Positron emission tomography imaging of peripheral benzodiazepine receptor binding in human immunodeficiency virus-infected subjects with and without cognitive impairment View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-07

AUTHORS

Clayton A. Wiley, Brian J. Lopresti, James T. Becker, Fernando Boada, Oscar L. Lopez, John Mellors, Carolyn C. Meltzer, Stephen R. Wisniewski, Chester A. Mathis

ABSTRACT

The pathology associated with late-stage dementia in human immunodeficiency virus (HIV) infection has been studied extensively. Neuropathological examination has demonstrated abundant activation and infection of macrophages/microglia termed HIV encephalitis. For obvious reasons, less is known regarding the neuropathology of minor cognitive impairment seen in earlier stages of HIV infection. The authors examined the utility of the peripheral benzodiazepine receptor ligand PK11195 in positron emission tomography (PET) imaging to assess microglial/macrophage activation in the brains of HIV-infected subjects with minor neurocognitive impairment in a cross-sectional study of 12 HIV infected individuals and 5 age-matched noninfected controls. Subjects were given a battery of neuropsychological tests in addition to assessing CD4 T-cell count and peripheral viremia followed by contrast enhanced magnetic resonance imaging (MRI) and PET with [15O]H2O followed by [11C](R)-PK11195. Two of the six neurocognitively impaired HIV-infected subjects demonstrated plasma viral breakthrough, whereas only one of six nonimpaired individuals demonstrated plasma viral load near the limits of detection. MRI demonstrated no abnormal enhancement and although atrophy was more prominent in impaired subjects, it was also present though to a lesser extent in nonimpaired subjects. None of the 12 HIV-infected subjects demonstrated increased retention of [11C](R)-PK11195 in the brain parenchyma compared to the 5 controls. These results suggest that either [11C](R)-PK11195 PET assessment is insensitive to the degree of macrophage activation in HIV-associated minor neurocognitive impairment or macrophage activation is not the pathological substrate of this neurological condition. More... »

