Striking Differences in Glucose and Lactate Levels Between Brain Extracellular Fluid and Plasma in Conscious Human Subjects: Effects of Hyperglycemia ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2002-03

AUTHORS

Walid M. Abi-Saab, David G. Maggs, Tim Jones, Ralph Jacob, Vinod Srihari, James Thompson, David Kerr, Paola Leone, John H. Krystal, Dennis D. Spencer, Matthew J. During, Robert S. Sherwin

ABSTRACT

Brain levels of glucose and lactate in the extracellular fluid (ECF), which reflects the environment to which neurons are exposed, have never been studied in humans under conditions of varying glycemia. The authors used intracerebral microdialysis in conscious human subjects undergoing electrophysiologic evaluation for medically intractable epilepsy and measured ECF levels of glucose and lactate under basal conditions and during a hyperglycemia-hypoglycemia clamp study. Only measurements from nonepileptogenic areas were included. Under basal conditions, the authors found the metabolic milieu in the brain to be strikingly different from that in the circulation. In contrast to plasma, lactate levels in brain ECF were threefold higher than glucose. Results from complementary studies in rats were consistent with the human data. During the hyperglycemia-hypoglycemia clamp study the relationship between plasma and brain ECF levels of glucose remained similar, but changes in brain ECF glucose lagged approximately 30 minutes behind changes in plasma. The data demonstrate that the brain is exposed to substantially lower levels of glucose and higher levels of lactate than those in plasma; moreover, the brain appears to be a site of significant anaerobic glycolysis, raising the possibility that glucose-derived lactate is an important fuel for the brain. More... »

