Expression of SHP-1 Phosphatase Indicates Post-Germinal Center Cell Derivation of B-Cell Posttransplant Lymphoproliferative Disorders View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2002-11-01

AUTHORS

Michele Paessler, Plamen Kossev, Donald Tsai, Puthiaveetil Raghunath, Miroslaw Majewski, Qian Zhang, Preetha Ramalingam, Stephen Schuster, John Tomaszewski, Daniel A Arber, Eric Hsi, Mariusz A Wasik

ABSTRACT

SHP-1 tyrosine phosphatase acts as a negative regulator of signaling by receptors for growth factors, cytokines, and chemokines and by receptors involved in immune response. Our recent study showed that SHP-1 is tightly regulated at various stages of B-cell differentiation and is expressed in the mantle and marginal zones, interfollicular B cells, and plasma cells, whereas it is nondetectable in germinal center cells. In this study we evaluated expression of SHP-1 in vitro and in vivo in nine cell lines representing three different types of EBV+ B-cell populations closely resembling or derived from posttransplant lymphoproliferative disorders (PTLDs). Furthermore, we examined tissue samples from 58 patients with B-cell PTLDs, both EBV+ (85% of the cases analyzed) and EBV− (15%). SHP-1 protein was strongly expressed in all cell lines and PTLD cases. In addition, the PTLD cases were essentially negative for germinal center B-cell markers: none expressed CD10 and only one expressed BCL-6. More than 40% expressed a late post-germinal B-cell marker, CD138. The universal expression of SHP-1, lack of expression of CD10 and BCL-6, and frequent expression of CD138 suggest that PTLDs are derived from post-germinal center B cells regardless of the EBV cell infection status. Based on the immunophenotype, B-cell PTLDs could be divided into two broad categories corresponding to the early (CD10−/BCL-6−/SHP-1+/CD138−) and late (CD10−/BCL-6−/SHP-1+/CD138+) post-germinal center cells. By being expressed earlier, SHP-1 is a more sensitive marker of post-germinal center B cells than CD138, which is seen on the terminally differentiated immunoblasts and plasma cells. More... »

PAGES

1599-1606

Identifiers

URI

http://scigraph.springernature.com/pub.10.1097/01.lab.0000036873.16297.a5

DOI

http://dx.doi.org/10.1097/01.lab.0000036873.16297.a5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1013079541

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12429820


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40 CD138
41 PTLD cases
42 Recent studies
43 SHP-1
44 SHP-1 phosphatase
45 SHP-1 protein
46 acts
47 addition
48 broad categories
49 cases
50 categories
51 cell derivation
52 cell differentiation
53 cell lines
54 cell markers
55 cell populations
56 cell posttransplant lymphoproliferative disorder
57 cells
58 center B
59 center cells
60 chemokines
61 cytokines
62 derivation
63 different types
64 differentiation
65 disorders
66 expression
67 factors
68 frequent expression
69 germinal center B
70 germinal center cells
71 growth factor
72 immune response
73 immunoblasts
74 immunophenotype
75 infection status
76 lack
77 lack of expression
78 lines
79 lymphoproliferative disorders
80 marginal zone
81 markers
82 negative regulator
83 patients
84 phosphatase
85 plasma cells
86 population
87 post-germinal center B cells
88 post-germinal center cells
89 posttransplant lymphoproliferative disorder
90 protein
91 receptors
92 regulator
93 response
94 samples
95 sensitive marker
96 stage
97 status
98 study
99 tissue samples
100 types
101 universal expression
102 vivo
103 zone
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