PAGES

262-271

Identifiers

URI

http://scigraph.springernature.com/pub.10.1080/13550280600873868

DOI

http://dx.doi.org/10.1080/13550280600873868

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1050789510

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16966217


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "AIDS Dementia Complex", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carbon Radioisotopes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HIV", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HIV Infections", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Isoquinolines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Macrophage Activation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Magnetic Resonance Imaging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Positron-Emission Tomography", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Radiopharmaceuticals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, GABA-A", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "UPMC Presbyterian", 
          "id": "https://www.grid.ac/institutes/grid.461860.d", 
          "name": [
            "Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA", 
            "Neuropathology Division, Presbyterian University Hospital, 200 Lothrop Street A515, 15213, Pittsburgh, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wiley", 
        "givenName": "Clayton A.", 
        "id": "sg:person.07361535744.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07361535744.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Pittsburgh", 
          "id": "https://www.grid.ac/institutes/grid.21925.3d", 
          "name": [
            "Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lopresti", 
        "givenName": "Brian J.", 
        "id": "sg:person.0646647430.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646647430.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Pittsburgh", 
          "id": "https://www.grid.ac/institutes/grid.21925.3d", 
          "name": [
            "Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA", 
            "Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA", 
            "Department of Psychology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Becker", 
        "givenName": "James T.", 
        "id": "sg:person.013325351152.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013325351152.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Pittsburgh", 
          "id": "https://www.grid.ac/institutes/grid.21925.3d", 
          "name": [
            "Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Boada", 
        "givenName": "Fernando", 
        "id": "sg:person.0576517546.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576517546.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Pittsburgh", 
          "id": "https://www.grid.ac/institutes/grid.21925.3d", 
          "name": [
            "Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA", 
            "Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lopez", 
        "givenName": "Oscar L.", 
        "id": "sg:person.01224507500.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224507500.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Pittsburgh", 
          "id": "https://www.grid.ac/institutes/grid.21925.3d", 
          "name": [
            "Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mellors", 
        "givenName": "John", 
        "id": "sg:person.0754764377.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0754764377.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Emory University", 
          "id": "https://www.grid.ac/institutes/grid.189967.8", 
          "name": [
            "Department of Radiology, Emory University School of Medicine, Atlanta, Georgia, USA", 
            "Department of Neurology, Emory University School of Medicine, Atlanta, Georgia, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Meltzer", 
        "givenName": "Carolyn C.", 
        "id": "sg:person.0762323203.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762323203.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Pittsburgh", 
          "id": "https://www.grid.ac/institutes/grid.21925.3d", 
          "name": [
            "Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wisniewski", 
        "givenName": "Stephen R.", 
        "id": "sg:person.014254740677.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014254740677.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Pittsburgh", 
          "id": "https://www.grid.ac/institutes/grid.21925.3d", 
          "name": [
            "Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mathis", 
        "givenName": "Chester A.", 
        "id": "sg:person.010547273677.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010547273677.85"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/ana.410290613", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001670728"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0969-8051(94)90022-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001764036"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004728-199207000-00024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002343965"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004728-199207000-00024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002343965"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/nimg.1996.0066", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002690366"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0733-8619(05)70262-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005699422"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0733-8619(05)70262-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005699422"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0037-198x(05)80041-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006823079"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005072-199405000-00010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007139868"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1037/0894-4105.11.4.592", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007224379"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1148/radiology.212.3.r99se22811", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008711896"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1258/0956462961918239", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009286121"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1258/0956462961918239", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009286121"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0166-2236(02)02234-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011706849"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1018567510105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011941229", 
          "https://doi.org/10.1023/a:1018567510105"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0924-977x(02)00107-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012397876"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0924-977x(02)00107-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012397876"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-4547(19971015)50:2<345::aid-jnr22>3.0.co;2-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012511713"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0197-4580(04)80947-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012568112"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0925-4927(00)00082-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012608716"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1053-8119(03)00232-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014178728"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1053-8119(03)00232-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014178728"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jnnp.65.3.301", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014281261"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ana.410240603", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014772020"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ana.20338", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016063889"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/brain/124.10.2014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017802132"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35073667", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018601522", 
          "https://doi.org/10.1038/35073667"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35073667", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018601522", 
          "https://doi.org/10.1038/35073667"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0024-3205(96)00043-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020000369"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/brain/123.11.2321", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020663409"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0149-7634(02)00006-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021757514"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/nimg.1997.0303", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021838870"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ana.410320304", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022691190"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(01)05625-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025952429"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1080/13550280500187351", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028725707", 
          "https://doi.org/10.1080/13550280500187351"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1080/13550280500187351", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028725707", 
