Hypertension increases expression of growth factors and MHC II in chronic allograft nephropathy View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2003-06

AUTHORS

Ralf Schindler, Stefan G Tullius, Yakup Tanriver, Kerstin Noack, Ye Qun, Jan-Steffen Jürgensen, Ulrich Frei

ABSTRACT

BACKGROUND: Hypertension of the recipient is strongly associated with chronic allograft nephropathy. It is unclear, however, whether hypertension is the cause or the consequence of chronic allograft nephropathy. METHODS: The present study was performed in the Fisher to Lewis rat kidney transplant model. Transplanted rats (N = eight in each group) received either no treatment or were made hypertensive by administration of deoxycorticosteron acetate (DOCA) and salt. Proteinuria and systolic blood pressure was measured monthly, grafts were harvested at 3 and 6 months for semiquantitative reverse transcription-polymerase chain reaction (RT-PCR) and for immunohistology. RESULTS: Systolic blood pressure was markedly elevated in rats receiving DOCA/salt. Allografts of hypertensive animals contained significantly more cells expressing the proliferating cell nuclear antigen compared to isografts and to allografts from normotensive animals (P < 0.05). Histologic staining and mRNA expression of major histocompatibility complex (MHC) II was markedly increased in allografts of hypertensive animals compared to all other groups (P < 0.05). Expression of mRNA for platelet-derived growth factor-B (PDGF-B), transforming growth factor-beta (TGF-beta) and collagen was higher in allografts than in isografts and was highest in hypertensive animals. CONCLUSION: We conclude that hypertension augments the expression of growth factors in the allograft possibly aggravating the intimal hyperplasia observed in chronic allograft nephropathy. By increasing the expression of MHC II antigens, hypertension may render the allograft more susceptible to alloantigen-dependent damage. Hypertension and alloantigen-dependent factors appear to exert additive or synergistic effects on inflammatory pathways leading to graft injury. More... »

PAGES

2302-2308

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1046/j.1523-1755.2003.00034.x

DOI

http://dx.doi.org/10.1046/j.1523-1755.2003.00034.x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1032721105

