Array-based technology and recommendations for utilization in medical genetics practice for detection of chromosomal abnormalities View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-11

AUTHORS

Melanie Manning, Louanne Hudgins

ABSTRACT

Laboratory evaluation of patients with developmental delay/intellectual disability, congenital anomalies, and dysmorphic features has changed significantly in the last several years with the introduction of microarray technologies. Using these techniques, a patient's genome can be examined for gains or losses of genetic material too small to be detected by standard G-banded chromosome studies. This increased resolution of microarray technology over conventional cytogenetic analysis allows for identification of chromosomal imbalances with greater precision, accuracy, and technical sensitivity. A variety of array-based platforms are now available for use in clinical practice, and utilization strategies are evolving. Thus, a review of the utility and limitations of these techniques and recommendations regarding present and future application in the clinical setting are presented in this study. More... »

PAGES

742-745

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1097/gim.0b013e3181f8baad

DOI

http://dx.doi.org/10.1097/gim.0b013e3181f8baad

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1048163304

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20962661


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