Calculation of the FDG Lumped Constant by Simultaneous Measurements of Global Glucose and FDG Metabolism in Humans View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1998-02

AUTHORS

Steen G. Hasselbalch, Peter L. Madsen, Gitte M. Knudsen, Søren Holm, Olaf B. Paulson

ABSTRACT

The lumped constant defined as the conversion factor between the net uptake of fluoro-2-deoxy-D-glucose (FDG) and glucose was calculated from global CMRglc and from positron emission tomography (PET) using FDG as tracer (CMRFDG). Fifteen healthy, normal volunteers (mean age 24 +/- 4 years) were studied. Global CBF and CMRglc were measured with the Kety-Schmidt technique using 133Xe as tracer, and values were corrected for errors from incomplete diffusion equilibrium for inert gas tracer between brain tissue and cerebral venous blood. Measurements of CMRFDG were obtained with PET using the dynamic and single-scan methods and the K1-k3 model. Measurements with the Kety-Schmidt technique and PET-FDG were performed simultaneously. Global CBF was 47.1 +/- 8.0 mL.100 g-1.min-1, and CMRglc was 22.8 +/- 4.1 mumol.100 g-1.min-1. No difference in CMRFDG was found with the two methods (17.8 +/- 1.6 and 18.2 +/- 1.3 mumol .100 g-1.min-1, dynamic and single scan methods, respectively). Accordingly, the lumped constant ranged from 0.80 +/- 0.16 to 0.82 +/- 0.15, with a mean value of 0.81 +/- 0.15. The mean ratio between phosphorylation of FDG and glucose (k3*/k3) was 0.39 +/- 0.25. The discrepancy between the lumped constant determined in this study and previously obtained values can be explained partly by methodologic problems, and we conclude that most of the discrepancy results from previous overestimation of global CBF. More... »

PAGES

154-160

References to SciGraph publications

  • 1963-10. Der Kohlenhydratstoffwechsel des menschlichen Gehirns in JOURNAL OF MOLECULAR MEDICINE
  • 1996-07. Transport of D-Glucose and 2-Fluorodeoxyglucose Across the Blood-Brain Barrier in Humans in JOURNAL OF CEREBRAL BLOOD FLOW & METABOLISM
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1097/00004647-199802000-00005