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12753322


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blood Pressure", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chronic Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Desoxycorticosterone", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Graft Rejection", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Histocompatibility Antigens Class II", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hypertension, Renal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kidney Transplantation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins c-sis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Messenger", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats, Inbred F344", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats, Inbred Lew", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transforming Growth Factor beta", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transplantation, Homologous", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Humboldt University of Berlin", 
          "id": "https://www.grid.ac/institutes/grid.7468.d", 
          "name": [
            "Department of Nephrology and Internal Intensive Care Medicine, Universit\u00e4tsklinikum Charit\u00e9, Campus Virchow Klinikum, Humboldt University, Berlin, Germany. ralf.schindler@charite.de"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schindler", 
        "givenName": "Ralf", 
        "id": "sg:person.01304311142.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304311142.41"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Tullius", 
        "givenName": "Stefan G", 
        "id": "sg:person.014774275474.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014774275474.25"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Tanriver", 
        "givenName": "Yakup", 
        "id": "sg:person.01032172522.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032172522.28"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Noack", 
        "givenName": "Kerstin", 
        "type": "Person"
      }, 
      {
        "familyName": "Qun", 
        "givenName": "Ye", 
        "id": "sg:person.01113760030.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01113760030.12"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "J\u00fcrgensen", 
        "givenName": "Jan-Steffen", 
        "id": "sg:person.0642540725.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642540725.57"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Frei", 
        "givenName": "Ulrich", 
        "id": "sg:person.01015577773.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015577773.54"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1172/jci117762", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002610062"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.103.2.319", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002797115"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/hy0202.103481", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005825904"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.hyp.17.6.888", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005878445"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/713803545", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007763216"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/13.7.2485", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008134818"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1046/j.1523-1755.2001.0590031158.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011292929", 
          "https://doi.org/10.1046/j.1523-1755.2001.0590031158.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.283.5.633", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013400216"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0934-8832(11)80006-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015513188"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1046/j.1523-1755.1998.00138.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020120254", 
          "https://doi.org/10.1046/j.1523-1755.1998.00138.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00002480-198907000-00036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020176376"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00002480-198907000-00036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020176376"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00002480-198907000-00036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020176376"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1982.163", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022459808", 
          "https://doi.org/10.1038/ki.1982.163"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1385/1-59259-192-2:365", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023668922", 
          "https://doi.org/10.1385/1-59259-192-2:365"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/excr.1994.1171", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026487051"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1046/j.1523-1755.2000.00926.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029377431", 
          "https://doi.org/10.1046/j.1523-1755.2000.00926.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199407150-00016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029986649"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199407150-00016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029986649"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00176166", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031960437", 
          "https://doi.org/10.1007/bf00176166"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199309000-00028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032170234"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199309000-00028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032170234"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199108000-00011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036056555"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199108000-00011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036056555"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1046/j.1523-1755.2000.00122.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036789907", 
          "https://doi.org/10.1046/j.1523-1755.2000.00122.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-200107150-00009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039415836"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-200107150-00009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039415836"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0076-6879(84)08118-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039486269"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1046/j.1523-1755.1998.00744.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040330932", 
          "https://doi.org/10.1046/j.1523-1755.1998.00744.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1992.42", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043105617", 
          "https://doi.org/10.1038/ki.1992.42"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0167-4781(93)90127-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044972369"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0167-4781(93)90127-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044972369"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/18.10.3059", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046704609"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(99)08421-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050041349"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199304000-00013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050067811"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199304000-00013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050067811"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199612150-00018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060276289"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199612150-00018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060276289"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199612150-00018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060276289"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199806270-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060278154"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199806270-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060278154"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199806270-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060278154"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.274.5289.985", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062554761"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074544770", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076115369", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ajh/2.5.341", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079178209"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ndt/10.7.1206", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082377612"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/oxfordjournals.ndt.a090861", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082480345"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082867182", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082944650", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083187103", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083237015", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2003-06", 
    "datePublishedReg": "2003-06-01", 
    "description": "BACKGROUND: Hypertension of the recipient is strongly associated with chronic allograft nephropathy. It is unclear, however, whether hypertension is the cause or the consequence of chronic allograft nephropathy.\nMETHODS: The present study was performed in the Fisher to Lewis rat kidney transplant model. Transplanted rats (N = eight in each group) received either no treatment or were made hypertensive by administration of deoxycorticosteron acetate (DOCA) and salt. Proteinuria and systolic blood pressure was measured monthly, grafts were harvested at 3 and 6 months for semiquantitative reverse transcription-polymerase chain reaction (RT-PCR) and for immunohistology.\nRESULTS: Systolic blood pressure was markedly elevated in rats receiving DOCA/salt. Allografts of hypertensive animals contained significantly more cells expressing the proliferating cell nuclear antigen compared to isografts and to allografts from normotensive animals (P < 0.05). Histologic staining and mRNA expression of major histocompatibility complex (MHC) II was markedly increased in allografts of hypertensive animals compared to all other groups (P < 0.05). Expression of mRNA for platelet-derived growth factor-B (PDGF-B), transforming growth factor-beta (TGF-beta) and collagen was higher in allografts than in isografts and was highest in hypertensive animals.\nCONCLUSION: We conclude that hypertension augments the expression of growth factors in the allograft possibly aggravating the intimal hyperplasia observed in chronic allograft nephropathy. By increasing the expression of MHC II antigens, hypertension may render the allograft more susceptible to alloantigen-dependent damage. Hypertension and alloantigen-dependent factors appear to exert additive or synergistic effects on inflammatory pathways leading to graft injury.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1046/j.1523-1755.2003.00034.x", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1015319", 
        "issn": [
          "0085-2538", 
          "1523-1755"
        ], 
        "name": "Kidney International", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "63"
      }
    ], 
    "name": "Hypertension increases expression of growth factors and MHC II in chronic allograft nephropathy", 
    "pagination": "2302-2308", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "9be141bb862cc8b576810d2916402d5f821a780da582d6c8bd9b10ebc200c7ac"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "12753322"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0323470"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1046/j.1523-1755.2003.00034.x"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1032721105"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1046/j.1523-1755.2003.00034.x", 
      "https://app.dimensions.ai/details/publication/pub.1032721105"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T00:55", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8697_00000425.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/ki/journal/v63/n6/full/4493705a.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1046/j.1523-1755.2003.00034.x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1046/j.1523-1755.2003.00034.x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1046/j.1523-1755.2003.00034.x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1046/j.1523-1755.2003.00034.x'


 

This table displays all metadata directly associated to this object as RDF triples.

