Imaging Synaptic Neurotransmission With in Vivo Binding Competition Techniques: A Critical Review View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2000-03

AUTHORS

Marc Laruelle

ABSTRACT

Several groups have provided evidence that positron emission tomography (PET) and single-photon emission computed tomography (SPECT) neuroreceptor imaging techniques might be applied to measure acute fluctuations in dopamine (DA) synaptic concentration in the living human brain. Competition between DA and radioligands for binding to D2 receptor is the principle underlying this approach. This new application of neuroreceptor imaging provides a dynamic measurement of neurotransmission that is likely to be informative to our understanding of neuropsychiatric conditions. This article reviews and discusses the body of data supporting the feasibility and potential of this imaging paradigm. Endogenous competition studies performed in rodents, nonhuman primates, and humans are first summarized. After this overview, the validity of the model underlying the interpretation of these imaging data is critically assessed. The current reference model is defined as the occupancy model, since changes in radiotracer binding potential (BP) are assumed to be directly caused by changes in occupancy of D2 receptors by DA. Experimental data supporting this model are presented. The evidence that manipulation of DA synaptic levels induces change in the BP of several D2 radiotracers (catecholamines and benzamides) is unequivocal. The fact that these changes in BP are mediated by changes in DA synaptic concentration is well documented. The relationship between the magnitude of BP changes measured with PET or SPECT and the magnitude of changes in DA concentration measured by microdialysis supports the use of these noninvasive techniques to measure changes in neurotransmission. On the other hand, several observations remain unexplained. First, the amphetamine-induced changes in the BP of D2 receptor antagonists [123I]IBZM and [11C]raclopride last longer than amphetamine-induced changes in DA extracellular concentration. Second, nonbenzamide D2 receptor antagonists, such as spiperone and pimozide, are not affected by changes in DA release, or are affected in a direction opposite to that predicted by the occupancy model. Similar observations are reported with D1 radiotracers. These results suggest that the changes in BP following changes in DA concentration might not be fully accounted by a simple occupancy model. Specifically, the data are reviewed supporting that agonist-mediated receptor internalization might play an important role in characterizing receptor-ligand interactions. Finally, it is proposed that a better understanding of the mechanism underlying the effects observed with benzamides is essential to develop this imaging technique to other receptor systems. More... »

PAGES

423-451

References to SciGraph publications

  • 1989-07. Kinetic properties of the in vivo accumulation of 3H-(−)-N-n-propylnorapomorphine in mouse brain in NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY
  • 1998-05. Evidence for striatal dopamine release during a video game in NATURE
  • 1978-10. Effect of guanine nucleotides on striatal dopamine receptors in NATURE
  • 1989-05. Effects of sodium, lithium, and magnesium onIn vitro binding of [3H]SCH23390 in rat neostriatum and cerebral cortex in NEUROCHEMICAL RESEARCH
  • 1999-05. 5-HT Modulation of Dopamine Release in Basal Ganglia in Psilocybin-Induced Psychosis in Man—A PET Study with [11C]raclopride in NEUROPSYCHOPHARMACOLOGY
  • 1998-11. Assessment of Dynamic Neurotransmitter Changes With Bolus or Infusion Delivery of Neuroreceptor Ligands in JOURNAL OF CEREBRAL BLOOD FLOW & METABOLISM
  • 1997-09. Imaging D2 Receptor Occupancy by Endogenous Dopamine in Humans in NEUROPSYCHOPHARMACOLOGY
  • 1989-07. Kinetic properties of the accumulation of 3H-raclopride in the mouse brain in vivo in NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY
  • 1997-02. COMMENTARY in NEUROPSYCHOPHARMACOLOGY
  • 1997-04. Decreased striatal dopaminergic responsiveness in detoxified cocaine-dependent subjects in NATURE
  • 1999-09. A PET study of D1-like dopamine receptor ligand binding in PSYCHOPHARMACOLOGY
  • 1985-06. Dopamine D2 receptors selectively labeled by a benzamide neuroleptic: [3H]-YM-09151-2 in NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY
  • 1993-06. Cortical regulation of subcortical dopamine systems and its possible relevance to schizophrenia in JOURNAL OF NEURAL TRANSMISSION
  • 1994-10. The effect of reserpine treatment in vivo upon L-dopa and amphetamine evoked dopamine and DOPAC efflux in vitro from the corpus striatum of male rats in JOURNAL OF NEURAL TRANSMISSION
  • 1997-08. Pergolide binds tightly to dopamine D2 short receptors and induces receptor sequestration in JOURNAL OF NEURAL TRANSMISSION
  • 1998-01. Glutamate Modulation of Dopamine Measured in Vivo with Positron Emission Tomography (PET) and 11C-Raclopride in Normal Human Subjects in NEUROPSYCHOPHARMACOLOGY
  • 1997-02. Atypical Neuroleptics Have Low Affinity for Dopamine D2 Receptors or Are Selective for D4 Receptors in NEUROPSYCHOPHARMACOLOGY
  • 1997-04. Amphetamine effects on dopamine release and synthesis rate studied in the Rhesus monkey brain by positron emission tomography in JOURNAL OF NEURAL TRANSMISSION
  • 1997-06. Assessment of endogenous dopamine release by methylphenidate challenge using iodine-123 iodobenzamide single-photon emission tomography in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 1998-03. Antipsychotic drugs which elicit little or no Parkinsonism bind more loosely than dopamine to brain D2 receptors, yet occupy high levels of these receptors in MOLECULAR PSYCHIATRY
  • 1997-09. Kinetic Modeling of [11C]Raclopride: Combined PET-Microdialysis Studies in JOURNAL OF CEREBRAL BLOOD FLOW & METABOLISM
  • 1997-05. The relationship between D2 receptor occupancy and plasma levels on low dose oral haloperidol: a PET study in PSYCHOPHARMACOLOGY
  • 1995-06. Difference in response of D2 receptor binding between11C-N-methylspiperone and11C-raclopride against anesthetics in rhesus monkey brain in JOURNAL OF NEURAL TRANSMISSION
  • 1988-02. Human dopamine receptor subtypes—in vitro binding analysis using3H-SCH 23390 and3H-raclopride in ACTA NEUROVEGETATIVA
  • 1997-04. Quantification of Amphetamine-Induced Changes in [11C] Raclopride Binding with Continuous Infusion in JOURNAL OF CEREBRAL BLOOD FLOW & METABOLISM
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1097/00004647-200003000-00001

