Redistribution of cytoplasmic VEGF to the basolateral aspect of renal tubular cells in ischemia-reperfusion injury View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2000-06

AUTHORS

J Kanellis, S J Mudge, S Fraser, M Katerelos, D A Power

ABSTRACT

BACKGROUND: Vascular endothelial growth factor (VEGF) mRNA and protein expression are increased by hypoxia in a variety of cell types and organs. In the kidney, however, chronic hypoxia does not up-regulate VEGF mRNA. This suggests that VEGF may be regulated by unique mechanisms in the kidney. METHODS: Unilateral ischemia was induced in rats by vascular cross-clamping (40 min) followed by reperfusion (0, 20, 40, and 80 min). The distribution of VEGF protein was determined by immunohistochemical staining and Western blotting. mRNA was detected by Northern blotting and semiquantitative reverse transcription-polymerase chain reaction (RT-PCR). Immunohistochemical staining for VEGF was verified using two VEGF antibodies. To further substantiate the immunohistochemical findings, laser scanning confocal fluorescence microscopy was used to demonstrate the distribution of VEGF protein in rat renal tubular epithelial cells (NRK52-E) subjected to hypoxia (40 min) and re-oxygenation (0, 5, 20, 40 and 80 min). RESULTS: Normal kidneys showed diffuse immunohistochemical staining for VEGF in all tubules of the renal cortex and medulla. Following ischemia, staining demonstrated a prominent shift of cytoplasmic VEGF to the basolateral aspect of tubular cells with both VEGF antibodies. The distribution of cytoplasmic VEGF returned to normal following 40 and 80 minutes of reperfusion. Western blots of cytoplasmic samples from ischemic kidneys reperfused for 0 and 20 minutes showed decreased levels of VEGF164 compared with normal (P < 0.01). VEGF164 and VEGF188 levels in the membrane fraction showed no change. Northern blots and semiquantitative RT-PCR showed no significant up-regulation of VEGF mRNA or change in the splice pattern. NRK52-E cells subjected to hypoxia and re-oxygenation for 0 and 5 minutes showed increased staining for VEGF compared with normal, with prominent VEGF staining at the periphery of the cell, similar to the appearance in ischemic kidneys. VEGF staining became more diffuse with further re-oxygenation. CONCLUSION: Although synthesis of VEGF mRNA and protein is not increased during ischemia reperfusion injury, pre-existing VEGF in the tubular cell cytoplasm redistributes to the basolateral aspect of the cells. These data suggest that the kidney may have evolved unique patterns of VEGF regulation to cope with acute hypoxia. More... »

PAGES

2445-2456

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1046/j.1523-1755.2000.00103.x

DOI

http://dx.doi.org/10.1046/j.1523-1755.2000.00103.x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1036851145

