Pinealectomy Aggravates and Melatonin Administration Attenuates Brain Damage in Focal Ischemia View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1999-05

AUTHORS

Ertugrul Kilic, Yasemin Gürsoy ÖUzdemir, Hayrunnisa Bolay, Haluk Keleştimur, Turgay Dalkara

ABSTRACT

Large infarcts develop in pinealectomized rats subjected to middle cerebral artery occlusion, which was attributed to loss of antioxidant action of melatonin. However, melatonin also has vascular actions, and pinealectomy may induce hypertension. The authors investigated (1) whether hemodynamic factors contribute to infarct development in pinealectomized rats, (2) whether melatonin administration can reverse the unfavorable effect of pinealectomy on infarct formation, and (3) whether melatonin can reduce the infarct volume in nonpinealectomized rats subjected to focal transient ischemia (2 hours middle cerebral artery occlusion, 22 hours reperfusion). Rats were pinealectomized 3 months before ischemia to eliminate any possible action of pinealectomy-induced hypertension on stroke. Blood pressure and regional CBF values during ischemia and reperfusion were not significantly different between pinealectomized and sham-operated rats, suggesting that pinealectomy-induced increase in infarct was not related to hemodynamic factors. The infarct volume resumed to the level of sham-operated rats on melatonin administration. Injection of melatonin (4 mg/kg) before both ischemia and reperfusion reduced infarct volume by 40% and significantly improved neurologic deficit scores in pinealectomized as well as sham-operated rats subjected to middle cerebral artery occlusion. These data suggest that physiologic melatonin release as well as exogenously given melatonin has a neuroprotective action in focal cerebral ischemia. More... »

PAGES

511-516

References to SciGraph publications

  • 1977-02. A new technique of pinealectomy for adult rats in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 1978-04. Effect of pinealectomy on arterial blood pressure and food and water intake in the rat in JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
  • 1992-04. Ischemic penumbra in a model of reversible middle cerebral artery occlusion in the rat in EXPERIMENTAL BRAIN RESEARCH
  • 1979-07. Elevated blood pressure after pinealectomy in the rat in JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1097/00004647-199905000-00005

    DOI

    http://dx.doi.org/10.1097/00004647-199905000-00005

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1026466354

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/10326718


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    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1097/00004647-199905000-00005'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1097/00004647-199905000-00005'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1097/00004647-199905000-00005'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1097/00004647-199905000-00005'


     

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