[2,4-13C2]-β-Hydroxybutyrate Metabolism in Human Brain View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2002-07

AUTHORS

Jullie W Pan, Robin A de Graaf, Kitt F Petersen, Gerald I Shulman, Hoby P Hetherington, Douglas L Rothman

ABSTRACT

Infusions of [2,4-13C2]-beta-hydroxybutyrate and 1H-13C polarization transfer spectroscopy were used in normal human subjects to detect the entry and metabolism of beta-hydroxybutyrate in the brain. During the 2-hour infusion study, 13C label was detectable in the beta-hydroxybutyrate resonance positions and in the amino acid pools of glutamate, glutamine, and aspartate. With a plasma concentration of 2.25 +/- 0.24 mmol/L (four volunteers), the apparent tissue beta-hydroxybutyrate concentration reached 0.18 +/- 0.06 mmol/L during the last 20 minutes of the study. The relative fractional enrichment of 13C-4-glutamate labeling was 6.78 +/- 1.71%, whereas 13C-4-glutamine was 5.68 +/- 1.84%. Steady-state modeling of the 13C label distribution in glutamate and glutamine suggests that, under these conditions, the consumption of the beta-hydroxybutyrate is predominantly neuronal, used at a rate of 0.032 +/- 0.009 mmol. kg-1. min-1, and accounts for 6.4 +/- 1.6% of total acetyl coenzyme A oxidation. These results are consistent with minimal accumulation of cerebral ketones with rapid utilization, implying blood-brain barrier control of ketone oxidation in the nonfasted adult human brain. More... »

PAGES

890-898

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1097/00004647-200207000-00014

DOI

http://dx.doi.org/10.1097/00004647-200207000-00014

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1020929252

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12142574


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