Acute effect of L‐796568, a novel β3‐adrenergic receptor agonist, on energy expenditure in obese men View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-04

AUTHORS

Marleen A. Baak, Gabby B. J. Hul, Søren Toubro, Arne Astrup, Keith M. Gottesdiener, Marina DeSmet, Wim H. M. Saris

ABSTRACT

OBJECTIVE: Our objective was to investigate the thermogenic efficacy of single oral doses of the novel beta(3)-adrenergic receptor agonist L-796568 [(R )-N -[4-[2-[[2-hydroxy-2-(3-pyridinyl)ethyl]amino]ethyl]-phenyl]-4-[4-[4-(trifluoromethyl)phenyl]thiazol-2-yl]-benzenesulfonamide, dihydrochloride] in humans. METHODS: Twelve healthy overweight to obese men participated in this 2-center, 3-period, randomized, placebo-controlled, crossover trial. In each period subjects received 250 mg L-796568, 1000 mg L-796568, or placebo. Energy expenditure and respiratory quotient were determined by indirect calorimetry; blood samples were taken; and ear temperature, heart rate, and blood pressure were measured at baseline and during the 4-hour period after administration. RESULTS: Energy expenditure increased significantly after the 1000-mg dose (about 8%) and this was accompanied by an increase in plasma glycerol and free fatty acid concentrations. Systolic blood pressure also increased significantly. No changes in heart rate, diastolic blood pressure, ear temperature, plasma catecholamine, potassium, or leptin were found. CONCLUSIONS: Single-dose administration of 1000 mg of the novel beta(3)-adrenergic receptor agonist L-796568 increased lipolysis and energy expenditure in overweight men. This is the first study to show such an effect of beta(3)-adrenergic receptor agonists in humans without significant evidence for beta(2)-adrenergic receptor involvement. More... »

PAGES

272-279

Identifiers

URI

http://scigraph.springernature.com/pub.10.1067/mcp.2002.122527

DOI

http://dx.doi.org/10.1067/mcp.2002.122527

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1020460087

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11956510


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