Long-term comparison of losartan and enalapril on kidney function in hypertensive type 2 diabetics with early nephropathy View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2000-08

AUTHORS

Y Lacourcière, A Bélanger, C Godin, J P Hallé, S Ross, N Wright, J Marion

ABSTRACT

BACKGROUND: The objectives of this study were to compare the effects of the angiotensin II receptor blocker, losartan, to those of the angiotensin-converting enzyme inhibitor, enalapril, on albuminuria and renal function in relationship to clinic and ambulatory blood pressure (ABP) in hypertensive type 2 diabetic subjects with early nephropathy. The tolerability of these agents and their effect on the metabolic profile were also evaluated. METHODS: The study was a one-year prospective, double-blind trial with losartan and enalapril administered alone or in combination with hydrochlorothiazide and other antihypertensive agents. ABP and renal and biochemical parameters were measured at baseline and after 12, 28, and 52 weeks of active treatment. Ninety-two hypertensive type 2 diabetics with early nephropathy completed the study. RESULTS: Both losartan and enalapril administered alone or in combination with other agents induced significant reductions in sitting clinic (P < 0.05) and ABP (P < 0.002) without a statistical difference between groups. Geometric means for urinary albumin excretion (UAE) decreased significantly (P < 0.001) in patients treated with losartan from 64. 1 to 41.5 microg/min and in those treated with enalapril from 73.9 to 33.5 microg/min after 52 weeks of therapy. A significant relationship (P < 0.05) between changes in systolic and diastolic ABP and the decrease in UAE at 52 weeks was seen in both groups. The decline in glomerular filtration rate (GFR) was stabilized at the end of therapy and was identical in both treatment groups. Treatment with enalapril was associated with a significantly higher incidence of cough (P = 0.006) and a rise in serum uric acid (P = 0.002) compared with losartan. CONCLUSIONS: Our results indicate that a one-year course of antihypertensive therapy with either losartan or enalapril significantly reduces UAE in hypertensive type 2 diabetic patients with early nephropathy. The reduction in UAE with each treatment is similarly related to decrements in ABP. In addition, the rate of decline in GFR is similar in both treatment groups. More... »

PAGES

762-769

Identifiers

URI

http://scigraph.springernature.com/pub.10.1046/j.1523-1755.2000.00224.x

DOI

http://dx.doi.org/10.1046/j.1523-1755.2000.00224.x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1049059041