295 TRIPLES      21 PREDICATES      86 URIs      38 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1046/j.1523-1755.2003.00034.x schema:about N1fb99b80efc54137974ce7ce38474190
2 N36799e6c73d44bf38588c8c0128a7d66
3 N3833cb48bcfb4a29b0dd9c5dadd3bb18
4 N3b41580a86b848148c33fac721cf4e74
5 N429a83d46d81438c98800291752bd7f0
6 N44f4198875944ef3b3fdb45a517a5f3c
7 N467c603d2b634e21910d23fcf44a5937
8 N48915af4dc6c4227b8ad867f83597ce2
9 N800014c1da1b4db689f02dd3e792ff52
10 N864a8575148249f6b8f2c552f37532f7
11 N91a3c163a158493abae7c7a12e05bbca
12 Nad93051c88ed49e0b43481519b1bf761
13 Naf9a4c2fe86344679d190ace637edb8e
14 Nc3efcd6e7a0e4a108daf64a7224c1103
15 Nc661b9b8d3e3438e98bff7b5a1c3c5ed
16 Ncb80441a62d642d0966392d59d90bed2
17 Ndf8cef50f9de49bea7325e319120f2ac
18 anzsrc-for:11
19 anzsrc-for:1103
20 schema:author Nec2dd91caecc4648bee04583de8fe1e0
21 schema:citation sg:pub.10.1007/bf00176166
22 sg:pub.10.1038/ki.1982.163
23 sg:pub.10.1038/ki.1992.42
24 sg:pub.10.1046/j.1523-1755.1998.00138.x
25 sg:pub.10.1046/j.1523-1755.1998.00744.x
26 sg:pub.10.1046/j.1523-1755.2000.00122.x
27 sg:pub.10.1046/j.1523-1755.2000.00926.x
28 sg:pub.10.1046/j.1523-1755.2001.0590031158.x
29 sg:pub.10.1385/1-59259-192-2:365
30 https://app.dimensions.ai/details/publication/pub.1074544770
31 https://app.dimensions.ai/details/publication/pub.1076115369
32 https://app.dimensions.ai/details/publication/pub.1082867182
33 https://app.dimensions.ai/details/publication/pub.1082944650
34 https://app.dimensions.ai/details/publication/pub.1083187103
35 https://app.dimensions.ai/details/publication/pub.1083237015
36 https://doi.org/10.1001/jama.283.5.633
37 https://doi.org/10.1006/excr.1994.1171
38 https://doi.org/10.1016/0167-4781(93)90127-y
39 https://doi.org/10.1016/s0076-6879(84)08118-0
40 https://doi.org/10.1016/s0140-6736(99)08421-4
41 https://doi.org/10.1016/s0934-8832(11)80006-5
42 https://doi.org/10.1080/713803545
43 https://doi.org/10.1093/ajh/2.5.341
44 https://doi.org/10.1093/nar/13.7.2485
45 https://doi.org/10.1093/nar/18.10.3059
46 https://doi.org/10.1093/ndt/10.7.1206
47 https://doi.org/10.1093/oxfordjournals.ndt.a090861
48 https://doi.org/10.1097/00002480-198907000-00036
49 https://doi.org/10.1097/00007890-199108000-00011
50 https://doi.org/10.1097/00007890-199304000-00013
51 https://doi.org/10.1097/00007890-199309000-00028
52 https://doi.org/10.1097/00007890-199407150-00016
53 https://doi.org/10.1097/00007890-199612150-00018
54 https://doi.org/10.1097/00007890-199806270-00001
55 https://doi.org/10.1097/00007890-200107150-00009
56 https://doi.org/10.1126/science.274.5289.985
57 https://doi.org/10.1161/01.cir.103.2.319
58 https://doi.org/10.1161/01.hyp.17.6.888
59 https://doi.org/10.1161/hy0202.103481
60 https://doi.org/10.1172/jci117762
61 schema:datePublished 2003-06
62 schema:datePublishedReg 2003-06-01
63 schema:description BACKGROUND: Hypertension of the recipient is strongly associated with chronic allograft nephropathy. It is unclear, however, whether hypertension is the cause or the consequence of chronic allograft nephropathy. METHODS: The present study was performed in the Fisher to Lewis rat kidney transplant model. Transplanted rats (N = eight in each group) received either no treatment or were made hypertensive by administration of deoxycorticosteron acetate (DOCA) and salt. Proteinuria and systolic blood pressure was measured monthly, grafts were harvested at 3 and 6 months for semiquantitative reverse transcription-polymerase chain reaction (RT-PCR) and for immunohistology. RESULTS: Systolic blood pressure was markedly elevated in rats receiving DOCA/salt. Allografts of hypertensive animals contained significantly more cells expressing the proliferating cell nuclear antigen compared to isografts and to allografts from normotensive animals (P < 0.05). Histologic staining and mRNA expression of major histocompatibility complex (MHC) II was markedly increased in allografts of hypertensive animals compared to all other groups (P < 0.05). Expression of mRNA for platelet-derived growth factor-B (PDGF-B), transforming growth factor-beta (TGF-beta) and collagen was higher in allografts than in isografts and was highest in hypertensive animals. CONCLUSION: We conclude that hypertension augments the expression of growth factors in the allograft possibly aggravating the intimal hyperplasia observed in chronic allograft nephropathy. By increasing the expression of MHC II antigens, hypertension may render the allograft more susceptible to alloantigen-dependent damage. Hypertension and alloantigen-dependent factors appear to exert additive or synergistic effects on inflammatory pathways leading to graft injury.
