E-cadherin as a prognostic indicator in primary breast cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2001-12

AUTHORS

C Parker, R S Rampaul, S E Pinder, J A Bell, P M Wencyk, R W Blamey, R I Nicholson, J F R Robertson, I O Ellis

ABSTRACT

Epithelial cadherin (E-CD) is a member of the cadherin family of cell adhesion molecules and has been implicated as an invasion suppressor molecule in vitro and in vivo. We analysed 174 breast tumours from the Nottingham/Tenovus Breast Cancer Series immunohistochemically for E-CD expression using the mouse monoclonal antibody HECD-1 (Zymed Laboratories Inc.). In normal epithelial cells E-CD was strongly expressed at cell-cell boundaries. 66% of the breast cancers examined had reduced intensity of E-CD expression with 74% having significant reductions in the proportion of E-CD-positive tumour cells. Using a combined intensity/proportion score, significant associations were found between E-CD expression and tumour type (P More... »

PAGES

1958-1963

Identifiers

URI

http://scigraph.springernature.com/pub.10.1054/bjoc.2001.2178

DOI

http://dx.doi.org/10.1054/bjoc.2001.2178

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1010002856

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11747340


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