Construction of cDNA Libraries from Microdissected Benign and Malignant Thyroid Tissue View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2002-12-01

AUTHORS

Klaus Kaserer, Vladimir Knezevic, Bettina Pichlhöfer, Christian Scheuba, Christian Passler, Jennifer Worth, Bruno Niederle, David Krizman

ABSTRACT

cDNA libraries were constructed from thyroid epithelial cells gained by laser capture microdissection for gene expression analysis of the progression of thyroid cancer. Six histologically diverse thyroid tissue specimens were used. A mean of 93 ng of total RNA was gained per tissue sample from a mean estimated number of 25,000 microdissected cells per sample. Analysis of randomly selected clones from six libraries showed an average insert size of 600 (range, 300–1500) bp. Preliminary sequencing of clones selected from the six libraries indicates a range of 46% to 62% known genes per library, 4% to 25% anonymous expressed sequence tags per library, and 15% to 43% novel expressed sequence tags per library. Thyroglobulin was found in normal thyroid epithelium and follicular thyroid adenoma, whereas calcitonin precursor transcripts were found in medullary thyroid carcinoma. We demonstrate production of high-quality cDNA libraries of microdissected tissue of the thyroid, which should prove useful for gene expression analysis of human thyroid tumors. More... »

PAGES

1707-1714

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1097/01.lab.0000043121.48152.79

DOI

http://dx.doi.org/10.1097/01.lab.0000043121.48152.79

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1041478880

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12480920


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