64 schema:genre research_article
65 schema:inLanguage en
66 schema:isAccessibleForFree true
67 schema:isPartOf N21a7ce2a39fc482eba2cb2d3d834a09b
68 Nd143b63fbb204a0bbe2a0c70cdce0e91
69 sg:journal.1015319
70 schema:name Hypertension increases expression of growth factors and MHC II in chronic allograft nephropathy
71 schema:pagination 2302-2308
72 schema:productId N885469ba515743b0bed0539558e8c1f1
73 Na9fb5765c4f14bdaaac4315c24e40e1f
74 Nc5d824309c994fa88588b5808112d87c
75 Ncc3e8577246943139204b67db8d64663
76 Necd45693b83d448e84a9bcdafdeee7f6
77 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032721105
78 https://doi.org/10.1046/j.1523-1755.2003.00034.x
79 schema:sdDatePublished 2019-04-11T00:55
80 schema:sdLicense https://scigraph.springernature.com/explorer/license/
81 schema:sdPublisher N9dbc139877de483a98dad66e90b8423e
82 schema:url http://www.nature.com/ki/journal/v63/n6/full/4493705a.html
83 sgo:license sg:explorer/license/
84 sgo:sdDataset articles
85 rdf:type schema:ScholarlyArticle
86 N1fb99b80efc54137974ce7ce38474190 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Gene Expression
88 rdf:type schema:DefinedTerm
89 N21a7ce2a39fc482eba2cb2d3d834a09b schema:issueNumber 6
90 rdf:type schema:PublicationIssue
91 N36799e6c73d44bf38588c8c0128a7d66 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Rats, Inbred F344
93 rdf:type schema:DefinedTerm
94 N3833cb48bcfb4a29b0dd9c5dadd3bb18 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Graft Rejection
96 rdf:type schema:DefinedTerm
97 N3b41580a86b848148c33fac721cf4e74 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Male
99 rdf:type schema:DefinedTerm
100 N429a83d46d81438c98800291752bd7f0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Kidney Transplantation
102 rdf:type schema:DefinedTerm
103 N44f4198875944ef3b3fdb45a517a5f3c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Histocompatibility Antigens Class II
105 rdf:type schema:DefinedTerm
106 N467c603d2b634e21910d23fcf44a5937 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Proto-Oncogene Proteins c-sis
108 rdf:type schema:DefinedTerm
109 N48915af4dc6c4227b8ad867f83597ce2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Rats
111 rdf:type schema:DefinedTerm
112 N6497c1ecedf04816bf1ac51a6c8b6434 rdf:first sg:person.01015577773.54
113 rdf:rest rdf:nil
114 N800014c1da1b4db689f02dd3e792ff52 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Transforming Growth Factor beta
116 rdf:type schema:DefinedTerm
117 N8157afcd59c64f089644324f0ca79ea6 rdf:first sg:person.01113760030.12
118 rdf:rest Nbd582fd9a2cb414eb8ac338358ac5e1d
119 N864a8575148249f6b8f2c552f37532f7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Transplantation, Homologous
121 rdf:type schema:DefinedTerm
122 N885469ba515743b0bed0539558e8c1f1 schema:name dimensions_id
123 schema:value pub.1032721105
124 rdf:type schema:PropertyValue
125 N91a3c163a158493abae7c7a12e05bbca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Hypertension, Renal
127 rdf:type schema:DefinedTerm
128 N93ae70e97a6d431f9ca3876e8ef4fe4a schema:familyName Noack
129 schema:givenName Kerstin
130 rdf:type schema:Person
131 N9dbc139877de483a98dad66e90b8423e schema:name Springer Nature - SN SciGraph project
132 rdf:type schema:Organization
133 Na471ef5d2b9b4d0c9e064fd3d21f5d2c rdf:first N93ae70e97a6d431f9ca3876e8ef4fe4a
134 rdf:rest N8157afcd59c64f089644324f0ca79ea6
135 Na9fb5765c4f14bdaaac4315c24e40e1f schema:name readcube_id
136 schema:value 9be141bb862cc8b576810d2916402d5f821a780da582d6c8bd9b10ebc200c7ac
137 rdf:type schema:PropertyValue
138 Nad93051c88ed49e0b43481519b1bf761 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Animals
140 rdf:type schema:DefinedTerm
141 Naf9a4c2fe86344679d190ace637edb8e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Rats, Inbred Lew
143 rdf:type schema:DefinedTerm
144 Nbd582fd9a2cb414eb8ac338358ac5e1d rdf:first sg:person.0642540725.57
145 rdf:rest N6497c1ecedf04816bf1ac51a6c8b6434
146 Nc3efcd6e7a0e4a108daf64a7224c1103 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Chronic Disease
148 rdf:type schema:DefinedTerm
