IL-1β transcript stability in monocytes is linked to cytoskeletal reorganization and the availability of mRNA degradation factors View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2002-08

AUTHORS

Oksana Sirenko, Ulrich Böcker, John S Morris, J Stephen Haskill, Joanna M Watson

ABSTRACT

Monocyte extravasation initiates reorganization of the cytoskeleton (CSK) and adhesion-dependent cytokine gene transcription. The actin CSK is thought to be crucial for compartmentalization and translation of mRNA, many of which contain AU-rich (ARE) instability motifs in the 3' untranslated region. We investigated regulation of adhesion-induced IL-1 beta expression by the monocyte CSK. In serum-free adherent monocytes, the induced IL-1 beta mRNA was stable and did not coextract with actin filaments. In contrast, in cells adherent in autologous serum, IL-1 beta transcripts were unstable, coextracted with actin filaments and were associated with only transient activation of the mitogen-activated protein kinases (MAPK). Under both conditions of adherence, the ARE-binding protein AUF1/hnRNP D was readily extracted in the cytosolic fraction. Electro-injection with AUF1/hnRNP D modified the actin CSK and, surprisingly, stabilized IL-1 beta transcripts. These data suggest that the control of mRNA degradation is linked with changes in the CSK. Mitogen-activated protein kinase activation or alterations in the availability of mRNA degradation factors may mediate these effects. More... »

PAGES

328

Identifiers

URI

http://scigraph.springernature.com/pub.10.1046/j.1440-1711.2002.01085.x

DOI

http://dx.doi.org/10.1046/j.1440-1711.2002.01085.x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1033872157

