Characteristics of the immunological response in the clearance of non-typeable Haemophilus influenzae from the lung View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1998-07

AUTHORS

A Ruth Foxwell, Jennelle M Kyd, Allan W Cripps

ABSTRACT

Clearance of non-typeable Haemophilus influenzae (NTHi) from the respiratory tract was investigated, over time, in immune and non-immune rats. A triphasic pattern characterized the clearance of bacteria from the lungs. Mucosal immunization enhanced bacterial clearance from the lungs in each of the three phases compared with clearance from non-immunized animals. Total clearance of bacteria was observed from lung tissue by 12 h in immune animals and 24 h in non-immune animals. Polymorphonuclear leucocytes not only arrived earlier and initially in greater numbers, but disappeared earlier in immune animals (peaking at 8 h post-challenge), compared with non-immune animals (peaking at 12h post-challenge). Systemically derived and locally produced NTHi-specific IgA and IgG correlated with enhanced bacterial clearance during the secondary phase. This model demonstrates that immunized animals up-regulate and resolve inflammatory responses to pulmonary infection more rapidly than the non-immunized controls. More... »

PAGES

323

Identifiers

URI

http://scigraph.springernature.com/pub.10.1046/j.1440-1711.1998.00740.x

DOI

http://dx.doi.org/10.1046/j.1440-1711.1998.00740.x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026197514

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9723773


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