Postrevascularization recovery of fatty acid utilization in ischemic myocardium: A randomized clinical trial of potassium channel opener View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2000-07

AUTHORS

Yoichi Kuwabara, Satoshi Watanabe, Jiro Nakaya, Rei Hasegawa, Kouki Matsuno, Toru Kuroda, Yuji Mikami, Kiyotaka Fujii, Akira Miyazaki, Toshihiro Saito, Yoshiaki Masuda

ABSTRACT

BackgroundAbnormal fatty acid metabolism persists in hibernating myocardium, even after reperfusion. This study was designed to determine whether the K+ channel opener, nicorandil, improves fatty acid utilization after percutaneous transluminal coronary angioplasty (PTCA)MethodsPatients undergoing elective PTCA were randomly assigned to treatment (group N, n=26) or control groups (group C, n=22). Group N received intracoronary and intravenous nicorandil during PTCA. Myocardial fatty acid use and perfusion were quantitatively evaluated by means of iodine-123-beta-methyl-p-iodophenyl-pentadecanoic acid single photon emission computed tomography (I-123 BMIPP SPECT) and thallium-201 (TI-201) imaging before PTCA, 72 hours after PTCA, and 3 months after PTCA. Left ventricular function was also evaluated by means of contrast ventriculography before and 3 to 6 months after PTCA.ResultsThe I-123 BMIPP defect score in group N significantly decreased, from 28%±13% to 20%±20% after PTCA and to 18%±17% 3 months later: In contrast, the I-123 BMIPP defect score in group C increased from 28%±20% to 36%±15% (P<.05 versus group N) after PTCA, then returned to 28%±17% (P<.05 versus group N) 3 months after PTCA. Recovery of left ventricular function paralleled the recovery of I-123 BMIPP uptake.ConclusionsNicorandil improves the recovery of myocardial fatty acid utilization and cardiac function after PTCA. KATP channel activation may have a protective effect during coronary artery occlusion and improve subsequent recovery. More... »

PAGES

320-327

Identifiers

URI

http://scigraph.springernature.com/pub.10.1067/mnc.2000.105382

DOI

http://dx.doi.org/10.1067/mnc.2000.105382

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1051231885

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10958273


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37 BackgroundAbnormal fatty acid metabolism
38 ConclusionsNicorandil
39 I-123 BMIPP defect score
40 I-123 BMIPP uptake
41 KATP channel activation
42 Myocardial fatty acid use
43 PTCA
44 acid metabolism
45 acid single photon emission
46 acid use
47 acid utilization
48 activation
49 angioplasty
50 artery occlusion
51 cardiac function
52 channel activation
53 channel openers
54 clinical trials
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60 defect score
61 effect
62 elective PTCA
63 emission
64 fatty acid metabolism
65 fatty acid use
66 fatty acid utilization
67 function
68 group
69 group C
70 group N
71 hours
72 intravenous nicorandil
73 iodine-123-beta-methyl
74 iodophenyl-pentadecanoic acid single photon emission
75 ischemic myocardium
76 left ventricular function
77 means
78 metabolism
79 months
80 myocardial fatty acid utilization
81 myocardium
82 nicorandil
83 occlusion
84 opener
85 percutaneous transluminal coronary angioplasty
86 perfusion
87 photon emission
88 postrevascularization recovery
89 potassium channel openers
90 protective effect
91 randomized clinical trials
92 recovery
93 reperfusion
94 scores
95 single photon emission
96 study
97 subsequent recovery
98 thallium-201
99 tomography
100 transluminal coronary angioplasty
101 treatment
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106 ventricular function
107 ventriculography
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