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12121221


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Actin Cytoskeleton", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Adhesion", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Culture Media", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytoskeletal Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Heterogeneous-Nuclear Ribonucleoprotein D", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interleukin-1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Intermediate Filaments", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kinetics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mitogen-Activated Protein Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Monocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA Stability", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Messenger", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA-Binding Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcription, Genetic", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of North Carolina at Chapel Hill", 
          "id": "https://www.grid.ac/institutes/grid.10698.36", 
          "name": [
            "Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, North Carolina, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sirenko", 
        "givenName": "Oksana", 
        "id": "sg:person.013662560064.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013662560064.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Medical Centre Mannheim", 
          "id": "https://www.grid.ac/institutes/grid.411778.c", 
          "name": [
            "Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, North Carolina, USA", 
            "Department of Medicine II, University Hospital Mannheim, University of Heidelberg, Medical Faculty of Mannheim, Mannheim, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "B\u00f6cker", 
        "givenName": "Ulrich", 
        "id": "sg:person.01054673652.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054673652.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of North Carolina at Chapel Hill", 
          "id": "https://www.grid.ac/institutes/grid.10698.36", 
          "name": [
            "Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, North Carolina, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Morris", 
        "givenName": "John S", 
        "id": "sg:person.015624150302.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015624150302.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of North Carolina at Chapel Hill", 
          "id": "https://www.grid.ac/institutes/grid.10698.36", 
          "name": [
            "Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, North Carolina, USA", 
            "Department of Obstetrics/Gynecology and Microbiology/Immunology, University of North Carolina at Chapel Hill, North Carolina, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Haskill", 
        "givenName": "J Stephen", 
        "id": "sg:person.01121150651.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121150651.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of North Carolina at Chapel Hill", 
          "id": "https://www.grid.ac/institutes/grid.10698.36", 
          "name": [
            "Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, North Carolina, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Watson", 
        "givenName": "Joanna M", 
        "id": "sg:person.012044107412.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012044107412.96"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1083/jcb.126.6.1585", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002444695"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00928931", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003433549", 
          "https://doi.org/10.1007/bf00928931"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.15.3.1737", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003968155"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1046/j.1440-1711.2001.01031.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004470398", 
          "https://doi.org/10.1046/j.1440-1711.2001.01031.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.141.5.1147", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004839967"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(05)80018-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006712740"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.11.5.2460", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011194372"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.89.19.9034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011783080"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.123.2.431", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012066365"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.17.7.3898", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012836412"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.83.6.1670", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015640488"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0014-5793(98)01342-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019919154"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci110338", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020621172"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.17.4.2158", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020809578"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(78)90031-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020853354"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0076-6879(90)81122-b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022507412"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.273.37.24266", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022597492"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.112.4.653", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023221334"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.91.7.2781", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023456176"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(92)90163-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024551498"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3181/00379727-200-43425", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027352094"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3181/00379727-200-43425", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027352094"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.270.38.22167", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027377410"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.13.12.7652", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028021305"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.17.8.4870", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030460530"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.126.5.1211", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032189129"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.123.2.269", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032245431"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.107.4.1517", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033617565"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1432-1033.1997.00730.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034352747"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/geno.1996.0269", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034922162"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-1759(79)90268-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042234930"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-1759(79)90268-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042234930"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bies.950151004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042330990"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bst0191108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042660007"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bst0191108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042660007"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00234167", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043097012", 
          "https://doi.org/10.1007/bf00234167"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00234167", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043097012", 
          "https://doi.org/10.1007/bf00234167"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0309-1651(05)80003-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044707087"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.134.4.971", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044940609"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(93)80043-e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045209738"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/1357-2725(96)00059-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046473821"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(95)90324-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046753588"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0169(1996)35:4<345::aid-cm6>3.0.co;2-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047095277"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0896-6273(94)90213-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047927740"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.16.10.5579", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050446974"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.119.5.1245", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051413650"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.273.35.22317", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051599147"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/17.20.6039", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052002386"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.271.21.12179", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052025810"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj2770001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052380490"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj2770001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052380490"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi00591a005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055181913"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1891715", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062512040"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.280.5371.1945", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062561507"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.8036511", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062652041"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpheart.1999.276.6.h2013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074473798"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jlb.67.2.216", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074589484"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077313035", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078691177", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078705336", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079645566", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082427086", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082499560", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082821473", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083008339", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083070655", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2002-08", 
    "datePublishedReg": "2002-08-01", 
    "description": "Monocyte extravasation initiates reorganization of the cytoskeleton (CSK) and adhesion-dependent cytokine gene transcription. The actin CSK is thought to be crucial for compartmentalization and translation of mRNA, many of which contain AU-rich (ARE) instability motifs in the 3' untranslated region. We investigated regulation of adhesion-induced IL-1 beta expression by the monocyte CSK. In serum-free adherent monocytes, the induced IL-1 beta mRNA was stable and did not coextract with actin filaments. In contrast, in cells adherent in autologous serum, IL-1 beta transcripts were unstable, coextracted with actin filaments and were associated with only transient activation of the mitogen-activated protein kinases (MAPK). Under both conditions of adherence, the ARE-binding protein AUF1/hnRNP D was readily extracted in the cytosolic fraction. Electro-injection with AUF1/hnRNP D modified the actin CSK and, surprisingly, stabilized IL-1 beta transcripts. These data suggest that the control of mRNA degradation is linked with changes in the CSK. Mitogen-activated protein kinase activation or alterations in the availability of mRNA degradation factors may mediate these effects.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1046/j.1440-1711.2002.01085.x", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2451485", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1019561", 
        "issn": [
          "0818-9641", 
          "1440-1711"
        ], 
        "name": "Immunology and Cell Biology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "80"
      }
    ], 
    "name": "IL-1\u03b2 transcript stability in monocytes is linked to cytoskeletal reorganization and the availability of mRNA degradation factors", 
    "pagination": "328", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "a15bbabb74ebcfacf4e5ea3efc163427579e897bbc328ca870a9e7e251603203"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "12121221"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8706300"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1046/j.1440-1711.2002.01085.x"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1033872157"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1046/j.1440-1711.2002.01085.x", 
      "https://app.dimensions.ai/details/publication/pub.1033872157"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T21:29", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8687_00000475.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/icb200246"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1046/j.1440-1711.2002.01085.x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1046/j.1440-1711.2002.01085.x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1046/j.1440-1711.2002.01085.x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1046/j.1440-1711.2002.01085.x'


 

This table displays all metadata directly associated to this object as RDF triples.

