HIV-associated cognitive impairment before and after the advent of combination therapy View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-03

AUTHORS

Ned Sacktor, Michael P. McDermott, Karen Marder, Giovanni Schifitto, Ola A. Selnes, Justin C. McArthur, Yaakov Stern, Steve Albert, Donna Palumbo, Karl Kieburtz, Joy A. De Marcaida, Bruce Cohen, Leon Epstein

ABSTRACT

The objective of this study was to describe the occurrence of HIV dementia and neuropsychological testing abnormalities in a new cohort of HIV-seropositive individuals at high risk for HIV dementia and to compare these results to a cohort before the advent of highly active antiretroviral therapy (HAART). HAART has been associated with improvements in cognitive performance in some HIV-infected patients. However, it is uncertain whether HAART has changed the frequency of specific neurocognitive abnormalities. Baseline data from 272 HIV-seropositive subjects in the Dana cohort recruited from January, 1994, to December, 1995, and 251 HIV-seropositive subjects in the Northeastern AIDS Dementia Consortium (NEAD) cohort recruited from April, 1998, to August, 1999, were compared. Participants in both cohorts received nearly identical assessments. After adjusting for differences in age, education, gender, race, and CD4 count between the two cohorts, there were no differences in the occurrence of HIV dementia or abnormalities either 1 SD or 2 SDs below established norms for any of the neuropsychological tests. Even though HAART has reduced the incidence of HIV dementia, HIV-associated cognitive impairment continues to be a major clinical problem among individuals with advanced infection. More... »

PAGES

136-142

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1080/13550280290049615

DOI

http://dx.doi.org/10.1080/13550280290049615

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1014940872

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11935465


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1080/13550280290049615'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1080/13550280290049615'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1080/13550280290049615'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1080/13550280290049615'


 

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304 https://www.grid.ac/institutes/grid.21729.3f schema:alternateName Columbia University
305 schema:name Department of Neurology, Columbia University, New York, New York
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307 https://www.grid.ac/institutes/grid.411940.9 schema:alternateName Johns Hopkins Bayview Medical Center
308 schema:name Department of Neurology, Johns Hopkins Bayview Medical Center, 4940 Eastern Avenue, B-Building, Room 122, 21224, Baltimore, MD, USA
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311 https://www.grid.ac/institutes/grid.412750.5 schema:alternateName University of Rochester Medical Center
312 schema:name Department of Biostatistics, University of Rochester Medical Center, Rochester, New York, USA
313 Department of Neurology, University of Rochester Medical Center, Rochester, New York, USA
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