149 Nc5d824309c994fa88588b5808112d87c schema:name nlm_unique_id
150 schema:value 0323470
151 rdf:type schema:PropertyValue
152 Nc661b9b8d3e3438e98bff7b5a1c3c5ed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Desoxycorticosterone
154 rdf:type schema:DefinedTerm
155 Ncb80441a62d642d0966392d59d90bed2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name RNA, Messenger
157 rdf:type schema:DefinedTerm
158 Ncc3e8577246943139204b67db8d64663 schema:name pubmed_id
159 schema:value 12753322
160 rdf:type schema:PropertyValue
161 Nd143b63fbb204a0bbe2a0c70cdce0e91 schema:volumeNumber 63
162 rdf:type schema:PublicationVolume
163 Ndf8cef50f9de49bea7325e319120f2ac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Blood Pressure
165 rdf:type schema:DefinedTerm
166 Ne41571a20ea449b7b43e373a48e63370 rdf:first sg:person.01032172522.28
167 rdf:rest Na471ef5d2b9b4d0c9e064fd3d21f5d2c
168 Ne77fb4d7ef834bf69fbcca88a799d76c rdf:first sg:person.014774275474.25
169 rdf:rest Ne41571a20ea449b7b43e373a48e63370
170 Nec2dd91caecc4648bee04583de8fe1e0 rdf:first sg:person.01304311142.41
171 rdf:rest Ne77fb4d7ef834bf69fbcca88a799d76c
172 Necd45693b83d448e84a9bcdafdeee7f6 schema:name doi
173 schema:value 10.1046/j.1523-1755.2003.00034.x
174 rdf:type schema:PropertyValue
175 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
176 schema:name Medical and Health Sciences
177 rdf:type schema:DefinedTerm
178 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
179 schema:name Clinical Sciences
180 rdf:type schema:DefinedTerm
181 sg:journal.1015319 schema:issn 0085-2538
182 1523-1755
183 schema:name Kidney International
184 rdf:type schema:Periodical
185 sg:person.01015577773.54 schema:familyName Frei
186 schema:givenName Ulrich
187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015577773.54
188 rdf:type schema:Person
189 sg:person.01032172522.28 schema:familyName Tanriver
190 schema:givenName Yakup
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032172522.28
192 rdf:type schema:Person
193 sg:person.01113760030.12 schema:familyName Qun
194 schema:givenName Ye
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01113760030.12
196 rdf:type schema:Person
197 sg:person.01304311142.41 schema:affiliation https://www.grid.ac/institutes/grid.7468.d
198 schema:familyName Schindler
199 schema:givenName Ralf
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304311142.41
201 rdf:type schema:Person
202 sg:person.014774275474.25 schema:familyName Tullius
203 schema:givenName Stefan G
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014774275474.25
205 rdf:type schema:Person
206 sg:person.0642540725.57 schema:familyName Jürgensen
207 schema:givenName Jan-Steffen
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642540725.57
209 rdf:type schema:Person
210 sg:pub.10.1007/bf00176166 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031960437
211 https://doi.org/10.1007/bf00176166
212 rdf:type schema:CreativeWork
213 sg:pub.10.1038/ki.1982.163 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022459808
214 https://doi.org/10.1038/ki.1982.163
215 rdf:type schema:CreativeWork
216 sg:pub.10.1038/ki.1992.42 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043105617
217 https://doi.org/10.1038/ki.1992.42
218 rdf:type schema:CreativeWork
219 sg:pub.10.1046/j.1523-1755.1998.00138.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1020120254
220 https://doi.org/10.1046/j.1523-1755.1998.00138.x
221 rdf:type schema:CreativeWork
222 sg:pub.10.1046/j.1523-1755.1998.00744.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1040330932
223 https://doi.org/10.1046/j.1523-1755.1998.00744.x
224 rdf:type schema:CreativeWork
225 sg:pub.10.1046/j.1523-1755.2000.00122.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1036789907
226 https://doi.org/10.1046/j.1523-1755.2000.00122.x
227 rdf:type schema:CreativeWork
228 sg:pub.10.1046/j.1523-1755.2000.00926.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1029377431
229 https://doi.org/10.1046/j.1523-1755.2000.00926.x
230 rdf:type schema:CreativeWork
231 sg:pub.10.1046/j.1523-1755.2001.0590031158.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1011292929
232 https://doi.org/10.1046/j.1523-1755.2001.0590031158.x
233 rdf:type schema:CreativeWork
234 sg:pub.10.1385/1-59259-192-2:365 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023668922
235 https://doi.org/10.1385/1-59259-192-2:365
