Long-term effect of simvastatin on the improvement of impaired myocardial flow reserve in patients with familial hypercholesterolemia without gender variance View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-07

AUTHORS

Ikuo Yokoyama, Katsunori Yonekura, Yusuke Inoue, Kuni Ohtomo, Ryozo Nagai

ABSTRACT

BackgroundImpaired myocardial flow reserve (MFR) in patients with familial hypercholesterolemia (FH) without evidence of ischemia has been reported. However, it has not been clarified whether diminished MFR in such male or female patients with FH can be reversed by simvastatin.Methods and ResultsSixteen patients with FH and 16 age-matched control subjects were studied. All patients were proved to have no evidence of exercise stress-induced myocardial ischemia. Baseline myocardial blood flow (MBF) and MBF during dipyridamole administration (MBF [DP]) were measured with positron emission tomography and nitrogen 13 ammonia; MFR was then calculated before and 9 to 15 months after therapy with simvastatin (5-10 mg/day). Total cholesterol level was significantly higher in patients with FH (277 ± 49.0) than in control subjects (190 ± 14.9) but was normalized after lipid-lowering therapy (205 ± 40.3). Baseline MBF was comparable among FH patients before (77.6 ± 11.6 mL/min/100 g) and after therapy (74.5 ± 9.62 mL/min/100 g) and control subjects (78.5 ± 29.9 mL/min/100 g). However, MBF (DP) in FH patients before therapy (178 ± 50.9 mL/min/100 g) was significantly lower than that in control subjects (282 ± 148 mL/min/100 g) and was significantly improved after therapy (228 ± 91.6 mL/min/100 g, P < .05). In fact, there was no statistically significant difference in the MBF (DP) value in FH patients after therapy compared with that in control subjects (P = .09). MFR significantly improved after therapy in patients with FH (3.33 ± 1.19 vs 2.27 ± 0.625, P < .01) and was then statistically comparable to that in control subjects (3.54 ± 1.11). Improvement of MFR was observed whether MBF (DP) before therapy was greater than or less than 200 mL/min/100 g. MFR was improved in both male and female patients with FH. There was a significant relationship between percent change in plasma total cholesterol concentration and percent change in MFR before and after lipid-lowering therapy (r = -0.57, P < .05).ConclusionsDiminished MFR in patients with FH without evidence of ischemia can be reversed by moderate- to long-term simvastatin therapy without gender variance. More... »