PAGES

271-279

Identifiers

URI

http://scigraph.springernature.com/pub.10.1097/00004647-200203000-00004

DOI

http://dx.doi.org/10.1097/00004647-200203000-00004

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1012550278

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11891432


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adolescent", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blood Glucose", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Consciousness", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Epilepsy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Extracellular Space", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glucose", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hyperglycemia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hypoglycemia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kinetics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lactates", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Microdialysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats, Sprague-Dawley", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Time Factors", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Psychiatry", 
            "Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut, U.S.A."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Abi-Saab", 
        "givenName": "Walid M.", 
        "id": "sg:person.01325120244.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01325120244.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, U.S.A."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Maggs", 
        "givenName": "David G.", 
        "id": "sg:person.0750171405.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750171405.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, U.S.A."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jones", 
        "givenName": "Tim", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, U.S.A."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jacob", 
        "givenName": "Ralph", 
        "id": "sg:person.01233554544.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233554544.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Psychiatry"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Srihari", 
        "givenName": "Vinod", 
        "id": "sg:person.0727126523.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727126523.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Neurology, Yale University School of Medicine, New Haven, Connecticut, U.S.A."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Thompson", 
        "givenName": "James", 
        "id": "sg:person.01122133401.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122133401.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut, U.S.A."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kerr", 
        "givenName": "David", 
        "id": "sg:person.015543051772.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015543051772.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut, U.S.A."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Leone", 
        "givenName": "Paola", 
        "id": "sg:person.0707273404.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707273404.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Psychiatry"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Krystal", 
        "givenName": "John H.", 
        "id": "sg:person.01301743656.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301743656.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut, U.S.A."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Spencer", 
        "givenName": "Dennis D.", 
        "id": "sg:person.0657751312.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657751312.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut, U.S.A."
          ], 
          "type": "Organization"
        }, 
        "familyName": "During", 
        "givenName": "Matthew J.", 
        "id": "sg:person.01304477527.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304477527.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, U.S.A."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sherwin", 
        "givenName": "Robert S.", 
        "id": "sg:person.0753661634.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753661634.46"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s0140-6736(94)90876-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003219098"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(94)90876-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003219098"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.95.7.3990", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003328231"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0304-3940(91)90268-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004926294"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0304-3940(91)90268-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004926294"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1471-4159.1994.62051939.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005139339"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1471-4159.1994.62051939.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005139339"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1096-9136(199701)14:1<19::aid-dia289>3.0.co;2-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005199009"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0165-0270(85)90107-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009848148"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0165-0270(85)90107-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009848148"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jnnp.64.5.611", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010955755"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000111426", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011229558"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1471-4159.1983.tb13562.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011429690"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1097/00004647-199607000-00014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012443223", 
          "https://doi.org/10.1097/00004647-199607000-00014"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004647-199607000-00014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012443223"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004647-199607000-00014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012443223"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.85.22.8727", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013698083"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/glia.440010603", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014316423"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0306-4522(98)00427-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015955199"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.str.30.2.460", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017417824"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-4615-2920-0_7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017629792", 
          "https://doi.org/10.1007/978-1-4615-2920-0_7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci118043", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018528331"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1471-4159.1993.tb03570.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018560818"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00006123-200009000-00035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019576342"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(93)91429-v", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022991200"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(93)91429-v", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022991200"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0165-3806(98)00188-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025586889"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-8993(96)01106-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026767907"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1471-4159.1986.tb13039.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028401302"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1471-4159.1995.64041734.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029289650"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1469-8749.1989.tb03974.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031576238"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1469-8749.1989.tb03974.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031576238"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0303-8467(94)00067-g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031784330"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/b978-0-444-81194-3.50024-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037117122"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1471-4159.1994.62062356.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037165557"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1471-4159.1994.62062356.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037165557"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1526-4610.1994.hed3401059.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038286548"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1179/016164101101198785", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039478338"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1528-1157.1991.tb05538.