          "https://doi.org/10.1080/13550280500187351"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/exnr.1999.7269", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031134654"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-2999(91)90594-g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038681021"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-2999(91)90594-g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038681021"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-8993(98)00909-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040059393"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1468-1331.2003.00571.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040357504"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1750-3639.1991.tb00656.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046039724"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/glia.10144", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046180840"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1148/radiol.2281010683", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046252042"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ana.410380510", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046544323"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00596333", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047599616", 
          "https://doi.org/10.1007/bf00596333"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00596333", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047599616", 
          "https://doi.org/10.1007/bf00596333"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004728-199307000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048828899"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004728-199307000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048828899"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00002030-199211000-00011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049481453"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00002030-199211000-00011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049481453"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-2952(97)00433-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049599485"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-642-79657-9_2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049608471", 
          "https://doi.org/10.1007/978-3-642-79657-9_2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1080/13550280390194109", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052280988", 
          "https://doi.org/10.1080/13550280390194109"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/infdis/162.6.1245", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059702324"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00002030-199901140-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060144191"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00002030-199901140-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060144191"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00002030-199901140-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060144191"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci20227", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063416530"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000078192.95645.e6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064345331"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000078192.95645.e6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064345331"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000078192.95645.e6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064345331"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.43.10.2099", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064371114"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.53.4.782", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064377724"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.53.4.782", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064377724"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.53.4.782", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064377724"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.53.9.2199", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064378047"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.53.9.2199", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064378047"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.53.9.2199", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064378047"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2214/ajr.151.2.373", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069315021"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2214/ajr.161.1.8517298", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069318008"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074368402", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074750572", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075032348", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077066228", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077159693", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077728246", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078791005", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079356208", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1148/radiology.169.2.3174991", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079594806"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.15-07-05263.1995", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082439136"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082735979", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082843364", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082895342", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083016771", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083074179", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083092855", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083175220", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083175221", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083176385", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2006-07", 
    "datePublishedReg": "2006-07-01", 
    "description": "The pathology associated with late-stage dementia in human immunodeficiency virus (HIV) infection has been studied extensively. Neuropathological examination has demonstrated abundant activation and infection of macrophages/microglia termed HIV encephalitis. For obvious reasons, less is known regarding the neuropathology of minor cognitive impairment seen in earlier stages of HIV infection. The authors examined the utility of the peripheral benzodiazepine receptor ligand PK11195 in positron emission tomography (PET) imaging to assess microglial/macrophage activation in the brains of HIV-infected subjects with minor neurocognitive impairment in a cross-sectional study of 12 HIV infected individuals and 5 age-matched noninfected controls. Subjects were given a battery of neuropsychological tests in addition to assessing CD4 T-cell count and peripheral viremia followed by contrast enhanced magnetic resonance imaging (MRI) and PET with [15O]H2O followed by [11C](R)-PK11195. Two of the six neurocognitively impaired HIV-infected subjects demonstrated plasma viral breakthrough, whereas only one of six nonimpaired individuals demonstrated plasma viral load near the limits of detection. MRI demonstrated no abnormal enhancement and although atrophy was more prominent in impaired subjects, it was also present though to a lesser extent in nonimpaired subjects. None of the 12 HIV-infected subjects demonstrated increased retention of [11C](R)-PK11195 in the brain parenchyma compared to the 5 controls. These results suggest that either [11C](R)-PK11195 PET assessment is insensitive to the degree of macrophage activation in HIV-associated minor neurocognitive impairment or macrophage activation is not the pathological substrate of this neurological condition.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1080/13550280600873868", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2421249", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2406456", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2547311", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2550044", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2447415", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1114176", 
        "issn": [
          "1355-0284", 
          "1538-2443"
        ], 
        "name": "Journal of NeuroVirology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "12"
      }
    ], 
    "name": "Positron emission tomography imaging of peripheral benzodiazepine receptor binding in human immunodeficiency virus-infected subjects with and without cognitive impairment", 
    "pagination": "262-271", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "f1f09869b7a3716dddb127f2fcc9ee9721450b629682056e12b717d3c79f2a9a"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "16966217"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9508123"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1080/13550280600873868"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1050789510"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1080/13550280600873868", 
      "https://app.dimensions.ai/details/publication/pub.1050789510"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T23:22", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8693_00000501.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1080/13550280600873868"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1080/13550280600873868'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1080/13550280600873868'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1080/13550280600873868'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1080/13550280600873868'