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10844613


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1116", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical Physiology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytoplasm", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Endothelial Growth Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ischemia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kidney Tubules", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphokines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Membrane Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Messenger", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats, Sprague-Dawley", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Renal Circulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reperfusion Injury", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tissue Distribution", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vascular Endothelial Growth Factor A", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vascular Endothelial Growth Factors", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "St Vincent's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.413105.2", 
          "name": [
            "Departments of Nephrology and Clinical Immunology, St. Vincent's Hospital Melbourne, Fitzroy, Victoria, Australia. kanellj@svhm.org.au"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kanellis", 
        "givenName": "J", 
        "id": "sg:person.0632561625.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632561625.57"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Mudge", 
        "givenName": "S J", 
        "id": "sg:person.0613322233.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0613322233.01"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Fraser", 
        "givenName": "S", 
        "id": "sg:person.01053227266.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053227266.83"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Katerelos", 
        "givenName": "M", 
        "id": "sg:person.01121342466.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121342466.28"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Power", 
        "givenName": "D A", 
        "id": "sg:person.01050643265.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050643265.26"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1074/jbc.270.52.31189", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000313948"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.270.22.13333", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006355584"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.273.21.13313", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006436940"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/13.7.2485", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008134818"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm0195-27", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008981922", 
          "https://doi.org/10.1038/nm0195-27"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s004240050348", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009420330", 
          "https://doi.org/10.1007/s004240050348"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.180.1.341", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016566769"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199412013312203", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018716626"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.271.5.2746", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019049306"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci118087", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019526766"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.87.7.2628", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020252185"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/08977199509003209", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021839026"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci114359", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022012664"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcb.240470305", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024021353"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcb.240470305", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024021353"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1993.337", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025544696", 
          "https://doi.org/10.1038/ki.1993.337"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/359843a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028884048", 
          "https://doi.org/10.1038/359843a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci117858", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030112284"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.273.46.30336", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030188573"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.174.5.1275", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036306308"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0046-8177(94)90166-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036526018"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1990.143", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037642757", 
          "https://doi.org/10.1038/ki.1990.143"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.me.44.020193.000331", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038079239"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1997.148", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038443863", 
          "https://doi.org/10.1038/ki.1997.148"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.270.34.19761", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038607124"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.270.44.26460", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045570142"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1997.59", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046007011", 
          "https://doi.org/10.1038/ki.1997.59"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1997.60", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046473371", 
