Lowest ever CD4 lymphocyte count (CD4 nadir) as a predictor of current cognitive and neurological status in human immunodeficiency virus ... View Full Text


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Article Info

DATE

2006-09

AUTHORS

Victor Valcour, Priscilla Yee, Andrew E. Williams, Bruce Shiramizu, Michael Watters, Ola Selnes, Robert Paul, Cecilia Shikuma, Ned Sacktor

ABSTRACT

Low CD4 lymphocyte count was a marker for neurological disease in human immunodeficiency virus type 1 (HIV-1); but is now less common among patients with access to highly active antiretroviral therapy. In this study, the authors determine the reliability of self-reported CD4 nadir and its predictive value for neurological status. The authors identify a high degree of reliability (r = .90). After adjusting for age, current CD4 count, and duration of HIV-1, CD4 nadir relates to a current diagnosis of HIV-associated dimentia (HAD) (odds ratio [OR]: 1.395 (1.106-1.761), P = .005) and distal symmetric polyneuropathy (DSPN) (OR: 1.479 (1.221-1.769, P < .001). More... »

PAGES

387-391

Identifiers

URI

http://scigraph.springernature.com/pub.10.1080/13550280600915339

DOI

http://dx.doi.org/10.1080/13550280600915339

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1023765368

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17065131


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