 

This table displays all metadata directly associated to this object as RDF triples.

410 TRIPLES      21 PREDICATES      115 URIs      36 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1080/13550280600873868 schema:about N1e17e6c0f1a14df8bff5d995504fdf08
2 N22565e7111214303828e517559b7cee3
3 N2e0392cf80ba437898282b57861c02c4
4 N5da8e83e7e104c1f8eb2a426f8723b37
5 N6a1795e543f64f21a5822243791543b5
6 N6efe755e12184774b0be6b351c27962b
7 N761d4c958db34890827c83f1959835d3
8 N76f01288e29748b1a043d6a8ca22ae16
9 N806f5d737b204d50b950553226ea2c21
10 N8336bfe5761847b8a43e12a51b3a842d
11 Na82d5971a29b448ca944493a7bf382f9
12 Naeafba58b1a943f584537da7d47871cc
13 Nbf13a4b2117842a5869c87321defb9b2
14 Nf09f3d45f569411685aa558c81ffdbed
15 Nf2115bd1dc3a4d77a29b370c02b4e38b
16 anzsrc-for:11
17 anzsrc-for:1103
18 schema:author N199f7bf73e904ecdb5a8db4341e4883c
19 schema:citation sg:pub.10.1007/978-3-642-79657-9_2
20 sg:pub.10.1007/bf00596333
21 sg:pub.10.1023/a:1018567510105
22 sg:pub.10.1038/35073667
23 sg:pub.10.1080/13550280390194109
24 sg:pub.10.1080/13550280500187351
25 https://app.dimensions.ai/details/publication/pub.1074368402
26 https://app.dimensions.ai/details/publication/pub.1074750572
27 https://app.dimensions.ai/details/publication/pub.1075032348
28 https://app.dimensions.ai/details/publication/pub.1077066228
29 https://app.dimensions.ai/details/publication/pub.1077159693
30 https://app.dimensions.ai/details/publication/pub.1077728246
31 https://app.dimensions.ai/details/publication/pub.1078791005
32 https://app.dimensions.ai/details/publication/pub.1079356208
33 https://app.dimensions.ai/details/publication/pub.1082735979
34 https://app.dimensions.ai/details/publication/pub.1082843364
35 https://app.dimensions.ai/details/publication/pub.1082895342
36 https://app.dimensions.ai/details/publication/pub.1083016771
37 https://app.dimensions.ai/details/publication/pub.1083074179
38 https://app.dimensions.ai/details/publication/pub.1083092855
39 https://app.dimensions.ai/details/publication/pub.1083175220
40 https://app.dimensions.ai/details/publication/pub.1083175221
41 https://app.dimensions.ai/details/publication/pub.1083176385
42 https://doi.org/10.1002/(sici)1097-4547(19971015)50:2<345::aid-jnr22>3.0.co;2-5
43 https://doi.org/10.1002/ana.20338
44 https://doi.org/10.1002/ana.410240603
45 https://doi.org/10.1002/ana.410290613
46 https://doi.org/10.1002/ana.410320304
47 https://doi.org/10.1002/ana.410380510
48 https://doi.org/10.1002/glia.10144
49 https://doi.org/10.1006/exnr.1999.7269
50 https://doi.org/10.1006/nimg.1996.0066
51 https://doi.org/10.1006/nimg.1997.0303
52 https://doi.org/10.1016/0014-2999(91)90594-g
53 https://doi.org/10.1016/0024-3205(96)00043-4
54 https://doi.org/10.1016/0969-8051(94)90022-1
55 https://doi.org/10.1016/s0006-2952(97)00433-4
56 https://doi.org/10.1016/s0006-8993(98)00909-3
57 https://doi.org/10.1016/s0037-198x(05)80041-0
58 https://doi.org/10.1016/s0140-6736(01)05625-2
59 https://doi.org/10.1016/s0149-7634(02)00006-4
60 https://doi.org/10.1016/s0166-2236(02)02234-8
61 https://doi.org/10.1016/s0197-4580(04)80947-3
62 https://doi.org/10.1016/s0733-8619(05)70262-0
63 https://doi.org/10.1016/s0924-977x(02)00107-4
64 https://doi.org/10.1016/s0925-4927(00)00082-2
65 https://doi.org/10.1016/s1053-8119(03)00232-5
66 https://doi.org/10.1037/0894-4105.11.4.592
67 https://doi.org/10.1046/j.1468-1331.2003.00571.x
68 https://doi.org/10.1093/brain/123.11.2321
69 https://doi.org/10.1093/brain/124.10.2014
70 https://doi.org/10.1093/infdis/162.6.1245
71 https://doi.org/10.1097/00002030-199211000-00011
72 https://doi.org/10.1097/00002030-199901140-00003
73 https://doi.org/10.1097/00004728-199207000-00024
74 https://doi.org/10.1097/00004728-199307000-00004
75 https://doi.org/10.1097/00005072-199405000-00010
76 https://doi.org/10.1111/j.1750-3639.1991.tb00656.x
77 https://doi.org/10.1136/jnnp.65.3.301
78 https://doi.org/10.1148/radiol.2281010683
79 https://doi.org/10.1148/radiology.169.2.3174991
80 https://doi.org/10.1148/radiology.212.3.r99se22811
81 https://doi.org/10.1172/jci20227
82 https://doi.org/10.1212/01.wnl.0000078192.95645.e6
83 https://doi.org/10.1212/wnl.43.10.2099
84 https://doi.org/10.1212/wnl.53.4.782
85 https://doi.org/10.1212/wnl.53.9.2199
86 https://doi.org/10.1258/0956462961918239
87 https://doi.org/10.1523/jneurosci.15-07-05263.1995
88 https://doi.org/10.2214/ajr.151.2.373
89 https://doi.org/10.2214/ajr.161.1.8517298
90 schema:datePublished 2006-07
91 schema:datePublishedReg 2006-07-01