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10916100


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Albuminuria", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antihypertensive Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blood Pressure", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diabetes Mellitus, Type 2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diabetic Nephropathies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diuretics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Double-Blind Method", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Therapy, Combination", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Enalapril", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glomerular Filtration Rate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hydrochlorothiazide", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hypertension, Renal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kidney", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Losartan", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sodium Chloride Symporter Inhibitors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Uric Acid", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Universit\u00e9 Laval", 
          "id": "https://www.grid.ac/institutes/grid.23856.3a", 
          "name": [
            "Hypertension Research Unit, Centre Hospitalier Universite Laval, Quebec, Canada."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lacourci\u00e8re", 
        "givenName": "Y", 
        "id": "sg:person.066536372.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.066536372.01"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "B\u00e9langer", 
        "givenName": "A", 
        "id": "sg:person.0754130401.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0754130401.45"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Godin", 
        "givenName": "C", 
        "type": "Person"
      }, 
      {
        "familyName": "Hall\u00e9", 
        "givenName": "J P", 
        "type": "Person"
      }, 
      {
        "familyName": "Ross", 
        "givenName": "S", 
        "id": "sg:person.01372703736.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01372703736.65"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Wright", 
        "givenName": "N", 
        "id": "sg:person.01043437524.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043437524.83"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Marion", 
        "givenName": "J", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1161/01.hyp.24.6.793", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000705211"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004872-199612002-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001702823"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004872-199612002-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001702823"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199807233390404", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002489021"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004872-199412000-00012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004449098"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004872-199412000-00012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004449098"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0002-8703(88)90181-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005619667"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.hyp.31.2.684", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010063234"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.hyp.34.1.144", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012297643"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1996.480", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012606780", 
          "https://doi.org/10.1038/ki.1996.480"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004872-199507001-00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014307921"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004872-199507001-00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014307921"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004872-199512010-00053", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021118536"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004872-199512010-00053", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021118536"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.hyp.21.6.786", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021590823"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1464-5491.1988.tb00958.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022211626"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1464-5491.1988.tb00958.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022211626"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00266358", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025911538", 
          "https://doi.org/10.1007/bf00266358"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00266358", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025911538", 
          "https://doi.org/10.1007/bf00266358"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm198402093100605", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029263631"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1464-5491.1984.tb01915.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031542570"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1464-5491.1984.tb01915.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031542570"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/00365517609068016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035220341"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000169003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037961251"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.305.6860.981", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040803348"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/00003495-199957050-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042640860", 
          "https://doi.org/10.2165/00003495-199957050-00002"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1994.113", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044960833", 
          "https://doi.org/10.1038/ki.1994.113"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.1983.03330440030027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045926154"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0895-7061(98)00118-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046993048"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004872-199511000-00017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047644783"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004872-199511000-00017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047644783"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/08860228509088195", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052070705"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diacare.17.5.420", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070746343"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7326/0003-4819-131-1-199907060-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073703308"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077678132", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ajh/3.2.81", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078359671"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082585478", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ajh/7.1.23", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082667703"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ndt/10.11.1963", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082890965"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083134655", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2000-08", 
    "datePublishedReg": "2000-08-01", 
    "description": "BACKGROUND: The objectives of this study were to compare the effects of the angiotensin II receptor blocker, losartan, to those of the angiotensin-converting enzyme inhibitor, enalapril, on albuminuria and renal function in relationship to clinic and ambulatory blood pressure (ABP) in hypertensive type 2 diabetic subjects with early nephropathy. The tolerability of these agents and their effect on the metabolic profile were also evaluated.\nMETHODS: The study was a one-year prospective, double-blind trial with losartan and enalapril administered alone or in combination with hydrochlorothiazide and other antihypertensive agents. ABP and renal and biochemical parameters were measured at baseline and after 12, 28, and 52 weeks of active treatment. Ninety-two hypertensive type 2 diabetics with early nephropathy completed the study.\nRESULTS: Both losartan and enalapril administered alone or in combination with other agents induced significant reductions in sitting clinic (P < 0.05) and ABP (P < 0.002) without a statistical difference between groups. Geometric means for urinary albumin excretion (UAE) decreased significantly (P < 0.001) in patients treated with losartan from 64. 1 to 41.5 microg/min and in those treated with enalapril from 73.9 to 33.5 microg/min after 52 weeks of therapy. A significant relationship (P < 0.05) between changes in systolic and diastolic ABP and the decrease in UAE at 52 weeks was seen in both groups. The decline in glomerular filtration rate (GFR) was stabilized at the end of therapy and was identical in both treatment groups. Treatment with enalapril was associated with a significantly higher incidence of cough (P = 0.006) and a rise in serum uric acid (P = 0.002) compared with losartan.\nCONCLUSIONS: Our results indicate that a one-year course of antihypertensive therapy with either losartan or enalapril significantly reduces UAE in hypertensive type 2 diabetic patients with early nephropathy. The reduction in UAE with each treatment is similarly related to decrements in ABP. In addition, the rate of decline in GFR is similar in both treatment groups.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1046/j.1523-1755.2000.00224.x", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1015319", 
        "issn": [
          "0085-2538", 
          "1523-1755"
        ], 
        "name": "Kidney International", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "58"
      }
    ], 
    "name": "Long-term comparison of losartan and enalapril on kidney function in hypertensive type 2 diabetics with early nephropathy", 
    "pagination": "762-769", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "e9b593a5c423e1a14e342939140c7eddff113b6a773fe0d5d83e9686c6ae3891"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "10916100"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0323470"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1046/j.1523-1755.2000.00224.x"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1049059041"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1046/j.1523-1755.2000.00224.x", 
      "https://app.dimensions.ai/details/publication/pub.1049059041"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T00:04", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8695_00000426.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/ki/journal/v58/n2/full/4491743a.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1046/j.1523-1755.2000.00224.x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1046/j.1523-1755.2000.00224.x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1046/j.1523-1755.2000.00224.x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1046/j.1523-1755.2000.00224.x'


 

This table displays all metadata directly associated to this object as RDF triples.