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040424816"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1098-1136(199803)22:3<272::aid-glia6>3.0.co;2-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042045210"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1471-4159.1989.tb07243.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042621544"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0140-6736(93)90754-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043061814"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0140-6736(93)90754-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043061814"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0304-3940(97)00840-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043586334"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1471-4159.1976.tb12254.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044578863"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj3430281", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048621238"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj3430281", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048621238"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.272.48.30096", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049932671"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj3410529", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050742306"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj3410529", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050742306"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.85.6.1821", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051256497"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.91.22.10625", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051993306"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/0264-6021:3410529", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056714092"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/00365519950185904", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058282633"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/01616412.1997.11740814", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058296304"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/01616412.1999.11740943", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058296576"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/neu.1998.15.509", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059299786"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003246-199909000-00041", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060174319"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003246-199909000-00041", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060174319"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003246-199909000-00041", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060174319"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003643-199605000-00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060178113"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003643-199605000-00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060178113"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003643-199605000-00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060178113"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00006123-199711000-00011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060247023"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diab.43.11.1311", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070737213"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diab.46.1.70", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070738003"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.1999.91.1.0001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071099223"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.1999.91.1.0001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071099223"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.1999.91.1.0001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071099223"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.2000.93.1.0037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071099612"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.2000.93.1.0037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071099612"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.2000.93.1.0037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071099612"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074271830", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074355081", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpendo.1999.277.3.e561", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074520286"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074576408", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074576412", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpcell.2000.278.5.c921", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074633971"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpendo.1987.253.2.e228", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079854939"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.04-01-00058.1984", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1081908679"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.15-07-05179.1995", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082439130"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.16-03-00877.1996", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082858617"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082982568", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpendo.1997.273.1.e207", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083127971"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpendo.1998.275.3.e516", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083312247"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpendo.1998.275.3.e516", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083312247"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/jappl.1976.41.4.565", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083361965"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2002-03", 
    "datePublishedReg": "2002-03-01", 
    "description": "Brain levels of glucose and lactate in the extracellular fluid (ECF), which reflects the environment to which neurons are exposed, have never been studied in humans under conditions of varying glycemia. The authors used intracerebral microdialysis in conscious human subjects undergoing electrophysiologic evaluation for medically intractable epilepsy and measured ECF levels of glucose and lactate under basal conditions and during a hyperglycemia-hypoglycemia clamp study. Only measurements from nonepileptogenic areas were included. Under basal conditions, the authors found the metabolic milieu in the brain to be strikingly different from that in the circulation. In contrast to plasma, lactate levels in brain ECF were threefold higher than glucose. Results from complementary studies in rats were consistent with the human data. During the hyperglycemia-hypoglycemia clamp study the relationship between plasma and brain ECF levels of glucose remained similar, but changes in brain ECF glucose lagged approximately 30 minutes behind changes in plasma. The data demonstrate that the brain is exposed to substantially lower levels of glucose and higher levels of lactate than those in plasma; moreover, the brain appears to be a site of significant anaerobic glycolysis, raising the possibility that glucose-derived lactate is an important fuel for the brain.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1097/00004647-200203000-00004", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2405812", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2439003", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2423996", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2491974", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2634620", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1092815", 
        "issn": [
          "0271-678X", 
          "1559-7016"
        ], 
        "name": "Journal of Cerebral Blood Flow & Metabolism", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "22"
      }
    ], 
    "name": "Striking Differences in Glucose and Lactate Levels Between Brain Extracellular Fluid and Plasma in Conscious Human Subjects: Effects of Hyperglycemia and Hypoglycemia", 
    "pagination": "271-279", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "3bcad7a9acc1cc5329ab4662f953de1fd8241e0714c411a0be19b5b17223feee"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "11891432"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8112566"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1097/00004647-200203000-00004"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1012550278"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1097/00004647-200203000-00004", 
      "https://app.dimensions.ai/details/publication/pub.1012550278"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T20:34", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8684_00000422.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/jcbfm/journal/v22/n3/full/9591215a.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1097/00004647-200203000-00004'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1097/00004647-200203000-00004'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1097/00004647-200203000-00004'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1097/00004647-200203000-00004'