    DOI

    http://dx.doi.org/10.1097/00004647-199802000-00005

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1037445543

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/9469157


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Clinical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Blood Glucose", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Brain", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Deoxyglucose", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Fluorine Radioisotopes", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Glucose", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Kinetics", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Phosphorylation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Tomography, Emission-Computed", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "familyName": "Hasselbalch", 
            "givenName": "Steen G.", 
            "id": "sg:person.0632617733.37", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632617733.37"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Madsen", 
            "givenName": "Peter L.", 
            "id": "sg:person.0707016340.63", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707016340.63"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Knudsen", 
            "givenName": "Gitte M.", 
            "id": "sg:person.013164351720.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013164351720.45"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Rigshospitalet", 
              "id": "https://www.grid.ac/institutes/grid.475435.4", 
              "name": [
                "Department of Nuclear Medicine, National University Hospital, Rigshospitalet, Copenhagen, Denmark"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Holm", 
            "givenName": "S\u00f8ren", 
            "id": "sg:person.0740340304.66", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740340304.66"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Paulson", 
            "givenName": "Olaf B.", 
            "id": "sg:person.01244010503.37", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01244010503.37"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1172/jci102150", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010838862"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/jcbfm.1993.83", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011903144"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/jcbfm.1993.83", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011903144"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/jcbfm.1985.24", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014141689"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/jcbfm.1985.24", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014141689"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/jcbfm.1990.33", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015224528"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/jcbfm.1990.33", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015224528"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1471-4159.1977.tb10649.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016554520"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/jcbfm.1991.50", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017605046"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/jcbfm.1991.50", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017605046"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ana.410060502", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017761252"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/jcbfm.1987.86", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020615396"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/jcbfm.1987.86", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020615396"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.res.44.1.127", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025521561"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1471-4159.1989.tb07292.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029838631"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01478536", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030919384", 
              "https://doi.org/10.1007/bf01478536"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01478536", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030919384", 
              "https://doi.org/10.1007/bf01478536"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00000542-197201000-00013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034425268"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00000542-197201000-00013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034425268"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1471-4159.1983.tb12666.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040754895"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci101994", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041169999"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/archneurpsyc.1948.02310030021002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046576858"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/jcbfm.1995.60", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047435411"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/jcbfm.1995.60", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047435411"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.cir.7.5.724", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049286097"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ana.410170208", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053012786"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/jcbfm.1994.17", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053192868"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/jcbfm.1994.17", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053192868"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1097/00004647-199607000-00017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053421680", 
              "https://doi.org/10.1097/00004647-199607000-00017"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00004647-199607000-00017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053421680"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00004647-199607000-00017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053421680"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/jcbfm.1990.89", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053494497"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/jcbfm.1990.89", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053494497"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/brain/111.5.1009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059438341"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/physrev.1959.39.2.183", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1075902621"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/jappl.1967.23.2.183", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1081525517"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajpendo.1980.238.1.e69", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1082072291"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajpendo.1996.270.5.e746", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083018822"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "1998-02", 
        "datePublishedReg": "1998-02-01", 
        "description": "The lumped constant defined as the conversion factor between the net uptake of fluoro-2-deoxy-D-glucose (FDG) and glucose was calculated from global CMRglc and from positron emission tomography (PET) using FDG as tracer (CMRFDG). Fifteen healthy, normal volunteers (mean age 24 +/- 4 years) were studied. Global CBF and CMRglc were measured with the Kety-Schmidt technique using 133Xe as tracer, and values were corrected for errors from incomplete diffusion equilibrium for inert gas tracer between brain tissue and cerebral venous blood. Measurements of CMRFDG were obtained with PET using the dynamic and single-scan methods and the K1-k3 model. Measurements with the Kety-Schmidt technique and PET-FDG were performed simultaneously. Global CBF was 47.1 +/- 8.0 mL.100 g-1.min-1, and CMRglc was 22.8 +/- 4.1 mumol.100 g-1.min-1. No difference in CMRFDG was found with the two methods (17.8 +/- 1.6 and 18.2 +/- 1.3 mumol .100 g-1.min-1, dynamic and single scan methods, respectively). Accordingly, the lumped constant ranged from 0.80 +/- 0.16 to 0.82 +/- 0.15, with a mean value of 0.81 +/- 0.15. The mean ratio between phosphorylation of FDG and glucose (k3*/k3) was 0.39 +/- 0.25. The discrepancy between the lumped constant determined in this study and previously obtained values can be explained partly by methodologic problems, and we conclude that most of the discrepancy results from previous overestimation of global CBF.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1097/00004647-199802000-00005", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1092815", 
            "issn": [
              "0271-678X", 
              "1559-7016"
            ], 
            "name": "Journal of Cerebral Blood Flow & Metabolism", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "2", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "18"
          }
        ], 
        "name": "Calculation of the FDG Lumped Constant by Simultaneous Measurements of Global Glucose and FDG Metabolism in Humans", 
        "pagination": "154-160", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "b25fcdf143efab6b091864bd399f5c2ab842d318cb1ded22aaf4af55001e27c8"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "9469157"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "8112566"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1097/00004647-199802000-00005"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1037445543"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1097/00004647-199802000-00005", 
          "https://app.dimensions.ai/details/publication/pub.1037445543"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T16:29", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8669_00000425.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.nature.com/jcbfm/journal/v18/n2/full/9590345a.html"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1097/00004647-199802000-00005'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1097/00004647-199802000-00005'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1097/00004647-199802000-00005'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1097/00004647-199802000-00005'


     

    This table displays all metadata directly associated to this object as RDF triples.