PAGES

445-451

Identifiers

URI

http://scigraph.springernature.com/pub.10.1067/mnc.2001.115517

DOI

http://dx.doi.org/10.1067/mnc.2001.115517

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1029936847

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11481566


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Anticholesteremic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cholesterol", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Coronary Circulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dipyridamole", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Electrocardiography", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hydroxymethylglutaryl-CoA Reductase Inhibitors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hyperlipoproteinemia Type II", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Simvastatin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tomography, Emission-Computed", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vasodilator Agents", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Departments of Cardiovascular Medicine and Radiology, University of Tokyo, Graduate School of Medicine, 7-3-1 Hongo, 113-8655, Bunkyo-ku, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.26999.3d", 
          "name": [
            "Departments of Cardiovascular Medicine and Radiology, University of Tokyo, Graduate School of Medicine, 7-3-1 Hongo, 113-8655, Bunkyo-ku, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yokoyama", 
        "givenName": "Ikuo", 
        "id": "sg:person.01355412055.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355412055.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Departments of Cardiovascular Medicine and Radiology, University of Tokyo, Graduate School of Medicine, 7-3-1 Hongo, 113-8655, Bunkyo-ku, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.26999.3d", 
          "name": [
            "Departments of Cardiovascular Medicine and Radiology, University of Tokyo, Graduate School of Medicine, 7-3-1 Hongo, 113-8655, Bunkyo-ku, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yonekura", 
        "givenName": "Katsunori", 
        "id": "sg:person.0746234355.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746234355.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Departments of Cardiovascular Medicine and Radiology, University of Tokyo, Graduate School of Medicine, 7-3-1 Hongo, 113-8655, Bunkyo-ku, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.26999.3d", 
          "name": [
            "Departments of Cardiovascular Medicine and Radiology, University of Tokyo, Graduate School of Medicine, 7-3-1 Hongo, 113-8655, Bunkyo-ku, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Inoue", 
        "givenName": "Yusuke", 
        "id": "sg:person.010476276272.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010476276272.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Departments of Cardiovascular Medicine and Radiology, University of Tokyo, Graduate School of Medicine, 7-3-1 Hongo, 113-8655, Bunkyo-ku, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.26999.3d", 
          "name": [
            "Departments of Cardiovascular Medicine and Radiology, University of Tokyo, Graduate School of Medicine, 7-3-1 Hongo, 113-8655, Bunkyo-ku, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ohtomo", 
        "givenName": "Kuni", 
        "id": "sg:person.01152022531.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152022531.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Departments of Cardiovascular Medicine and Radiology, University of Tokyo, Graduate School of Medicine, 7-3-1 Hongo, 113-8655, Bunkyo-ku, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.26999.3d", 
          "name": [
            "Departments of Cardiovascular Medicine and Radiology, University of Tokyo, Graduate School of Medicine, 7-3-1 Hongo, 113-8655, Bunkyo-ku, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nagai", 
        "givenName": "Ryozo", 
        "id": "sg:person.0772176333.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0772176333.38"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "2001-07", 
    "datePublishedReg": "2001-07-01", 