92 schema:description The pathology associated with late-stage dementia in human immunodeficiency virus (HIV) infection has been studied extensively. Neuropathological examination has demonstrated abundant activation and infection of macrophages/microglia termed HIV encephalitis. For obvious reasons, less is known regarding the neuropathology of minor cognitive impairment seen in earlier stages of HIV infection. The authors examined the utility of the peripheral benzodiazepine receptor ligand PK11195 in positron emission tomography (PET) imaging to assess microglial/macrophage activation in the brains of HIV-infected subjects with minor neurocognitive impairment in a cross-sectional study of 12 HIV infected individuals and 5 age-matched noninfected controls. Subjects were given a battery of neuropsychological tests in addition to assessing CD4 T-cell count and peripheral viremia followed by contrast enhanced magnetic resonance imaging (MRI) and PET with [15O]H2O followed by [11C](R)-PK11195. Two of the six neurocognitively impaired HIV-infected subjects demonstrated plasma viral breakthrough, whereas only one of six nonimpaired individuals demonstrated plasma viral load near the limits of detection. MRI demonstrated no abnormal enhancement and although atrophy was more prominent in impaired subjects, it was also present though to a lesser extent in nonimpaired subjects. None of the 12 HIV-infected subjects demonstrated increased retention of [11C](R)-PK11195 in the brain parenchyma compared to the 5 controls. These results suggest that either [11C](R)-PK11195 PET assessment is insensitive to the degree of macrophage activation in HIV-associated minor neurocognitive impairment or macrophage activation is not the pathological substrate of this neurological condition.
93 schema:genre research_article
94 schema:inLanguage en
95 schema:isAccessibleForFree false
96 schema:isPartOf N93f465aaf0b442ae9d396d0a635638e4
97 Nc5560c4903d74574a091e356c744ab9c
98 sg:journal.1114176
99 schema:name Positron emission tomography imaging of peripheral benzodiazepine receptor binding in human immunodeficiency virus-infected subjects with and without cognitive impairment
100 schema:pagination 262-271
101 schema:productId N143acb1d6177414ab0569eb302ab2494
102 N21945f6487e54277920b13deeacb5cdf
103 N2f73d3f1b7964240a74e54050e59fed7
104 N41f2f2a5e4cb4c9ea05d155065148a04
105 N99e93d1fffca4e6dacbecbdd89b500b0
106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050789510
107 https://doi.org/10.1080/13550280600873868
108 schema:sdDatePublished 2019-04-10T23:22
109 schema:sdLicense https://scigraph.springernature.com/explorer/license/
110 schema:sdPublisher Nb28e3615b64f400fa57faf5b2948d118
111 schema:url http://link.springer.com/10.1080/13550280600873868
112 sgo:license sg:explorer/license/
113 sgo:sdDataset articles
114 rdf:type schema:ScholarlyArticle
115 N143acb1d6177414ab0569eb302ab2494 schema:name doi
116 schema:value 10.1080/13550280600873868
117 rdf:type schema:PropertyValue
118 N199f7bf73e904ecdb5a8db4341e4883c rdf:first sg:person.07361535744.62
119 rdf:rest Nc3ed98d18d7146d2b1bdaa172312a948
120 N1aa03acb731945efb6204f8e99cf6999 rdf:first sg:person.0576517546.59
121 rdf:rest N79c39c2c2eb94f7499c6ee25b8ee9bec
122 N1cecb6838374412abc60341e5f773063 rdf:first sg:person.013325351152.78
123 rdf:rest N1aa03acb731945efb6204f8e99cf6999
124 N1e17e6c0f1a14df8bff5d995504fdf08 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Humans
126 rdf:type schema:DefinedTerm
127 N21945f6487e54277920b13deeacb5cdf schema:name dimensions_id
128 schema:value pub.1050789510
129 rdf:type schema:PropertyValue
130 N22565e7111214303828e517559b7cee3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name HIV Infections
132 rdf:type schema:DefinedTerm
133 N2e0392cf80ba437898282b57861c02c4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Macrophage Activation
135 rdf:type schema:DefinedTerm
136 N2f73d3f1b7964240a74e54050e59fed7 schema:name pubmed_id
137 schema:value 16966217
138 rdf:type schema:PropertyValue
139 N33a75732d0c0438a8e8cc63e242f0812 rdf:first sg:person.014254740677.08
140 rdf:rest N9717efa742984a909056f5983139a7a2
141 N41f2f2a5e4cb4c9ea05d155065148a04 schema:name nlm_unique_id
142 schema:value 9508123
143 rdf:type schema:PropertyValue
144 N4d1006744a3b4c48bcc2c6dca0d96691 rdf:first sg:person.0754764377.76
145 rdf:rest Nba5a36bb3e5e4fd08a423c91918925f4
146 N5da8e83e7e104c1f8eb2a426f8723b37 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Magnetic Resonance Imaging
148 rdf:type schema:DefinedTerm
149 N6a1795e543f64f21a5822243791543b5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Positron-Emission Tomography
151 rdf:type schema:DefinedTerm
152 N6efe755e12184774b0be6b351c27962b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Brain
154 rdf:type schema:DefinedTerm
155 N761d4c958db34890827c83f1959835d3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name HIV
157 rdf:type schema:DefinedTerm
158 N76f01288e29748b1a043d6a8ca22ae16 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Receptors, GABA-A
160 rdf:type schema:DefinedTerm
161 N79c39c2c2eb94f7499c6ee25b8ee9bec rdf:first sg:person.01224507500.34
162 rdf:rest N4d1006744a3b4c48bcc2c6dca0d96691
163 N806f5d737b204d50b950553226ea2c21 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Aged
165 rdf:type schema:DefinedTerm
166 N8336bfe5761847b8a43e12a51b3a842d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name AIDS Dementia Complex
168 rdf:type schema:DefinedTerm
169 N93f465aaf0b442ae9d396d0a635638e4 schema:issueNumber 4
170 rdf:type schema:PublicationIssue
