Current Perspectives on HER2 Testing: A Review of National Testing Guidelines View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2003-02

AUTHORS

Michael Bilous, Mitch Dowsett, Wedad Hanna, Jorma Isola, Annette Lebeau, Aberlardo Moreno, Frédérique Penault-Llorca, Josef Rüschoff, Gorana Tomasic, Marc van de Vijver

ABSTRACT

Knowledge of HER2 status is a prerequisite when considering a patient's eligibility for Herceptin (trastuzumab) therapy. Accurate assessment of HER2 status is essential to ensure that all patients who may benefit from Herceptin are correctly identified. There are several assays available to determine HER2 status: the most common in routine clinical practice are immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH). Various factors can affect the results achieved with these assays, including the assay antibody/probe, the methodology and the experience of personnel. Many countries have implemented national testing guidelines in an attempt to standardize testing procedures and make results more accurate. These guidelines vary in the level of detail and the number of recommendations. This review looks at areas of consensus between the different national testing guidelines and highlights where errors may arise during the testing procedure. The key point underlined by this review is that whatever method is used to test for HER2 status, the technology must be validated first, and there must be regular internal and external quality control and quality assurance procedures. More... »

PAGES

3880738

Identifiers

URI

http://scigraph.springernature.com/pub.10.1097/01.mp.0000052102.90815.82

DOI

http://dx.doi.org/10.1097/01.mp.0000052102.90815.82

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1043809974

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12591971


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