    "description": "BackgroundImpaired myocardial flow reserve (MFR) in patients with familial hypercholesterolemia (FH) without evidence of ischemia has been reported. However, it has not been clarified whether diminished MFR in such male or female patients with FH can be reversed by simvastatin.Methods and ResultsSixteen patients with FH and 16 age-matched control subjects were studied. All patients were proved to have no evidence of exercise stress-induced myocardial ischemia. Baseline myocardial blood flow (MBF) and MBF during dipyridamole administration (MBF [DP]) were measured with positron emission tomography and nitrogen 13 ammonia; MFR was then calculated before and 9 to 15 months after therapy with simvastatin (5-10 mg/day). Total cholesterol level was significantly higher in patients with FH (277 \u00b1 49.0) than in control subjects (190 \u00b1 14.9) but was normalized after lipid-lowering therapy (205 \u00b1 40.3). Baseline MBF was comparable among FH patients before (77.6 \u00b1 11.6 mL/min/100 g) and after therapy (74.5 \u00b1 9.62 mL/min/100 g) and control subjects (78.5 \u00b1 29.9 mL/min/100 g). However, MBF (DP) in FH patients before therapy (178 \u00b1 50.9 mL/min/100 g) was significantly lower than that in control subjects (282 \u00b1 148 mL/min/100 g) and was significantly improved after therapy (228 \u00b1 91.6 mL/min/100 g, P < .05). In fact, there was no statistically significant difference in the MBF (DP) value in FH patients after therapy compared with that in control subjects (P = .09). MFR significantly improved after therapy in patients with FH (3.33 \u00b1 1.19 vs 2.27 \u00b1 0.625, P < .01) and was then statistically comparable to that in control subjects (3.54 \u00b1 1.11). Improvement of MFR was observed whether MBF (DP) before therapy was greater than or less than 200 mL/min/100 g. MFR was improved in both male and female patients with FH. There was a significant relationship between percent change in plasma total cholesterol concentration and percent change in MFR before and after lipid-lowering therapy (r = -0.57, P < .05).ConclusionsDiminished MFR in patients with FH without evidence of ischemia can be reversed by moderate- to long-term simvastatin therapy without gender variance.", 
    "genre": "article", 
    "id": "sg:pub.10.1067/mnc.2001.115517", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1106202", 
        "issn": [
          "1071-3581", 
          "1532-6551"
        ], 
        "name": "Journal of Nuclear Cardiology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "8"
      }
    ], 
    "keywords": [
      "myocardial blood flow", 
      "myocardial flow reserve", 
      "baseline myocardial blood flow", 
      "lipid-lowering therapy", 
      "evidence of ischemia", 
      "control subjects", 
      "familial hypercholesterolemia", 
      "FH patients", 
      "female patients", 
      "flow reserve", 
      "long-term simvastatin therapy", 
      "stress-induced myocardial ischemia", 
      "percent change", 
      "age-matched control subjects", 
      "plasma total cholesterol concentration", 
      "mL/min/100 g.", 
      "total cholesterol levels", 
      "total cholesterol concentration", 
      "positron emission tomography", 
      "nitrogen 13 ammonia", 
      "long-term effects", 
      "ResultsSixteen patients", 
      "simvastatin therapy", 
      "dipyridamole administration", 
      "min/100 g.", 
      "myocardial ischemia", 
      "cholesterol levels", 
      "blood flow", 
      "cholesterol concentrations", 
      "patients", 
      "therapy", 
      "emission tomography", 
      "ischemia", 
      "simvastatin", 
      "significant differences", 
      "hypercholesterolemia", 
      "MBF values", 
      "subjects", 
      "significant relationship", 
      "evidence", 
      "administration", 
      "months", 
      "tomography", 
      "improvement", 
      "changes", 
      "levels", 
      "differences", 
      "reserves", 
      "effect", 
      "concentration", 
      "gender variance", 
      "variance", 
      "relationship", 
      "G.", 
      "values", 
      "method", 
      "fact", 
      "flow", 
      "ammonia", 
      "BackgroundImpaired myocardial flow reserve", 
      "exercise stress-induced myocardial ischemia", 
      "Improvement of MFR", 
      "ConclusionsDiminished MFR"
    ], 
    "name": "Long-term effect of simvastatin on the improvement of impaired myocardial flow reserve in patients with familial hypercholesterolemia without gender variance", 
    "pagination": "445-451", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1029936847"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1067/mnc.2001.115517"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "11481566"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1067/mnc.2001.115517", 
      "https://app.dimensions.ai/details/publication/pub.1029936847"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-11-01T18:03", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211101/entities/gbq_results/article/article_314.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1067/mnc.2001.115517"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1067/mnc.2001.115517'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1067/mnc.2001.115517'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1067/mnc.2001.115517'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1067/mnc.2001.115517'


