Kidney transplanted children come of age View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1999-04

AUTHORS

G Offner, K Latta, P F Hoyer, H J Baum, J H Ehrich, R Pichlmayr, J Brodehl

ABSTRACT

BACKGROUND: The aim of renal replacement therapy in children is to restore their potential for normal growth and development in order to reach mature adulthood. Because pediatric kidney transplantation started in the late 1960s, it is now possible to document the progress and outcome of these patients from transplantation in childhood to survival into adulthood. METHODS: In this single-center study, all 150 children born before December 1977 and having received a kidney transplant between 1970 and 1993 were selected for long-term follow-up. The mean age at transplantation was 12.1 years (range 3.2 to 16.7), and the mean follow-up was 13.1 years (range 2.0 to 25.0). In December 1995, 124 grown-up patients with a mean age of 25.4 years (range 18.4 to 40.3) were alive, 89 with a functioning graft. Fifty had the first graft functioning longer than 10 years. The fate of all patients was traced, and those living were analyzed in regard to their somatic and socioeconomic states. RESULTS: The actuarial 25-year survival rate for the patients was 81%, and for the first graft it was 31%. The best graft survival rates were observed after living related donation, preemptive transplantation, and immunosuppression with cyclosporine. The latter benefit, however, vanished after eight years. The mean creatinine clearance declined over the years from 76 to 45 ml/min/1.73 m2, and the incidence of hypertension increased to more than 80% of the patients. Malignancies occurred in 2.6%. Final height was stunted in 44% of noncystinotic patients, whereas all patients with cystinosis were extremely growth retarded. Twenty-seven percent suffered from additional disabilities. A majority of adult patients were rehabilitated in regard to education and socioeconomic status, and 14% were unemployed. CONCLUSIONS: The results indicate that renal transplantation in children leads to a high degree of rehabilitation in adulthood. The life of a kidney transplant, however, is limited, which points out the need for more specific immunosuppression with fewer side-effects in order to reach the goal of lifelong graft function. More... »

PAGES

1509-1517

References to SciGraph publications

  • 1994-09. Final Height and Its Predictive Factors after Renal Transplantation in Childhood in PEDIATRIC RESEARCH
  • 1995-01. Do children exhibit catch-up growth post transplant: North American Pediatric Renal Transplant Cooperative Study special study in PEDIATRIC NEPHROLOGY
  • 1995-06. Chronic renal transplant loss in KIDNEY INTERNATIONAL
  • 1991-03. Prior dialysis does not affect the outcome of pediatric renal transplantation in PEDIATRIC NEPHROLOGY
  • 1993-05. Post-transplant conversion from cyclosporin to azathioprine: effect on cardiovascular risk profile in TRANSPLANT INTERNATIONAL
  • 1994-02. Causes of kidney allograft loss in a large pediatric population at a single center in PEDIATRIC NEPHROLOGY
  • 1991-01. The psychosocial implications of pre-emptive transplantation in PEDIATRIC NEPHROLOGY
  • 1996-04. Chronic rejection and late renal allograft dysfunction in PEDIATRIC NEPHROLOGY
  • 1991-10. Long-term results of renal transplantation in children in KIDNEY INTERNATIONAL
  • 1995-02. Renal transplantation and chronic dialysis in children and adolescents: the 1993 annual report of the North American Pediatric Renal Transplant Cooperative Study in PEDIATRIC NEPHROLOGY
  • 1992-09. Psychosocial adaptation of children and adolescents with chronic renal failure in PEDIATRIC NEPHROLOGY
  • 1997-01. Renal transplantation, chronic dialysis, and chronic renal insufficiency in children and adolescents. The 1995 Annual Report of the North American Pediatric Renal Transplant Cooperative Study in PEDIATRIC NEPHROLOGY
  • 1993-12. The paediatric registry of the European Dialysis and Transplant Association: 20 years' experience in PEDIATRIC NEPHROLOGY
  • 1996-02. Mortality trends in pediatric patients with chronic renal failure in PEDIATRIC NEPHROLOGY
  • 1996. German multicenter analysis of malignancies following renal replacement therapy in children in CANCER IN TRANSPLANTATION: PREVENTION AND TREATMENT
  • 1987-06. Cyclosporin A in paediatric kidney transplantation in PEDIATRIC NEPHROLOGY
  • 1984. Kidney Transplantation in PAEDIATRIC NEPHROLOGY
  • 1992. Nonparametric Estimation from Incomplete Observations in BREAKTHROUGHS IN STATISTICS
  • 1995-07. Chronic renal allograft rejection can be predicted by area under the serum creatinine versus time curve (AUCCr) in KIDNEY INTERNATIONAL
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1046/j.1523-1755.1999.00356.x

    DOI

    http://dx.doi.org/10.1046/j.1523-1755.1999.00356.x

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1042352751

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/10201017


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