Papillary thyroid carcinoma: 6 cases from 2 families with associated lymphocytic thyroiditis harbouring RET/PTC rearrangements View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2001-12-11

AUTHORS

C Mechler, A Bounacer, H Suarez, M Saint Frison, C Magois, G Aillet, A Gaulier

ABSTRACT

Familial papillary thyroid carcinoma (PTC) is a well recognized disease. However, genetic predisposition to familial PTC is rare and the molecular alterations at the origin of the pathology are unknown. The association between PTC and lymphocytic thyroiditis (LT) has been reported recently. We communicate here 6 cases of PTC associated with LT in 2 unrelated families. PTC was diagnosed on classical nuclear and architectural criteria. It was bilateral in 5 cases. Architecture was equally distributed between typical PTC and its follicular variant. LT was present in variable degrees, including in 4 cases, oncocytic metaplasia. Using the RT-PCR technique, we observed a RET/PTC rearrangement in the carcinomatous areas of patients of both families: PTC1 in family 1 and PTC3 in family 2 and a RET/PTC rearrangement in non-malignant thyroid tissue with LT in family 2. The RET/PTC band was weaker or absent in pure LT areas. Furthermore, using a polyclonal ret antibody, an apical or a diffuse cytoplasmic ret onc protein immunolabelling was observed in the three patients with RET/PTC1 rearrangement and in the three patients with RET/PTC3 rearrangement. In conclusion our data: (1) show the presence of a RET/PTC 1 or 3 rearrangement (depending on the family) together with a variable expression of ret protein in all the PTCs; (2) suggest that the molecular event at the origin of the PTCs seems to be particular to each one of the studied families; and (3) confirm that the ret proto-oncogene activating rearrangement(s) is an early event in the thyroid tumorigenic process and that it can be observed in association with LT. © 2001 Cancer Research Campaign http://www.bjcancer.com More... »

PAGES

1831-1837

Identifiers

URI

http://scigraph.springernature.com/pub.10.1054/bjoc.2001.2187

DOI

http://dx.doi.org/10.1054/bjoc.2001.2187

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1023058351

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11747322


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43 schema:description Familial papillary thyroid carcinoma (PTC) is a well recognized disease. However, genetic predisposition to familial PTC is rare and the molecular alterations at the origin of the pathology are unknown. The association between PTC and lymphocytic thyroiditis (LT) has been reported recently. We communicate here 6 cases of PTC associated with LT in 2 unrelated families. PTC was diagnosed on classical nuclear and architectural criteria. It was bilateral in 5 cases. Architecture was equally distributed between typical PTC and its follicular variant. LT was present in variable degrees, including in 4 cases, oncocytic metaplasia. Using the RT-PCR technique, we observed a RET/PTC rearrangement in the carcinomatous areas of patients of both families: PTC1 in family 1 and PTC3 in family 2 and a RET/PTC rearrangement in non-malignant thyroid tissue with LT in family 2. The RET/PTC band was weaker or absent in pure LT areas. Furthermore, using a polyclonal ret antibody, an apical or a diffuse cytoplasmic ret onc protein immunolabelling was observed in the three patients with RET/PTC1 rearrangement and in the three patients with RET/PTC3 rearrangement. In conclusion our data: (1) show the presence of a RET/PTC 1 or 3 rearrangement (depending on the family) together with a variable expression of ret protein in all the PTCs; (2) suggest that the molecular event at the origin of the PTCs seems to be particular to each one of the studied families; and (3) confirm that the ret proto-oncogene activating rearrangement(s) is an early event in the thyroid tumorigenic process and that it can be observed in association with LT. © 2001 Cancer Research Campaign http://www.bjcancer.com
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51 PTC 1
52 PTC1
53 PTC3
54 RET antibodies
55 RET protein
56 RET proto-oncogene
57 RET/PTC 1
58 RET/PTC rearrangements
59 RET/PTC1 rearrangement
60 RET/PTC3 rearrangements
61 RT-PCR technique
62 alterations
63 antibodies
64 architectural criteria
65 architecture
66 area
67 association
68 band
69 carcinoma
70 carcinomatous areas
71 cases
72 cases of PTC
73 conclusion
74 criteria
75 data
76 degree
77 disease
78 early events
79 events
80 expression
81 familial papillary thyroid carcinoma
82 family
83 family 1
84 family 2
85 follicular variant
86 genetic predisposition
87 immunolabelling
88 lymphocytic thyroiditis
89 metaplasia
90 molecular alterations
91 molecular events
92 non-malignant thyroid tissues
93 oncocytic metaplasia
94 origin
95 papillary thyroid carcinoma
96 pathology
97 patients
98 predisposition
99 presence
100 process
101 protein
102 proto-oncogene
103 rearrangement
104 technique
105 thyroid carcinoma
106 thyroid tissue
107 thyroiditis
108 tissue
109 tumorigenic process
110 typical papillary thyroid carcinoma
111 unrelated families
112 variable degrees
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114 variants
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