 

This table displays all metadata directly associated to this object as RDF triples.

209 TRIPLES      21 PREDICATES      104 URIs      96 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1067/mnc.2001.115517 schema:about N0c47c9282a0a4aa38b8423f7e52f7af1
2 N36a2dbca10a7475c9a4692b2e3698924
3 N4395a0e2443442f4b7597c9e3d2bcb8b
4 N43f62ef6b59a4409856749eceb3880aa
5 N49dfba904f8e4facab4e6cc6afe2a3fb
6 N62216b785bf947a5a99d6419a52de00d
7 N68f85fd19aa043fba16b4e591f087caa
8 N70cd05fe65b3464b82acdc5ba984d2d5
9 N91be6bdeee574766a8fd48a1060293be
10 Naa9df45e621c432281897a4cff5e0ded
11 Nb378beaed27140368422be6bdaca7e43
12 Nb5aaf963807d4cd8a15a115d31c8056f
13 Ncc7bf95ce7ca48ec9b921dd7da7661ae
14 Nfdcfe23276fe44788bdbe52c6c0c193c
15 anzsrc-for:11
16 anzsrc-for:1102
17 schema:author N593d2aa5a153488399a2bb04088dfd60
18 schema:datePublished 2001-07
19 schema:datePublishedReg 2001-07-01
20 schema:description BackgroundImpaired myocardial flow reserve (MFR) in patients with familial hypercholesterolemia (FH) without evidence of ischemia has been reported. However, it has not been clarified whether diminished MFR in such male or female patients with FH can be reversed by simvastatin.Methods and ResultsSixteen patients with FH and 16 age-matched control subjects were studied. All patients were proved to have no evidence of exercise stress-induced myocardial ischemia. Baseline myocardial blood flow (MBF) and MBF during dipyridamole administration (MBF [DP]) were measured with positron emission tomography and nitrogen 13 ammonia; MFR was then calculated before and 9 to 15 months after therapy with simvastatin (5-10 mg/day). Total cholesterol level was significantly higher in patients with FH (277 ± 49.0) than in control subjects (190 ± 14.9) but was normalized after lipid-lowering therapy (205 ± 40.3). Baseline MBF was comparable among FH patients before (77.6 ± 11.6 mL/min/100 g) and after therapy (74.5 ± 9.62 mL/min/100 g) and control subjects (78.5 ± 29.9 mL/min/100 g). However, MBF (DP) in FH patients before therapy (178 ± 50.9 mL/min/100 g) was significantly lower than that in control subjects (282 ± 148 mL/min/100 g) and was significantly improved after therapy (228 ± 91.6 mL/min/100 g, P < .05). In fact, there was no statistically significant difference in the MBF (DP) value in FH patients after therapy compared with that in control subjects (P = .09). MFR significantly improved after therapy in patients with FH (3.33 ± 1.19 vs 2.27 ± 0.625, P < .01) and was then statistically comparable to that in control subjects (3.54 ± 1.11). Improvement of MFR was observed whether MBF (DP) before therapy was greater than or less than 200 mL/min/100 g. MFR was improved in both male and female patients with FH. There was a significant relationship between percent change in plasma total cholesterol concentration and percent change in MFR before and after lipid-lowering therapy (r = -0.57, P < .05).ConclusionsDiminished MFR in patients with FH without evidence of ischemia can be reversed by moderate- to long-term simvastatin therapy without gender variance.
21 schema:genre article
22 schema:inLanguage en
23 schema:isAccessibleForFree false
24 schema:isPartOf N68a6740e6a7e40098cef3254b5c7664d
25 Nd11b321625484d94a0e984c738a309e4
26 sg:journal.1106202
27 schema:keywords BackgroundImpaired myocardial flow reserve
28 ConclusionsDiminished MFR
29 FH patients
30 G.
31 Improvement of MFR
32 MBF values
33 ResultsSixteen patients
34 administration
35 age-matched control subjects
36 ammonia
37 baseline myocardial blood flow
38 blood flow
39 changes
40 cholesterol concentrations
41 cholesterol levels
42 concentration
43 control subjects
44 differences
45 dipyridamole administration
46 effect
47 emission tomography
48 evidence
49 evidence of ischemia
50 exercise stress-induced myocardial ischemia
51 fact
52 familial hypercholesterolemia
53 female patients
54 flow
55 flow reserve
56 gender variance
57 hypercholesterolemia
58 improvement
59 ischemia
60 levels
61 lipid-lowering therapy
62 long-term effects
63 long-term simvastatin therapy
64 mL/min/100 g.
65 method
66 min/100 g.
67 months
68 myocardial blood flow
69 myocardial flow reserve
70 myocardial ischemia
71 nitrogen 13 ammonia
72 patients
73 percent change
74 plasma total cholesterol concentration
75 positron emission tomography
76 relationship
77 reserves
78 significant differences
79 significant relationship
80 simvastatin
81 simvastatin therapy
82 stress-induced myocardial ischemia
83 subjects
84 therapy
85 tomography
86 total cholesterol concentration
87 total cholesterol levels
88 values
89 variance
90 schema:name Long-term effect of simvastatin on the improvement of impaired myocardial flow reserve in patients with familial hypercholesterolemia without gender variance
91 schema:pagination 445-451
92 schema:productId N13dd143f80094698b3f18d94bac4ee3e
93 N977305d87c5849c2b058b5118fddb6dd
94 Na6a8410a69974de6a0f43358722008ad
95 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029936847
96 https://doi.org/10.1067/mnc.2001.115517
97 schema:sdDatePublished 2021-11-01T18:03
98 schema:sdLicense https://scigraph.springernature.com/explorer/license/
99 schema:sdPublisher N557b9ae64a8e433f93b8b46ba9a487bb
100 schema:url https://doi.org/10.1067/mnc.2001.115517
101 sgo:license sg:explorer/license/
102 sgo:sdDataset articles