287 TRIPLES      21 PREDICATES      83 URIs      43 LITERALS      31 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1046/j.1523-1755.2000.00224.x schema:about N0119533563d8400c801d87ae962010d2
2 N07f2707071a24fc48ea6c6d5f1a28ae4
3 N1d8e3f9b0c3d4581b9e4ada671704a7f
4 N2f0a718664bc4b1da237f3bb83bab09e
5 N321087650db7422cb17a0d1b67d0e2b5
6 N394007448ab942e2bc5ad7902bb5c8e5
7 N53c7db805e4f4554bcdcfa6c4886cbbd
8 N582589804db743a19c08cc42d67be95f
9 N5952cdee9b2a4778a30f0d5f6003f112
10 N6a195be7de9949ca81063760d48cadbf
11 N7929e1c6a40a4edca6d9f024d972dddc
12 N7e1ac3b221ba41b1a31b9439a6c8466e
13 N803859cb43164155925c0f30f9ccfaae
14 Na141a1e39e894c889a54a5723a85ea08
15 Na6d75934dd784a7ab526a09ea6c2a066
16 Ndc174a00ad0048cd975bb9bb511bbfce
17 Nde4105f5fdd84b96a7e12adc745d3304
18 Nee7b71307639470d88375e1be2d0bd34
19 Nf0d4f83d7d34441c8a0e505903532dca
20 Nf67f53ae0ba0454eb11ca468d65be8c3
21 Nf8ce98b7c9f045ce8bbd28b8763b3e45
22 Nfda1519a5e774944852c86a54a770e20
23 anzsrc-for:11
24 anzsrc-for:1103
25 schema:author N8328dd3592464bee97e184c0b982c4b4
26 schema:citation sg:pub.10.1007/bf00266358
27 sg:pub.10.1038/ki.1994.113
28 sg:pub.10.1038/ki.1996.480
29 sg:pub.10.2165/00003495-199957050-00002
30 https://app.dimensions.ai/details/publication/pub.1077678132
31 https://app.dimensions.ai/details/publication/pub.1082585478
32 https://app.dimensions.ai/details/publication/pub.1083134655
33 https://doi.org/10.1001/jama.1983.03330440030027
34 https://doi.org/10.1016/0002-8703(88)90181-0
35 https://doi.org/10.1016/s0895-7061(98)00118-6
36 https://doi.org/10.1056/nejm198402093100605
37 https://doi.org/10.1056/nejm199807233390404
38 https://doi.org/10.1080/00365517609068016
39 https://doi.org/10.1093/ajh/3.2.81
40 https://doi.org/10.1093/ajh/7.1.23
41 https://doi.org/10.1093/ndt/10.11.1963
42 https://doi.org/10.1097/00004872-199412000-00012
43 https://doi.org/10.1097/00004872-199507001-00005
44 https://doi.org/10.1097/00004872-199511000-00017
45 https://doi.org/10.1097/00004872-199512010-00053
46 https://doi.org/10.1097/00004872-199612002-00003
47 https://doi.org/10.1111/j.1464-5491.1984.tb01915.x
48 https://doi.org/10.1111/j.1464-5491.1988.tb00958.x
49 https://doi.org/10.1136/bmj.305.6860.981
50 https://doi.org/10.1159/000169003
51 https://doi.org/10.1161/01.hyp.21.6.786
52 https://doi.org/10.1161/01.hyp.24.6.793
53 https://doi.org/10.1161/01.hyp.31.2.684
54 https://doi.org/10.1161/01.hyp.34.1.144
55 https://doi.org/10.2337/diacare.17.5.420
56 https://doi.org/10.3109/08860228509088195
57 https://doi.org/10.7326/0003-4819-131-1-199907060-00003
58 schema:datePublished 2000-08
59 schema:datePublishedReg 2000-08-01
60 schema:description BACKGROUND: The objectives of this study were to compare the effects of the angiotensin II receptor blocker, losartan, to those of the angiotensin-converting enzyme inhibitor, enalapril, on albuminuria and renal function in relationship to clinic and ambulatory blood pressure (ABP) in hypertensive type 2 diabetic subjects with early nephropathy. The tolerability of these agents and their effect on the metabolic profile were also evaluated. METHODS: The study was a one-year prospective, double-blind trial with losartan and enalapril administered alone or in combination with hydrochlorothiazide and other antihypertensive agents. ABP and renal and biochemical parameters were measured at baseline and after 12, 28, and 52 weeks of active treatment. Ninety-two hypertensive type 2 diabetics with early nephropathy completed the study. RESULTS: Both losartan and enalapril administered alone or in combination with other agents induced significant reductions in sitting clinic (P < 0.05) and ABP (P < 0.002) without a statistical difference between groups. Geometric means for urinary albumin excretion (UAE) decreased significantly (P < 0.001) in patients treated with losartan from 64. 1 to 41.5 microg/min and in those treated with enalapril from 73.9 to 33.5 microg/min after 52 weeks of therapy. A significant relationship (P < 0.05) between changes in systolic and diastolic ABP and the decrease in UAE at 52 weeks was seen in both groups. The decline in glomerular filtration rate (GFR) was stabilized at the end of therapy and was identical in both treatment groups. Treatment with enalapril was associated with a significantly higher incidence of cough (P = 0.006) and a rise in serum uric acid (P = 0.002) compared with losartan. CONCLUSIONS: Our results indicate that a one-year course of antihypertensive therapy with either losartan or enalapril significantly reduces UAE in hypertensive type 2 diabetic patients with early nephropathy. The reduction in UAE with each treatment is similarly related to decrements in ABP. In addition, the rate of decline in GFR is similar in both treatment groups.
