Heparin-binding epidermal growth factor-like growth factor is expressed in the adhesive lesions of experimental focal glomerular sclerosis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1999-06

AUTHORS

K Paizis, G Kirkland, T Khong, M Katerelos, S Fraser, J Kanellis, D A Power

ABSTRACT

BACKGROUND: In this study, we attempted to determine whether heparin-binding epidermal growth factor-like growth factor (HB-EGF) was up-regulated in two chronic models of proteinuria. METHODS: Chronic passive Heymann nephritis (PHN) and puromycin aminonucleoside (PAN) models were induced in Sprague-Dawley rats. HB-EGF expression was studied by Northern blotting, in situ hybridization, and immunohistochemistry. RESULTS: The chronic PAN model was associated with the development of glomerular lesions of focal glomerular sclerosis (FGS), severe interstitial fibrosis, and renal failure. Lesions of FGS were seen in approximately 80% of glomeruli at all time points, with a slight increase in the number of glomeruli showing extensive adhesion between 40 and 90 days. Northern blots of whole kidney tissue showed a 3- to 5.8-fold increased expression of HB-EGF mRNA in the chronic PAN group. Increased mRNA and protein were localized by in situ hybridization and immunohistochemistry to tubules, glomerular epithelial cells (GECs), and cells of Bowman's capsule. HB-EGF mRNA and protein were strongly expressed by epithelial cells involved in the formation of the lesions of FGS. By contrast, in chronic PHN, there was a small increase in HB-EGF, and the extensive lesions of FGS did not develop despite continued, heavy proteinuria. CONCLUSIONS: These data suggest that HB-EGF may contribute to formation of the lesions of FGS, perhaps through stimulation of abortive mitogenesis in GECs or an adhesive interaction between transmembrane HB-EGF and the exposed glomerular basement membrane. More... »

PAGES

2310-2321

Identifiers

URI

http://scigraph.springernature.com/pub.10.1046/j.1523-1755.1999.00469.x

DOI

http://dx.doi.org/10.1046/j.1523-1755.1999.00469.x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1035699409

