A Role for Caspase-1 in Serum Withdrawal-Induced Apoptosis of Endothelial Cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2003-10

AUTHORS

Andrea R King, Sheila E Francis, Collette J Bridgeman, Helen Bird, Moira K B Whyte, David C Crossman

ABSTRACT

Mouse lung endothelial cells (MLEC) and HUVEC were used under serum withdrawal (SW) conditions as a model of endothelial cell (EC) apoptosis. Apoptosis was quantified by time-lapse video microscopy. Mouse lung ECs from caspase-1(-/-) mice had significantly reduced rates of SW-induced apoptosis compared with wild-type mice, specifically implicating caspase-1 in proapoptotic signaling in ECs. SW conditions induced HUVEC apoptosis with concomitant activation of caspase-1. Further studies demonstrated that the caspase-1 inhibitors z-VAD and z-YVAD significantly reduced the rate of SW-induced HUVEC apoptosis. HUVEC, when transfected with caspase-1, showed a highly significant increase in apoptosis. SW was associated with increases in reactive oxygen species production that were significantly inhibited by the antioxidant N-acetyl-L-cysteine, although rates of apoptosis and caspase-1 activation were unaffected. These results demonstrate the involvement of caspase-1 in SW-induced EC apoptosis, independently of reactive oxygen species production. More... »

PAGES

3780740

Identifiers

URI

http://scigraph.springernature.com/pub.10.1097/01.lab.0000093096.62765.85

DOI

http://dx.doi.org/10.1097/01.lab.0000093096.62765.85

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1013846957

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/14563951


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