    DOI

    http://dx.doi.org/10.1097/00004647-200003000-00001

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1052956062

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/10724107


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Clinical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Binding, Competitive", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Brain", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Dopamine", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Ligands", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Models, Neurological", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Receptors, Dopamine", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Synaptic Transmission", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Tomography, Emission-Computed", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Tomography, Emission-Computed, Single-Photon", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "NewYork\u2013Presbyterian Hospital", 
              "id": "https://www.grid.ac/institutes/grid.413734.6", 
              "name": [
                "Department of Psychiatry and Radiology, Columbia University College of Physicians and Surgeons and New York State Psychiatric Institute, New York, New York, U.S.A."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Laruelle", 
            "givenName": "Marc", 
            "id": "sg:person.015367440337.39", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015367440337.39"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/bf01244618", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000895794", 
              "https://doi.org/10.1007/bf01244618"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0024-3205(91)90261-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001045771"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0024-3205(91)90261-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001045771"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0969-8051(94)90007-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001102613"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1471-4159.1991.tb06341.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001169220"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1098-2396(199704)25:4<321::aid-syn2>3.0.co;2-c", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001176004"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0006-3223(99)00067-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001261123"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0922-4106(92)90121-b", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001460814"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-8993(96)00424-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002174926"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-8993(96)00424-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002174926"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0969-8051(94)00117-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003413741"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0028-3908(92)90020-p", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003863402"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0028-3908(92)90020-p", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003863402"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/archpsyc.1994.03950020040004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004236463"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0028-3908(93)90154-u", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004291956"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0028-3908(93)90154-u", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004291956"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-8993(93)90741-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004521537"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-8993(93)90741-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004521537"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0306-4522(92)90470-m", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005136668"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0306-4522(92)90470-m", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005136668"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ana.410150713", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005386366"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0014-2999(95)00233-b", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006116145"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1432-1327.1999.00125.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007172337"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0197-4580(93)90018-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007433893"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0197-4580(93)90018-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007433893"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-2952(91)90187-a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007752268"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-2952(91)90187-a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007752268"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1471-4159.1988.tb03069.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008054507"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1098-2396(19990315)31:4<302::aid-syn9>3.0.co;2-a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008188448"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1471-4159.1993.tb03181.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008423238"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/386830a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008799479", 
              "https://doi.org/10.1038/386830a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0024-3205(93)90005-n", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009089594"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0024-3205(93)90005-n", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009089594"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1098-2396(199905)32:2<93::aid-syn3>3.0.co;2-c", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009155078"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01271537", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010447484", 
              "https://doi.org/10.1007/bf01271537"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01271537", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010447484", 
              "https://doi.org/10.1007/bf01271537"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1471-4159.1988.tb01830.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010581358"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jps.2600830309", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010697227"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0091-3057(96)00449-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010782520"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0091-3057(96)00449-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010782520"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1097/00004647-199709000-00002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010888187", 
              "https://doi.org/10.1097/00004647-199709000-00002"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00004647-199709000-00002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010888187"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00004647-199709000-00002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010888187"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01277655", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011480172", 
              "https://doi.org/10.1007/bf01277655"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01277655", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011480172", 
              "https://doi.org/10.1007/bf01277655"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.93.17.9241", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011719646"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1471-4159.1985.tb08740.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011875967"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1432-1327.1999.00549.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012310547"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1097/00004647-199811000-00006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012322495", 
              "https://doi.org/10.1097/00004647-199811000-00006"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00004647-199811000-00006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012322495"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00004647-199811000-00006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012322495"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.mp.4000336", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013499912", 
              "https://doi.org/10.1038/sj.mp.4000336"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.mp.4000336", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013499912", 
              "https://doi.org/10.1038/sj.mp.4000336"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/b978-012161340-2/50068-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013876731"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-2952(78)90233-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014380514"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-2952(78)90233-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014380514"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/syn.890200207", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014884627"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-2952(86)90396-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015110642"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/jcbfm.1986.27", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015266413"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/jcbfm.1986.27", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015266413"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0020-708x(85)90083-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015497629"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0020-708x(85)90083-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015497629"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0024-3205(77)90116-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015503768"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0024-3205(77)90116-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015503768"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00004424-199212002-00010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015875573"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00004424-199212002-00010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015875573"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0969-8051(93)90131-d", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015977116"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1097/00004647-199704000-00009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016064522", 
              "https://doi.org/10.1097/00004647-199704000-00009"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00004647-199704000-00009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016064522"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00004647-199704000-00009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016064522"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.2042-7158.1978.tb13223.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016077747"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.93.17.9235", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016086472"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1471-4159.1985.tb07233.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016141763"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1098-2396(199603)22:3<232::aid-syn5>3.0.co;2-d", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016288947"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/syn.890120106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016365525"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0306-4522(94)00507-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016700716"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0306-4522(94)00536-e", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016855926"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/jcbfm.1990.127", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016880702"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/jcbfm.1990.127", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016880702"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/jcbfm.1988.64", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017572287"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/jcbfm.1988.64", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017572287"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0925-4927(95)02732-d", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017626135"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/archpsyc.1989.01810050096021", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018485184"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0014-2999(89)90516-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018555150"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0014-2999(89)90516-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018555150"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/jcbfm.1983.1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018753419"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/jcbfm.1983.1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018753419"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0197-0186(95)00123-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018841034"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/bbrc.1996.1489", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019915245"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1016/s0893-133x(97)00092-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020048502", 
              "https://doi.org/10.1016/s0893-133x(97)00092-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00496365", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020363995", 
              "https://doi.org/10.1007/bf00496365"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00496365", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020363995", 
              "https://doi.org/10.1007/bf00496365"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/archpsyc.1988.01800300096017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021009201"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/syn.890060403", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021418130"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-8993(80)90229-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021560944"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-8993(80)90229-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021560944"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0165-6147(97)90643-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021609920"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0024-3205(86)90652-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021716825"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0024-3205(86)90652-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021716825"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/syn.890150302", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022306272"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1098-2396(199901)31:1<59::aid-syn8>3.0.co;2-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022614059"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1098-2396(199712)27:4<313::aid-syn5>3.0.co;2-f", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022650271"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-2952(94)90439-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023170411"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-2952(94)90439-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023170411"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0014-5793(98)01588-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023368471"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-2952(89)90387-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023598592"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-2952(89)90387-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023598592"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00169200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023714743", 
              "https://doi.org/10.1007/bf00169200"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00169200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023714743", 
              "https://doi.org/10.1007/bf00169200"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/syn.890090305", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024064631"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.128.6.1029", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024218923"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-2952(92)90016-c", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024373124"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-2952(92)90016-c", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024373124"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1016/s0893-133x(97)00043-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024594849", 
              "https://doi.org/10.1016/s0893-133x(97)00043-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1471-4159.1990.tb05794.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024940132"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01271567", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024950460", 
              "https://doi.org/10.1007/bf01271567"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01271567", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024950460", 
              "https://doi.org/10.1007/bf01271567"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/jcbfm.1994.56", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025038829"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/jcbfm.1994.56", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025038829"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/archpsyc.1990.01810150013003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025048651"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1471-4159.1994.63051589.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025844320"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3109/10799899109066397", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025952757"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.91.12.5720", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025971024"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-8993(86)90707-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026164872"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-8993(86)90707-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026164872"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0024-3205(85)90028-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026335916"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0024-3205(85)90028-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026335916"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0306-4522(91)90196-u", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026731268"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0306-4522(91)90196-u", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026731268"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1098-2396(199709)27:1<1::aid-syn1>3.0.co;2-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027286080"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.92.7.2622", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027314150"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/jcbfm.1994.132", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028739369"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/jcbfm.1994.132", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028739369"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0024-3205(84)90540-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028889739"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0024-3205(84)90540-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028889739"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1016/s0893-133x(98)00108-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029057763", 
              "https://doi.org/10.1016/s0893-133x(98)00108-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.144.1.31", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029319410"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1098-2396(199701)25:1<1::aid-syn1>3.0.co;2-h", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030098331"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0197-0186(87)90167-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030334941"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0197-0186(87)90167-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030334941"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0014-2999(94)90521-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030436407"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0014-2999(94)90521-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030436407"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0024-3205(79)90539-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030584009"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0024-3205(79)90539-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030584009"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0006-8993(99)01834-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030623788"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0014-2999(80)90224-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030766238"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0014-2999(80)90224-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030766238"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s002130051110", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032886043", 