          "https://doi.org/10.1038/ki.1997.60"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(94)90187-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046752632"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0039-6060(96)80120-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047746915"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1046/j.1523-1755.1998.00846.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048426004", 
          "https://doi.org/10.1046/j.1523-1755.1998.00846.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.91.5.1691", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048592119"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.272.20.13390", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049319751"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-0348-7001-6_2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049764289", 
          "https://doi.org/10.1007/978-3-0348-7001-6_2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199503093321006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050463480"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0076-6879(84)04097-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050935599"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1091/mbc.4.12.1317", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051224202"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.271.13.7788", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052270689"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/cvr/28.8.1176", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059488265"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/mend-5-12-1806", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064331012"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076034910", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076604442", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076970932", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077325111", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079684378", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpheart.1994.267.5.h1948", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082592270"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajprenal.1994.266.1.f81", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082748280"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082881127", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/physrev.1996.76.3.839", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082940693"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpheart.1996.270.5.h1803", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083003118"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2000-06", 
    "datePublishedReg": "2000-06-01", 
    "description": "BACKGROUND: Vascular endothelial growth factor (VEGF) mRNA and protein expression are increased by hypoxia in a variety of cell types and organs. In the kidney, however, chronic hypoxia does not up-regulate VEGF mRNA. This suggests that VEGF may be regulated by unique mechanisms in the kidney.\nMETHODS: Unilateral ischemia was induced in rats by vascular cross-clamping (40 min) followed by reperfusion (0, 20, 40, and 80 min). The distribution of VEGF protein was determined by immunohistochemical staining and Western blotting. mRNA was detected by Northern blotting and semiquantitative reverse transcription-polymerase chain reaction (RT-PCR). Immunohistochemical staining for VEGF was verified using two VEGF antibodies. To further substantiate the immunohistochemical findings, laser scanning confocal fluorescence microscopy was used to demonstrate the distribution of VEGF protein in rat renal tubular epithelial cells (NRK52-E) subjected to hypoxia (40 min) and re-oxygenation (0, 5, 20, 40 and 80 min).\nRESULTS: Normal kidneys showed diffuse immunohistochemical staining for VEGF in all tubules of the renal cortex and medulla. Following ischemia, staining demonstrated a prominent shift of cytoplasmic VEGF to the basolateral aspect of tubular cells with both VEGF antibodies. The distribution of cytoplasmic VEGF returned to normal following 40 and 80 minutes of reperfusion. Western blots of cytoplasmic samples from ischemic kidneys reperfused for 0 and 20 minutes showed decreased levels of VEGF164 compared with normal (P < 0.01). VEGF164 and VEGF188 levels in the membrane fraction showed no change. Northern blots and semiquantitative RT-PCR showed no significant up-regulation of VEGF mRNA or change in the splice pattern. NRK52-E cells subjected to hypoxia and re-oxygenation for 0 and 5 minutes showed increased staining for VEGF compared with normal, with prominent VEGF staining at the periphery of the cell, similar to the appearance in ischemic kidneys. VEGF staining became more diffuse with further re-oxygenation.\nCONCLUSION: Although synthesis of VEGF mRNA and protein is not increased during ischemia reperfusion injury, pre-existing VEGF in the tubular cell cytoplasm redistributes to the basolateral aspect of the cells. These data suggest that the kidney may have evolved unique patterns of VEGF regulation to cope with acute hypoxia.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1046/j.1523-1755.2000.00103.x", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1015319", 
        "issn": [
          "0085-2538", 
          "1523-1755"
        ], 
        "name": "Kidney International", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "57"
      }
    ], 
    "name": "Redistribution of cytoplasmic VEGF to the basolateral aspect of renal tubular cells in ischemia-reperfusion injury", 
    "pagination": "2445-2456", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "af8b9a547c4d0239e85f07b4520e87c1d6f162558f07763e2a28fa7531486bd7"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "10844613"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0323470"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1046/j.1523-1755.2000.00103.x"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1036851145"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1046/j.1523-1755.2000.00103.x", 
      "https://app.dimensions.ai/details/publication/pub.1036851145"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T00:55", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8697_00000425.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/ki/journal/v57/n6/full/4491584a.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1046/j.1523-1755.2000.00103.x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1046/j.1523-1755.2000.00103.x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1046/j.1523-1755.2000.00103.x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1046/j.1523-1755.2000.00103.x'