 

This table displays all metadata directly associated to this object as RDF triples.

441 TRIPLES      21 PREDICATES      116 URIs      41 LITERALS      29 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1097/00004647-200203000-00004 schema:about N092383ae70e84c029b6bd18ab575e2c7
2 N096471dc536e4cbcbec5c5b817e16458
3 N1c5dbb039acc42c081e0015d525e5932
4 N284338ee04e2421b92ec5b2ad8afa7c5
5 N30fc9a8f19f546fba193411b6774aae5
6 N41228dc99a4c4377a3a2426cd8721c5b
7 N48d2196630b648e0ad1e8492c7c49cfb
8 N4e454aa8156b474fa224d8395f896091
9 N59c82a1c2271423abbcd39654949394e
10 N5ebff9b398d4455481e68d6469458268
11 N7c8e08b1b7274998b9df7dfb654e910e
12 N8ed5687cdb4e45b38018cd65e0acff58
13 N97ad5e3659e14b69ab3daa5b538e0c5a
14 Nbab962a526f44ff8b0cd20fa1117eede
15 Ncedc2a0b226749e8b7b9f84ad199e481
16 Nd17e491b0ffa44d1b8b93fe3b58486a6
17 Nd4b89adf95b44738b32e6b466181052b
18 Nde8e691f94774e6a977f9231a67b47e7
19 Nf2bbe9b848d4438a82672c61483f5acf
20 Nf86e4e2a061d4818a6bec0b4f04f1d7c
21 anzsrc-for:11
22 anzsrc-for:1109
23 schema:author N55496780c65a411f8c85254cb96a6714
24 schema:citation sg:pub.10.1007/978-1-4615-2920-0_7
25 sg:pub.10.1097/00004647-199607000-00014
26 https://app.dimensions.ai/details/publication/pub.1074271830
27 https://app.dimensions.ai/details/publication/pub.1074355081
28 https://app.dimensions.ai/details/publication/pub.1074576408
29 https://app.dimensions.ai/details/publication/pub.1074576412
30 https://app.dimensions.ai/details/publication/pub.1082982568
31 https://doi.org/10.1002/(sici)1096-9136(199701)14:1<19::aid-dia289>3.0.co;2-0
32 https://doi.org/10.1002/(sici)1098-1136(199803)22:3<272::aid-glia6>3.0.co;2-7
33 https://doi.org/10.1002/glia.440010603
34 https://doi.org/10.1016/0006-8993(93)91429-v
35 https://doi.org/10.1016/0140-6736(93)90754-5
36 https://doi.org/10.1016/0165-0270(85)90107-4
37 https://doi.org/10.1016/0303-8467(94)00067-g
38 https://doi.org/10.1016/0304-3940(91)90268-x
39 https://doi.org/10.1016/b978-0-444-81194-3.50024-1
40 https://doi.org/10.1016/s0006-8993(96)01106-7
41 https://doi.org/10.1016/s0140-6736(94)90876-1
42 https://doi.org/10.1016/s0165-3806(98)00188-6
43 https://doi.org/10.1016/s0304-3940(97)00840-9
44 https://doi.org/10.1016/s0306-4522(98)00427-8
45 https://doi.org/10.1042/0264-6021:3410529
46 https://doi.org/10.1042/bj3410529
47 https://doi.org/10.1042/bj3430281
48 https://doi.org/10.1046/j.1471-4159.1994.62051939.x
49 https://doi.org/10.1046/j.1471-4159.1994.62062356.x
50 https://doi.org/10.1046/j.1471-4159.1995.64041734.x
51 https://doi.org/10.1073/pnas.85.22.8727
52 https://doi.org/10.1073/pnas.85.6.1821
53 https://doi.org/10.1073/pnas.91.22.10625
54 https://doi.org/10.1073/pnas.95.7.3990
55 https://doi.org/10.1074/jbc.272.48.30096
56 https://doi.org/10.1080/00365519950185904
57 https://doi.org/10.1080/01616412.1997.11740814
58 https://doi.org/10.1080/01616412.1999.11740943
59 https://doi.org/10.1089/neu.1998.15.509
60 https://doi.org/10.1097/00003246-199909000-00041
61 https://doi.org/10.1097/00003643-199605000-00005
62 https://doi.org/10.1097/00004647-199607000-00014
63 https://doi.org/10.1097/00006123-199711000-00011
64 https://doi.org/10.1097/00006123-200009000-00035
65 https://doi.org/10.1111/j.1469-8749.1989.tb03974.x
66 https://doi.org/10.1111/j.1471-4159.1976.tb12254.x
67 https://doi.org/10.1111/j.1471-4159.1983.tb13562.x
68 https://doi.org/10.1111/j.1471-4159.1986.tb13039.x
69 https://doi.org/10.1111/j.1471-4159.1989.tb07243.x
70 https://doi.org/10.1111/j.1471-4159.1993.tb03570.x
71 https://doi.org/10.1111/j.1526-4610.1994.hed3401059.x
72 https://doi.org/10.1111/j.1528-1157.1991.tb05538.x
73 https://doi.org/10.1136/jnnp.64.5.611
74 https://doi.org/10.1152/ajpcell.2000.278.5.c921
75 https://doi.org/10.1152/ajpendo.1987.253.2.e228
76 https://doi.org/10.1152/ajpendo.1997.273.1.e207
77 https://doi.org/10.1152/ajpendo.1998.275.3.e516
78 https://doi.org/10.1152/ajpendo.1999.277.3.e561
79 https://doi.org/10.1152/jappl.1976.41.4.565
80 https://doi.org/10.1159/000111426
81 https://doi.org/10.1161/01.str.30.2.460
82 https://doi.org/10.1172/jci118043
83 https://doi.org/10.1179/016164101101198785
84 https://doi.org/10.1523/jneurosci.04-01-00058.1984
85 https://doi.org/10.1523/jneurosci.15-07-05179.1995
86 https://doi.org/10.1523/jneurosci.16-03-00877.1996
87 https://doi.org/10.2337/diab.43.11.1311
88 https://doi.org/10.2337/diab.46.1.70
89 https://doi.org/10.3171/jns.1999.91.1.0001
90 https://doi.org/10.3171/jns.2000.93.1.0037
91 schema:datePublished 2002-03
92 schema:datePublishedReg 2002-03-01
93 schema:description Brain levels of glucose and lactate in the extracellular fluid (ECF), which reflects the environment to which neurons are exposed, have never been studied in humans under conditions of varying glycemia. The authors used intracerebral microdialysis in conscious human subjects undergoing electrophysiologic evaluation for medically intractable epilepsy and measured ECF levels of glucose and lactate under basal conditions and during a hyperglycemia-hypoglycemia clamp study. Only measurements from nonepileptogenic areas were included. Under basal conditions, the authors found the metabolic milieu in the brain to be strikingly different from that in the circulation. In contrast to plasma, lactate levels in brain ECF were threefold higher than glucose. Results from complementary studies in rats were consistent with the human data. During the hyperglycemia-hypoglycemia clamp study the relationship between plasma and brain ECF levels of glucose remained similar, but changes in brain ECF glucose lagged approximately 30 minutes behind changes in plasma. The data demonstrate that the brain is exposed to substantially lower levels of glucose and higher levels of lactate than those in plasma; moreover, the brain appears to be a site of significant anaerobic glycolysis, raising the possibility that glucose-derived lactate is an important fuel for the brain.
