Ontology type: schema:ScholarlyArticle Open Access: True
1999-02
AUTHORSHideki Tsumura, Mitsuo Kawano, Masanori Tajima, Takashi Kusaura, Yuuji Kozuka, Satoshi Yoshimura, Hiroshi Komada, Masato Tsurudome, Machiko Nishio, Shigeru Kusagawa, Keishirou Shimura, Yasuhiko Ito
ABSTRACTNineteen mAb directed against murine fusion regulatory protein-1 (mFRP-1)/4F2/CD98 were isolated and their biological properties were analysed. Intriguingly, mFRP-1 was found to be an alloantigen, namely, FRP-1.1 (DBA/2 and CBA mice type) and FRP-1.2 (BALB/c, C57BL/6 and C3H/He mice type). The nucleotide sequences of FRP-1.1 and FRP-1.2 were determined, demonstrating that amino acid change at 129 (P<-->R) is related to the alloantigenicity. mFRP-1 is expressed on thymocytes, on spleen cells, on peripheral lymphocytes and on blood monocytes, suggesting that the physiological role in vivo of murine FRP-1 is different from that of human FRP-1. The biological activities of antimFRP-1 mAbs showed by the present study are: (i) enhancement of Newcastle disease virus-induced cell fusion; (ii) suppression of HIVgp160-mediated cell fusion; and (iii) induction of aggregation and multinucleated giant cells of monocytes/macrophages. More... »
PAGES19
http://scigraph.springernature.com/pub.10.1046/j.1440-1711.1999.00792.x
DOIhttp://dx.doi.org/10.1046/j.1440-1711.1999.00792.x
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