Topical Gene Delivery to Murine Skin View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1999-03

AUTHORS

Wei Hong Yu, Mohammed Kashani-Sabet, Denny Liggitt, Dan Moore, Timothy D Heath, Robert J Debs

ABSTRACT

We topically applied naked plasmid DNA containing the luciferase or chloramphenicol acetyltransferase cDNA directly to mouse skin. Gene expression was detected in skin samples as early as 4 h after DNA application, plateaued from 16 to 72 h post-application, and had decreased significantly by 7 d post-application. Reporter gene activity following topical DNA delivery was comparable with that produced by intradermal injection of DNA. Plasmid DNA at concentrations > or =0.25 microg per microl were required to achieve maximal expression levels. Reporter gene expression following topical administration was largely confined to the superficial layers of the epidermis and to hair follicles. Surprisingly, certain cationic liposomes inhibited the efficiency of cutaneous gene transfer. This technique provides a simple, clinically relevant approach to deliver genes to the skin, with potential application in treating a variety of cutaneous disorders. More... »

PAGES

370-375

Journal

TITLE

Journal of Investigative Dermatology

ISSUE

3

VOLUME

112

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1046/j.1523-1747.1999.00513.x

DOI

http://dx.doi.org/10.1046/j.1523-1747.1999.00513.x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1045342729

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10084316


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