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10354279


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Actins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Creatinine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Models, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Epidermal Growth Factor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glomerulonephritis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glomerulosclerosis, Focal Segmental", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Heparin-binding EGF-like Growth Factor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunohistochemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Intercellular Signaling Peptides and Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Macrophages", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proteinuria", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Puromycin Aminonucleoside", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Messenger", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats, Sprague-Dawley", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Up-Regulation", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Department of Nephrology, St. Vincent's Hospital, Victoria, Australia."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Paizis", 
        "givenName": "K", 
        "id": "sg:person.01120617545.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120617545.34"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Kirkland", 
        "givenName": "G", 
        "id": "sg:person.01106203352.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106203352.46"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Khong", 
        "givenName": "T", 
        "id": "sg:person.01335455776.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01335455776.72"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Katerelos", 
        "givenName": "M", 
        "id": "sg:person.01121342466.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121342466.28"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Fraser", 
        "givenName": "S", 
        "id": "sg:person.01053227266.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053227266.83"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Kanellis", 
        "givenName": "J", 
        "id": "sg:person.0632561625.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632561625.57"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Power", 
        "givenName": "D A", 
        "id": "sg:person.01050643265.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050643265.26"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1006/bbrc.1993.1020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000567715"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.272.49.31036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000821988"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1991.310", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005063288", 
          "https://doi.org/10.1038/ki.1991.310"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-4613-2463-8_50", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019590164", 
          "https://doi.org/10.1007/978-1-4613-2463-8_50"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1995.433", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020532839", 
          "https://doi.org/10.1038/ki.1995.433"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.103.6.2787", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023744698"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1992.173", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033218774", 
          "https://doi.org/10.1038/ki.1992.173"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0304-419x(97)00024-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042389470"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci118351", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042461679"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1996.17", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043668529", 
          "https://doi.org/10.1038/ki.1996.17"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1046/j.1523-1755.1998.00846.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048426004", 
          "https://doi.org/10.1046/j.1523-1755.1998.00846.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci115089", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053074066"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1840698", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062509886"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.7123245", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062644230"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075586886", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajprenal.1992.262.5.f770", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077054668"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080012491", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082745996", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082884262", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082894386", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082894398", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083004182", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083060477", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083158427", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083160801", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083303584", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1999-06", 
    "datePublishedReg": "1999-06-01", 
    "description": "BACKGROUND: In this study, we attempted to determine whether heparin-binding epidermal growth factor-like growth factor (HB-EGF) was up-regulated in two chronic models of proteinuria.\nMETHODS: Chronic passive Heymann nephritis (PHN) and puromycin aminonucleoside (PAN) models were induced in Sprague-Dawley rats. HB-EGF expression was studied by Northern blotting, in situ hybridization, and immunohistochemistry.\nRESULTS: The chronic PAN model was associated with the development of glomerular lesions of focal glomerular sclerosis (FGS), severe interstitial fibrosis, and renal failure. Lesions of FGS were seen in approximately 80% of glomeruli at all time points, with a slight increase in the number of glomeruli showing extensive adhesion between 40 and 90 days. Northern blots of whole kidney tissue showed a 3- to 5.8-fold increased expression of HB-EGF mRNA in the chronic PAN group. Increased mRNA and protein were localized by in situ hybridization and immunohistochemistry to tubules, glomerular epithelial cells (GECs), and cells of Bowman's capsule. HB-EGF mRNA and protein were strongly expressed by epithelial cells involved in the formation of the lesions of FGS. By contrast, in chronic PHN, there was a small increase in HB-EGF, and the extensive lesions of FGS did not develop despite continued, heavy proteinuria.\nCONCLUSIONS: These data suggest that HB-EGF may contribute to formation of the lesions of FGS, perhaps through stimulation of abortive mitogenesis in GECs or an adhesive interaction between transmembrane HB-EGF and the exposed glomerular basement membrane.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1046/j.1523-1755.1999.00469.x", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1015319", 
        "issn": [
          "0085-2538", 
          "1523-1755"
        ], 
        "name": "Kidney International", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "55"
      }
    ], 
    "name": "Heparin-binding epidermal growth factor-like growth factor is expressed in the adhesive lesions of experimental focal glomerular sclerosis", 
    "pagination": "2310-2321", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "aa0f34c11bfa34e847a5a5d9f51d394760bb148cbbb315e43b930d994ec6c94d"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "10354279"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0323470"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1046/j.1523-1755.1999.00469.x"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1035699409"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1046/j.1523-1755.1999.00469.x", 
      "https://app.dimensions.ai/details/publication/pub.1035699409"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T13:56", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000425.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/ki/journal/v55/n6/full/4490807a.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1046/j.1523-1755.1999.00469.x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1046/j.1523-1755.1999.00469.x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1046/j.1523-1755.1999.00469.x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1046/j.1523-1755.1999.00469.x'


 

This table displays all metadata directly associated to this object as RDF triples.