 

This table displays all metadata directly associated to this object as RDF triples.

312 TRIPLES      21 PREDICATES      95 URIs      38 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1046/j.1523-1755.2000.00103.x schema:about N0b325253a977433494c09d46bc635123
2 N13abb5141cf742a39a4122506521153a
3 N21e0f29c0f4a4bbbaf417aa35fe6f95d
4 N27f9f3ad6b81424eaceac451e22e5210
5 N2e31f82ef8ee4fbb8a49b12548886d3b
6 N4aa9f274ab03440682c745f58cbdb86c
7 N55923f9c573441f18744e54d8bf0133a
8 N68f4758c7c8945e681eee2230266e0c8
9 N6a85645e0390478980e1df3efeedcbb2
10 N6e4e55ca9a154d1f9bded036453d83d2
11 N70dd3b60f55b4440962da0f92ec54253
12 N8605d99c41e04ed08700f91cd85782b5
13 N8b53bcdb8c6348c89e9ef6b0025224fa
14 Naee3588250124dc9aba46ee368c70d3d
15 Nd07656acc54145e79fe201196a6c4c0c
16 Nd2f6fb4f73364aa6b4faa870e5b07ef9
17 Nff959fd8818a4363864b4c1e32e547a6
18 anzsrc-for:11
19 anzsrc-for:1116
20 schema:author N9d63ba9efa3342adaca4e99b4dbfa3ab
21 schema:citation sg:pub.10.1007/978-3-0348-7001-6_2
22 sg:pub.10.1007/s004240050348
23 sg:pub.10.1038/359843a0
24 sg:pub.10.1038/ki.1990.143
25 sg:pub.10.1038/ki.1993.337
26 sg:pub.10.1038/ki.1997.148
27 sg:pub.10.1038/ki.1997.59
28 sg:pub.10.1038/ki.1997.60
29 sg:pub.10.1038/nm0195-27
30 sg:pub.10.1046/j.1523-1755.1998.00846.x
31 https://app.dimensions.ai/details/publication/pub.1076034910
32 https://app.dimensions.ai/details/publication/pub.1076604442
33 https://app.dimensions.ai/details/publication/pub.1076970932
34 https://app.dimensions.ai/details/publication/pub.1077325111
35 https://app.dimensions.ai/details/publication/pub.1079684378
36 https://app.dimensions.ai/details/publication/pub.1082881127
37 https://doi.org/10.1002/jcb.240470305
38 https://doi.org/10.1016/0046-8177(94)90166-x
39 https://doi.org/10.1016/0092-8674(94)90187-2
40 https://doi.org/10.1016/s0039-6060(96)80120-6
41 https://doi.org/10.1016/s0076-6879(84)04097-0
42 https://doi.org/10.1056/nejm199412013312203
43 https://doi.org/10.1056/nejm199503093321006
44 https://doi.org/10.1073/pnas.87.7.2628
45 https://doi.org/10.1073/pnas.91.5.1691
46 https://doi.org/10.1074/jbc.270.22.13333
47 https://doi.org/10.1074/jbc.270.34.19761
48 https://doi.org/10.1074/jbc.270.44.26460
49 https://doi.org/10.1074/jbc.270.52.31189
50 https://doi.org/10.1074/jbc.271.13.7788
51 https://doi.org/10.1074/jbc.271.5.2746
52 https://doi.org/10.1074/jbc.272.20.13390
53 https://doi.org/10.1074/jbc.273.21.13313
54 https://doi.org/10.1074/jbc.273.46.30336
55 https://doi.org/10.1084/jem.174.5.1275
56 https://doi.org/10.1084/jem.180.1.341
57 https://doi.org/10.1091/mbc.4.12.1317
58 https://doi.org/10.1093/cvr/28.8.1176
59 https://doi.org/10.1093/nar/13.7.2485
60 https://doi.org/10.1146/annurev.me.44.020193.000331
61 https://doi.org/10.1152/ajpheart.1994.267.5.h1948
62 https://doi.org/10.1152/ajpheart.1996.270.5.h1803
63 https://doi.org/10.1152/ajprenal.1994.266.1.f81
64 https://doi.org/10.1152/physrev.1996.76.3.839
65 https://doi.org/10.1172/jci114359
66 https://doi.org/10.1172/jci117858
67 https://doi.org/10.1172/jci118087
68 https://doi.org/10.1210/mend-5-12-1806
69 https://doi.org/10.3109/08977199509003209
70 schema:datePublished 2000-06
71 schema:datePublishedReg 2000-06-01
72 schema:description BACKGROUND: Vascular endothelial growth factor (VEGF) mRNA and protein expression are increased by hypoxia in a variety of cell types and organs. In the kidney, however, chronic hypoxia does not up-regulate VEGF mRNA. This suggests that VEGF may be regulated by unique mechanisms in the kidney. METHODS: Unilateral ischemia was induced in rats by vascular cross-clamping (40 min) followed by reperfusion (0, 20, 40, and 80 min). The distribution of VEGF protein was determined by immunohistochemical staining and Western blotting. mRNA was detected by Northern blotting and semiquantitative reverse transcription-polymerase chain reaction (RT-PCR). Immunohistochemical staining for VEGF was verified using two VEGF antibodies. To further substantiate the immunohistochemical findings, laser scanning confocal fluorescence microscopy was used to demonstrate the distribution of VEGF protein in rat renal tubular epithelial cells (NRK52-E) subjected to hypoxia (40 min) and re-oxygenation (0, 5, 20, 40 and 80 min). RESULTS: Normal kidneys showed diffuse immunohistochemical staining for VEGF in all tubules of the renal cortex and medulla. Following ischemia, staining demonstrated a prominent shift of cytoplasmic VEGF to the basolateral aspect of tubular cells with both VEGF antibodies. The distribution of cytoplasmic VEGF returned to normal following 40 and 80 minutes of reperfusion. Western blots of cytoplasmic samples from ischemic kidneys reperfused for 0 and 20 minutes showed decreased levels of VEGF164 