94 schema:genre research_article
95 schema:inLanguage en
96 schema:isAccessibleForFree true
97 schema:isPartOf N05a471a9b75c4f558f646f692a6d0dcb
98 N4b764834369741f4951ab2af71c54190
99 sg:journal.1092815
100 schema:name Striking Differences in Glucose and Lactate Levels Between Brain Extracellular Fluid and Plasma in Conscious Human Subjects: Effects of Hyperglycemia and Hypoglycemia
101 schema:pagination 271-279
102 schema:productId N39c51412f8b3468698b822fe2ec47f70
103 N5b6e6d82ed0746ac8fa0b8e5ee4bd726
104 N63bd8841407a43b9a7dca6a97f0b3e83
105 N9b54668e03f54fe5b71db5ce283d6dcc
106 Nb05f7721b9b843e19eb811b2cad5ae67
107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012550278
108 https://doi.org/10.1097/00004647-200203000-00004
109 schema:sdDatePublished 2019-04-10T20:34
110 schema:sdLicense https://scigraph.springernature.com/explorer/license/
111 schema:sdPublisher Nd33e6bd878994bde8dd40a125310cf02
112 schema:url http://www.nature.com/jcbfm/journal/v22/n3/full/9591215a.html
113 sgo:license sg:explorer/license/
114 sgo:sdDataset articles
115 rdf:type schema:ScholarlyArticle
116 N05a471a9b75c4f558f646f692a6d0dcb schema:volumeNumber 22
117 rdf:type schema:PublicationVolume
118 N092383ae70e84c029b6bd18ab575e2c7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Hypoglycemia
120 rdf:type schema:DefinedTerm
121 N096471dc536e4cbcbec5c5b817e16458 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Brain
123 rdf:type schema:DefinedTerm
124 N19c6c518d0b542ec9cb6cfda5c512e9c schema:affiliation https://www.grid.ac/institutes/grid.47100.32
125 schema:familyName Jones
126 schema:givenName Tim
127 rdf:type schema:Person
128 N1c5dbb039acc42c081e0015d525e5932 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Adult
130 rdf:type schema:DefinedTerm
131 N284338ee04e2421b92ec5b2ad8afa7c5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Female
133 rdf:type schema:DefinedTerm
134 N30fc9a8f19f546fba193411b6774aae5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Rats
136 rdf:type schema:DefinedTerm
137 N39c51412f8b3468698b822fe2ec47f70 schema:name dimensions_id
138 schema:value pub.1012550278
139 rdf:type schema:PropertyValue
140 N3e270c06ea794b329723f59b667042c8 rdf:first sg:person.01301743656.30
141 rdf:rest N67c3aea0638143dfaaddad3e579af18c
142 N41228dc99a4c4377a3a2426cd8721c5b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Adolescent
144 rdf:type schema:DefinedTerm
145 N479a2a5e9d364a2689d0a053a80344c7 rdf:first sg:person.0753661634.46
146 rdf:rest rdf:nil
147 N48d2196630b648e0ad1e8492c7c49cfb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Extracellular Space
149 rdf:type schema:DefinedTerm
150 N4b764834369741f4951ab2af71c54190 schema:issueNumber 3
151 rdf:type schema:PublicationIssue
152 N4e454aa8156b474fa224d8395f896091 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Consciousness
154 rdf:type schema:DefinedTerm
155 N5420dc39788b4d0abface6e85bb97747 schema:name Department of Psychiatry
156 rdf:type schema:Organization
157 N55496780c65a411f8c85254cb96a6714 rdf:first sg:person.01325120244.47
158 rdf:rest Nb7cd9a55be14464b8ac1ebe57a60f241
159 N59c82a1c2271423abbcd39654949394e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Epilepsy
161 rdf:type schema:DefinedTerm
162 N5b6e6d82ed0746ac8fa0b8e5ee4bd726 schema:name readcube_id
163 schema:value 3bcad7a9acc1cc5329ab4662f953de1fd8241e0714c411a0be19b5b17223feee
164 rdf:type schema:PropertyValue
165 N5ebff9b398d4455481e68d6469458268 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Microdialysis
167 rdf:type schema:DefinedTerm
168 N63bd8841407a43b9a7dca6a97f0b3e83 schema:name nlm_unique_id
169 schema:value 8112566
170 rdf:type schema:PropertyValue
171 N67c3aea0638143dfaaddad3e579af18c rdf:first sg:person.0657751312.09
172 rdf:rest Ne5327106f94a42f793bc67aee6b304aa
173 N724f91294efb49a39ff3c4734a6b4b27 rdf:first sg:person.0727126523.06
174 rdf:rest Nb50a251186474c3c9bf5b2340bbb6f1a
175 N7c8e08b1b7274998b9df7dfb654e910e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Rats, Sprague-Dawley
177 rdf:type schema:DefinedTerm
178 N857621755af74f35a5643f3fd080f4ea schema:name Department of Psychiatry
179 rdf:type schema:Organization
180 N8ed5687cdb4e45b38018cd65e0acff58 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Lactates
182 rdf:type schema:DefinedTerm
183 N97ad5e3659e14b69ab3daa5b538e0c5a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Hyperglycemia
185 rdf:type schema:DefinedTerm
186 N9b54668e03f54fe5b71db5ce283d6dcc schema:name doi
187 schema:value 10.1097/00004647-200203000-00004
188 rdf:type schema:PropertyValue
