Dominant T cells in idiopathic nephrotic syndrome of childhood View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2000-10

AUTHORS

C Frank, M Herrmann, S Fernandez, D Dirnecker, M Böswald, W Kolowos, H Ruder, J P Haas

ABSTRACT

BACKGROUND: Because of several studies, idiopathic nephrotic syndrome (INS) of childhood is suspected to have an immunologic pathogenesis with T cells playing a major role. To investigate this hypothesis further, we studied the diversity of the CDR3 region of the T-cell receptor (TCR) beta-chain from peripheral T cells isolated from patients with INS. METHODS: The study was performed over a three-year period to obtain longitudinal data on the repertoire of peripheral T cells. mRNA from peripheral mononuclear cells (PBMCs) of seven INS patients and two healthy controls (NHD) was prepared and analyzed for CDR3 length polymorphism of TCR beta-chain by spectratyping. RESULTS: All INS patients presented individually skewed spectratype histograms in at least one Vbeta-family. Patients suffering from a frequent relapsing course of INS or a focal global sclerosis showed some alterations to persist in all samples isolated in the observation period (up to 3 years). In addition, sequence analyses of the beta-chain of the TCR CDR3 region confirmed clonal expansion of peripheral T cells in those patients who had displayed spectratype alterations. CONCLUSIONS: The data give strong evidence for an direct involvement of CD8+ T cells in the complicated course of INS. More... »

PAGES

510-517

Identifiers

URI

http://scigraph.springernature.com/pub.10.1046/j.1523-1755.2000.00870.x

DOI

http://dx.doi.org/10.1046/j.1523-1755.2000.00870.x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1001521132

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10652027


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