    224 TRIPLES      21 PREDICATES      68 URIs      33 LITERALS      21 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1097/00004647-199802000-00005 schema:about N14e7695f3205465faae4a41e3d67fceb
    2 N1e8c7d82b9724482ae0fa4c91623b3d3
    3 N2d5ac3034d6d44f3ae3c7cd467821f6a
    4 N40c75dc603004bebba7be2e8bd1e1fe0
    5 N547ca0c3603348d4a41d79b80bf80e5a
    6 N648dd38e8cf04a738e451df4e96f8597
    7 Na50b0d3afa6a4ab2a70b9db04b327f90
    8 Na7c3cc36ce664fd48175c6b9147321bf
    9 Nbca1819108ac4367a37cb58d2f8775c3
    10 Nca0074c4a16e4e118b7670e54716df3f
    11 Ne30f4aa9ddc04339a56ead8c9b713529
    12 Ned31cbf3aa274accb02ef05a3bac6083
    13 anzsrc-for:11
    14 anzsrc-for:1103
    15 schema:author Nfee1b43384c148c8b2dd7ab11d0737ed
    16 schema:citation sg:pub.10.1007/bf01478536
    17 sg:pub.10.1097/00004647-199607000-00017
    18 https://doi.org/10.1001/archneurpsyc.1948.02310030021002
    19 https://doi.org/10.1002/ana.410060502
    20 https://doi.org/10.1002/ana.410170208
    21 https://doi.org/10.1038/jcbfm.1985.24
    22 https://doi.org/10.1038/jcbfm.1987.86
    23 https://doi.org/10.1038/jcbfm.1990.33
    24 https://doi.org/10.1038/jcbfm.1990.89
    25 https://doi.org/10.1038/jcbfm.1991.50
    26 https://doi.org/10.1038/jcbfm.1993.83
    27 https://doi.org/10.1038/jcbfm.1994.17
    28 https://doi.org/10.1038/jcbfm.1995.60
    29 https://doi.org/10.1093/brain/111.5.1009
    30 https://doi.org/10.1097/00000542-197201000-00013
    31 https://doi.org/10.1097/00004647-199607000-00017
    32 https://doi.org/10.1111/j.1471-4159.1977.tb10649.x
    33 https://doi.org/10.1111/j.1471-4159.1983.tb12666.x
    34 https://doi.org/10.1111/j.1471-4159.1989.tb07292.x
    35 https://doi.org/10.1152/ajpendo.1980.238.1.e69
    36 https://doi.org/10.1152/ajpendo.1996.270.5.e746
    37 https://doi.org/10.1152/jappl.1967.23.2.183
    38 https://doi.org/10.1152/physrev.1959.39.2.183
    39 https://doi.org/10.1161/01.cir.7.5.724
    40 https://doi.org/10.1161/01.res.44.1.127
    41 https://doi.org/10.1172/jci101994
    42 https://doi.org/10.1172/jci102150
    43 schema:datePublished 1998-02
    44 schema:datePublishedReg 1998-02-01
    45 schema:description The lumped constant defined as the conversion factor between the net uptake of fluoro-2-deoxy-D-glucose (FDG) and glucose was calculated from global CMRglc and from positron emission tomography (PET) using FDG as tracer (CMRFDG). Fifteen healthy, normal volunteers (mean age 24 +/- 4 years) were studied. Global CBF and CMRglc were measured with the Kety-Schmidt technique using 133Xe as tracer, and values were corrected for errors from incomplete diffusion equilibrium for inert gas tracer between brain tissue and cerebral venous blood. Measurements of CMRFDG were obtained with PET using the dynamic and single-scan methods and the K1-k3 model. Measurements with the Kety-Schmidt technique and PET-FDG were performed simultaneously. Global CBF was 47.1 +/- 8.0 mL.100 g-1.min-1, and CMRglc was 22.8 +/- 4.1 mumol.100 g-1.min-1. No difference in CMRFDG was found with the two methods (17.8 +/- 1.6 and 18.2 +/- 1.3 mumol .100 g-1.min-1, dynamic and single scan methods, respectively). Accordingly, the lumped constant ranged from 0.80 +/- 0.16 to 0.82 +/- 0.15, with a mean value of 0.81 +/- 0.15. The mean ratio between phosphorylation of FDG and glucose (k3*/k3) was 0.39 +/- 0.25. The discrepancy between the lumped constant determined in this study and previously obtained values can be explained partly by methodologic problems, and we conclude that most of the discrepancy results from previous overestimation of global CBF.
    46 schema:genre research_article
    47 schema:inLanguage en
    48 schema:isAccessibleForFree true
    49 schema:isPartOf N241723b76cb943e3a5f5ddfa15c1b483
    50 Nd5a4c746547745c999c8b77d41b562bc
    51 sg:journal.1092815
    52 schema:name Calculation of the FDG Lumped Constant by Simultaneous Measurements of Global Glucose and FDG Metabolism in Humans
    53 schema:pagination 154-160
    54 schema:productId N1c45d6e88eea4d239e06da62f8e28559
    55 N23dbc732e4514fe8b4b674cd6d32a729
    56 Na3cad5121088404a9b828c52f862a498
    57 Nc8d3873ab76a48a7a7eef1ea54718c5c
    58 Nfddb0b0b25ba4bdb8751cd5647721ec3
    59 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037445543
    60 https://doi.org/10.1097/00004647-199802000-00005
    61 schema:sdDatePublished 2019-04-10T16:29
    62 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    63 schema:sdPublisher N8419f965a5e7412cad8157421464a132
    64 schema:url http://www.nature.com/jcbfm/journal/v18/n2/full/9590345a.html
    65 sgo:license sg:explorer/license/
    66 sgo:sdDataset articles
    67 rdf:type schema:ScholarlyArticle
