Papillary thyroid carcinoma: 6 cases from 2 families with associated lymphocytic thyroiditis harbouring RET/PTC rearrangements View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2001-12-11

AUTHORS

C Mechler, A Bounacer, H Suarez, M Saint Frison, C Magois, G Aillet, A Gaulier

ABSTRACT

Familial papillary thyroid carcinoma (PTC) is a well recognized disease. However, genetic predisposition to familial PTC is rare and the molecular alterations at the origin of the pathology are unknown. The association between PTC and lymphocytic thyroiditis (LT) has been reported recently. We communicate here 6 cases of PTC associated with LT in 2 unrelated families. PTC was diagnosed on classical nuclear and architectural criteria. It was bilateral in 5 cases. Architecture was equally distributed between typical PTC and its follicular variant. LT was present in variable degrees, including in 4 cases, oncocytic metaplasia. Using the RT-PCR technique, we observed a RET/PTC rearrangement in the carcinomatous areas of patients of both families: PTC1 in family 1 and PTC3 in family 2 and a RET/PTC rearrangement in non-malignant thyroid tissue with LT in family 2. The RET/PTC band was weaker or absent in pure LT areas. Furthermore, using a polyclonal ret antibody, an apical or a diffuse cytoplasmic ret onc protein immunolabelling was observed in the three patients with RET/PTC1 rearrangement and in the three patients with RET/PTC3 rearrangement. In conclusion our data: (1) show the presence of a RET/PTC 1 or 3 rearrangement (depending on the family) together with a variable expression of ret protein in all the PTCs; (2) suggest that the molecular event at the origin of the PTCs seems to be particular to each one of the studied families; and (3) confirm that the ret proto-oncogene activating rearrangement(s) is an early event in the thyroid tumorigenic process and that it can be observed in association with LT. More... »

PAGES

1831-1837

Identifiers

URI

http://scigraph.springernature.com/pub.10.1054/bjoc.2001.2187

DOI

http://dx.doi.org/10.1054/bjoc.2001.2187

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1023058351

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11747322


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42 schema:description Familial papillary thyroid carcinoma (PTC) is a well recognized disease. However, genetic predisposition to familial PTC is rare and the molecular alterations at the origin of the pathology are unknown. The association between PTC and lymphocytic thyroiditis (LT) has been reported recently. We communicate here 6 cases of PTC associated with LT in 2 unrelated families. PTC was diagnosed on classical nuclear and architectural criteria. It was bilateral in 5 cases. Architecture was equally distributed between typical PTC and its follicular variant. LT was present in variable degrees, including in 4 cases, oncocytic metaplasia. Using the RT-PCR technique, we observed a RET/PTC rearrangement in the carcinomatous areas of patients of both families: PTC1 in family 1 and PTC3 in family 2 and a RET/PTC rearrangement in non-malignant thyroid tissue with LT in family 2. The RET/PTC band was weaker or absent in pure LT areas. Furthermore, using a polyclonal ret antibody, an apical or a diffuse cytoplasmic ret onc protein immunolabelling was observed in the three patients with RET/PTC1 rearrangement and in the three patients with RET/PTC3 rearrangement. In conclusion our data: (1) show the presence of a RET/PTC 1 or 3 rearrangement (depending on the family) together with a variable expression of ret protein in all the PTCs; (2) suggest that the molecular event at the origin of the PTCs seems to be particular to each one of the studied families; and (3) confirm that the ret proto-oncogene activating rearrangement(s) is an early event in the thyroid tumorigenic process and that it can be observed in association with LT.
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50 PTC 1
51 PTC band
52 PTC rearrangement
53 PTC1
54 PTC1 rearrangement
55 PTC3
56 PTC3 rearrangement
57 RET antibodies
58 RET protein
59 RET proto-oncogene
60 RET/PTC 1
61 RET/PTC band
62 RET/PTC rearrangements
63 RET/PTC1 rearrangement
64 RET/PTC3 rearrangements
65 RT-PCR technique
66 alterations
67 antibodies
68 architectural criteria
69 architecture
70 area
71 association
72 band
73 carcinoma
74 carcinomatous areas
75 cases
76 cases of PTC
77 conclusion
78 criteria
79 cytoplasmic ret onc protein immunolabelling
80 data
81 degree
82 diffuse cytoplasmic ret onc protein immunolabelling
83 disease
84 early events
85 events
86 expression
87 familial papillary thyroid carcinoma
88 family
89 family 1
90 family 2
91 follicular variant
92 genetic predisposition
93 immunolabelling
94 lymphocytic thyroiditis
95 metaplasia
96 molecular alterations
97 molecular events
98 non-malignant thyroid tissues
99 onc protein immunolabelling
100 oncocytic metaplasia
101 origin
102 papillary thyroid carcinoma
103 pathology
104 patients
105 polyclonal ret antibody
106 predisposition
107 presence
108 process
109 protein
110 protein immunolabelling
111 proto-oncogene
112 pure LT areas
113 rearrangement
114 ret onc protein immunolabelling
115 technique
116 thyroid carcinoma
117 thyroid tissue
118 thyroid tumorigenic process
119 thyroiditis
120 tissue
121 tumorigenic process
122 typical papillary thyroid carcinoma
123 unrelated families
124 variable degrees
125 variable expression
126 variants
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