349 TRIPLES      21 PREDICATES      107 URIs      38 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1046/j.1440-1711.2002.01085.x schema:about N3f33ce29059c4b9296760e2f6db82fb6
2 N4c504abaca6b40afac9083e9829e9a14
3 N5cb5ac2c13284678bfafbfd1a1e29411
4 N6cc5cce81853456fa23303f96629ee6d
5 N774200f15be64007909e0744c9e35ee2
6 N7dfbef5735144659b3f42d5786c681ab
7 N7ec9c0c39d3c411da1eb9baf5ed1bc5f
8 N921305a34fc04fcd9bec81b560b06ea1
9 N98b92eac29de4df48b989ed7ca916d8b
10 N9a92a36387e845cf822a7fe1e20ea70f
11 N9c118ae4ecdc4aab944657faefb7acc1
12 Nb9a08c498ed64cb29309941a3eb42480
13 Nc41e6e9f7d754008b904874a44060b9b
14 Nce7e7204e9824f81b2aecad9218a64bc
15 Nf48f3eeacfb7486b980431a8955693eb
16 Nf5139d7d1f0a4669a02073ede57768bb
17 Nffd524bd9e604ba38b293a7531af64f3
18 anzsrc-for:06
19 anzsrc-for:0601
20 schema:author N97c72b7c9ae940d2827d25a8d64a8f4b
21 schema:citation sg:pub.10.1007/bf00234167
22 sg:pub.10.1007/bf00928931
23 sg:pub.10.1046/j.1440-1711.2001.01031.x
24 https://app.dimensions.ai/details/publication/pub.1077313035
25 https://app.dimensions.ai/details/publication/pub.1078691177
26 https://app.dimensions.ai/details/publication/pub.1078705336
27 https://app.dimensions.ai/details/publication/pub.1079645566
28 https://app.dimensions.ai/details/publication/pub.1082427086
29 https://app.dimensions.ai/details/publication/pub.1082499560
30 https://app.dimensions.ai/details/publication/pub.1082821473
31 https://app.dimensions.ai/details/publication/pub.1083008339
32 https://app.dimensions.ai/details/publication/pub.1083070655
33 https://doi.org/10.1002/(sici)1097-0169(1996)35:4<345::aid-cm6>3.0.co;2-5
34 https://doi.org/10.1002/bies.950151004
35 https://doi.org/10.1002/jlb.67.2.216
36 https://doi.org/10.1006/geno.1996.0269
37 https://doi.org/10.1016/0022-1759(79)90268-0
38 https://doi.org/10.1016/0076-6879(90)81122-b
39 https://doi.org/10.1016/0092-8674(78)90031-4
40 https://doi.org/10.1016/0092-8674(92)90163-7
41 https://doi.org/10.1016/0092-8674(93)80043-e
42 https://doi.org/10.1016/0092-8674(95)90324-0
43 https://doi.org/10.1016/0896-6273(94)90213-5
44 https://doi.org/10.1016/1357-2725(96)00059-3
45 https://doi.org/10.1016/s0014-5793(98)01342-8
46 https://doi.org/10.1016/s0092-8674(05)80018-2
47 https://doi.org/10.1016/s0309-1651(05)80003-7
48 https://doi.org/10.1021/bi00591a005
49 https://doi.org/10.1042/bj2770001
50 https://doi.org/10.1042/bst0191108
51 https://doi.org/10.1073/pnas.83.6.1670
52 https://doi.org/10.1073/pnas.89.19.9034
53 https://doi.org/10.1073/pnas.91.7.2781
54 https://doi.org/10.1074/jbc.270.38.22167
55 https://doi.org/10.1074/jbc.271.21.12179
56 https://doi.org/10.1074/jbc.273.35.22317
57 https://doi.org/10.1074/jbc.273.37.24266
58 https://doi.org/10.1083/jcb.107.4.1517
59 https://doi.org/10.1083/jcb.112.4.653
60 https://doi.org/10.1083/jcb.119.5.1245
61 https://doi.org/10.1083/jcb.123.2.269
62 https://doi.org/10.1083/jcb.123.2.431
63 https://doi.org/10.1083/jcb.126.5.1211
64 https://doi.org/10.1083/jcb.126.6.1585
65 https://doi.org/10.1083/jcb.134.4.971
66 https://doi.org/10.1083/jcb.141.5.1147
67 https://doi.org/10.1093/emboj/17.20.6039
68 https://doi.org/10.1111/j.1432-1033.1997.00730.x
69 https://doi.org/10.1126/science.1891715
70 https://doi.org/10.1126/science.280.5371.1945
71 https://doi.org/10.1126/science.8036511
72 https://doi.org/10.1128/mcb.11.5.2460
73 https://doi.org/10.1128/mcb.13.12.7652
74 https://doi.org/10.1128/mcb.15.3.1737
75 https://doi.org/10.1128/mcb.16.10.5579
76 https://doi.org/10.1128/mcb.17.4.2158
77 https://doi.org/10.1128/mcb.17.7.3898
78 https://doi.org/10.1128/mcb.17.8.4870
79 https://doi.org/10.1152/ajpheart.1999.276.6.h2013
80 https://doi.org/10.1172/jci110338
81 https://doi.org/10.3181/00379727-200-43425
82 schema:datePublished 2002-08
83 schema:datePublishedReg 2002-08-01
84 schema:description Monocyte extravasation initiates reorganization of the cytoskeleton (CSK) and adhesion-dependent cytokine gene transcription. The actin CSK is thought to be crucial for compartmentalization and translation of mRNA, many of which contain AU-rich (ARE) instability motifs in the 3' untranslated region. We investigated regulation of adhesion-induced IL-1 beta expression by the monocyte CSK. In serum-free adherent monocytes, the induced IL-1 beta mRNA was stable and did not coextract with actin filaments. In contrast, in cells adherent in autologous serum, IL-1 beta transcripts were unstable, coextracted with actin filaments and were associated with only transient activation of the mitogen-activated protein kinases (MAPK). Under both conditions of adherence, the ARE-binding protein AUF1/hnRNP D was readily extracted in the cytosolic fraction. Electro-injection with AUF1/hnRNP D modified the actin CSK and, surprisingly, stabilized IL-1 beta transcripts. These data suggest that the control of mRNA degradation is linked with changes in the CSK. Mitogen-activated protein kinase activation or alterations in the availability of mRNA degradation factors may mediate these effects.
85 schema:genre research_article
86 schema:inLanguage en
87 schema:isAccessibleForFree true
88 schema:isPartOf Nb24de1047a98449d9be77aab55ea23e7