249 TRIPLES      21 PREDICATES      73 URIs      39 LITERALS      27 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1046/j.1523-1755.1999.00469.x schema:about N087542bb2b954d8e97f7e45343da702d
2 N25ab47cd7c054a0f94075d2d9beeaf53
3 N43bd5447dabf45d88414dffc5c1eb8ca
4 N45d5273035dc4a98afd11fa842e0c98c
5 N52ae762c9d38441f941a6e2bda8c355e
6 N7475db497b3e48afa0051f80b8d963ef
7 N80033bf4f91041ef991b8628809e9718
8 N8069a915b5064ab3a1616d38c6edba82
9 N8b4aee4771f942438a9ddc765f3ccf54
10 N945a7704e0ff438a8b461a1bd6ebfba2
11 N9b876522169e45b2886653b9fe3d5608
12 Nad0f1231180d4532af764d6b3ccbd249
13 Naf81c7d5503a46c1b5094fbd2461951d
14 Nc235f732e1744ab7901803d3d7b67698
15 Ncb633be7fce54684bd114f0767478e9a
16 Nd1b7e5d010d84e4f8f8bb43e3978147e
17 Nf286e503aa75499ab6f2395d23327861
18 Nfd5f7ac341ec4a73953cfcead804f7bc
19 anzsrc-for:11
20 anzsrc-for:1103
21 schema:author N22e0c07fe9a541b393d8fc7ace2d89b4
22 schema:citation sg:pub.10.1007/978-1-4613-2463-8_50
23 sg:pub.10.1038/ki.1991.310
24 sg:pub.10.1038/ki.1992.173
25 sg:pub.10.1038/ki.1995.433
26 sg:pub.10.1038/ki.1996.17
27 sg:pub.10.1046/j.1523-1755.1998.00846.x
28 https://app.dimensions.ai/details/publication/pub.1075586886
29 https://app.dimensions.ai/details/publication/pub.1080012491
30 https://app.dimensions.ai/details/publication/pub.1082745996
31 https://app.dimensions.ai/details/publication/pub.1082884262
32 https://app.dimensions.ai/details/publication/pub.1082894386
33 https://app.dimensions.ai/details/publication/pub.1082894398
34 https://app.dimensions.ai/details/publication/pub.1083004182
35 https://app.dimensions.ai/details/publication/pub.1083060477
36 https://app.dimensions.ai/details/publication/pub.1083158427
37 https://app.dimensions.ai/details/publication/pub.1083160801
38 https://app.dimensions.ai/details/publication/pub.1083303584
39 https://doi.org/10.1006/bbrc.1993.1020
40 https://doi.org/10.1016/s0304-419x(97)00024-3
41 https://doi.org/10.1074/jbc.272.49.31036
42 https://doi.org/10.1083/jcb.103.6.2787
43 https://doi.org/10.1126/science.1840698
44 https://doi.org/10.1126/science.7123245
45 https://doi.org/10.1152/ajprenal.1992.262.5.f770
46 https://doi.org/10.1172/jci115089
47 https://doi.org/10.1172/jci118351
48 schema:datePublished 1999-06
49 schema:datePublishedReg 1999-06-01
50 schema:description BACKGROUND: In this study, we attempted to determine whether heparin-binding epidermal growth factor-like growth factor (HB-EGF) was up-regulated in two chronic models of proteinuria. METHODS: Chronic passive Heymann nephritis (PHN) and puromycin aminonucleoside (PAN) models were induced in Sprague-Dawley rats. HB-EGF expression was studied by Northern blotting, in situ hybridization, and immunohistochemistry. RESULTS: The chronic PAN model was associated with the development of glomerular lesions of focal glomerular sclerosis (FGS), severe interstitial fibrosis, and renal failure. Lesions of FGS were seen in approximately 80% of glomeruli at all time points, with a slight increase in the number of glomeruli showing extensive adhesion between 40 and 90 days. Northern blots of whole kidney tissue showed a 3- to 5.8-fold increased expression of HB-EGF mRNA in the chronic PAN group. Increased mRNA and protein were localized by in situ hybridization and immunohistochemistry to tubules, glomerular epithelial cells (GECs), and cells of Bowman's capsule. HB-EGF mRNA and protein were strongly expressed by epithelial cells involved in the formation of the lesions of FGS. By contrast, in chronic PHN, there was a small increase in HB-EGF, and the extensive lesions of FGS did not develop despite continued, heavy proteinuria. CONCLUSIONS: These data suggest that HB-EGF may contribute to formation of the lesions of FGS, perhaps through stimulation of abortive mitogenesis in GECs or an adhesive interaction between transmembrane HB-EGF and the exposed glomerular basement membrane.
51 schema:genre research_article
52 schema:inLanguage en
53 schema:isAccessibleForFree true
54 schema:isPartOf N1a84918adc4d49b8831be48cbdca6c4f
55 N39b14cb73c564856977ea9f6a87a15c3
56 sg:journal.1015319
57 schema:name Heparin-binding epidermal growth factor-like growth factor is expressed in the adhesive lesions of experimental focal glomerular sclerosis
58 schema:pagination 2310-2321
59 schema:productId N00eb9b8f26d549f7aaa43c8ece64cbe0
60 N3432aa578c6e4e0090c87ff79cdfba73
61 N776ba47c16d54fe6a7c27853fe7b51de
62 Nebbcbdc7a0f64b9d9ae63b4f6e9914ea
63 Ned928a8b0f3944569dbd49ef65cdbcd2
64 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035699409
65 https://doi.org/10.1046/j.1523-1755.1999.00469.x
66 schema:sdDatePublished 2019-04-10T13:56
67 schema:sdLicense https://scigraph.springernature.com/explorer/license/
68 schema:sdPublisher N2d3398cb59c447d7baf6365302e2b45e
