Carboxyfullerenes Protect Human Keratinocytes from Ultraviolet-B-Induced Apoptosis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2000-11

AUTHORS

Cristiana Fumelli, Alessandra Marconi, Stefano Salvioli, Elisabetta Straface, Walter Malorni, Anna Maria Offidani, Roberto Pellicciari, Gennaro Schettini, Alberto Giannetti, Daniela Monti, Claudio Franceschi, Carlo Pincelli

ABSTRACT

Carboxyfullerene, a water-soluble carboxylic acid derivative of a fullerene, which acts as a free-radical scavenger, was investigated as a protective agent against ultraviolet-light-induced damage in human keratinocytes. First, we demonstrate that carboxyfullerene is not cytotoxic for these cells. In addition, this compound significantly reduces the ultraviolet-B-induced inhibition of keratinocyte proliferation and protects keratinocytes from apoptosis caused by ultraviolet B irradiation in a time- and dose-dependent fashion. Furthermore, the percentage of cells with depolarized mitochondria is significantly lower in ultraviolet-B-irradiated keratinocytes pretreated with carboxyfullerene than in cells provided with diluent alone. Carboxyfullerene also protects human keratinocytes from apoptosis induced by exposure to deoxy-D-ribose, a sugar that causes cell death through a pathway involving oxidative stress. On the other hand, ultraviolet B downregulates bcl-2 levels in human keratinocytes, and carboxyfullerene fails to prevent this effect. These results suggest that carboxy- fullerene protects human keratinocytes from ultraviolet B damage possibly via a mechanism interfering with the generation of reactive oxygen species from depolarized mitochondria without the involvement of bcl-2. More... »

PAGES

835-841

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1046/j.1523-1747.2000.00140.x

    DOI

    http://dx.doi.org/10.1046/j.1523-1747.2000.00140.x

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1020347615

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/11069621


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