89 Ncb92f56398a943a2af68835be3f801cd
90 sg:journal.1019561
91 schema:name IL-1β transcript stability in monocytes is linked to cytoskeletal reorganization and the availability of mRNA degradation factors
92 schema:pagination 328
93 schema:productId N1194c6cdd0554cac9c225e17f2196c30
94 N1ff97a407c5c4762a40057156fef738f
95 N2e1bceed5fbd4f3fafe2d8713ad3cd1a
96 Nec81374fd33e489997cbed92337d4bc0
97 Nfda62a489c0f41cd99c96bc88375c6b0
98 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033872157
99 https://doi.org/10.1046/j.1440-1711.2002.01085.x
100 schema:sdDatePublished 2019-04-10T21:29
101 schema:sdLicense https://scigraph.springernature.com/explorer/license/
102 schema:sdPublisher N8f8416e9495344db808ff1a584a07f1b
103 schema:url https://www.nature.com/articles/icb200246
104 sgo:license sg:explorer/license/
105 sgo:sdDataset articles
106 rdf:type schema:ScholarlyArticle
107 N1194c6cdd0554cac9c225e17f2196c30 schema:name readcube_id
108 schema:value a15bbabb74ebcfacf4e5ea3efc163427579e897bbc328ca870a9e7e251603203
109 rdf:type schema:PropertyValue
110 N13df1aef10a64d7098db207f519dc479 rdf:first sg:person.01121150651.54
111 rdf:rest N3ceda0738da746ff9634fc94f6f54a67
112 N1ff97a407c5c4762a40057156fef738f schema:name nlm_unique_id
113 schema:value 8706300
114 rdf:type schema:PropertyValue
115 N2e1bceed5fbd4f3fafe2d8713ad3cd1a schema:name dimensions_id
116 schema:value pub.1033872157
117 rdf:type schema:PropertyValue
118 N353f3af5f22e4ad29a37a0e4a7439cc0 rdf:first sg:person.015624150302.80
119 rdf:rest N13df1aef10a64d7098db207f519dc479
120 N3ceda0738da746ff9634fc94f6f54a67 rdf:first sg:person.012044107412.96
121 rdf:rest rdf:nil
122 N3f33ce29059c4b9296760e2f6db82fb6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Intermediate Filaments
124 rdf:type schema:DefinedTerm
125 N4c504abaca6b40afac9083e9829e9a14 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Humans
127 rdf:type schema:DefinedTerm
128 N5cb5ac2c13284678bfafbfd1a1e29411 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Cytoskeletal Proteins
130 rdf:type schema:DefinedTerm
131 N6cc5cce81853456fa23303f96629ee6d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Heterogeneous-Nuclear Ribonucleoprotein D
133 rdf:type schema:DefinedTerm
134 N774200f15be64007909e0744c9e35ee2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name RNA-Binding Proteins
136 rdf:type schema:DefinedTerm
137 N7dfbef5735144659b3f42d5786c681ab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Monocytes
139 rdf:type schema:DefinedTerm
140 N7ec9c0c39d3c411da1eb9baf5ed1bc5f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Signal Transduction
142 rdf:type schema:DefinedTerm
143 N8f8416e9495344db808ff1a584a07f1b schema:name Springer Nature - SN SciGraph project
144 rdf:type schema:Organization
145 N921305a34fc04fcd9bec81b560b06ea1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Cells, Cultured
147 rdf:type schema:DefinedTerm
148 N97c72b7c9ae940d2827d25a8d64a8f4b rdf:first sg:person.013662560064.34
149 rdf:rest Nccb0f3d72cd349cca3c16f76daaf9dbe
150 N98b92eac29de4df48b989ed7ca916d8b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Mitogen-Activated Protein Kinases
152 rdf:type schema:DefinedTerm
153 N9a92a36387e845cf822a7fe1e20ea70f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Interleukin-1
155 rdf:type schema:DefinedTerm
156 N9c118ae4ecdc4aab944657faefb7acc1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Culture Media
158 rdf:type schema:DefinedTerm
159 Nb24de1047a98449d9be77aab55ea23e7 schema:volumeNumber 80
160 rdf:type schema:PublicationVolume
161 Nb9a08c498ed64cb29309941a3eb42480 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name RNA, Messenger
163 rdf:type schema:DefinedTerm
164 Nc41e6e9f7d754008b904874a44060b9b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Transcription, Genetic
166 rdf:type schema:DefinedTerm
167 Ncb92f56398a943a2af68835be3f801cd schema:issueNumber 4
168 rdf:type schema:PublicationIssue
169 Nccb0f3d72cd349cca3c16f76daaf9dbe rdf:first sg:person.01054673652.43
170 rdf:rest N353f3af5f22e4ad29a37a0e4a7439cc0
171 Nce7e7204e9824f81b2aecad9218a64bc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name RNA Stability
173 rdf:type schema:DefinedTerm
174 Nec81374fd33e489997cbed92337d4bc0 schema:name pubmed_id
175 schema:value 12121221
176 rdf:type schema:PropertyValue
177 Nf48f3eeacfb7486b980431a8955693eb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Cell Adhesion
179 rdf:type schema:DefinedTerm
180 Nf5139d7d1f0a4669a02073ede57768bb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Kinetics
182 rdf:type schema:DefinedTerm
183 Nfda62a489c0f41cd99c96bc88375c6b0 schema:name doi
184 schema:value 10.1046/j.1440-1711.2002.01085.x
185 rdf:type schema:PropertyValue
186 Nffd524bd9e604ba38b293a7531af64f3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Actin Cytoskeleton
188 rdf:type schema:DefinedTerm
189 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
190 schema:name Biological Sciences
191 rdf:type schema:DefinedTerm
192 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
193 schema:name Biochemistry and Cell Biology
194 rdf:type schema:DefinedTerm