              "https://doi.org/10.1007/s002130051110"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/syn.890030113", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033635539"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/30498", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033741154", 
              "https://doi.org/10.1038/30498"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/30498", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033741154", 
              "https://doi.org/10.1038/30498"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1016/s0893-133x(96)00187-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034155060", 
              "https://doi.org/10.1016/s0893-133x(96)00187-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-2952(73)90196-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034157975"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-2952(73)90196-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034157975"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-8993(94)91263-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034532255"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-8993(94)91263-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034532255"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0014-2999(83)90336-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035601556"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0014-2999(83)90336-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035601556"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/jcbfm.1989.98", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035762647"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/jcbfm.1989.98", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035762647"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0014-2999(92)90578-r", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035918078"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0014-2999(92)90578-r", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035918078"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.94.6.2569", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036506224"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/b978-012161340-2/50069-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036757731"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/syn.890100302", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036913323"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-8993(84)91113-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037556238"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-8993(84)91113-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037556238"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-2952(83)90016-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037688842"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-2952(83)90016-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037688842"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/275453a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038706616", 
              "https://doi.org/10.1038/275453a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/275453a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038706616", 
              "https://doi.org/10.1038/275453a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1471-4159.1981.tb02396.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039253540"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/syn.890090306", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040181844"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/syn.890070409", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040226853"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0014-2999(91)90513-p", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040677830"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0014-2999(91)90513-p", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040677830"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1471-4159.1984.tb00935.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040680590"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1471-4159.1988.tb02919.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041075683"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1471-4159.1995.64020940.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041099650"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0165-6147(97)01091-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041215190"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/jcbfm.1991.102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041643730"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/jcbfm.1991.102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041643730"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/nimg.1997.0269", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041948158"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1098-2396(199902)31:2<154::aid-syn9>3.0.co;2-k", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042689763"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0014-2999(84)90386-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042697254"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0014-2999(84)90386-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042697254"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.90.19.8861", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043016071"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1098-2396(199806)29:2<142::aid-syn5>3.0.co;2-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043304291"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0014-2999(81)90584-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043789522"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0014-2999(81)90584-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043789522"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01245228", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044071957", 
              "https://doi.org/10.1007/bf01245228"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-2952(85)90778-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044146434"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-2952(85)90778-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044146434"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0014-2999(96)00080-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044174762"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/archpsyc.1990.01810240090014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044193889"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/syn.890130407", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044629879"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-8993(80)90360-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045268197"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-8993(80)90360-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045268197"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0167-4889(84)90103-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045505366"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0167-4889(84)90103-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045505366"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1471-4159.1995.65020691.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045533156"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/archpsyc.1992.01820070032005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045606546"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/syn.890160402", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045982865"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0165-1781(93)90063-m", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046250107"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.270.15.8902", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047099007"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3109/10799899509045236", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047895771"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1016/s0893-133x(96)00188-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048088780", 
              "https://doi.org/10.1016/s0893-133x(96)00188-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00964855", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048841937", 
              "https://doi.org/10.1007/bf00964855"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0306-4522(89)90168-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049008252"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0306-4522(89)90168-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049008252"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0028-3908(98)00043-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049100137"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00841408", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049454244", 
              "https://doi.org/10.1007/bf00841408"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00169199", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049859814", 
              "https://doi.org/10.1007/bf00169199"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00169199", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049859814", 
              "https://doi.org/10.1007/bf00169199"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.2042-7158.1990.tb07071.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049974533"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01285554", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050292731", 
              "https://doi.org/10.1007/bf01285554"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01285554", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050292731", 
              "https://doi.org/10.1007/bf01285554"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0306-4522(96)00631-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051199543"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0024-3205(88)90123-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051548026"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0024-3205(88)90123-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051548026"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0014-2999(87)90592-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051989123"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0014-2999(87)90592-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051989123"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s002130050277", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052307485", 
              "https://doi.org/10.1007/s002130050277"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1471-4159.1990.tb03147.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052533623"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1098-2396(199802)28:2<167::aid-syn7>3.0.co;2-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052840810"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0163-7258(98)00019-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053296433"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0883-2897(88)90088-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053497040"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3109/10799899709036618", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053592170"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi00041a044", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055158443"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jm00054a002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055933794"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jm00081a002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055934439"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jm00116a004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055935714"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jm00400a027", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055946316"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.2878495", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062568977"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.6604315", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062639159"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1176/ajp.152.2.173", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063483605"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1176/ajp.154.9.1209", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063485206"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1176/ajp.155.11.1550", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063485353"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/43.5.7730588", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064094709"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/43.5.7730588", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064094709"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1064242960", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/endo-117-2-690", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064259056"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/endo.138.10.5433", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064281273"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074508167", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.12-10-03773.1992", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1075843917"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077249401", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077614587", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077951618", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078051329", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078364121", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078411599", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079460134", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.06-10-02941.1986", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1079468212"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079504509", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079702055", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.05-02-00421.1985", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1080060912"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1081604254", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082359397", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082436290", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.15-07-05222.1995", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1082439133"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082440366", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.15-05-04102.1995", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1082492596"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.15-06-04140.1995", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1082509020"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082509065", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.15-01-00821.1995", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1082523799"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082526439", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082543939", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082545374", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082687451", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082890939", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1124/mol.51.2.177", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083109494"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajpgi.1997.273.3.g586", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083154544"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.18-05-01650.1998", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083211642"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1176/ajp.155.6.761", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083275115"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1053-8119(18)31879-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1107166516"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1053-8119(18)31876-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1107184160"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2000-03", 
        "datePublishedReg": "2000-03-01", 
        "description": "Several groups have provided evidence that positron emission tomography (PET) and single-photon emission computed tomography (SPECT) neuroreceptor imaging techniques might be applied to measure acute fluctuations in dopamine (DA) synaptic concentration in the living human brain. Competition between DA and radioligands for binding to D2 receptor is the principle underlying this approach. This new application of neuroreceptor imaging provides a dynamic measurement of neurotransmission that is likely to be informative to our understanding of neuropsychiatric conditions. This article reviews and discusses the body of data supporting the feasibility and potential of this imaging paradigm. Endogenous competition studies performed in rodents, nonhuman primates, and humans are first summarized. After this overview, the validity of the model underlying the interpretation of these imaging data is critically assessed. The current reference model is defined as the occupancy model, since changes in radiotracer binding potential (BP) are assumed to be directly caused by changes in occupancy of D2 receptors by DA. Experimental data supporting this model are presented. The evidence that manipulation of DA synaptic levels induces change in the BP of several D2 radiotracers (catecholamines and benzamides) is unequivocal. The fact that these changes in BP are mediated by changes in DA synaptic concentration is well documented. The relationship between the magnitude of BP changes measured with PET or SPECT and the magnitude of changes in DA concentration measured by microdialysis supports the use of these noninvasive techniques to measure changes in neurotransmission. On the other hand, several observations remain unexplained. First, the amphetamine-induced changes in the BP of D2 receptor antagonists [123I]IBZM and [11C]raclopride last longer than amphetamine-induced changes in DA extracellular concentration. Second, nonbenzamide D2 receptor antagonists, such as spiperone and pimozide, are not affected by changes in DA release, or are affected in a direction opposite to that predicted by the occupancy model. Similar observations are reported with D1 radiotracers. These results suggest that the changes in BP following changes in DA concentration might not be fully accounted by a simple occupancy model. Specifically, the data are reviewed supporting that agonist-mediated receptor internalization might play an important role in characterizing receptor-ligand interactions. Finally, it is proposed that a better understanding of the mechanism underlying the effects observed with benzamides is essential to develop this imaging technique to other receptor systems.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1097/00004647-200003000-00001", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2406537", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1092815", 
            "issn": [
              "0271-678X", 
              "1559-7016"
            ], 
            "name": "Journal of Cerebral Blood Flow & Metabolism", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "3", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "20"
          }
        ], 
        "name": "Imaging Synaptic Neurotransmission With in Vivo Binding Competition Techniques: A Critical Review", 
        "pagination": "423-451", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "fc3e9478284caded618fbf3b13e6971872f576ccb3bbe0ecc1e528040959b218"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "10724107"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "8112566"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1097/00004647-200003000-00001"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1052956062"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1097/00004647-200003000-00001", 
          "https://app.dimensions.ai/details/publication/pub.1052956062"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T16:54", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8669_00000596.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.nature.com/jcbfm/journal/v20/n3/full/9590897a.html"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1097/00004647-200003000-00001'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1097/00004647-200003000-00001'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1097/00004647-200003000-00001'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1097/00004647-200003000-00001'