compared with normal (P < 0.01). VEGF164 and VEGF188 levels in the membrane fraction showed no change. Northern blots and semiquantitative RT-PCR showed no significant up-regulation of VEGF mRNA or change in the splice pattern. NRK52-E cells subjected to hypoxia and re-oxygenation for 0 and 5 minutes showed increased staining for VEGF compared with normal, with prominent VEGF staining at the periphery of the cell, similar to the appearance in ischemic kidneys. VEGF staining became more diffuse with further re-oxygenation. CONCLUSION: Although synthesis of VEGF mRNA and protein is not increased during ischemia reperfusion injury, pre-existing VEGF in the tubular cell cytoplasm redistributes to the basolateral aspect of the cells. These data suggest that the kidney may have evolved unique patterns of VEGF regulation to cope with acute hypoxia.
73 schema:genre research_article
74 schema:inLanguage en
75 schema:isAccessibleForFree true
76 schema:isPartOf N2c1da833a03341f988f7fb1413cd6138
77 Nb3396d0526d2424bae583c74f7ef5619
78 sg:journal.1015319
79 schema:name Redistribution of cytoplasmic VEGF to the basolateral aspect of renal tubular cells in ischemia-reperfusion injury
80 schema:pagination 2445-2456
81 schema:productId N3f272c76f31e413bb1e960ff0bbd31be
82 N4dee08d58ba44804942af4f1694f96c4
83 N4e41f787ff1b4757a2b5e37d37010cb1
84 N58761d9e31bd440fb135c79433ed0b44
85 Nfa558c7ef96a46bdae9becaea0334ae3
86 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036851145
87 https://doi.org/10.1046/j.1523-1755.2000.00103.x
88 schema:sdDatePublished 2019-04-11T00:55
89 schema:sdLicense https://scigraph.springernature.com/explorer/license/
90 schema:sdPublisher N84ac78ab700249dbbf46b0c637c2c512
91 schema:url http://www.nature.com/ki/journal/v57/n6/full/4491584a.html
92 sgo:license sg:explorer/license/
93 sgo:sdDataset articles
94 rdf:type schema:ScholarlyArticle
95 N0b325253a977433494c09d46bc635123 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Endothelial Growth Factors
97 rdf:type schema:DefinedTerm
98 N0bb94ceaff234616b5080fe429bab8e9 rdf:first sg:person.0613322233.01
99 rdf:rest Nc1b587f2251745338570d0372a030ea0
100 N13a4ea16efed43f980a0428002419b5a rdf:first sg:person.01050643265.26
101 rdf:rest rdf:nil
102 N13abb5141cf742a39a4122506521153a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Vascular Endothelial Growth Factor A
104 rdf:type schema:DefinedTerm
105 N191822e4cc544bdc8e73e44471edc64e rdf:first sg:person.01121342466.28
106 rdf:rest N13a4ea16efed43f980a0428002419b5a
107 N21e0f29c0f4a4bbbaf417aa35fe6f95d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Lymphokines
109 rdf:type schema:DefinedTerm
110 N27f9f3ad6b81424eaceac451e22e5210 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Male
112 rdf:type schema:DefinedTerm
113 N2c1da833a03341f988f7fb1413cd6138 schema:volumeNumber 57
114 rdf:type schema:PublicationVolume
115 N2e31f82ef8ee4fbb8a49b12548886d3b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Ischemia
117 rdf:type schema:DefinedTerm
118 N3f272c76f31e413bb1e960ff0bbd31be schema:name pubmed_id
119 schema:value 10844613
120 rdf:type schema:PropertyValue
121 N4aa9f274ab03440682c745f58cbdb86c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Animals
123 rdf:type schema:DefinedTerm
124 N4dee08d58ba44804942af4f1694f96c4 schema:name nlm_unique_id
125 schema:value 0323470
126 rdf:type schema:PropertyValue
127 N4e41f787ff1b4757a2b5e37d37010cb1 schema:name dimensions_id
128 schema:value pub.1036851145
129 rdf:type schema:PropertyValue
130 N55923f9c573441f18744e54d8bf0133a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Renal Circulation
132 rdf:type schema:DefinedTerm
133 N58761d9e31bd440fb135c79433ed0b44 schema:name readcube_id
134 schema:value af8b9a547c4d0239e85f07b4520e87c1d6f162558f07763e2a28fa7531486bd7
135 rdf:type schema:PropertyValue
136 N68f4758c7c8945e681eee2230266e0c8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Cytoplasm
138 rdf:type schema:DefinedTerm
139 N6a85645e0390478980e1df3efeedcbb2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Rats, Sprague-Dawley
141 rdf:type schema:DefinedTerm
142 N6e4e55ca9a154d1f9bded036453d83d2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Cell Line
144 rdf:type schema:DefinedTerm
145 N70dd3b60f55b4440962da0f92ec54253 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Membrane Proteins
147 rdf:type schema:DefinedTerm
148 N84ac78ab700249dbbf46b0c637c2c512 schema:name Springer Nature - SN SciGraph project
149 rdf:type schema:Organization
150 N8605d99c41e04ed08700f91cd85782b5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Kidney Tubules
152 rdf:type schema:DefinedTerm
153 N8b53bcdb8c6348c89e9ef6b0025224fa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name RNA, Messenger