103 rdf:type schema:ScholarlyArticle
104 N0c47c9282a0a4aa38b8423f7e52f7af1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Male
106 rdf:type schema:DefinedTerm
107 N13dd143f80094698b3f18d94bac4ee3e schema:name dimensions_id
108 schema:value pub.1029936847
109 rdf:type schema:PropertyValue
110 N35f7acd6921f4526a6219b5598b04de9 rdf:first sg:person.010476276272.43
111 rdf:rest N5c6584284bdb4a21895a0f99513ce069
112 N36a2dbca10a7475c9a4692b2e3698924 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Female
114 rdf:type schema:DefinedTerm
115 N4395a0e2443442f4b7597c9e3d2bcb8b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Electrocardiography
117 rdf:type schema:DefinedTerm
118 N43f62ef6b59a4409856749eceb3880aa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Dipyridamole
120 rdf:type schema:DefinedTerm
121 N49dfba904f8e4facab4e6cc6afe2a3fb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Hyperlipoproteinemia Type II
123 rdf:type schema:DefinedTerm
124 N557b9ae64a8e433f93b8b46ba9a487bb schema:name Springer Nature - SN SciGraph project
125 rdf:type schema:Organization
126 N593d2aa5a153488399a2bb04088dfd60 rdf:first sg:person.01355412055.69
127 rdf:rest Na8cc9bc962f7465ab8ac19e6e30a495d
128 N5c6584284bdb4a21895a0f99513ce069 rdf:first sg:person.01152022531.08
129 rdf:rest Ncd67c691b44d4fa0b5819bb7e2c43366
130 N62216b785bf947a5a99d6419a52de00d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Humans
132 rdf:type schema:DefinedTerm
133 N68a6740e6a7e40098cef3254b5c7664d schema:volumeNumber 8
134 rdf:type schema:PublicationVolume
135 N68f85fd19aa043fba16b4e591f087caa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Tomography, Emission-Computed
137 rdf:type schema:DefinedTerm
138 N70cd05fe65b3464b82acdc5ba984d2d5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Simvastatin
140 rdf:type schema:DefinedTerm
141 N91be6bdeee574766a8fd48a1060293be schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Hydroxymethylglutaryl-CoA Reductase Inhibitors
143 rdf:type schema:DefinedTerm
144 N977305d87c5849c2b058b5118fddb6dd schema:name doi
145 schema:value 10.1067/mnc.2001.115517
146 rdf:type schema:PropertyValue
147 Na6a8410a69974de6a0f43358722008ad schema:name pubmed_id
148 schema:value 11481566
149 rdf:type schema:PropertyValue
150 Na8cc9bc962f7465ab8ac19e6e30a495d rdf:first sg:person.0746234355.31
151 rdf:rest N35f7acd6921f4526a6219b5598b04de9
152 Naa9df45e621c432281897a4cff5e0ded schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Anticholesteremic Agents
154 rdf:type schema:DefinedTerm
155 Nb378beaed27140368422be6bdaca7e43 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Middle Aged
157 rdf:type schema:DefinedTerm
158 Nb5aaf963807d4cd8a15a115d31c8056f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Coronary Circulation
160 rdf:type schema:DefinedTerm
161 Ncc7bf95ce7ca48ec9b921dd7da7661ae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Cholesterol
163 rdf:type schema:DefinedTerm
164 Ncd67c691b44d4fa0b5819bb7e2c43366 rdf:first sg:person.0772176333.38
165 rdf:rest rdf:nil
166 Nd11b321625484d94a0e984c738a309e4 schema:issueNumber 4
167 rdf:type schema:PublicationIssue
168 Nfdcfe23276fe44788bdbe52c6c0c193c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Vasodilator Agents
170 rdf:type schema:DefinedTerm
171 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
172 schema:name Medical and Health Sciences
173 rdf:type schema:DefinedTerm
174 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
175 schema:name Cardiorespiratory Medicine and Haematology
176 rdf:type schema:DefinedTerm
177 sg:journal.1106202 schema:issn 1071-3581
178 1532-6551
179 schema:name Journal of Nuclear Cardiology
180 schema:publisher Springer Nature
181 rdf:type schema:Periodical
182 sg:person.010476276272.43 schema:affiliation grid-institutes:grid.26999.3d
183 schema:familyName Inoue
184 schema:givenName Yusuke
185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010476276272.43
186 rdf:type schema:Person
187 sg:person.01152022531.08 schema:affiliation grid-institutes:grid.26999.3d
188 schema:familyName Ohtomo
189 schema:givenName Kuni
190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152022531.08
191 rdf:type schema:Person
192 sg:person.01355412055.69 schema:affiliation grid-institutes:grid.26999.3d
193 schema:familyName Yokoyama
194 schema:givenName Ikuo
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355412055.69
196 rdf:type schema:Person
197 sg:person.0746234355.31 schema:affiliation grid-institutes:grid.26999.3d
198 schema:familyName Yonekura
199 schema:givenName Katsunori
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746234355.31
201 rdf:type schema:Person
202 sg:person.0772176333.38 schema:affiliation grid-institutes:grid.26999.3d
203 schema:familyName Nagai
204 schema:givenName Ryozo
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0772176333.38
206 rdf:type schema:Person
207 grid-institutes:grid.26999.3d schema:alternateName Departments of Cardiovascular Medicine and Radiology, University of Tokyo, Graduate School of Medicine, 7-3-1 Hongo, 113-8655, Bunkyo-ku, Tokyo, Japan
208 schema:name Departments of Cardiovascular Medicine and Radiology, University of Tokyo, Graduate School of Medicine, 7-3-1 Hongo, 113-8655, Bunkyo-ku, Tokyo, Japan
209 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...