195 sg:grant.2451485 http://pending.schema.org/fundedItem sg:pub.10.1046/j.1440-1711.2002.01085.x
196 rdf:type schema:MonetaryGrant
197 sg:journal.1019561 schema:issn 0818-9641
198 1440-1711
199 schema:name Immunology and Cell Biology
200 rdf:type schema:Periodical
201 sg:person.01054673652.43 schema:affiliation https://www.grid.ac/institutes/grid.411778.c
202 schema:familyName Böcker
203 schema:givenName Ulrich
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054673652.43
205 rdf:type schema:Person
206 sg:person.01121150651.54 schema:affiliation https://www.grid.ac/institutes/grid.10698.36
207 schema:familyName Haskill
208 schema:givenName J Stephen
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121150651.54
210 rdf:type schema:Person
211 sg:person.012044107412.96 schema:affiliation https://www.grid.ac/institutes/grid.10698.36
212 schema:familyName Watson
213 schema:givenName Joanna M
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012044107412.96
215 rdf:type schema:Person
216 sg:person.013662560064.34 schema:affiliation https://www.grid.ac/institutes/grid.10698.36
217 schema:familyName Sirenko
218 schema:givenName Oksana
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013662560064.34
220 rdf:type schema:Person
221 sg:person.015624150302.80 schema:affiliation https://www.grid.ac/institutes/grid.10698.36
222 schema:familyName Morris
223 schema:givenName John S
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015624150302.80
225 rdf:type schema:Person
226 sg:pub.10.1007/bf00234167 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043097012
227 https://doi.org/10.1007/bf00234167
228 rdf:type schema:CreativeWork
229 sg:pub.10.1007/bf00928931 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003433549
230 https://doi.org/10.1007/bf00928931
231 rdf:type schema:CreativeWork
232 sg:pub.10.1046/j.1440-1711.2001.01031.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004470398
233 https://doi.org/10.1046/j.1440-1711.2001.01031.x
234 rdf:type schema:CreativeWork
235 https://app.dimensions.ai/details/publication/pub.1077313035 schema:CreativeWork
236 https://app.dimensions.ai/details/publication/pub.1078691177 schema:CreativeWork
237 https://app.dimensions.ai/details/publication/pub.1078705336 schema:CreativeWork
238 https://app.dimensions.ai/details/publication/pub.1079645566 schema:CreativeWork
239 https://app.dimensions.ai/details/publication/pub.1082427086 schema:CreativeWork
240 https://app.dimensions.ai/details/publication/pub.1082499560 schema:CreativeWork
241 https://app.dimensions.ai/details/publication/pub.1082821473 schema:CreativeWork
242 https://app.dimensions.ai/details/publication/pub.1083008339 schema:CreativeWork
243 https://app.dimensions.ai/details/publication/pub.1083070655 schema:CreativeWork
244 https://doi.org/10.1002/(sici)1097-0169(1996)35:4<345::aid-cm6>3.0.co;2-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047095277
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1002/bies.950151004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042330990
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1002/jlb.67.2.216 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074589484
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1006/geno.1996.0269 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034922162
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1016/0022-1759(79)90268-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042234930
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1016/0076-6879(90)81122-b schema:sameAs https://app.dimensions.ai/details/publication/pub.1022507412
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1016/0092-8674(78)90031-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020853354
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1016/0092-8674(92)90163-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024551498
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1016/0092-8674(93)80043-e schema:sameAs https://app.dimensions.ai/details/publication/pub.1045209738
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1016/0092-8674(95)90324-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046753588
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1016/0896-6273(94)90213-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047927740
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1016/1357-2725(96)00059-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046473821
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1016/s0014-5793(98)01342-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019919154
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1016/s0092-8674(05)80018-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006712740
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1016/s0309-1651(05)80003-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044707087
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1021/bi00591a005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055181913
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1042/bj2770001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052380490