155 rdf:type schema:DefinedTerm
156 N9d63ba9efa3342adaca4e99b4dbfa3ab rdf:first sg:person.0632561625.57
157 rdf:rest N0bb94ceaff234616b5080fe429bab8e9
158 Naee3588250124dc9aba46ee368c70d3d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Rats
160 rdf:type schema:DefinedTerm
161 Nb3396d0526d2424bae583c74f7ef5619 schema:issueNumber 6
162 rdf:type schema:PublicationIssue
163 Nc1b587f2251745338570d0372a030ea0 rdf:first sg:person.01053227266.83
164 rdf:rest N191822e4cc544bdc8e73e44471edc64e
165 Nd07656acc54145e79fe201196a6c4c0c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Tissue Distribution
167 rdf:type schema:DefinedTerm
168 Nd2f6fb4f73364aa6b4faa870e5b07ef9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Reperfusion Injury
170 rdf:type schema:DefinedTerm
171 Nfa558c7ef96a46bdae9becaea0334ae3 schema:name doi
172 schema:value 10.1046/j.1523-1755.2000.00103.x
173 rdf:type schema:PropertyValue
174 Nff959fd8818a4363864b4c1e32e547a6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Vascular Endothelial Growth Factors
176 rdf:type schema:DefinedTerm
177 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
178 schema:name Medical and Health Sciences
179 rdf:type schema:DefinedTerm
180 anzsrc-for:1116 schema:inDefinedTermSet anzsrc-for:
181 schema:name Medical Physiology
182 rdf:type schema:DefinedTerm
183 sg:journal.1015319 schema:issn 0085-2538
184 1523-1755
185 schema:name Kidney International
186 rdf:type schema:Periodical
187 sg:person.01050643265.26 schema:familyName Power
188 schema:givenName D A
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050643265.26
190 rdf:type schema:Person
191 sg:person.01053227266.83 schema:familyName Fraser
192 schema:givenName S
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053227266.83
194 rdf:type schema:Person
195 sg:person.01121342466.28 schema:familyName Katerelos
196 schema:givenName M
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121342466.28
198 rdf:type schema:Person
199 sg:person.0613322233.01 schema:familyName Mudge
200 schema:givenName S J
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0613322233.01
202 rdf:type schema:Person
203 sg:person.0632561625.57 schema:affiliation https://www.grid.ac/institutes/grid.413105.2
204 schema:familyName Kanellis
205 schema:givenName J
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632561625.57
207 rdf:type schema:Person
208 sg:pub.10.1007/978-3-0348-7001-6_2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049764289
209 https://doi.org/10.1007/978-3-0348-7001-6_2
210 rdf:type schema:CreativeWork
211 sg:pub.10.1007/s004240050348 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009420330
212 https://doi.org/10.1007/s004240050348
213 rdf:type schema:CreativeWork
214 sg:pub.10.1038/359843a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028884048
215 https://doi.org/10.1038/359843a0
216 rdf:type schema:CreativeWork
217 sg:pub.10.1038/ki.1990.143 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037642757
218 https://doi.org/10.1038/ki.1990.143
219 rdf:type schema:CreativeWork
220 sg:pub.10.1038/ki.1993.337 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025544696
221 https://doi.org/10.1038/ki.1993.337
222 rdf:type schema:CreativeWork
223 sg:pub.10.1038/ki.1997.148 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038443863
224 https://doi.org/10.1038/ki.1997.148
225 rdf:type schema:CreativeWork
226 sg:pub.10.1038/ki.1997.59 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046007011
227 https://doi.org/10.1038/ki.1997.59
228 rdf:type schema:CreativeWork
229 sg:pub.10.1038/ki.1997.60 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046473371
230 https://doi.org/10.1038/ki.1997.60
231 rdf:type schema:CreativeWork
232 sg:pub.10.1038/nm0195-27 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008981922
233 https://doi.org/10.1038/nm0195-27
234 rdf:type schema:CreativeWork
235 sg:pub.10.1046/j.1523-1755.1998.00846.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1048426004
236 https://doi.org/10.1046/j.1523-1755.1998.00846.x
237 rdf:type schema:CreativeWork
238 https://app.dimensions.ai/details/publication/pub.1076034910 schema:CreativeWork
239 https://app.dimensions.ai/details/publication/pub.1076604442 schema:CreativeWork
240 https://app.dimensions.ai/details/publication/pub.1076970932 schema:CreativeWork
241 https://app.dimensions.ai/details/publication/pub.1077325111 schema:CreativeWork
242 https://app.dimensions.ai/details/publication/pub.1079684378 schema:CreativeWork
243 https://app.dimensions.ai/details/publication/pub.1082881127 schema:CreativeWork
244 https://doi.org/10.1002/jcb.240470305 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024021353
