In Vivo Gene Therapy with Interleukin-12 Inhibits Primary Vascular Tumor Growth and Induces Apoptosis in a Mouse Model1 View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1999-05

AUTHORS

C Wang, M E Quevedo, B J Lannutti, K B Gordon, D Guo, W Sun, A S Paller

ABSTRACT

Interleukin-12 is proposed to have anti-neoplastic activity on the basis of both its anti-angiogenic and immunologic effects. Gene gun therapy with interleukin-12 cDNA into the peritumoral area of immunocompetent 129/J mice with life-threatening primary vascular tumors reduced tumor volume 7.5-fold and almost tripled the duration of mouse survival, in contrast with luciferase-bombarded control mice. Epidermal expression of mouse interleukin-12 elevated tumoral and serum levels of interferon-gamma and tumor necrosis factor-alpha, increased the tumoral populations of T lymphocyte and natural killer cells, and induced tumor apoptosis. Gene transfer of interleukin-12 had little effect on tumor volumes and survival of tumor-bearing athymic nude mice, emphasizing the requirement for T cell directed cellular immunity. Peritumoral gene gun introduction of interleukin-12 may be a novel, cost-effective approach to limit the growth and associated mortality of life-threatening tumors. More... »

PAGES

775-781

Identifiers

URI

http://scigraph.springernature.com/pub.10.1046/j.1523-1747.1999.00587.x

DOI

http://dx.doi.org/10.1046/j.1523-1747.1999.00587.x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1023035539

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10233771


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