    68 N14e7695f3205465faae4a41e3d67fceb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    69 schema:name Adult
    70 rdf:type schema:DefinedTerm
    71 N1c45d6e88eea4d239e06da62f8e28559 schema:name readcube_id
    72 schema:value b25fcdf143efab6b091864bd399f5c2ab842d318cb1ded22aaf4af55001e27c8
    73 rdf:type schema:PropertyValue
    74 N1e8c7d82b9724482ae0fa4c91623b3d3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    75 schema:name Brain
    76 rdf:type schema:DefinedTerm
    77 N23dbc732e4514fe8b4b674cd6d32a729 schema:name doi
    78 schema:value 10.1097/00004647-199802000-00005
    79 rdf:type schema:PropertyValue
    80 N241723b76cb943e3a5f5ddfa15c1b483 schema:volumeNumber 18
    81 rdf:type schema:PublicationVolume
    82 N2d5ac3034d6d44f3ae3c7cd467821f6a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    83 schema:name Glucose
    84 rdf:type schema:DefinedTerm
    85 N40c75dc603004bebba7be2e8bd1e1fe0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    86 schema:name Phosphorylation
    87 rdf:type schema:DefinedTerm
    88 N45c780834a0241cd8b2b956d9c61a986 rdf:first sg:person.01244010503.37
    89 rdf:rest rdf:nil
    90 N547ca0c3603348d4a41d79b80bf80e5a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    91 schema:name Male
    92 rdf:type schema:DefinedTerm
    93 N59e2b82c8a5f43009cc5e373c6b13ca2 rdf:first sg:person.0740340304.66
    94 rdf:rest N45c780834a0241cd8b2b956d9c61a986
    95 N648dd38e8cf04a738e451df4e96f8597 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    96 schema:name Humans
    97 rdf:type schema:DefinedTerm
    98 N8419f965a5e7412cad8157421464a132 schema:name Springer Nature - SN SciGraph project
    99 rdf:type schema:Organization
    100 N95b59610d24f4e979dcf9eb958fcb840 rdf:first sg:person.0707016340.63
    101 rdf:rest Nfe2bc77119474e3fb03305db28c424eb
    102 Na3cad5121088404a9b828c52f862a498 schema:name nlm_unique_id
    103 schema:value 8112566
    104 rdf:type schema:PropertyValue
    105 Na50b0d3afa6a4ab2a70b9db04b327f90 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    106 schema:name Deoxyglucose
    107 rdf:type schema:DefinedTerm
    108 Na7c3cc36ce664fd48175c6b9147321bf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    109 schema:name Female
    110 rdf:type schema:DefinedTerm
    111 Nbca1819108ac4367a37cb58d2f8775c3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    112 schema:name Fluorine Radioisotopes
    113 rdf:type schema:DefinedTerm
    114 Nc8d3873ab76a48a7a7eef1ea54718c5c schema:name dimensions_id
    115 schema:value pub.1037445543
    116 rdf:type schema:PropertyValue
    117 Nca0074c4a16e4e118b7670e54716df3f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    118 schema:name Kinetics
    119 rdf:type schema:DefinedTerm
    120 Nd5a4c746547745c999c8b77d41b562bc schema:issueNumber 2
    121 rdf:type schema:PublicationIssue
    122 Ne30f4aa9ddc04339a56ead8c9b713529 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    123 schema:name Tomography, Emission-Computed
    124 rdf:type schema:DefinedTerm
    125 Ned31cbf3aa274accb02ef05a3bac6083 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    126 schema:name Blood Glucose
    127 rdf:type schema:DefinedTerm
    128 Nfddb0b0b25ba4bdb8751cd5647721ec3 schema:name pubmed_id
    129 schema:value 9469157
    130 rdf:type schema:PropertyValue
    131 Nfe2bc77119474e3fb03305db28c424eb rdf:first sg:person.013164351720.45
    132 rdf:rest N59e2b82c8a5f43009cc5e373c6b13ca2
    133 Nfee1b43384c148c8b2dd7ab11d0737ed rdf:first sg:person.0632617733.37
    134 rdf:rest N95b59610d24f4e979dcf9eb958fcb840
    135 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    136 schema:name Medical and Health Sciences
    137 rdf:type schema:DefinedTerm
    138 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
    139 schema:name Clinical Sciences
    140 rdf:type schema:DefinedTerm
    141 sg:journal.1092815 schema:issn 0271-678X
    142 1559-7016
    143 schema:name Journal of Cerebral Blood Flow & Metabolism
    144 rdf:type schema:Periodical
    145 sg:person.01244010503.37 schema:familyName Paulson
    146 schema:givenName Olaf B.
    147 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01244010503.37
    148 rdf:type schema:Person
    149 sg:person.013164351720.45 schema:familyName Knudsen
    150 schema:givenName Gitte M.
    151 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013164351720.45
    152 rdf:type schema:Person
    153 sg:person.0632617733.37 schema:familyName Hasselbalch
    154 schema:givenName Steen G.
    155 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632617733.37
    156 rdf:type schema:Person
    157 sg:person.0707016340.63 schema:familyName Madsen
    158 schema:givenName Peter L.