189 Nb05f7721b9b843e19eb811b2cad5ae67 schema:name pubmed_id
190 schema:value 11891432
191 rdf:type schema:PropertyValue
192 Nb2f122f795b84617b08962d97311088c rdf:first sg:person.015543051772.37
193 rdf:rest Nf320409d477a44e68e7037fc25dda695
194 Nb46ca4b447c84aaf8e6886139ef33bf2 rdf:first N19c6c518d0b542ec9cb6cfda5c512e9c
195 rdf:rest Nd6e278170abd4cae990ae9a52a6ac453
196 Nb50a251186474c3c9bf5b2340bbb6f1a rdf:first sg:person.01122133401.33
197 rdf:rest Nb2f122f795b84617b08962d97311088c
198 Nb7cd9a55be14464b8ac1ebe57a60f241 rdf:first sg:person.0750171405.36
199 rdf:rest Nb46ca4b447c84aaf8e6886139ef33bf2
200 Nbab962a526f44ff8b0cd20fa1117eede schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
201 schema:name Animals
202 rdf:type schema:DefinedTerm
203 Ncedc2a0b226749e8b7b9f84ad199e481 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
204 schema:name Glucose
205 rdf:type schema:DefinedTerm
206 Nd17e491b0ffa44d1b8b93fe3b58486a6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
207 schema:name Humans
208 rdf:type schema:DefinedTerm
209 Nd33e6bd878994bde8dd40a125310cf02 schema:name Springer Nature - SN SciGraph project
210 rdf:type schema:Organization
211 Nd4b89adf95b44738b32e6b466181052b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
212 schema:name Time Factors
213 rdf:type schema:DefinedTerm
214 Nd6e278170abd4cae990ae9a52a6ac453 rdf:first sg:person.01233554544.43
215 rdf:rest N724f91294efb49a39ff3c4734a6b4b27
216 Nde8e691f94774e6a977f9231a67b47e7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
217 schema:name Male
218 rdf:type schema:DefinedTerm
219 Ne5327106f94a42f793bc67aee6b304aa rdf:first sg:person.01304477527.38
220 rdf:rest N479a2a5e9d364a2689d0a053a80344c7
221 Nf2bbe9b848d4438a82672c61483f5acf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
222 schema:name Blood Glucose
223 rdf:type schema:DefinedTerm
224 Nf320409d477a44e68e7037fc25dda695 rdf:first sg:person.0707273404.07
225 rdf:rest N3e270c06ea794b329723f59b667042c8
226 Nf86e4e2a061d4818a6bec0b4f04f1d7c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
227 schema:name Kinetics
228 rdf:type schema:DefinedTerm
229 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
230 schema:name Medical and Health Sciences
231 rdf:type schema:DefinedTerm
232 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
233 schema:name Neurosciences
234 rdf:type schema:DefinedTerm
235 sg:grant.2405812 http://pending.schema.org/fundedItem sg:pub.10.1097/00004647-200203000-00004
236 rdf:type schema:MonetaryGrant
237 sg:grant.2423996 http://pending.schema.org/fundedItem sg:pub.10.1097/00004647-200203000-00004
238 rdf:type schema:MonetaryGrant
239 sg:grant.2439003 http://pending.schema.org/fundedItem sg:pub.10.1097/00004647-200203000-00004
240 rdf:type schema:MonetaryGrant
241 sg:grant.2491974 http://pending.schema.org/fundedItem sg:pub.10.1097/00004647-200203000-00004
242 rdf:type schema:MonetaryGrant
243 sg:grant.2634620 http://pending.schema.org/fundedItem sg:pub.10.1097/00004647-200203000-00004
244 rdf:type schema:MonetaryGrant
245 sg:journal.1092815 schema:issn 0271-678X
246 1559-7016
247 schema:name Journal of Cerebral Blood Flow & Metabolism
248 rdf:type schema:Periodical
249 sg:person.01122133401.33 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
250 schema:familyName Thompson
251 schema:givenName James
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122133401.33
253 rdf:type schema:Person
254 sg:person.01233554544.43 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
255 schema:familyName Jacob
256 schema:givenName Ralph
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233554544.43
258 rdf:type schema:Person
259 sg:person.01301743656.30 schema:affiliation N5420dc39788b4d0abface6e85bb97747
260 schema:familyName Krystal
261 schema:givenName John H.
262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301743656.30
263 rdf:type schema:Person
264 sg:person.01304477527.38 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
265 schema:familyName During
266 schema:givenName Matthew J.
267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304477527.38
268 rdf:type schema:Person
269 sg:person.01325120244.47 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
270 schema:familyName Abi-Saab
271 schema:givenName Walid M.
272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01325120244.47
273 rdf:type schema:Person
274 sg:person.015543051772.37 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
275 schema:familyName Kerr
276 schema:givenName David
277 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015543051772.37
278 rdf:type schema:Person
279 sg:person.0657751312.09 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
280 schema:familyName Spencer
281 schema:givenName Dennis D.
282 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657751312.09
283 rdf:type schema:Person
284 sg:person.0707273404.07 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
285 schema:familyName Leone
286 schema:givenName Paola
287 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707273404.07
288 rdf:type schema:Person
289 sg:person.0727126523.06 schema:affiliation N857621755af74f35a5643f3fd080f4ea
290 schema:familyName Srihari
291 schema:givenName Vinod
292 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727126523.06
