Stem Cell Concepts View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2013

AUTHORS

Melinda Bonnie Fagan

ABSTRACT

One of the first features of stem cell biology that strikes an outside observer is the sheer variety of stem cells: adult, embryonic, pluripotent, induced, neural, muscle, skin, blood, and so on. What ‘core’ stem cell concept unifies this long (and expanding) list? The straightforward answer is that a stem cell can both self-renew and give rise to other, more differentiated, cells.6 This general definition appears in influential textbooks, journal articles, and statements by scientific organizations. For example: (a) [A] working definition of a stem cell is a clonal, self-renewing entity that is multipotent and thus can generate several differentiated cell types. (b) Stem cells are defined as having the capacity to both self-renew and give rise to differentiated cells. (c) Stem cells are distinguished from other cell types by two important characteristics. First, they are unspecialized cells capable of renewing themselves through cell division, sometimes after long periods of inactivity. Second, under certain physiological or experimental conditions, they can be induced to become tissue-or organ-specific cells with special functions. (d) Stem cell: a cell that can continuously produce unaltered daughters and also has the ability to produce daughter cells that have different, more restricted properties.7 More... »

PAGES

15-47

Book

TITLE

Philosophy of Stem Cell Biology

ISBN

978-1-349-34985-2
978-1-137-29602-3

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1057/9781137296023_2

DOI

http://dx.doi.org/10.1057/9781137296023_2

DIMENSIONS

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