61 schema:genre research_article
62 schema:inLanguage en
63 schema:isAccessibleForFree true
64 schema:isPartOf N4e6ad19e2b5848e6afead7f0461b1a0f
65 Ndf78b7d6e493418684ef55db87b419a1
66 sg:journal.1015319
67 schema:name Long-term comparison of losartan and enalapril on kidney function in hypertensive type 2 diabetics with early nephropathy
68 schema:pagination 762-769
69 schema:productId N123c23f3372d48b7bc65e56be8e21c9a
70 N283be6d587c643d481df5b0939b3a517
71 Na5851a85f6a344f289423ae48cb1deb5
72 Nc7437ebb7b244a1bb35bb4df133f41f4
73 Ncf9928f1758a45eb94fc202e7100c276
74 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049059041
75 https://doi.org/10.1046/j.1523-1755.2000.00224.x
76 schema:sdDatePublished 2019-04-11T00:04
77 schema:sdLicense https://scigraph.springernature.com/explorer/license/
78 schema:sdPublisher Nbfbb9953bbc943319097770df96a61d4
79 schema:url http://www.nature.com/ki/journal/v58/n2/full/4491743a.html
80 sgo:license sg:explorer/license/
81 sgo:sdDataset articles
82 rdf:type schema:ScholarlyArticle
83 N0119533563d8400c801d87ae962010d2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Hypertension, Renal
85 rdf:type schema:DefinedTerm
86 N07f2707071a24fc48ea6c6d5f1a28ae4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Humans
88 rdf:type schema:DefinedTerm
89 N123c23f3372d48b7bc65e56be8e21c9a schema:name dimensions_id
90 schema:value pub.1049059041
91 rdf:type schema:PropertyValue
92 N1d8e3f9b0c3d4581b9e4ada671704a7f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Aged
94 rdf:type schema:DefinedTerm
95 N283be6d587c643d481df5b0939b3a517 schema:name pubmed_id
96 schema:value 10916100
97 rdf:type schema:PropertyValue
98 N2f0a718664bc4b1da237f3bb83bab09e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Losartan
100 rdf:type schema:DefinedTerm
101 N321087650db7422cb17a0d1b67d0e2b5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Kidney
103 rdf:type schema:DefinedTerm
104 N394007448ab942e2bc5ad7902bb5c8e5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Uric Acid
106 rdf:type schema:DefinedTerm
107 N3c4d5ed15dfc4f90bf0ba31fcb829b15 schema:familyName Hallé
108 schema:givenName J P
109 rdf:type schema:Person
110 N4e6ad19e2b5848e6afead7f0461b1a0f schema:volumeNumber 58
111 rdf:type schema:PublicationVolume
112 N53c7db805e4f4554bcdcfa6c4886cbbd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Blood Pressure
114 rdf:type schema:DefinedTerm
115 N582589804db743a19c08cc42d67be95f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Enalapril
117 rdf:type schema:DefinedTerm
118 N5952cdee9b2a4778a30f0d5f6003f112 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Sodium Chloride Symporter Inhibitors
120 rdf:type schema:DefinedTerm
121 N6a195be7de9949ca81063760d48cadbf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Drug Therapy, Combination
123 rdf:type schema:DefinedTerm
124 N7929e1c6a40a4edca6d9f024d972dddc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Middle Aged
126 rdf:type schema:DefinedTerm
127 N7e1ac3b221ba41b1a31b9439a6c8466e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Antihypertensive Agents
129 rdf:type schema:DefinedTerm
130 N803859cb43164155925c0f30f9ccfaae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Diabetic Nephropathies
132 rdf:type schema:DefinedTerm
133 N8328dd3592464bee97e184c0b982c4b4 rdf:first sg:person.066536372.01
134 rdf:rest Nf7489729a04a4964b4e98f016a9753b7
135 N86203468749d4d27a1f3e8d8902f5b34 schema:familyName Godin
136 schema:givenName C
137 rdf:type schema:Person
138 N9cd03af1cd3c4fe7b3de0fbd932eadfc rdf:first sg:person.01372703736.65
139 rdf:rest Ndaeac686286c440ebd2155b31b46f3c8
140 N9d520f3406084400ad762a7adecbf37a schema:familyName Marion