     

    This table displays all metadata directly associated to this object as RDF triples.

    752 TRIPLES      21 PREDICATES      251 URIs      32 LITERALS      20 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1097/00004647-200003000-00001 schema:about N0a80565239824ec8944e9554cdb6bc2c
    2 N24d046fa84c54fe685f3039c60bab7f5
    3 N2593228ffb904daa9c1cd46d77c3a5ba
    4 N31fca5039deb4651bd1b548630b0cd69
    5 N92f373e187394a9c8a23d17dd30535ac
    6 N98d1b28f2538474581f4165092e5d0ff
    7 N99a13617a1a84a1e80e9f00afbde3ab0
    8 Na6eb0dfde3c94d478842d39850efbd04
    9 Naa6ff25e4cdb4fe6a3bc9202ca1de903
    10 Nc0b7653bb81a400fa9fbc821dbe386a3
    11 Ndf1168f818bb4b3d938a1abf2b493d12
    12 anzsrc-for:11
    13 anzsrc-for:1103
    14 schema:author Nd1bab67fa03f49208acf70b7db20f665
    15 schema:citation sg:pub.10.1007/bf00169199
    16 sg:pub.10.1007/bf00169200
    17 sg:pub.10.1007/bf00496365
    18 sg:pub.10.1007/bf00841408
    19 sg:pub.10.1007/bf00964855
    20 sg:pub.10.1007/bf01244618
    21 sg:pub.10.1007/bf01245228
    22 sg:pub.10.1007/bf01271537
    23 sg:pub.10.1007/bf01271567
    24 sg:pub.10.1007/bf01277655
    25 sg:pub.10.1007/bf01285554
    26 sg:pub.10.1007/s002130050277
    27 sg:pub.10.1007/s002130051110
    28 sg:pub.10.1016/s0893-133x(96)00187-x
    29 sg:pub.10.1016/s0893-133x(96)00188-1
    30 sg:pub.10.1016/s0893-133x(97)00043-2
    31 sg:pub.10.1016/s0893-133x(97)00092-4
    32 sg:pub.10.1016/s0893-133x(98)00108-0
    33 sg:pub.10.1038/275453a0
    34 sg:pub.10.1038/30498
    35 sg:pub.10.1038/386830a0
    36 sg:pub.10.1038/sj.mp.4000336
    37 sg:pub.10.1097/00004647-199704000-00009
    38 sg:pub.10.1097/00004647-199709000-00002
    39 sg:pub.10.1097/00004647-199811000-00006
    40 https://app.dimensions.ai/details/publication/pub.1064242960
    41 https://app.dimensions.ai/details/publication/pub.1074508167
    42 https://app.dimensions.ai/details/publication/pub.1077249401
    43 https://app.dimensions.ai/details/publication/pub.1077614587
    44 https://app.dimensions.ai/details/publication/pub.1077951618
    45 https://app.dimensions.ai/details/publication/pub.1078051329
    46 https://app.dimensions.ai/details/publication/pub.1078364121
    47 https://app.dimensions.ai/details/publication/pub.1078411599
    48 https://app.dimensions.ai/details/publication/pub.1079460134
    49 https://app.dimensions.ai/details/publication/pub.1079504509
    50 https://app.dimensions.ai/details/publication/pub.1079702055
    51 https://app.dimensions.ai/details/publication/pub.1081604254
    52 https://app.dimensions.ai/details/publication/pub.1082359397
    53 https://app.dimensions.ai/details/publication/pub.1082436290
    54 https://app.dimensions.ai/details/publication/pub.1082440366
    55 https://app.dimensions.ai/details/publication/pub.1082509065
    56 https://app.dimensions.ai/details/publication/pub.1082526439
    57 https://app.dimensions.ai/details/publication/pub.1082543939
    58 https://app.dimensions.ai/details/publication/pub.1082545374
    59 https://app.dimensions.ai/details/publication/pub.1082687451
    60 https://app.dimensions.ai/details/publication/pub.1082890939
    61 https://doi.org/10.1001/archpsyc.1988.01800300096017
    62 https://doi.org/10.1001/archpsyc.1989.01810050096021
    63 https://doi.org/10.1001/archpsyc.1990.01810150013003
    64 https://doi.org/10.1001/archpsyc.1990.01810240090014
    65 https://doi.org/10.1001/archpsyc.1992.01820070032005
    66 https://doi.org/10.1001/archpsyc.1994.03950020040004
    67 https://doi.org/10.1002/(sici)1098-2396(199603)22:3<232::aid-syn5>3.0.co;2-d
    68 https://doi.org/10.1002/(sici)1098-2396(199701)25:1<1::aid-syn1>3.0.co;2-h
    69 https://doi.org/10.1002/(sici)1098-2396(199704)25:4<321::aid-syn2>3.0.co;2-c
    70 https://doi.org/10.1002/(sici)1098-2396(199709)27:1<1::aid-syn1>3.0.co;2-9
    71 https://doi.org/10.1002/(sici)1098-2396(199712)27:4<313::aid-syn5>3.0.co;2-f
    72 https://doi.org/10.1002/(sici)1098-2396(199802)28:2<167::aid-syn7>3.0.co;2-9
    73 https://doi.org/10.1002/(sici)1098-2396(199806)29:2<142::aid-syn5>3.0.co;2-7
    74 https://doi.org/10.1002/(sici)1098-2396(199901)31:1<59::aid-syn8>3.0.co;2-y
    75 https://doi.org/10.1002/(sici)1098-2396(199902)31:2<154::aid-syn9>3.0.co;2-k
    76 https://doi.org/10.1002/(sici)1098-2396(19990315)31:4<302::aid-syn9>3.0.co;2-a
    77 https://doi.org/10.1002/(sici)1098-2396(199905)32:2<93::aid-syn3>3.0.co;2-c
    78 https://doi.org/10.1002/ana.410150713
    79 https://doi.org/10.1002/jps.2600830309
    80 https://doi.org/10.1002/syn.890030113
    81 https://doi.org/10.1002/syn.890060403
    82 https://doi.org/10.1002/syn.890070409
    83 https://doi.org/10.1002/syn.890090305
    84 https://doi.org/10.1002/syn.890090306
    85 https://doi.org/10.1002/syn.890100302
    86 https://doi.org/10.1002/syn.890120106
    87 https://doi.org/10.1002/syn.890130407
    88 https://doi.org/10.1002/syn.890150302
    89 https://doi.org/10.1002/syn.890160402
    90 https://doi.org/10.1002/syn.890200207
    91 https://doi.org/10.1006/bbrc.1996.1489
    92 https://doi.org/10.1006/nimg.1997.0269
    93 https://doi.org/10.1016/0006-2952(73)90196-2
    94 https://doi.org/10.1016/0006-2952(78)90233-2
    95 https://doi.org/10.1016/0006-2952(83)90016-3
    96 https://doi.org/10.1016/0006-2952(85)90778-6
    97 https://doi.org/10.1016/0006-2952(86)90396-5
    98 https://doi.org/10.1016/0006-2952(89)90387-0
    99 https://doi.org/10.1016/0006-2952(91)90187-a
    100 https://doi.org/10.1016/0006-2952(92)90016-c
    101 https://doi.org/10.1016/0006-2952(94)90439-1
    102 https://doi.org/10.1016/0006-8993(80)90229-2
    103 https://doi.org/10.1016/0006-8993(80)90360-1
    104 https://doi.org/10.1016/0006-8993(84)91113-2
    105 https://doi.org/10.1016/0006-8993(86)90707-9
    106 https://doi.org/10.1016/0006-8993(93)90741-5
    107 https://doi.org/10.1016/0006-8993(94)91263-7
    108 https://doi.org/10.1016/0006-8993(96)00424-6
    109 https://doi.org/10.1016/0014-2999(80)90224-1
    110 https://doi.org/10.1016/0014-2999(81)90584-7
    111 https://doi.org/10.1016/0014-2999(83)90336-9
    112 https://doi.org/10.1016/0014-2999(84)90386-8
    113 https://doi.org/10.1016/0014-2999(87)90592-9
    114 https://doi.org/10.1016/0014-2999(89)90516-5
    115 https://doi.org/10.1016/0014-2999(91)90513-p
    116 https://doi.org/10.1016/0014-2999(92)90578-r
    117 https://doi.org/10.1016/0014-2999(94)90521-5
    118 https://doi.org/10.1016/0014-2999(95)00233-b
    119 https://doi.org/10.1016/0014-2999(96)00080-5
    120 https://doi.org/10.1016/0020-708x(85)90083-3
    121 https://doi.org/10.1016/0024-3205(77)90116-3
    122 https://doi.org/10.1016/0024-3205(79)90539-3
    123 https://doi.org/10.1016/0024-3205(84)90540-x
    124 https://doi.org/10.1016/0024-3205(85)90028-1
    125 https://doi.org/10.1016/0024-3205(86)90652-1
    126 https://doi.org/10.1016/0024-3205(88)90123-3
    127 https://doi.org/10.1016/0024-3205(91)90261-9
    128 https://doi.org/10.1016/0024-3205(93)90005-n
    129 https://doi.org/10.1016/0028-3908(92)90020-p
    130 https://doi.org/10.1016/0028-3908(93)90154-u
    131 https://doi.org/10.1016/0165-1781(93)90063-m
    132 https://doi.org/10.1016/0167-4889(84)90103-4
    133 https://doi.org/10.1016/0197-0186(87)90167-7
    134 https://doi.org/10.1016/0197-0186(95)00123-9
    135 https://doi.org/10.1016/0197-4580(93)90018-7
    136 https://doi.org/10.1016/0306-4522(89)90168-1
    137 https://doi.org/10.1016/0306-4522(91)90196-u
    138 https://doi.org/10.1016/0306-4522(92)90470-m
    139 https://doi.org/10.1016/0306-4522(94)00507-2
    140 https://doi.org/10.1016/0306-4522(94)00536-e
    141 https://doi.org/10.1016/0883-2897(88)90088-8
    142 https://doi.org/10.1016/0922-4106(92)90121-b
    143 https://doi.org/10.1016/0925-4927(95)02732-d
    144 https://doi.org/10.1016/0969-8051(93)90131-d
    145 https://doi.org/10.1016/0969-8051(94)00117-3
    146 https://doi.org/10.1016/0969-8051(94)90007-8
    147 https://doi.org/10.1016/b978-012161340-2/50068-8
    148 https://doi.org/10.1016/b978-012161340-2/50069-x
    149 https://doi.org/10.1016/s0006-3223(99)00067-0
    150 https://doi.org/10.1016/s0006-8993(99)01834-x
    151 https://doi.org/10.1016/s0014-5793(98)01588-9
    152 https://doi.org/10.1016/s0028-3908(98)00043-4
    153 https://doi.org/10.1016/s0091-3057(96)00449-2
    154 https://doi.org/10.1016/s0163-7258(98)00019-9
    155 https://doi.org/10.1016/s0165-6147(97)01091-2
    156 https://doi.org/10.1016/s0165-6147(97)90643-x
    157 https://doi.org/10.1016/s0306-4522(96)00631-8
    158 https://doi.org/10.1016/s1053-8119(18)31876-7
    159 https://doi.org/10.1016/s1053-8119(18)31879-2
    160 https://doi.org/10.1021/bi00041a044
    161 https://doi.org/10.1021/jm00054a002
    162 https://doi.org/10.1021/jm00081a002
    163 https://doi.org/10.1021/jm00116a004
    164 https://doi.org/10.1021/jm00400a027
    165 https://doi.org/10.1038/jcbfm.1983.1
    166 https://doi.org/10.1038/jcbfm.1986.27
    167 https://doi.org/10.1038/jcbfm.1988.64
    168 https://doi.org/10.1038/jcbfm.1989.98
    169 https://doi.org/10.1038/jcbfm.1990.127
    170 https://doi.org/10.1038/jcbfm.1991.102
    171 https://doi.org/10.1038/jcbfm.1994.132
    172 https://doi.org/10.1038/jcbfm.1994.56
    173 https://doi.org/10.1046/j.1432-1327.1999.00125.x
    174 https://doi.org/10.1046/j.1432-1327.1999.00549.x
    175 https://doi.org/10.1046/j.1471-4159.1994.63051589.x
    176 https://doi.org/10.1046/j.1471-4159.1995.64020940.x
    177 https://doi.org/10.1046/j.1471-4159.1995.65020691.x
    178 https://doi.org/10.1073/pnas.90.19.8861
    179 https://doi.org/10.1073/pnas.91.12.5720
    180 https://doi.org/10.1073/pnas.92.7.2622
    181 https://doi.org/10.1073/pnas.93.17.9235
    182 https://doi.org/10.1073/pnas.93.17.9241
    183 https://doi.org/10.1073/pnas.94.6.2569
    184 https://doi.org/10.1074/jbc.270.15.8902
    185 https://doi.org/10.1083/jcb.128.6.1029
    186 https://doi.org/10.1083/jcb.144.1.31
    187 https://doi.org/10.1097/00004424-199212002-00010
    188 https://doi.org/10.1097/00004647-199704000-00009
    189 https://doi.org/10.1097/00004647-199709000-00002
    190 https://doi.org/10.1097/00004647-199811000-00006
    191 https://doi.org/10.1111/j.1471-4159.1981.tb02396.x
    192 https://doi.org/10.1111/j.1471-4159.1984.tb00935.x
    193 https://doi.org/10.1111/j.1471-4159.1985.tb07233.x
    194 https://doi.org/10.1111/j.1471-4159.1985.tb08740.x