    159 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707016340.63
    160 rdf:type schema:Person
    161 sg:person.0740340304.66 schema:affiliation https://www.grid.ac/institutes/grid.475435.4
    162 schema:familyName Holm
    163 schema:givenName Søren
    164 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740340304.66
    165 rdf:type schema:Person
    166 sg:pub.10.1007/bf01478536 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030919384
    167 https://doi.org/10.1007/bf01478536
    168 rdf:type schema:CreativeWork
    169 sg:pub.10.1097/00004647-199607000-00017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053421680
    170 https://doi.org/10.1097/00004647-199607000-00017
    171 rdf:type schema:CreativeWork
    172 https://doi.org/10.1001/archneurpsyc.1948.02310030021002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046576858
    173 rdf:type schema:CreativeWork
    174 https://doi.org/10.1002/ana.410060502 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017761252
    175 rdf:type schema:CreativeWork
    176 https://doi.org/10.1002/ana.410170208 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053012786
    177 rdf:type schema:CreativeWork
    178 https://doi.org/10.1038/jcbfm.1985.24 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014141689
    179 rdf:type schema:CreativeWork
    180 https://doi.org/10.1038/jcbfm.1987.86 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020615396
    181 rdf:type schema:CreativeWork
    182 https://doi.org/10.1038/jcbfm.1990.33 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015224528
    183 rdf:type schema:CreativeWork
    184 https://doi.org/10.1038/jcbfm.1990.89 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053494497
    185 rdf:type schema:CreativeWork
    186 https://doi.org/10.1038/jcbfm.1991.50 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017605046
    187 rdf:type schema:CreativeWork
    188 https://doi.org/10.1038/jcbfm.1993.83 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011903144
    189 rdf:type schema:CreativeWork
    190 https://doi.org/10.1038/jcbfm.1994.17 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053192868
    191 rdf:type schema:CreativeWork
    192 https://doi.org/10.1038/jcbfm.1995.60 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047435411
    193 rdf:type schema:CreativeWork
    194 https://doi.org/10.1093/brain/111.5.1009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059438341
    195 rdf:type schema:CreativeWork
    196 https://doi.org/10.1097/00000542-197201000-00013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034425268
    197 rdf:type schema:CreativeWork
    198 https://doi.org/10.1097/00004647-199607000-00017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053421680
    199 rdf:type schema:CreativeWork
    200 https://doi.org/10.1111/j.1471-4159.1977.tb10649.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1016554520
    201 rdf:type schema:CreativeWork
    202 https://doi.org/10.1111/j.1471-4159.1983.tb12666.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1040754895
    203 rdf:type schema:CreativeWork
    204 https://doi.org/10.1111/j.1471-4159.1989.tb07292.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1029838631
    205 rdf:type schema:CreativeWork
    206 https://doi.org/10.1152/ajpendo.1980.238.1.e69 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082072291
    207 rdf:type schema:CreativeWork
    208 https://doi.org/10.1152/ajpendo.1996.270.5.e746 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083018822
    209 rdf:type schema:CreativeWork
    210 https://doi.org/10.1152/jappl.1967.23.2.183 schema:sameAs https://app.dimensions.ai/details/publication/pub.1081525517
    211 rdf:type schema:CreativeWork
    212 https://doi.org/10.1152/physrev.1959.39.2.183 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075902621
    213 rdf:type schema:CreativeWork
    214 https://doi.org/10.1161/01.cir.7.5.724 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049286097
    215 rdf:type schema:CreativeWork
    216 https://doi.org/10.1161/01.res.44.1.127 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025521561
    217 rdf:type schema:CreativeWork
    218 https://doi.org/10.1172/jci101994 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041169999
    219 rdf:type schema:CreativeWork
    220 https://doi.org/10.1172/jci102150 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010838862
    221 rdf:type schema:CreativeWork
    222 https://www.grid.ac/institutes/grid.475435.4 schema:alternateName Rigshospitalet
    223 schema:name Department of Nuclear Medicine, National University Hospital, Rigshospitalet, Copenhagen, Denmark
    224 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...