141 schema:givenName J
142 rdf:type schema:Person
143 Na106752450624783970ebb425a43bf76 rdf:first N86203468749d4d27a1f3e8d8902f5b34
144 rdf:rest Nf6cd66999162467b85b22c250e53bccd
145 Na141a1e39e894c889a54a5723a85ea08 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Diuretics
147 rdf:type schema:DefinedTerm
148 Na5851a85f6a344f289423ae48cb1deb5 schema:name nlm_unique_id
149 schema:value 0323470
150 rdf:type schema:PropertyValue
151 Na6d75934dd784a7ab526a09ea6c2a066 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Male
153 rdf:type schema:DefinedTerm
154 Nbfbb9953bbc943319097770df96a61d4 schema:name Springer Nature - SN SciGraph project
155 rdf:type schema:Organization
156 Nc7437ebb7b244a1bb35bb4df133f41f4 schema:name readcube_id
157 schema:value e9b593a5c423e1a14e342939140c7eddff113b6a773fe0d5d83e9686c6ae3891
158 rdf:type schema:PropertyValue
159 Ncf9928f1758a45eb94fc202e7100c276 schema:name doi
160 schema:value 10.1046/j.1523-1755.2000.00224.x
161 rdf:type schema:PropertyValue
162 Ndaeac686286c440ebd2155b31b46f3c8 rdf:first sg:person.01043437524.83
163 rdf:rest Nea422cf91804415caa6e19d1e1c39cb8
164 Ndc174a00ad0048cd975bb9bb511bbfce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Hydrochlorothiazide
166 rdf:type schema:DefinedTerm
167 Nde4105f5fdd84b96a7e12adc745d3304 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Double-Blind Method
169 rdf:type schema:DefinedTerm
170 Ndf78b7d6e493418684ef55db87b419a1 schema:issueNumber 2
171 rdf:type schema:PublicationIssue
172 Nea422cf91804415caa6e19d1e1c39cb8 rdf:first N9d520f3406084400ad762a7adecbf37a
173 rdf:rest rdf:nil
174 Nee7b71307639470d88375e1be2d0bd34 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Diabetes Mellitus, Type 2
176 rdf:type schema:DefinedTerm
177 Nf0d4f83d7d34441c8a0e505903532dca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Female
179 rdf:type schema:DefinedTerm
180 Nf67f53ae0ba0454eb11ca468d65be8c3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Albuminuria
182 rdf:type schema:DefinedTerm
183 Nf6cd66999162467b85b22c250e53bccd rdf:first N3c4d5ed15dfc4f90bf0ba31fcb829b15
184 rdf:rest N9cd03af1cd3c4fe7b3de0fbd932eadfc
185 Nf7489729a04a4964b4e98f016a9753b7 rdf:first sg:person.0754130401.45
186 rdf:rest Na106752450624783970ebb425a43bf76
187 Nf8ce98b7c9f045ce8bbd28b8763b3e45 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Prospective Studies
189 rdf:type schema:DefinedTerm
190 Nfda1519a5e774944852c86a54a770e20 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Glomerular Filtration Rate
192 rdf:type schema:DefinedTerm
193 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
194 schema:name Medical and Health Sciences
195 rdf:type schema:DefinedTerm
196 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
197 schema:name Clinical Sciences
198 rdf:type schema:DefinedTerm
199 sg:journal.1015319 schema:issn 0085-2538
200 1523-1755
201 schema:name Kidney International
202 rdf:type schema:Periodical
203 sg:person.01043437524.83 schema:familyName Wright
204 schema:givenName N
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043437524.83
206 rdf:type schema:Person
207 sg:person.01372703736.65 schema:familyName Ross
208 schema:givenName S
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01372703736.65
210 rdf:type schema:Person
211 sg:person.066536372.01 schema:affiliation https://www.grid.ac/institutes/grid.23856.3a
212 schema:familyName Lacourcière
213 schema:givenName Y
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.066536372.01
215 rdf:type schema:Person
216 sg:person.0754130401.45 schema:familyName Bélanger
217 schema:givenName A
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0754130401.45
219 rdf:type schema:Person
220 sg:pub.10.1007/bf00266358 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025911538
221 https://doi.org/10.1007/bf00266358
222 rdf:type schema:CreativeWork
223 sg:pub.10.1038/ki.1994.113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044960833
224 https://doi.org/10.1038/ki.1994.113
225 rdf:type schema:CreativeWork
226 sg:pub.10.1038/ki.1996.480 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012606780
227 https://doi.org/10.1038/ki.1996.480
228 rdf:type schema:CreativeWork