    195 https://doi.org/10.1111/j.1471-4159.1988.tb01830.x
    196 https://doi.org/10.1111/j.1471-4159.1988.tb02919.x
    197 https://doi.org/10.1111/j.1471-4159.1988.tb03069.x
    198 https://doi.org/10.1111/j.1471-4159.1990.tb03147.x
    199 https://doi.org/10.1111/j.1471-4159.1990.tb05794.x
    200 https://doi.org/10.1111/j.1471-4159.1991.tb06341.x
    201 https://doi.org/10.1111/j.1471-4159.1993.tb03181.x
    202 https://doi.org/10.1111/j.2042-7158.1978.tb13223.x
    203 https://doi.org/10.1111/j.2042-7158.1990.tb07071.x
    204 https://doi.org/10.1124/mol.51.2.177
    205 https://doi.org/10.1126/science.2878495
    206 https://doi.org/10.1126/science.6604315
    207 https://doi.org/10.1152/ajpgi.1997.273.3.g586
    208 https://doi.org/10.1176/ajp.152.2.173
    209 https://doi.org/10.1176/ajp.154.9.1209
    210 https://doi.org/10.1176/ajp.155.11.1550
    211 https://doi.org/10.1176/ajp.155.6.761
    212 https://doi.org/10.1177/43.5.7730588
    213 https://doi.org/10.1210/endo-117-2-690
    214 https://doi.org/10.1210/endo.138.10.5433
    215 https://doi.org/10.1523/jneurosci.05-02-00421.1985
    216 https://doi.org/10.1523/jneurosci.06-10-02941.1986
    217 https://doi.org/10.1523/jneurosci.12-10-03773.1992
    218 https://doi.org/10.1523/jneurosci.15-01-00821.1995
    219 https://doi.org/10.1523/jneurosci.15-05-04102.1995
    220 https://doi.org/10.1523/jneurosci.15-06-04140.1995
    221 https://doi.org/10.1523/jneurosci.15-07-05222.1995
    222 https://doi.org/10.1523/jneurosci.18-05-01650.1998
    223 https://doi.org/10.3109/10799899109066397
    224 https://doi.org/10.3109/10799899509045236
    225 https://doi.org/10.3109/10799899709036618
    226 schema:datePublished 2000-03
    227 schema:datePublishedReg 2000-03-01
    228 schema:description Several groups have provided evidence that positron emission tomography (PET) and single-photon emission computed tomography (SPECT) neuroreceptor imaging techniques might be applied to measure acute fluctuations in dopamine (DA) synaptic concentration in the living human brain. Competition between DA and radioligands for binding to D2 receptor is the principle underlying this approach. This new application of neuroreceptor imaging provides a dynamic measurement of neurotransmission that is likely to be informative to our understanding of neuropsychiatric conditions. This article reviews and discusses the body of data supporting the feasibility and potential of this imaging paradigm. Endogenous competition studies performed in rodents, nonhuman primates, and humans are first summarized. After this overview, the validity of the model underlying the interpretation of these imaging data is critically assessed. The current reference model is defined as the occupancy model, since changes in radiotracer binding potential (BP) are assumed to be directly caused by changes in occupancy of D2 receptors by DA. Experimental data supporting this model are presented. The evidence that manipulation of DA synaptic levels induces change in the BP of several D2 radiotracers (catecholamines and benzamides) is unequivocal. The fact that these changes in BP are mediated by changes in DA synaptic concentration is well documented. The relationship between the magnitude of BP changes measured with PET or SPECT and the magnitude of changes in DA concentration measured by microdialysis supports the use of these noninvasive techniques to measure changes in neurotransmission. On the other hand, several observations remain unexplained. First, the amphetamine-induced changes in the BP of D2 receptor antagonists [123I]IBZM and [11C]raclopride last longer than amphetamine-induced changes in DA extracellular concentration. Second, nonbenzamide D2 receptor antagonists, such as spiperone and pimozide, are not affected by changes in DA release, or are affected in a direction opposite to that predicted by the occupancy model. Similar observations are reported with D1 radiotracers. These results suggest that the changes in BP following changes in DA concentration might not be fully accounted by a simple occupancy model. Specifically, the data are reviewed supporting that agonist-mediated receptor internalization might play an important role in characterizing receptor-ligand interactions. Finally, it is proposed that a better understanding of the mechanism underlying the effects observed with benzamides is essential to develop this imaging technique to other receptor systems.
    229 schema:genre research_article
    230 schema:inLanguage en
    231 schema:isAccessibleForFree true
    232 schema:isPartOf N6d3601d233b24663b31b5740a21ab915
    233 Nbb192247603e4aaf9a6a0b8d48b3cb27
    234 sg:journal.1092815
    235 schema:name Imaging Synaptic Neurotransmission With in Vivo Binding Competition Techniques: A Critical Review
    236 schema:pagination 423-451
    237 schema:productId N3ce6d7ffb4f3438297b0c5f9e2c88f8b
    238 N42ae92f9f83f4606bcb63fafa902fdb5
    239 N655185b7ef214a24b6994b2e30b3aec8
    240 N7192a9658d7b41cc8090fd30f1d73bad
    241 N794f010fdb314b2a94a00009e53e7751
    242 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052956062
    243 https://doi.org/10.1097/00004647-200003000-00001
    244 schema:sdDatePublished 2019-04-10T16:54
    245 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    246 schema:sdPublisher N107f8e57f9d345079bcc1d438c729e77
    247 schema:url http://www.nature.com/jcbfm/journal/v20/n3/full/9590897a.html
    248 sgo:license sg:explorer/license/
    249 sgo:sdDataset articles
    250 rdf:type schema:ScholarlyArticle
    251 N0a80565239824ec8944e9554cdb6bc2c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    252 schema:name Brain
    253 rdf:type schema:DefinedTerm
    254 N107f8e57f9d345079bcc1d438c729e77 schema:name Springer Nature - SN SciGraph project
    255 rdf:type schema:Organization
    256 N24d046fa84c54fe685f3039c60bab7f5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    257 schema:name Synaptic Transmission
    258 rdf:type schema:DefinedTerm
    259 N2593228ffb904daa9c1cd46d77c3a5ba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    260 schema:name Models, Neurological
    261 rdf:type schema:DefinedTerm
    262 N31fca5039deb4651bd1b548630b0cd69 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    263 schema:name Tomography, Emission-Computed
    264 rdf:type schema:DefinedTerm
    265 N3ce6d7ffb4f3438297b0c5f9e2c88f8b schema:name nlm_unique_id
    266 schema:value 8112566
    267 rdf:type schema:PropertyValue
    268 N42ae92f9f83f4606bcb63fafa902fdb5 schema:name pubmed_id
    269 schema:value 10724107
    270 rdf:type schema:PropertyValue
    271 N655185b7ef214a24b6994b2e30b3aec8 schema:name dimensions_id
    272 schema:value pub.1052956062
    273 rdf:type schema:PropertyValue
    274 N6d3601d233b24663b31b5740a21ab915 schema:issueNumber 3
    275 rdf:type schema:PublicationIssue
    276 N7192a9658d7b41cc8090fd30f1d73bad schema:name doi
    277 schema:value 10.1097/00004647-200003000-00001
    278 rdf:type schema:PropertyValue
    279 N794f010fdb314b2a94a00009e53e7751 schema:name readcube_id
    280 schema:value fc3e9478284caded618fbf3b13e6971872f576ccb3bbe0ecc1e528040959b218
    281 rdf:type schema:PropertyValue
    282 N92f373e187394a9c8a23d17dd30535ac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    283 schema:name Animals
    284 rdf:type schema:DefinedTerm
    285 N98d1b28f2538474581f4165092e5d0ff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    286 schema:name Receptors, Dopamine
    287 rdf:type schema:DefinedTerm
    288 N99a13617a1a84a1e80e9f00afbde3ab0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    289 schema:name Binding, Competitive
    290 rdf:type schema:DefinedTerm
    291 Na6eb0dfde3c94d478842d39850efbd04 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    292 schema:name Dopamine
    293 rdf:type schema:DefinedTerm
    294 Naa6ff25e4cdb4fe6a3bc9202ca1de903 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    295 schema:name Humans
    296 rdf:type schema:DefinedTerm
    297 Nbb192247603e4aaf9a6a0b8d48b3cb27 schema:volumeNumber 20
    298 rdf:type schema:PublicationVolume
    299 Nc0b7653bb81a400fa9fbc821dbe386a3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    300 schema:name Tomography, Emission-Computed, Single-Photon
    301 rdf:type schema:DefinedTerm
    302 Nd1bab67fa03f49208acf70b7db20f665 rdf:first sg:person.015367440337.39
    303 rdf:rest rdf:nil
    304 Ndf1168f818bb4b3d938a1abf2b493d12 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    305 schema:name Ligands
    306 rdf:type schema:DefinedTerm
    307 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    308 schema:name Medical and Health Sciences
    309 rdf:type schema:DefinedTerm
    310 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
    311 schema:name Clinical Sciences
    312 rdf:type schema:DefinedTerm
    313 sg:grant.2406537 http://pending.schema.org/fundedItem sg:pub.10.1097/00004647-200003000-00001
    314 rdf:type schema:MonetaryGrant
    315 sg:journal.1092815 schema:issn 0271-678X
    316 1559-7016
    317 schema:name Journal of Cerebral Blood Flow & Metabolism
    318 rdf:type schema:Periodical
    319 sg:person.015367440337.39 schema:affiliation https://www.grid.ac/institutes/grid.413734.6
    320 schema:familyName Laruelle
    321 schema:givenName Marc
    322 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015367440337.39
    323 rdf:type schema:Person
    324 sg:pub.10.1007/bf00169199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049859814
    325 https://doi.org/10.1007/bf00169199
    326 rdf:type schema:CreativeWork
    327 sg:pub.10.1007/bf00169200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023714743
    328 https://doi.org/10.1007/bf00169200
    329 rdf:type schema:CreativeWork
    330 sg:pub.10.1007/bf00496365 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020363995
    331 https://doi.org/10.1007/bf00496365
    332 rdf:type schema:CreativeWork
    333 sg:pub.10.1007/bf00841408 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049454244
    334 https://doi.org/10.1007/bf00841408
    335 rdf:type schema:CreativeWork
    336 sg:pub.10.1007/bf00964855 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048841937
    337 https://doi.org/10.1007/bf00964855
    338 rdf:type schema:CreativeWork
    339 sg:pub.10.1007/bf01244618 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000895794
    340 https://doi.org/10.1007/bf01244618
