P2X Purinergic Receptor Antagonist Accelerates SkinBarrier Repair and Prevents Epidermal Hyperplasia Inducedby Skin Barrier Disruption View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2002-11

AUTHORS

Mitsuhiro Denda, Kaori Inoue, Shigeyoshi Fuziwara, Sumiko Denda

ABSTRACT

The effects of ATP receptor agonists/antagonists on skin barrier recovery rate were evaluated in hairless mice. Topical application of ATP and alpha,beta-methylene ATP (agonist of P2X receptor) delayed barrier recovery. Topical application of suramin (nonspecific ATP receptor antagonist), pyridoxal-phosphate-6-azophenyl-2',4'-disulfonic acid (PPADS) (P2X receptor antagonist), and 2',3'-O-(2,4,6-trinitrophenyl)adenosine 5'-triphosphate (TNP-ATP) (P2X1, P2X3, P2X2/3 antagonist) after barrier disruption accelerated the barrier repair. The P2Y type receptor antagonist Reactive Blue 2 did not affect the barrier repair process. Moreover, topical application of TNP-ATP prevented epidermal hyperplasia induced by barrier insult under low environmental humidity. ATP was secreted immediately after tape stripping on skin in organ culture. alpha,beta-Methylene ATP increased intercellular calcium in cultured keratinocytes and the increase was blocked by TNP-ATP. Both reverse transcription polymerase chain reaction assay and immunohistochemical study showed the existence of protein that had a structure similar to P2X3 on hairless mouse epidermis. These results suggest that cutaneous barrier homeostasis can be regulated by cation flux through a P2X3-like ATP receptor. More... »

PAGES

1034-1040

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1046/j.1523-1747.2002.19505.x

    DOI

    http://dx.doi.org/10.1046/j.1523-1747.2002.19505.x

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1041085017

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/12445189


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