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1016/0046-8177(94)90166-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1036526018
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1016/0092-8674(94)90187-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046752632
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1016/s0039-6060(96)80120-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047746915
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1016/s0076-6879(84)04097-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050935599
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1056/nejm199412013312203 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018716626
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1056/nejm199503093321006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050463480
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1073/pnas.87.7.2628 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020252185
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1073/pnas.91.5.1691 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048592119
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1074/jbc.270.22.13333 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006355584
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1074/jbc.270.34.19761 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038607124
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1074/jbc.270.44.26460 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045570142
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1074/jbc.270.52.31189 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000313948
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1074/jbc.271.13.7788 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052270689
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1074/jbc.271.5.2746 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019049306
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1074/jbc.272.20.13390 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049319751
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1074/jbc.273.21.13313 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006436940
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1074/jbc.273.46.30336 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030188573
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1084/jem.174.5.1275 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036306308
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1084/jem.180.1.341 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016566769
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1091/mbc.4.12.1317 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051224202
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1093/cvr/28.8.1176 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059488265
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1093/nar/13.7.2485 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008134818
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1146/annurev.me.44.020193.000331 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038079239
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1152/ajpheart.1994.267.5.h1948 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082592270
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1152/ajpheart.1996.270.5.h1803 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083003118
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1152/ajprenal.1994.266.1.f81 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082748280
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1152/physrev.1996.76.3.839 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082940693
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1172/jci114359 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022012664
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1172/jci117858 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030112284
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1172/jci118087 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019526766
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1210/mend-5-12-1806 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064331012
307 rdf:type schema:CreativeWork
308 https://doi.org/10.3109/08977199509003209 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021839026
309 rdf:type schema:CreativeWork
310 https://www.grid.ac/institutes/grid.413105.2 schema:alternateName St Vincent's Hospital
311 schema:name Departments of Nephrology and Clinical Immunology, St. Vincent's Hospital Melbourne, Fitzroy, Victoria, Australia. kanellj@svhm.org.au
312 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...