    341 rdf:type schema:CreativeWork
    342 sg:pub.10.1007/bf01245228 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044071957
    343 https://doi.org/10.1007/bf01245228
    344 rdf:type schema:CreativeWork
    345 sg:pub.10.1007/bf01271537 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010447484
    346 https://doi.org/10.1007/bf01271537
    347 rdf:type schema:CreativeWork
    348 sg:pub.10.1007/bf01271567 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024950460
    349 https://doi.org/10.1007/bf01271567
    350 rdf:type schema:CreativeWork
    351 sg:pub.10.1007/bf01277655 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011480172
    352 https://doi.org/10.1007/bf01277655
    353 rdf:type schema:CreativeWork
    354 sg:pub.10.1007/bf01285554 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050292731
    355 https://doi.org/10.1007/bf01285554
    356 rdf:type schema:CreativeWork
    357 sg:pub.10.1007/s002130050277 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052307485
    358 https://doi.org/10.1007/s002130050277
    359 rdf:type schema:CreativeWork
    360 sg:pub.10.1007/s002130051110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032886043
    361 https://doi.org/10.1007/s002130051110
    362 rdf:type schema:CreativeWork
    363 sg:pub.10.1016/s0893-133x(96)00187-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1034155060
    364 https://doi.org/10.1016/s0893-133x(96)00187-x
    365 rdf:type schema:CreativeWork
    366 sg:pub.10.1016/s0893-133x(96)00188-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048088780
    367 https://doi.org/10.1016/s0893-133x(96)00188-1
    368 rdf:type schema:CreativeWork
    369 sg:pub.10.1016/s0893-133x(97)00043-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024594849
    370 https://doi.org/10.1016/s0893-133x(97)00043-2
    371 rdf:type schema:CreativeWork
    372 sg:pub.10.1016/s0893-133x(97)00092-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020048502
    373 https://doi.org/10.1016/s0893-133x(97)00092-4
    374 rdf:type schema:CreativeWork
    375 sg:pub.10.1016/s0893-133x(98)00108-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029057763
    376 https://doi.org/10.1016/s0893-133x(98)00108-0
    377 rdf:type schema:CreativeWork
    378 sg:pub.10.1038/275453a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038706616
    379 https://doi.org/10.1038/275453a0
    380 rdf:type schema:CreativeWork
    381 sg:pub.10.1038/30498 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033741154
    382 https://doi.org/10.1038/30498
    383 rdf:type schema:CreativeWork
    384 sg:pub.10.1038/386830a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008799479
    385 https://doi.org/10.1038/386830a0
    386 rdf:type schema:CreativeWork
    387 sg:pub.10.1038/sj.mp.4000336 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013499912
    388 https://doi.org/10.1038/sj.mp.4000336
    389 rdf:type schema:CreativeWork
    390 sg:pub.10.1097/00004647-199704000-00009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016064522
    391 https://doi.org/10.1097/00004647-199704000-00009
    392 rdf:type schema:CreativeWork
    393 sg:pub.10.1097/00004647-199709000-00002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010888187
    394 https://doi.org/10.1097/00004647-199709000-00002
    395 rdf:type schema:CreativeWork
    396 sg:pub.10.1097/00004647-199811000-00006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012322495
    397 https://doi.org/10.1097/00004647-199811000-00006
    398 rdf:type schema:CreativeWork
    399 https://app.dimensions.ai/details/publication/pub.1064242960 schema:CreativeWork
    400 https://app.dimensions.ai/details/publication/pub.1074508167 schema:CreativeWork
    401 https://app.dimensions.ai/details/publication/pub.1077249401 schema:CreativeWork
    402 https://app.dimensions.ai/details/publication/pub.1077614587 schema:CreativeWork
    403 https://app.dimensions.ai/details/publication/pub.1077951618 schema:CreativeWork
    404 https://app.dimensions.ai/details/publication/pub.1078051329 schema:CreativeWork
    405 https://app.dimensions.ai/details/publication/pub.1078364121 schema:CreativeWork
    406 https://app.dimensions.ai/details/publication/pub.1078411599 schema:CreativeWork
    407 https://app.dimensions.ai/details/publication/pub.1079460134 schema:CreativeWork
    408 https://app.dimensions.ai/details/publication/pub.1079504509 schema:CreativeWork
    409 https://app.dimensions.ai/details/publication/pub.1079702055 schema:CreativeWork
    410 https://app.dimensions.ai/details/publication/pub.1081604254 schema:CreativeWork
    411 https://app.dimensions.ai/details/publication/pub.1082359397 schema:CreativeWork
    412 https://app.dimensions.ai/details/publication/pub.1082436290 schema:CreativeWork
    413 https://app.dimensions.ai/details/publication/pub.1082440366 schema:CreativeWork
    414 https://app.dimensions.ai/details/publication/pub.1082509065 schema:CreativeWork
    415 https://app.dimensions.ai/details/publication/pub.1082526439 schema:CreativeWork
    416 https://app.dimensions.ai/details/publication/pub.1082543939 schema:CreativeWork
    417 https://app.dimensions.ai/details/publication/pub.1082545374 schema:CreativeWork
    418 https://app.dimensions.ai/details/publication/pub.1082687451 schema:CreativeWork
    419 https://app.dimensions.ai/details/publication/pub.1082890939 schema:CreativeWork
    420 https://doi.org/10.1001/archpsyc.1988.01800300096017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021009201
    421 rdf:type schema:CreativeWork
    422 https://doi.org/10.1001/archpsyc.1989.01810050096021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018485184
    423 rdf:type schema:CreativeWork
    424 https://doi.org/10.1001/archpsyc.1990.01810150013003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025048651
    425 rdf:type schema:CreativeWork
    426 https://doi.org/10.1001/archpsyc.1990.01810240090014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044193889
    427 rdf:type schema:CreativeWork
    428 https://doi.org/10.1001/archpsyc.1992.01820070032005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045606546
    429 rdf:type schema:CreativeWork
    430 https://doi.org/10.1001/archpsyc.1994.03950020040004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004236463
    431 rdf:type schema:CreativeWork
    432 https://doi.org/10.1002/(sici)1098-2396(199603)22:3<232::aid-syn5>3.0.co;2-d schema:sameAs https://app.dimensions.ai/details/publication/pub.1016288947
    433 rdf:type schema:CreativeWork
    434 https://doi.org/10.1002/(sici)1098-2396(199701)25:1<1::aid-syn1>3.0.co;2-h schema:sameAs https://app.dimensions.ai/details/publication/pub.1030098331
    435 rdf:type schema:CreativeWork
    436 https://doi.org/10.1002/(sici)1098-2396(199704)25:4<321::aid-syn2>3.0.co;2-c schema:sameAs https://app.dimensions.ai/details/publication/pub.1001176004
    437 rdf:type schema:CreativeWork
    438 https://doi.org/10.1002/(sici)1098-2396(199709)27:1<1::aid-syn1>3.0.co;2-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027286080
    439 rdf:type schema:CreativeWork
    440 https://doi.org/10.1002/(sici)1098-2396(199712)27:4<313::aid-syn5>3.0.co;2-f schema:sameAs https://app.dimensions.ai/details/publication/pub.1022650271
    441 rdf:type schema:CreativeWork
    442 https://doi.org/10.1002/(sici)1098-2396(199802)28:2<167::aid-syn7>3.0.co;2-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052840810
    443 rdf:type schema:CreativeWork
    444 https://doi.org/10.1002/(sici)1098-2396(199806)29:2<142::aid-syn5>3.0.co;2-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043304291
    445 rdf:type schema:CreativeWork
    446 https://doi.org/10.1002/(sici)1098-2396(199901)31:1<59::aid-syn8>3.0.co;2-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1022614059
    447 rdf:type schema:CreativeWork
    448 https://doi.org/10.1002/(sici)1098-2396(199902)31:2<154::aid-syn9>3.0.co;2-k schema:sameAs https://app.dimensions.ai/details/publication/pub.1042689763
    449 rdf:type schema:CreativeWork
    450 https://doi.org/10.1002/(sici)1098-2396(19990315)31:4<302::aid-syn9>3.0.co;2-a schema:sameAs https://app.dimensions.ai/details/publication/pub.1008188448
    451 rdf:type schema:CreativeWork
    452 https://doi.org/10.1002/(sici)1098-2396(199905)32:2<93::aid-syn3>3.0.co;2-c schema:sameAs https://app.dimensions.ai/details/publication/pub.1009155078
    453 rdf:type schema:CreativeWork
    454 https://doi.org/10.1002/ana.410150713 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005386366
    455 rdf:type schema:CreativeWork
    456 https://doi.org/10.1002/jps.2600830309 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010697227
    457 rdf:type schema:CreativeWork
    458 https://doi.org/10.1002/syn.890030113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033635539
    459 rdf:type schema:CreativeWork
    460 https://doi.org/10.1002/syn.890060403 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021418130
    461 rdf:type schema:CreativeWork
    462 https://doi.org/10.1002/syn.890070409 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040226853
    463 rdf:type schema:CreativeWork
    464 https://doi.org/10.1002/syn.890090305 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024064631
    465 rdf:type schema:CreativeWork
    466 https://doi.org/10.1002/syn.890090306 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040181844
    467 rdf:type schema:CreativeWork
    468 https://doi.org/10.1002/syn.890100302 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036913323
    469 rdf:type schema:CreativeWork
    470 https://doi.org/10.1002/syn.890120106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016365525
    471 rdf:type schema:CreativeWork
    472 https://doi.org/10.1002/syn.890130407 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044629879
    473 rdf:type schema:CreativeWork
    474 https://doi.org/10.1002/syn.890150302 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022306272
    475 rdf:type schema:CreativeWork
    476 https://doi.org/10.1002/syn.890160402 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045982865
    477 rdf:type schema:CreativeWork
    478 https://doi.org/10.1002/syn.890200207 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014884627
    479 rdf:type schema:CreativeWork
    480 https://doi.org/10.1006/bbrc.1996.1489 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019915245