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1042/bst0191108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042660007
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1073/pnas.83.6.1670 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015640488
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1073/pnas.89.19.9034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011783080
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1073/pnas.91.7.2781 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023456176
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1074/jbc.270.38.22167 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027377410
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1074/jbc.271.21.12179 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052025810
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1074/jbc.273.35.22317 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051599147
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1074/jbc.273.37.24266 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022597492
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1083/jcb.107.4.1517 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033617565
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1083/jcb.112.4.653 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023221334
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1083/jcb.119.5.1245 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051413650
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1083/jcb.123.2.269 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032245431
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1083/jcb.123.2.431 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012066365
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1083/jcb.126.5.1211 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032189129
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1083/jcb.126.6.1585 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002444695
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1083/jcb.134.4.971 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044940609
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1083/jcb.141.5.1147 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004839967
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1093/emboj/17.20.6039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052002386
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1111/j.1432-1033.1997.00730.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1034352747
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1126/science.1891715 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062512040
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1126/science.280.5371.1945 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062561507
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1126/science.8036511 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062652041
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1128/mcb.11.5.2460 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011194372
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1128/mcb.13.12.7652 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028021305
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1128/mcb.15.3.1737 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003968155
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1128/mcb.16.10.5579 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050446974
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1128/mcb.17.4.2158 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020809578
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1128/mcb.17.7.3898 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012836412
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1128/mcb.17.8.4870 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030460530
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1152/ajpheart.1999.276.6.h2013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074473798
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1172/jci110338 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020621172
339 rdf:type schema:CreativeWork
340 https://doi.org/10.3181/00379727-200-43425 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027352094
341 rdf:type schema:CreativeWork
342 https://www.grid.ac/institutes/grid.10698.36 schema:alternateName University of North Carolina at Chapel Hill
343 schema:name Department of Obstetrics/Gynecology and Microbiology/Immunology, University of North Carolina at Chapel Hill, North Carolina, USA
344 Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, North Carolina, USA
345 rdf:type schema:Organization
346 https://www.grid.ac/institutes/grid.411778.c schema:alternateName University Medical Centre Mannheim
347 schema:name Department of Medicine II, University Hospital Mannheim, University of Heidelberg, Medical Faculty of Mannheim, Mannheim, Germany
348 Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, North Carolina, USA
349 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...