171 N9717efa742984a909056f5983139a7a2 rdf:first sg:person.010547273677.85
172 rdf:rest rdf:nil
173 N99e93d1fffca4e6dacbecbdd89b500b0 schema:name readcube_id
174 schema:value f1f09869b7a3716dddb127f2fcc9ee9721450b629682056e12b717d3c79f2a9a
175 rdf:type schema:PropertyValue
176 Na82d5971a29b448ca944493a7bf382f9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Isoquinolines
178 rdf:type schema:DefinedTerm
179 Naeafba58b1a943f584537da7d47871cc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Carbon Radioisotopes
181 rdf:type schema:DefinedTerm
182 Nb28e3615b64f400fa57faf5b2948d118 schema:name Springer Nature - SN SciGraph project
183 rdf:type schema:Organization
184 Nba5a36bb3e5e4fd08a423c91918925f4 rdf:first sg:person.0762323203.48
185 rdf:rest N33a75732d0c0438a8e8cc63e242f0812
186 Nbf13a4b2117842a5869c87321defb9b2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Adult
188 rdf:type schema:DefinedTerm
189 Nc3ed98d18d7146d2b1bdaa172312a948 rdf:first sg:person.0646647430.44
190 rdf:rest N1cecb6838374412abc60341e5f773063
191 Nc5560c4903d74574a091e356c744ab9c schema:volumeNumber 12
192 rdf:type schema:PublicationVolume
193 Nf09f3d45f569411685aa558c81ffdbed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
194 schema:name Middle Aged
195 rdf:type schema:DefinedTerm
196 Nf2115bd1dc3a4d77a29b370c02b4e38b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
197 schema:name Radiopharmaceuticals
198 rdf:type schema:DefinedTerm
199 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
200 schema:name Medical and Health Sciences
201 rdf:type schema:DefinedTerm
202 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
203 schema:name Clinical Sciences
204 rdf:type schema:DefinedTerm
205 sg:grant.2406456 http://pending.schema.org/fundedItem sg:pub.10.1080/13550280600873868
206 rdf:type schema:MonetaryGrant
207 sg:grant.2421249 http://pending.schema.org/fundedItem sg:pub.10.1080/13550280600873868
208 rdf:type schema:MonetaryGrant
209 sg:grant.2447415 http://pending.schema.org/fundedItem sg:pub.10.1080/13550280600873868
210 rdf:type schema:MonetaryGrant
211 sg:grant.2547311 http://pending.schema.org/fundedItem sg:pub.10.1080/13550280600873868
212 rdf:type schema:MonetaryGrant
213 sg:grant.2550044 http://pending.schema.org/fundedItem sg:pub.10.1080/13550280600873868
214 rdf:type schema:MonetaryGrant
215 sg:journal.1114176 schema:issn 1355-0284
216 1538-2443
217 schema:name Journal of NeuroVirology
218 rdf:type schema:Periodical
219 sg:person.010547273677.85 schema:affiliation https://www.grid.ac/institutes/grid.21925.3d
220 schema:familyName Mathis
221 schema:givenName Chester A.
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010547273677.85
223 rdf:type schema:Person
224 sg:person.01224507500.34 schema:affiliation https://www.grid.ac/institutes/grid.21925.3d
225 schema:familyName Lopez
226 schema:givenName Oscar L.
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224507500.34
228 rdf:type schema:Person
229 sg:person.013325351152.78 schema:affiliation https://www.grid.ac/institutes/grid.21925.3d
230 schema:familyName Becker
231 schema:givenName James T.
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013325351152.78
233 rdf:type schema:Person
234 sg:person.014254740677.08 schema:affiliation https://www.grid.ac/institutes/grid.21925.3d
235 schema:familyName Wisniewski
236 schema:givenName Stephen R.
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014254740677.08
238 rdf:type schema:Person
239 sg:person.0576517546.59 schema:affiliation https://www.grid.ac/institutes/grid.21925.3d
240 schema:familyName Boada
241 schema:givenName Fernando
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576517546.59
243 rdf:type schema:Person
244 sg:person.0646647430.44 schema:affiliation https://www.grid.ac/institutes/grid.21925.3d
245 schema:familyName Lopresti
246 schema:givenName Brian J.
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646647430.44
248 rdf:type schema:Person
249 sg:person.07361535744.62 schema:affiliation https://www.grid.ac/institutes/grid.461860.d
250 schema:familyName Wiley
251 schema:givenName Clayton A.
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07361535744.62
253 rdf:type schema:Person
254 sg:person.0754764377.76 schema:affiliation https://www.grid.ac/institutes/grid.21925.3d
255 schema:familyName Mellors
256 schema:givenName John
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0754764377.76
258 rdf:type schema:Person
259 sg:person.0762323203.48 schema:affiliation https://www.grid.ac/institutes/grid.189967.8
260 schema:familyName Meltzer
261 schema:givenName Carolyn C.
262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762323203.48
263 rdf:type schema:Person
264 sg:pub.10.1007/978-3-642-79657-9_2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049608471
265 https://doi.org/10.1007/978-3-642-79657-9_2
266 rdf:type schema:CreativeWork
267 sg:pub.10.1007/bf00596333 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047599616
268 https://doi.org/10.1007/bf00596333
269 rdf:type schema:CreativeWork