    481 rdf:type schema:CreativeWork
    482 https://doi.org/10.1006/nimg.1997.0269 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041948158
    483 rdf:type schema:CreativeWork
    484 https://doi.org/10.1016/0006-2952(73)90196-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034157975
    485 rdf:type schema:CreativeWork
    486 https://doi.org/10.1016/0006-2952(78)90233-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014380514
    487 rdf:type schema:CreativeWork
    488 https://doi.org/10.1016/0006-2952(83)90016-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037688842
    489 rdf:type schema:CreativeWork
    490 https://doi.org/10.1016/0006-2952(85)90778-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044146434
    491 rdf:type schema:CreativeWork
    492 https://doi.org/10.1016/0006-2952(86)90396-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015110642
    493 rdf:type schema:CreativeWork
    494 https://doi.org/10.1016/0006-2952(89)90387-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023598592
    495 rdf:type schema:CreativeWork
    496 https://doi.org/10.1016/0006-2952(91)90187-a schema:sameAs https://app.dimensions.ai/details/publication/pub.1007752268
    497 rdf:type schema:CreativeWork
    498 https://doi.org/10.1016/0006-2952(92)90016-c schema:sameAs https://app.dimensions.ai/details/publication/pub.1024373124
    499 rdf:type schema:CreativeWork
    500 https://doi.org/10.1016/0006-2952(94)90439-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023170411
    501 rdf:type schema:CreativeWork
    502 https://doi.org/10.1016/0006-8993(80)90229-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021560944
    503 rdf:type schema:CreativeWork
    504 https://doi.org/10.1016/0006-8993(80)90360-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045268197
    505 rdf:type schema:CreativeWork
    506 https://doi.org/10.1016/0006-8993(84)91113-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037556238
    507 rdf:type schema:CreativeWork
    508 https://doi.org/10.1016/0006-8993(86)90707-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026164872
    509 rdf:type schema:CreativeWork
    510 https://doi.org/10.1016/0006-8993(93)90741-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004521537
    511 rdf:type schema:CreativeWork
    512 https://doi.org/10.1016/0006-8993(94)91263-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034532255
    513 rdf:type schema:CreativeWork
    514 https://doi.org/10.1016/0006-8993(96)00424-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002174926
    515 rdf:type schema:CreativeWork
    516 https://doi.org/10.1016/0014-2999(80)90224-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030766238
    517 rdf:type schema:CreativeWork
    518 https://doi.org/10.1016/0014-2999(81)90584-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043789522
    519 rdf:type schema:CreativeWork
    520 https://doi.org/10.1016/0014-2999(83)90336-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035601556
    521 rdf:type schema:CreativeWork
    522 https://doi.org/10.1016/0014-2999(84)90386-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042697254
    523 rdf:type schema:CreativeWork
    524 https://doi.org/10.1016/0014-2999(87)90592-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051989123
    525 rdf:type schema:CreativeWork
    526 https://doi.org/10.1016/0014-2999(89)90516-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018555150
    527 rdf:type schema:CreativeWork
    528 https://doi.org/10.1016/0014-2999(91)90513-p schema:sameAs https://app.dimensions.ai/details/publication/pub.1040677830
    529 rdf:type schema:CreativeWork
    530 https://doi.org/10.1016/0014-2999(92)90578-r schema:sameAs https://app.dimensions.ai/details/publication/pub.1035918078
    531 rdf:type schema:CreativeWork
    532 https://doi.org/10.1016/0014-2999(94)90521-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030436407
    533 rdf:type schema:CreativeWork
    534 https://doi.org/10.1016/0014-2999(95)00233-b schema:sameAs https://app.dimensions.ai/details/publication/pub.1006116145
    535 rdf:type schema:CreativeWork
    536 https://doi.org/10.1016/0014-2999(96)00080-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044174762
    537 rdf:type schema:CreativeWork
    538 https://doi.org/10.1016/0020-708x(85)90083-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015497629
    539 rdf:type schema:CreativeWork
    540 https://doi.org/10.1016/0024-3205(77)90116-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015503768
    541 rdf:type schema:CreativeWork
    542 https://doi.org/10.1016/0024-3205(79)90539-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030584009
    543 rdf:type schema:CreativeWork
    544 https://doi.org/10.1016/0024-3205(84)90540-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1028889739
    545 rdf:type schema:CreativeWork
    546 https://doi.org/10.1016/0024-3205(85)90028-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026335916
    547 rdf:type schema:CreativeWork
    548 https://doi.org/10.1016/0024-3205(86)90652-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021716825
    549 rdf:type schema:CreativeWork
    550 https://doi.org/10.1016/0024-3205(88)90123-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051548026
    551 rdf:type schema:CreativeWork
    552 https://doi.org/10.1016/0024-3205(91)90261-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001045771
    553 rdf:type schema:CreativeWork
    554 https://doi.org/10.1016/0024-3205(93)90005-n schema:sameAs https://app.dimensions.ai/details/publication/pub.1009089594
    555 rdf:type schema:CreativeWork
    556 https://doi.org/10.1016/0028-3908(92)90020-p schema:sameAs https://app.dimensions.ai/details/publication/pub.1003863402
    557 rdf:type schema:CreativeWork
    558 https://doi.org/10.1016/0028-3908(93)90154-u schema:sameAs https://app.dimensions.ai/details/publication/pub.1004291956
    559 rdf:type schema:CreativeWork
    560 https://doi.org/10.1016/0165-1781(93)90063-m schema:sameAs https://app.dimensions.ai/details/publication/pub.1046250107
    561 rdf:type schema:CreativeWork
    562 https://doi.org/10.1016/0167-4889(84)90103-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045505366
    563 rdf:type schema:CreativeWork
    564 https://doi.org/10.1016/0197-0186(87)90167-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030334941
    565 rdf:type schema:CreativeWork
    566 https://doi.org/10.1016/0197-0186(95)00123-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018841034
    567 rdf:type schema:CreativeWork
    568 https://doi.org/10.1016/0197-4580(93)90018-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007433893
    569 rdf:type schema:CreativeWork
    570 https://doi.org/10.1016/0306-4522(89)90168-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049008252
    571 rdf:type schema:CreativeWork
    572 https://doi.org/10.1016/0306-4522(91)90196-u schema:sameAs https://app.dimensions.ai/details/publication/pub.1026731268
    573 rdf:type schema:CreativeWork
    574 https://doi.org/10.1016/0306-4522(92)90470-m schema:sameAs https://app.dimensions.ai/details/publication/pub.1005136668
    575 rdf:type schema:CreativeWork
    576 https://doi.org/10.1016/0306-4522(94)00507-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016700716
    577 rdf:type schema:CreativeWork
    578 https://doi.org/10.1016/0306-4522(94)00536-e schema:sameAs https://app.dimensions.ai/details/publication/pub.1016855926
    579 rdf:type schema:CreativeWork
    580 https://doi.org/10.1016/0883-2897(88)90088-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053497040
    581 rdf:type schema:CreativeWork
    582 https://doi.org/10.1016/0922-4106(92)90121-b schema:sameAs https://app.dimensions.ai/details/publication/pub.1001460814
    583 rdf:type schema:CreativeWork
    584 https://doi.org/10.1016/0925-4927(95)02732-d schema:sameAs https://app.dimensions.ai/details/publication/pub.1017626135
    585 rdf:type schema:CreativeWork
    586 https://doi.org/10.1016/0969-8051(93)90131-d schema:sameAs https://app.dimensions.ai/details/publication/pub.1015977116
    587 rdf:type schema:CreativeWork
    588 https://doi.org/10.1016/0969-8051(94)00117-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003413741
    589 rdf:type schema:CreativeWork
    590 https://doi.org/10.1016/0969-8051(94)90007-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001102613
    591 rdf:type schema:CreativeWork
    592 https://doi.org/10.1016/b978-012161340-2/50068-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013876731
    593 rdf:type schema:CreativeWork
    594 https://doi.org/10.1016/b978-012161340-2/50069-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1036757731
    595 rdf:type schema:CreativeWork
    596 https://doi.org/10.1016/s0006-3223(99)00067-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001261123
    597 rdf:type schema:CreativeWork
    598 https://doi.org/10.1016/s0006-8993(99)01834-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1030623788
    599 rdf:type schema:CreativeWork
    600 https://doi.org/10.1016/s0014-5793(98)01588-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023368471
    601 rdf:type schema:CreativeWork
    602 https://doi.org/10.1016/s0028-3908(98)00043-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049100137
    603 rdf:type schema:CreativeWork
    604 https://doi.org/10.1016/s0091-3057(96)00449-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010782520
    605 rdf:type schema:CreativeWork
    606 https://doi.org/10.1016/s0163-7258(98)00019-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053296433
    607 rdf:type schema:CreativeWork
    608 https://doi.org/10.1016/s0165-6147(97)01091-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041215190
    609 rdf:type schema:CreativeWork
    610 https://doi.org/10.1016/s0165-6147(97)90643-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1021609920
    611 rdf:type schema:CreativeWork
    612 https://doi.org/10.1016/s0306-4522(96)00631-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051199543
    613 rdf:type schema:CreativeWork
    614 https://doi.org/10.1016/s1053-8119(18)31876-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107184160
    615 rdf:type schema:CreativeWork