293 rdf:type schema:Person
294 sg:person.0750171405.36 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
295 schema:familyName Maggs
296 schema:givenName David G.
297 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750171405.36
298 rdf:type schema:Person
299 sg:person.0753661634.46 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
300 schema:familyName Sherwin
301 schema:givenName Robert S.
302 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753661634.46
303 rdf:type schema:Person
304 sg:pub.10.1007/978-1-4615-2920-0_7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017629792
305 https://doi.org/10.1007/978-1-4615-2920-0_7
306 rdf:type schema:CreativeWork
307 sg:pub.10.1097/00004647-199607000-00014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012443223
308 https://doi.org/10.1097/00004647-199607000-00014
309 rdf:type schema:CreativeWork
310 https://app.dimensions.ai/details/publication/pub.1074271830 schema:CreativeWork
311 https://app.dimensions.ai/details/publication/pub.1074355081 schema:CreativeWork
312 https://app.dimensions.ai/details/publication/pub.1074576408 schema:CreativeWork
313 https://app.dimensions.ai/details/publication/pub.1074576412 schema:CreativeWork
314 https://app.dimensions.ai/details/publication/pub.1082982568 schema:CreativeWork
315 https://doi.org/10.1002/(sici)1096-9136(199701)14:1<19::aid-dia289>3.0.co;2-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005199009
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1002/(sici)1098-1136(199803)22:3<272::aid-glia6>3.0.co;2-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042045210
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1002/glia.440010603 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014316423
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1016/0006-8993(93)91429-v schema:sameAs https://app.dimensions.ai/details/publication/pub.1022991200
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1016/0140-6736(93)90754-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043061814
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1016/0165-0270(85)90107-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009848148
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1016/0303-8467(94)00067-g schema:sameAs https://app.dimensions.ai/details/publication/pub.1031784330
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1016/0304-3940(91)90268-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004926294
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1016/b978-0-444-81194-3.50024-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037117122
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1016/s0006-8993(96)01106-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026767907
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1016/s0140-6736(94)90876-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003219098
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1016/s0165-3806(98)00188-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025586889
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1016/s0304-3940(97)00840-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043586334
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1016/s0306-4522(98)00427-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015955199
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1042/0264-6021:3410529 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056714092
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1042/bj3410529 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050742306
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1042/bj3430281 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048621238
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1046/j.1471-4159.1994.62051939.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1005139339
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1046/j.1471-4159.1994.62062356.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1037165557
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1046/j.1471-4159.1995.64041734.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1029289650
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1073/pnas.85.22.8727 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013698083
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1073/pnas.85.6.1821 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051256497
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1073/pnas.91.22.10625 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051993306
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1073/pnas.95.7.3990 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003328231
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1074/jbc.272.48.30096 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049932671
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1080/00365519950185904 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058282633
366 rdf:type schema:CreativeWork
367 https://doi.org/10.1080/01616412.1997.11740814 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058296304
368 rdf:type schema:CreativeWork
369 https://doi.org/10.1080/01616412.1999.11740943 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058296576