69 schema:url http://www.nature.com/ki/journal/v55/n6/full/4490807a.html
70 sgo:license sg:explorer/license/
71 sgo:sdDataset articles
72 rdf:type schema:ScholarlyArticle
73 N00eb9b8f26d549f7aaa43c8ece64cbe0 schema:name pubmed_id
74 schema:value 10354279
75 rdf:type schema:PropertyValue
76 N087542bb2b954d8e97f7e45343da702d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
77 schema:name Male
78 rdf:type schema:DefinedTerm
79 N0d0103b018cc4c149e5c267b23e48f07 rdf:first sg:person.01121342466.28
80 rdf:rest Nb34475aed3ca4d64b9137f04c76532fb
81 N1a84918adc4d49b8831be48cbdca6c4f schema:volumeNumber 55
82 rdf:type schema:PublicationVolume
83 N1cee709d51384eab9535a0842c154a42 rdf:first sg:person.01050643265.26
84 rdf:rest rdf:nil
85 N22e0c07fe9a541b393d8fc7ace2d89b4 rdf:first sg:person.01120617545.34
86 rdf:rest Neb016f2876ac4251beba0a6a75f1fca0
87 N25ab47cd7c054a0f94075d2d9beeaf53 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Glomerulonephritis
89 rdf:type schema:DefinedTerm
90 N2d3398cb59c447d7baf6365302e2b45e schema:name Springer Nature - SN SciGraph project
91 rdf:type schema:Organization
92 N3432aa578c6e4e0090c87ff79cdfba73 schema:name doi
93 schema:value 10.1046/j.1523-1755.1999.00469.x
94 rdf:type schema:PropertyValue
95 N39b14cb73c564856977ea9f6a87a15c3 schema:issueNumber 6
96 rdf:type schema:PublicationIssue
97 N4211b0fb01fe49cca80d53f02d7ca545 rdf:first sg:person.01335455776.72
98 rdf:rest N0d0103b018cc4c149e5c267b23e48f07
99 N43bd5447dabf45d88414dffc5c1eb8ca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Rats, Sprague-Dawley
101 rdf:type schema:DefinedTerm
102 N45d5273035dc4a98afd11fa842e0c98c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Intercellular Signaling Peptides and Proteins
104 rdf:type schema:DefinedTerm
105 N52ae762c9d38441f941a6e2bda8c355e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Animals
107 rdf:type schema:DefinedTerm
108 N7475db497b3e48afa0051f80b8d963ef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Immunohistochemistry
110 rdf:type schema:DefinedTerm
111 N776ba47c16d54fe6a7c27853fe7b51de schema:name readcube_id
112 schema:value aa0f34c11bfa34e847a5a5d9f51d394760bb148cbbb315e43b930d994ec6c94d
113 rdf:type schema:PropertyValue
114 N80033bf4f91041ef991b8628809e9718 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Puromycin Aminonucleoside
116 rdf:type schema:DefinedTerm
117 N8069a915b5064ab3a1616d38c6edba82 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name RNA, Messenger
119 rdf:type schema:DefinedTerm
120 N8b4aee4771f942438a9ddc765f3ccf54 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Macrophages
122 rdf:type schema:DefinedTerm
123 N945a7704e0ff438a8b461a1bd6ebfba2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Rats
125 rdf:type schema:DefinedTerm
126 N9b876522169e45b2886653b9fe3d5608 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Up-Regulation
128 rdf:type schema:DefinedTerm
129 Nad0f1231180d4532af764d6b3ccbd249 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Epidermal Growth Factor
131 rdf:type schema:DefinedTerm
132 Naf81c7d5503a46c1b5094fbd2461951d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Disease Models, Animal
134 rdf:type schema:DefinedTerm
135 Nb056375485f445dca2dd68590259f378 schema:name Department of Nephrology, St. Vincent's Hospital, Victoria, Australia.
136 rdf:type schema:Organization
137 Nb34475aed3ca4d64b9137f04c76532fb rdf:first sg:person.01053227266.83
138 rdf:rest Nc3be34fe7858462f887cde443f7b5c23
139 Nc235f732e1744ab7901803d3d7b67698 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Actins
141 rdf:type schema:DefinedTerm
142 Nc3be34fe7858462f887cde443f7b5c23 rdf:first sg:person.0632561625.57
143 rdf:rest N1cee709d51384eab9535a0842c154a42
144 Ncb633be7fce54684bd114f0767478e9a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Heparin-binding EGF-like Growth Factor
146 rdf:type schema:DefinedTerm
147 Nd1b7e5d010d84e4f8f8bb43e3978147e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Glomerulosclerosis, Focal Segmental
149 rdf:type schema:DefinedTerm
150 Neb016f2876ac4251beba0a6a75f1fca0 rdf:first sg:person.01106203352.46
151 rdf:rest N4211b0fb01fe49cca80d53f02d7ca545
152 Nebbcbdc7a0f64b9d9ae63b4f6e9914ea schema:name nlm_unique_id
153 schema:value 0323470
154 rdf:type schema:PropertyValue
155 Ned928a8b0f3944569dbd49ef65cdbcd2 schema:name dimensions_id
156 schema:value pub.1035699409
157 rdf:type schema:PropertyValue
158 Nf286e503aa75499ab6f2395d23327861 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Proteinuria
160 rdf:type schema:DefinedTerm
161 Nfd5f7ac341ec4a73953cfcead804f7bc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Creatinine
163 rdf:type schema:DefinedTerm
164 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
165 schema:name Medical and Health Sciences
166 rdf:type schema:DefinedTerm