236 rdf:type schema:CreativeWork
237 https://app.dimensions.ai/details/publication/pub.1074544770 schema:CreativeWork
238 https://app.dimensions.ai/details/publication/pub.1076115369 schema:CreativeWork
239 https://app.dimensions.ai/details/publication/pub.1082867182 schema:CreativeWork
240 https://app.dimensions.ai/details/publication/pub.1082944650 schema:CreativeWork
241 https://app.dimensions.ai/details/publication/pub.1083187103 schema:CreativeWork
242 https://app.dimensions.ai/details/publication/pub.1083237015 schema:CreativeWork
243 https://doi.org/10.1001/jama.283.5.633 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013400216
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1006/excr.1994.1171 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026487051
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1016/0167-4781(93)90127-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1044972369
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1016/s0076-6879(84)08118-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039486269
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1016/s0140-6736(99)08421-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050041349
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1016/s0934-8832(11)80006-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015513188
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1080/713803545 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007763216
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1093/ajh/2.5.341 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079178209
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1093/nar/13.7.2485 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008134818
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1093/nar/18.10.3059 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046704609
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1093/ndt/10.7.1206 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082377612
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1093/oxfordjournals.ndt.a090861 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082480345
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1097/00002480-198907000-00036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020176376
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1097/00007890-199108000-00011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036056555
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1097/00007890-199304000-00013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050067811
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1097/00007890-199309000-00028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032170234
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1097/00007890-199407150-00016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029986649
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1097/00007890-199612150-00018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060276289
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1097/00007890-199806270-00001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060278154
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1097/00007890-200107150-00009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039415836
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1126/science.274.5289.985 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062554761
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1161/01.cir.103.2.319 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002797115
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1161/01.hyp.17.6.888 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005878445
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1161/hy0202.103481 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005825904
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1172/jci117762 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002610062
292 rdf:type schema:CreativeWork
293 https://www.grid.ac/institutes/grid.7468.d schema:alternateName Humboldt University of Berlin
294 schema:name Department of Nephrology and Internal Intensive Care Medicine, Universitätsklinikum Charité, Campus Virchow Klinikum, Humboldt University, Berlin, Germany. ralf.schindler@charite.de
295 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...