    616 https://doi.org/10.1016/s1053-8119(18)31879-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107166516
    617 rdf:type schema:CreativeWork
    618 https://doi.org/10.1021/bi00041a044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055158443
    619 rdf:type schema:CreativeWork
    620 https://doi.org/10.1021/jm00054a002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055933794
    621 rdf:type schema:CreativeWork
    622 https://doi.org/10.1021/jm00081a002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055934439
    623 rdf:type schema:CreativeWork
    624 https://doi.org/10.1021/jm00116a004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055935714
    625 rdf:type schema:CreativeWork
    626 https://doi.org/10.1021/jm00400a027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055946316
    627 rdf:type schema:CreativeWork
    628 https://doi.org/10.1038/jcbfm.1983.1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018753419
    629 rdf:type schema:CreativeWork
    630 https://doi.org/10.1038/jcbfm.1986.27 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015266413
    631 rdf:type schema:CreativeWork
    632 https://doi.org/10.1038/jcbfm.1988.64 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017572287
    633 rdf:type schema:CreativeWork
    634 https://doi.org/10.1038/jcbfm.1989.98 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035762647
    635 rdf:type schema:CreativeWork
    636 https://doi.org/10.1038/jcbfm.1990.127 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016880702
    637 rdf:type schema:CreativeWork
    638 https://doi.org/10.1038/jcbfm.1991.102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041643730
    639 rdf:type schema:CreativeWork
    640 https://doi.org/10.1038/jcbfm.1994.132 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028739369
    641 rdf:type schema:CreativeWork
    642 https://doi.org/10.1038/jcbfm.1994.56 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025038829
    643 rdf:type schema:CreativeWork
    644 https://doi.org/10.1046/j.1432-1327.1999.00125.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1007172337
    645 rdf:type schema:CreativeWork
    646 https://doi.org/10.1046/j.1432-1327.1999.00549.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1012310547
    647 rdf:type schema:CreativeWork
    648 https://doi.org/10.1046/j.1471-4159.1994.63051589.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1025844320
    649 rdf:type schema:CreativeWork
    650 https://doi.org/10.1046/j.1471-4159.1995.64020940.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1041099650
    651 rdf:type schema:CreativeWork
    652 https://doi.org/10.1046/j.1471-4159.1995.65020691.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1045533156
    653 rdf:type schema:CreativeWork
    654 https://doi.org/10.1073/pnas.90.19.8861 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043016071
    655 rdf:type schema:CreativeWork
    656 https://doi.org/10.1073/pnas.91.12.5720 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025971024
    657 rdf:type schema:CreativeWork
    658 https://doi.org/10.1073/pnas.92.7.2622 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027314150
    659 rdf:type schema:CreativeWork
    660 https://doi.org/10.1073/pnas.93.17.9235 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016086472
    661 rdf:type schema:CreativeWork
    662 https://doi.org/10.1073/pnas.93.17.9241 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011719646
    663 rdf:type schema:CreativeWork
    664 https://doi.org/10.1073/pnas.94.6.2569 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036506224
    665 rdf:type schema:CreativeWork
    666 https://doi.org/10.1074/jbc.270.15.8902 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047099007
    667 rdf:type schema:CreativeWork
    668 https://doi.org/10.1083/jcb.128.6.1029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024218923
    669 rdf:type schema:CreativeWork
    670 https://doi.org/10.1083/jcb.144.1.31 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029319410
    671 rdf:type schema:CreativeWork
    672 https://doi.org/10.1097/00004424-199212002-00010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015875573
    673 rdf:type schema:CreativeWork
    674 https://doi.org/10.1097/00004647-199704000-00009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016064522
    675 rdf:type schema:CreativeWork
    676 https://doi.org/10.1097/00004647-199709000-00002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010888187
    677 rdf:type schema:CreativeWork
    678 https://doi.org/10.1097/00004647-199811000-00006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012322495
    679 rdf:type schema:CreativeWork
    680 https://doi.org/10.1111/j.1471-4159.1981.tb02396.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1039253540
    681 rdf:type schema:CreativeWork
    682 https://doi.org/10.1111/j.1471-4159.1984.tb00935.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1040680590
    683 rdf:type schema:CreativeWork
    684 https://doi.org/10.1111/j.1471-4159.1985.tb07233.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1016141763
    685 rdf:type schema:CreativeWork
    686 https://doi.org/10.1111/j.1471-4159.1985.tb08740.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1011875967
    687 rdf:type schema:CreativeWork
    688 https://doi.org/10.1111/j.1471-4159.1988.tb01830.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1010581358
    689 rdf:type schema:CreativeWork
    690 https://doi.org/10.1111/j.1471-4159.1988.tb02919.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1041075683
    691 rdf:type schema:CreativeWork
    692 https://doi.org/10.1111/j.1471-4159.1988.tb03069.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1008054507
    693 rdf:type schema:CreativeWork
    694 https://doi.org/10.1111/j.1471-4159.1990.tb03147.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1052533623
    695 rdf:type schema:CreativeWork
    696 https://doi.org/10.1111/j.1471-4159.1990.tb05794.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1024940132
    697 rdf:type schema:CreativeWork
    698 https://doi.org/10.1111/j.1471-4159.1991.tb06341.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1001169220
    699 rdf:type schema:CreativeWork
    700 https://doi.org/10.1111/j.1471-4159.1993.tb03181.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1008423238
    701 rdf:type schema:CreativeWork
    702 https://doi.org/10.1111/j.2042-7158.1978.tb13223.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1016077747
    703 rdf:type schema:CreativeWork
    704 https://doi.org/10.1111/j.2042-7158.1990.tb07071.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1049974533
    705 rdf:type schema:CreativeWork
    706 https://doi.org/10.1124/mol.51.2.177 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083109494
    707 rdf:type schema:CreativeWork
    708 https://doi.org/10.1126/science.2878495 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062568977
    709 rdf:type schema:CreativeWork
    710 https://doi.org/10.1126/science.6604315 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062639159
    711 rdf:type schema:CreativeWork
    712 https://doi.org/10.1152/ajpgi.1997.273.3.g586 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083154544
    713 rdf:type schema:CreativeWork
    714 https://doi.org/10.1176/ajp.152.2.173 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063483605
    715 rdf:type schema:CreativeWork
    716 https://doi.org/10.1176/ajp.154.9.1209 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063485206
    717 rdf:type schema:CreativeWork
    718 https://doi.org/10.1176/ajp.155.11.1550 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063485353
    719 rdf:type schema:CreativeWork
    720 https://doi.org/10.1176/ajp.155.6.761 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083275115
    721 rdf:type schema:CreativeWork
    722 https://doi.org/10.1177/43.5.7730588 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064094709
    723 rdf:type schema:CreativeWork
    724 https://doi.org/10.1210/endo-117-2-690 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064259056
    725 rdf:type schema:CreativeWork
    726 https://doi.org/10.1210/endo.138.10.5433 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064281273
    727 rdf:type schema:CreativeWork
    728 https://doi.org/10.1523/jneurosci.05-02-00421.1985 schema:sameAs https://app.dimensions.ai/details/publication/pub.1080060912
    729 rdf:type schema:CreativeWork
    730 https://doi.org/10.1523/jneurosci.06-10-02941.1986 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079468212
    731 rdf:type schema:CreativeWork
    732 https://doi.org/10.1523/jneurosci.12-10-03773.1992 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075843917
    733 rdf:type schema:CreativeWork
    734 https://doi.org/10.1523/jneurosci.15-01-00821.1995 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082523799
    735 rdf:type schema:CreativeWork
    736 https://doi.org/10.1523/jneurosci.15-05-04102.1995 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082492596
    737 rdf:type schema:CreativeWork
    738 https://doi.org/10.1523/jneurosci.15-06-04140.1995 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082509020
    739 rdf:type schema:CreativeWork
    740 https://doi.org/10.1523/jneurosci.15-07-05222.1995 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082439133
    741 rdf:type schema:CreativeWork
    742 https://doi.org/10.1523/jneurosci.18-05-01650.1998 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083211642
    743 rdf:type schema:CreativeWork
    744 https://doi.org/10.3109/10799899109066397 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025952757
    745 rdf:type schema:CreativeWork
    746 https://doi.org/10.3109/10799899509045236 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047895771
    747 rdf:type schema:CreativeWork
    748 https://doi.org/10.3109/10799899709036618 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053592170
    749 rdf:type schema:CreativeWork
    750 https://www.grid.ac/institutes/grid.413734.6 schema:alternateName NewYork–Presbyterian Hospital
    751 schema:name Department of Psychiatry and Radiology, Columbia University College of Physicians and Surgeons and New York State Psychiatric Institute, New York, New York, U.S.A.
    752 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...