229 sg:pub.10.2165/00003495-199957050-00002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042640860
230 https://doi.org/10.2165/00003495-199957050-00002
231 rdf:type schema:CreativeWork
232 https://app.dimensions.ai/details/publication/pub.1077678132 schema:CreativeWork
233 https://app.dimensions.ai/details/publication/pub.1082585478 schema:CreativeWork
234 https://app.dimensions.ai/details/publication/pub.1083134655 schema:CreativeWork
235 https://doi.org/10.1001/jama.1983.03330440030027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045926154
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1016/0002-8703(88)90181-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005619667
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1016/s0895-7061(98)00118-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046993048
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1056/nejm198402093100605 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029263631
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1056/nejm199807233390404 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002489021
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1080/00365517609068016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035220341
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1093/ajh/3.2.81 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078359671
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1093/ajh/7.1.23 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082667703
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1093/ndt/10.11.1963 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082890965
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1097/00004872-199412000-00012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004449098
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1097/00004872-199507001-00005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014307921
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1097/00004872-199511000-00017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047644783
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1097/00004872-199512010-00053 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021118536
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1097/00004872-199612002-00003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001702823
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1111/j.1464-5491.1984.tb01915.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1031542570
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1111/j.1464-5491.1988.tb00958.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1022211626
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1136/bmj.305.6860.981 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040803348
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1159/000169003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037961251
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1161/01.hyp.21.6.786 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021590823
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1161/01.hyp.24.6.793 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000705211
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1161/01.hyp.31.2.684 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010063234
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1161/01.hyp.34.1.144 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012297643
278 rdf:type schema:CreativeWork
279 https://doi.org/10.2337/diacare.17.5.420 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070746343
280 rdf:type schema:CreativeWork
281 https://doi.org/10.3109/08860228509088195 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052070705
282 rdf:type schema:CreativeWork
283 https://doi.org/10.7326/0003-4819-131-1-199907060-00003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073703308
284 rdf:type schema:CreativeWork
285 https://www.grid.ac/institutes/grid.23856.3a schema:alternateName Université Laval
286 schema:name Hypertension Research Unit, Centre Hospitalier Universite Laval, Quebec, Canada.
287 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...