370 rdf:type schema:CreativeWork
371 https://doi.org/10.1089/neu.1998.15.509 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059299786
372 rdf:type schema:CreativeWork
373 https://doi.org/10.1097/00003246-199909000-00041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060174319
374 rdf:type schema:CreativeWork
375 https://doi.org/10.1097/00003643-199605000-00005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060178113
376 rdf:type schema:CreativeWork
377 https://doi.org/10.1097/00004647-199607000-00014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012443223
378 rdf:type schema:CreativeWork
379 https://doi.org/10.1097/00006123-199711000-00011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060247023
380 rdf:type schema:CreativeWork
381 https://doi.org/10.1097/00006123-200009000-00035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019576342
382 rdf:type schema:CreativeWork
383 https://doi.org/10.1111/j.1469-8749.1989.tb03974.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1031576238
384 rdf:type schema:CreativeWork
385 https://doi.org/10.1111/j.1471-4159.1976.tb12254.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1044578863
386 rdf:type schema:CreativeWork
387 https://doi.org/10.1111/j.1471-4159.1983.tb13562.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1011429690
388 rdf:type schema:CreativeWork
389 https://doi.org/10.1111/j.1471-4159.1986.tb13039.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1028401302
390 rdf:type schema:CreativeWork
391 https://doi.org/10.1111/j.1471-4159.1989.tb07243.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1042621544
392 rdf:type schema:CreativeWork
393 https://doi.org/10.1111/j.1471-4159.1993.tb03570.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1018560818
394 rdf:type schema:CreativeWork
395 https://doi.org/10.1111/j.1526-4610.1994.hed3401059.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1038286548
396 rdf:type schema:CreativeWork
397 https://doi.org/10.1111/j.1528-1157.1991.tb05538.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1040424816
398 rdf:type schema:CreativeWork
399 https://doi.org/10.1136/jnnp.64.5.611 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010955755
400 rdf:type schema:CreativeWork
401 https://doi.org/10.1152/ajpcell.2000.278.5.c921 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074633971
402 rdf:type schema:CreativeWork
403 https://doi.org/10.1152/ajpendo.1987.253.2.e228 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079854939
404 rdf:type schema:CreativeWork
405 https://doi.org/10.1152/ajpendo.1997.273.1.e207 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083127971
406 rdf:type schema:CreativeWork
407 https://doi.org/10.1152/ajpendo.1998.275.3.e516 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083312247
408 rdf:type schema:CreativeWork
409 https://doi.org/10.1152/ajpendo.1999.277.3.e561 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074520286
410 rdf:type schema:CreativeWork
411 https://doi.org/10.1152/jappl.1976.41.4.565 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083361965
412 rdf:type schema:CreativeWork
413 https://doi.org/10.1159/000111426 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011229558
414 rdf:type schema:CreativeWork
415 https://doi.org/10.1161/01.str.30.2.460 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017417824
416 rdf:type schema:CreativeWork
417 https://doi.org/10.1172/jci118043 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018528331
418 rdf:type schema:CreativeWork
419 https://doi.org/10.1179/016164101101198785 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039478338
420 rdf:type schema:CreativeWork
421 https://doi.org/10.1523/jneurosci.04-01-00058.1984 schema:sameAs https://app.dimensions.ai/details/publication/pub.1081908679
422 rdf:type schema:CreativeWork
423 https://doi.org/10.1523/jneurosci.15-07-05179.1995 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082439130
424 rdf:type schema:CreativeWork
425 https://doi.org/10.1523/jneurosci.16-03-00877.1996 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082858617
426 rdf:type schema:CreativeWork
427 https://doi.org/10.2337/diab.43.11.1311 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070737213
428 rdf:type schema:CreativeWork
429 https://doi.org/10.2337/diab.46.1.70 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070738003
430 rdf:type schema:CreativeWork
431 https://doi.org/10.3171/jns.1999.91.1.0001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071099223
432 rdf:type schema:CreativeWork
433 https://doi.org/10.3171/jns.2000.93.1.0037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071099612
434 rdf:type schema:CreativeWork
435 https://www.grid.ac/institutes/grid.47100.32 schema:alternateName Yale University
436 schema:name Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, U.S.A.
437 Department of Neurology, Yale University School of Medicine, New Haven, Connecticut, U.S.A.
438 Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut, U.S.A.
439 Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut, U.S.A.
440 Department of Psychiatry
441 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...