Ontology type: schema:ScholarlyArticle Open Access: True
2001-12
AUTHORSC Parker, R S Rampaul, S E Pinder, J A Bell, P M Wencyk, R W Blamey, R I Nicholson, J F R Robertson, I O Ellis
ABSTRACTEpithelial cadherin (E-CD) is a member of the cadherin family of cell adhesion molecules and has been implicated as an invasion suppressor molecule in vitro and in vivo. We analysed 174 breast tumours from the Nottingham/Tenovus Breast Cancer Series immunohistochemically for E-CD expression using the mouse monoclonal antibody HECD-1 (Zymed Laboratories Inc.). In normal epithelial cells E-CD was strongly expressed at cell-cell boundaries. 66% of the breast cancers examined had reduced intensity of E-CD expression with 74% having significant reductions in the proportion of E-CD-positive tumour cells. Using a combined intensity/proportion score, significant associations were found between E-CD expression and tumour type (P More... »
PAGES1958-1963
http://scigraph.springernature.com/pub.10.1054/bjoc.2001.2178
DOIhttp://dx.doi.org/10.1054/bjoc.2001.2178
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1010002856
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/11747340
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