270 sg:pub.10.1023/a:1018567510105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011941229
271 https://doi.org/10.1023/a:1018567510105
272 rdf:type schema:CreativeWork
273 sg:pub.10.1038/35073667 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018601522
274 https://doi.org/10.1038/35073667
275 rdf:type schema:CreativeWork
276 sg:pub.10.1080/13550280390194109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052280988
277 https://doi.org/10.1080/13550280390194109
278 rdf:type schema:CreativeWork
279 sg:pub.10.1080/13550280500187351 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028725707
280 https://doi.org/10.1080/13550280500187351
281 rdf:type schema:CreativeWork
282 https://app.dimensions.ai/details/publication/pub.1074368402 schema:CreativeWork
283 https://app.dimensions.ai/details/publication/pub.1074750572 schema:CreativeWork
284 https://app.dimensions.ai/details/publication/pub.1075032348 schema:CreativeWork
285 https://app.dimensions.ai/details/publication/pub.1077066228 schema:CreativeWork
286 https://app.dimensions.ai/details/publication/pub.1077159693 schema:CreativeWork
287 https://app.dimensions.ai/details/publication/pub.1077728246 schema:CreativeWork
288 https://app.dimensions.ai/details/publication/pub.1078791005 schema:CreativeWork
289 https://app.dimensions.ai/details/publication/pub.1079356208 schema:CreativeWork
290 https://app.dimensions.ai/details/publication/pub.1082735979 schema:CreativeWork
291 https://app.dimensions.ai/details/publication/pub.1082843364 schema:CreativeWork
292 https://app.dimensions.ai/details/publication/pub.1082895342 schema:CreativeWork
293 https://app.dimensions.ai/details/publication/pub.1083016771 schema:CreativeWork
294 https://app.dimensions.ai/details/publication/pub.1083074179 schema:CreativeWork
295 https://app.dimensions.ai/details/publication/pub.1083092855 schema:CreativeWork
296 https://app.dimensions.ai/details/publication/pub.1083175220 schema:CreativeWork
297 https://app.dimensions.ai/details/publication/pub.1083175221 schema:CreativeWork
298 https://app.dimensions.ai/details/publication/pub.1083176385 schema:CreativeWork
299 https://doi.org/10.1002/(sici)1097-4547(19971015)50:2<345::aid-jnr22>3.0.co;2-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012511713
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1002/ana.20338 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016063889
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1002/ana.410240603 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014772020
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1002/ana.410290613 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001670728
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1002/ana.410320304 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022691190
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1002/ana.410380510 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046544323
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1002/glia.10144 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046180840
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1006/exnr.1999.7269 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031134654
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1006/nimg.1996.0066 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002690366
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1006/nimg.1997.0303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021838870
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1016/0014-2999(91)90594-g schema:sameAs https://app.dimensions.ai/details/publication/pub.1038681021
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1016/0024-3205(96)00043-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020000369
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1016/0969-8051(94)90022-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001764036
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1016/s0006-2952(97)00433-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049599485
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1016/s0006-8993(98)00909-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040059393
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1016/s0037-198x(05)80041-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006823079
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1016/s0140-6736(01)05625-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025952429
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1016/s0149-7634(02)00006-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021757514
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1016/s0166-2236(02)02234-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011706849
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1016/s0197-4580(04)80947-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012568112
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1016/s0733-8619(05)70262-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005699422
