A phase II study of temozolomide vs. procarbazine in patients with glioblastoma multiforme at first relapse View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2000-08-16

AUTHORS

W K A Yung, R E Albright, J Olson, R Fredericks, K Fink, M D Prados, M Brada, A Spence, R J Hohl, W Shapiro, M Glantz, H Greenberg, R G Selker, N A Vick, R Rampling, H Friedman, P Phillips, J Bruner, N Yue, D Osoba, S Zaknoen, V A Levin

ABSTRACT

A randomized, multicentre, open-label, phase II study compared temozolomide (TMZ), an oral second-generation alkylating agent, and procarbazine (PCB) in 225 patients with glioblastoma multiforme at first relapse. Primary objectives were to determine progression-free survival (PFS) at 6 months and safety for TMZ and PCB in adult patients who failed conventional treatment. Secondary objectives were to assess overall survival and health-related quality of life (HRQL). TMZ was given orally at 200 mg/m(2)/day or 150 mg/m(2)/day (prior chemotherapy) for 5 days, repeated every 28 days. PCB was given orally at 150 mg/m(2)/day or 125 mg/m(2)/day (prior chemotherapy) for 28 days, repeated every 56 days. HRQL was assessed using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30 [+3]) and the Brain Cancer Module 20 (BCM20). The 6-month PFS rate for patients who received TMZ was 21%, which met the protocol objective. The 6-month PFS rate for those who received PCB was 8% (P = 0.008, for the comparison). Overall PFS significantly improved with TMZ, with a median PFS of 12.4 weeks in the TMZ group and 8.32 weeks in the PCB group (P = 0.0063). The 6-month overall survival rate for TMZ patients was 60% vs. 44% for PCB patients (P = 0.019). Freedom from disease progression was associated with maintenance of HRQL, regardless of treatment received. TMZ had an acceptable safety profile; most adverse events were mild or moderate in severity. More... »

PAGES

588-593

Journal

TITLE

British Journal of Cancer

ISSUE

5

VOLUME

83

Author Affiliations

  • Department of Neuro-Oncology, UTMD Anderson Cancer Center, Box 100, 1515 Holcombe Boulevard, Houston, Texas, 77030
  • Barret Cancer Center, 234 Goodman Street, Cincinnati, Ohio, 45267
  • Department of Neurosurgery, Emory University, 1327 Clifton Road, Atlanta, Georgia, 30322
  • University of Mississippi Medical Center, 2500 North State Street, Jackson, Mississippi, 39216
  • Department of Neurology, University of Texas, Southwestern Medical School, 5323 Harry Hines Boulevard, Dallas, Texas, 75235
  • Department of Neurosurgery, University of California San Francisco, 533 Parnassus Street, Room U107, San Francisco, CaliCityfornia, 94143
  • The Royal Marsden NHS Trust and the Institute of Cancer Research, Royal Marsden Hospital, Downs Road, Sutton, Surrey, SM2 5PT, United Kingdom
  • Department of Neurology, University of Washington, Box 356465, 1959 N.E. Pacific Street, Seattle, Washington, 98195
  • University of Iowa, Hospitals and Clinics, 200 Hawkins Drive, Iowa City, Iowa, 52242
  • Division of Neurology, Barrow Neurological Institute, 350 West Thomas Road, Phoenix, Arizona, 85013
  • Memorial Hospital of Rhode Island, 710 Robinson Road, PO Box 665, Hinsdale, Massachusetts, 01235
  • Department of Neurology, University of Michigan Medical Center, 1500 East Medical Center Drive, 1914 Taubman Center, Box 0316, Ann Arbor, Michigan, 48109
  • West Penn Hospital, Center for Neuro-Oncology, 4800 Friendship Avenue – Suite 1614, Pittsburgh, Pennsylvania, 15224
  • Division of Neurology, Evanston Hospital, 2650 Ridge Avenue, Evanston, Illinois, 60201
  • Beatson Oncology Centre, Western Infirmary, Glasgow, G11 6NT, United Kingdom
  • Department of Pediatric Hematology-Oncology, Duke University Medical Center, Duke North – Room 5418, Erwin Road, Durham, North Carolina, 27710
  • Department of Neuroscience, University of Pennsylvania Medical Center, Abramson 516, 3400 Civic Center Boulevard, Philadelphia, Pennsylvania, 19104
  • MRI Reading Center at St. Joseph, 8216 Carrbridge Circle, Baltimore, Maryland, 21204
  • British Columbia Cancer Agency, 1515 Larch Street, Vancouver, British Columbia, V6K 3N6, Canada
  • Schering-Plough Research Institute, 2000 Galloping Hill Road, Kenilworth, New Jersey, 07033, USA
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1054/bjoc.2000.1316

    DOI

    http://dx.doi.org/10.1054/bjoc.2000.1316

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1045826895

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/10944597


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