Regulatory interactions of αβ and γδ T cells in glomerulonephritis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2000-09

AUTHORS

A R Rosenkranz, S Knight, S Sethi, S I Alexander, R S Cotran, T N Mayadas

ABSTRACT

BACKGROUND: Several lines of evidence suggest that cellular immune mechanisms contribute to glomerulonephritis. METHODS: The roles of alphabeta and gammadelta T cells in the pathogenesis of glomerulonephritis were investigated in a model of nephrotoxic nephritis in mice deficient in either T-cell population [T-cell receptor (TCR)beta and TCRdelta knockout mice]. The model, induced by the injection of rabbit anti-mouse glomerular basement membrane antibody, is characterized by the development of proteinuria and glomerular damage over a 21-day observation period in wild-type mice. RESULTS: Mice deficient in either alphabeta or gammadelta T cells developed minimal proteinuria and glomerular lesions and had a significant reduction in macrophage accumulation compared with wild-type mice. In gammadelta T-cell-deficient mice, circulating levels and glomerular deposition of autologous IgG were comparable to wild-type levels, while alphabeta T-cell-deficient mice had no autologous IgG production. Autologous antibody production was not required for the development of glomerulonephritis since mice that lack IgG and B cells (micro-chain-/-) developed similar proteinuria to that observed in wild-type mice. CONCLUSIONS: These studies suggest a proinflammatory role for both alphabeta and gammadelta T cells in glomerular injury, independent of the humoral response. This is the first demonstration, to our knowledge, that both T-cell subsets contribute to the progression of a disease, and it suggests that complex regulatory interactions between alphabeta and gammadelta T cells play a role in glomerular injury. More... »

PAGES

1055-1066

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1046/j.1523-1755.2000.00263.x

DOI

http://dx.doi.org/10.1046/j.1523-1755.2000.00263.x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022720332

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10972670


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curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1046/j.1523-1755.2000.00263.x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1046/j.1523-1755.2000.00263.x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1046/j.1523-1755.2000.00263.x'


 

This table displays all metadata directly associated to this object as RDF triples.

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