

J Fuchs, M E Huflejt, L M Rothfuss, D S Wilson, G Carcamo, L Packer

ABSTRACT

Antioxidants may play a significant role in ameliorating or preventing photobiologic damage in skin that could lead to cutaneous disorders such as cancer and premature aging. The objective of this study was to assess the acute cutaneous enzymic and nonenzymic antioxidant response to a single exposure of large fluence (300 mJ/cm2) ultraviolet radiation (greater than 280 nm) in hairless mice. This treatment caused an immediate and statistically significant inhibition of glutathione reductase and catalase activity. Glutathione peroxidase and superoxide dismutase were not affected. Glutathione levels decreased and, conversely glutathione disulfide concentrations increased. A slight depletion of the total glutathione was observed, while the content of total ascorbic acid did not change. The lipophilic antioxidants alpha-tocopherol, ubiquinol 9 and ubiquinone 9 also decreased significantly, and the concentration of malondialdehyde remained constant. The free radical scavenging activity of epidermis, as assessed by reduction of the stable, cationic nitroxide radical [2,2,6,6-tetramethyl-1-piperidinoxy-4-(2',4',6'-trimethyl) methylpyridinium perchlorate] was considerably inhibited. The study indicates that immediately after exposure to a large fluence of ultraviolet radiation the enzymic and nonenzymic antioxidant capacity of skin decreases significantly. More... »

PAGES

769-773

References to SciGraph publications

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  • 1984-08. Protective enzymes in human epidermal carcinomas and psoriasis in ARCHIVES OF DERMATOLOGICAL RESEARCH
  • 1986-12. Free Radical Reduction by Thioredoxin Reductase at the Surface of Normal and Vitiliginous Human Keratinocytes in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 1984-09. Role of Oxygen Intermediates in UV-Induced Epidermal Cell Injury in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 1987-07. Decreased Skin Superoxide Dismutase Activity by a Single Exposure of Ultraviolet Radiation Is Reduced by Liposomal Superoxide Dismutase Pretreatment in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 1988-07. REPLY in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 1988-07. Free Radical Reduction by Thioredoxin Reductase in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 1984-12. Glutathione reductase activity in heterocysts and vegetative cells of the cyanobacterium Nostoc muscorum in ARCHIVES OF MICROBIOLOGY
  • 1979-08. Inhibition of ultraviolet light-induced erythema by antioxidants in ARCHIVES OF DERMATOLOGICAL RESEARCH
  • 1979-04. Direct observation of a free radical interaction between vitamin E and vitamin C in NATURE
  • 1987-06. Oxygen Intermediates Are Involved in Ultraviolet Radiation-Induced Damage of Langerhans Cells in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 1972-10. A CLINICAL TRIAL OF THE EFFECTS OF ORAL BETA-CAROTENE ON THE RESPONSES OF HUMAN SKIN TO SOLAR RADIATION in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 1979-04. Thiobarbituric acid test for detecting lipid peroxides in LIPIDS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1111/1523-1747.ep12284412

    DOI

    http://dx.doi.org/10.1111/1523-1747.ep12284412

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1005454579

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/2584742


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