167 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
168 schema:name Clinical Sciences
169 rdf:type schema:DefinedTerm
170 sg:journal.1015319 schema:issn 0085-2538
171 1523-1755
172 schema:name Kidney International
173 rdf:type schema:Periodical
174 sg:person.01050643265.26 schema:familyName Power
175 schema:givenName D A
176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050643265.26
177 rdf:type schema:Person
178 sg:person.01053227266.83 schema:familyName Fraser
179 schema:givenName S
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053227266.83
181 rdf:type schema:Person
182 sg:person.01106203352.46 schema:familyName Kirkland
183 schema:givenName G
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106203352.46
185 rdf:type schema:Person
186 sg:person.01120617545.34 schema:affiliation Nb056375485f445dca2dd68590259f378
187 schema:familyName Paizis
188 schema:givenName K
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120617545.34
190 rdf:type schema:Person
191 sg:person.01121342466.28 schema:familyName Katerelos
192 schema:givenName M
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121342466.28
194 rdf:type schema:Person
195 sg:person.01335455776.72 schema:familyName Khong
196 schema:givenName T
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01335455776.72
198 rdf:type schema:Person
199 sg:person.0632561625.57 schema:familyName Kanellis
200 schema:givenName J
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632561625.57
202 rdf:type schema:Person
203 sg:pub.10.1007/978-1-4613-2463-8_50 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019590164
204 https://doi.org/10.1007/978-1-4613-2463-8_50
205 rdf:type schema:CreativeWork
206 sg:pub.10.1038/ki.1991.310 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005063288
207 https://doi.org/10.1038/ki.1991.310
208 rdf:type schema:CreativeWork
209 sg:pub.10.1038/ki.1992.173 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033218774
210 https://doi.org/10.1038/ki.1992.173
211 rdf:type schema:CreativeWork
212 sg:pub.10.1038/ki.1995.433 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020532839
213 https://doi.org/10.1038/ki.1995.433
214 rdf:type schema:CreativeWork
215 sg:pub.10.1038/ki.1996.17 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043668529
216 https://doi.org/10.1038/ki.1996.17
217 rdf:type schema:CreativeWork
218 sg:pub.10.1046/j.1523-1755.1998.00846.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1048426004
219 https://doi.org/10.1046/j.1523-1755.1998.00846.x
220 rdf:type schema:CreativeWork
221 https://app.dimensions.ai/details/publication/pub.1075586886 schema:CreativeWork
222 https://app.dimensions.ai/details/publication/pub.1080012491 schema:CreativeWork
223 https://app.dimensions.ai/details/publication/pub.1082745996 schema:CreativeWork
224 https://app.dimensions.ai/details/publication/pub.1082884262 schema:CreativeWork
225 https://app.dimensions.ai/details/publication/pub.1082894386 schema:CreativeWork
226 https://app.dimensions.ai/details/publication/pub.1082894398 schema:CreativeWork
227 https://app.dimensions.ai/details/publication/pub.1083004182 schema:CreativeWork
228 https://app.dimensions.ai/details/publication/pub.1083060477 schema:CreativeWork
229 https://app.dimensions.ai/details/publication/pub.1083158427 schema:CreativeWork
230 https://app.dimensions.ai/details/publication/pub.1083160801 schema:CreativeWork
231 https://app.dimensions.ai/details/publication/pub.1083303584 schema:CreativeWork
232 https://doi.org/10.1006/bbrc.1993.1020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000567715
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1016/s0304-419x(97)00024-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042389470
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1074/jbc.272.49.31036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000821988
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1083/jcb.103.6.2787 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023744698
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1126/science.1840698 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062509886
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1126/science.7123245 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062644230
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1152/ajprenal.1992.262.5.f770 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077054668
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1172/jci115089 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053074066
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1172/jci118351 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042461679
249 rdf:type schema:CreativeWork
 




Preview window. Press ESC to close (or click here)


...