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1016/s0924-977x(02)00107-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012397876
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1016/s0925-4927(00)00082-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012608716
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1016/s1053-8119(03)00232-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014178728
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1037/0894-4105.11.4.592 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007224379
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1046/j.1468-1331.2003.00571.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1040357504
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1093/brain/123.11.2321 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020663409
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1093/brain/124.10.2014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017802132
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1093/infdis/162.6.1245 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059702324
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1097/00002030-199211000-00011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049481453
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1097/00002030-199901140-00003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060144191
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1097/00004728-199207000-00024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002343965
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1097/00004728-199307000-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048828899
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1097/00005072-199405000-00010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007139868
366 rdf:type schema:CreativeWork
367 https://doi.org/10.1111/j.1750-3639.1991.tb00656.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1046039724
368 rdf:type schema:CreativeWork
369 https://doi.org/10.1136/jnnp.65.3.301 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014281261
370 rdf:type schema:CreativeWork
371 https://doi.org/10.1148/radiol.2281010683 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046252042
372 rdf:type schema:CreativeWork
373 https://doi.org/10.1148/radiology.169.2.3174991 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079594806
374 rdf:type schema:CreativeWork
375 https://doi.org/10.1148/radiology.212.3.r99se22811 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008711896
376 rdf:type schema:CreativeWork
377 https://doi.org/10.1172/jci20227 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063416530
378 rdf:type schema:CreativeWork
379 https://doi.org/10.1212/01.wnl.0000078192.95645.e6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064345331
380 rdf:type schema:CreativeWork
381 https://doi.org/10.1212/wnl.43.10.2099 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064371114
382 rdf:type schema:CreativeWork
383 https://doi.org/10.1212/wnl.53.4.782 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064377724
384 rdf:type schema:CreativeWork
385 https://doi.org/10.1212/wnl.53.9.2199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064378047
386 rdf:type schema:CreativeWork
387 https://doi.org/10.1258/0956462961918239 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009286121
388 rdf:type schema:CreativeWork
389 https://doi.org/10.1523/jneurosci.15-07-05263.1995 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082439136
390 rdf:type schema:CreativeWork
391 https://doi.org/10.2214/ajr.151.2.373 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069315021
392 rdf:type schema:CreativeWork
393 https://doi.org/10.2214/ajr.161.1.8517298 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069318008
394 rdf:type schema:CreativeWork
395 https://www.grid.ac/institutes/grid.189967.8 schema:alternateName Emory University
396 schema:name Department of Neurology, Emory University School of Medicine, Atlanta, Georgia, USA
397 Department of Radiology, Emory University School of Medicine, Atlanta, Georgia, USA
398 rdf:type schema:Organization
399 https://www.grid.ac/institutes/grid.21925.3d schema:alternateName University of Pittsburgh
400 schema:name Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania, USA
401 Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
402 Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
403 Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
404 Department of Psychology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
405 Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
406 rdf:type schema:Organization
407 https://www.grid.ac/institutes/grid.461860.d schema:alternateName UPMC Presbyterian
408 schema:name Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
409 Neuropathology Division, Presbyterian University Hospital, 200 Lothrop Street A515, 15213, Pittsburgh, PA, USA
410 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...