Antibody Binding to Fas Ligand Attenuates Inflammatory Cell Infiltration and Cytokine Secretion, Leading to Reduction of Myocardial Infarct Areas and ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2002-09

AUTHORS

Hirokazu Shiraishi, Tetsuya Toyozaki, Yoshiaki Tsukamoto, Toshihiro Saito, Yoshiaki Masuda, Kenzo Hiroshima, Hidemi Ohwada, Nobuyuki Kobayashi, Michiaki Hiroe

ABSTRACT

Fas ligand (FasL) induces apoptotic cell death when bound to Fas antigen. The engagement of FasL has anti-inflammatory effects through the prevention of cell proliferation and cytokine secretion. However, the role of FasL in myocardial ischemia/reperfusion (MI/R) injury is unclear. We examined the expression of FasL mRNA in the myocardium of MI/R rats by ligating the left coronary artery for 30 minutes and allowing reperfusion to occur for 0, 1, 3, and 24 hours. The expression of FasL mRNA was enhanced 1 hour after reperfusion, and enhanced levels were consistently seen after 24 hours of reperfusion. FasL immunostaining was observed on neutrophils, macrophages, T cells, and vascular endothelial cells. We then assessed the potential role of FasL in the cell proliferation and cytokine production seen in MI/R injury after 24 hours of reperfusion. Rats were divided into three groups; Group A, without treatment; Group B, treated with nonspecific rabbit IgG; and Group C, treated with anti-FasL antibody. Anti-FasL antibody or rabbit IgG were administered intravenously before coronary artery occlusion. In Group C, interleukin-1beta and interleukin-2 mRNA levels were decreased, and neutrophil and T cell accumulation was attenuated. The infarct area determined by triphenyltetrazolium chloride staining was significantly smaller in Group C (18 +/- 4%) than in Group A (34 +/- 2%) or Group B (33 +/- 4%) (p< 0.0001). However, there was no significant difference in the prevalence of terminal deoxynucleotidyltransferase-mediated dUTP-biotin nick end-labeling-positive cardiomyocytes among the three groups. These findings suggest that the cardioprotective effect of anti-FasL antibody is due to its anti-inflammatory action, rather than antiapoptotic action. The Fas/FasL system may be involved in the development of MI/R injury. More... »

PAGES

1121

Identifiers

URI

http://scigraph.springernature.com/pub.10.1097/01.lab.0000029148.88524.ce

DOI

http://dx.doi.org/10.1097/01.lab.0000029148.88524.ce

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1035770088

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12218072


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curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1097/01.lab.0000029148.88524.ce'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1097/01.lab.0000029148.88524.ce'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1097/01.lab.0000029148.88524.ce'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1097/01.lab.0000029148.88524.ce'


 

This table displays all metadata directly associated to this object as RDF triples.

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